MOAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MOAP1
Entrez Gene ID	64112
Full Name	modulator of apoptosis 1
Synonyms	MAP-1,PNMA4
General protein information	Preferred Names modulator of apoptosis 1 Names modulator of apoptosis 1 MAP1 paraneoplastic Ma antigen family member 4 paraneoplastic antigen Ma4 paraneoplastic antigen like 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.12
Summary	The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	609485

mRNA and Protein(s)

mRNA	Protein	Name
NM_022151.5	NP_071434.2	modulator of apoptosis 1
NM_022151.4	NP_071434.2	modulator of apoptosis 1

Pathways from BioSystems

Homologies

	MOAP1	XP_001089203.1
Homo sapiens (human)	MOAP1	NP_071434.2
Mus musculus (house mouse)	Moap1	NP_071718.1
	PNMA2	XP_001089776.1
Rattus norvegicus (Norway rat)	Moap1	NP_001013119.1
Pan troglodytes (chimpanzee)	MOAP1	XP_510137.2

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.
Matsuura K, Huang NJ, Cocce K, Zhang L, Kornbluth S
Oncogene36(12)1698-1706(2017 Mar)

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.
Tan CT, Zhou QL, Su YC, Fu NY, Chang HC, Tao RN, Sukumaran SK, Baksh S, Tan YJ, Sabapathy K, Yu CD, Yu VC
Cell reports16(1)174-185(2016 06)

PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.
Lee YH, Pang SW, Tan KO
Biochemical and biophysical research communications473(1)224-229(2016 Apr)

Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.
Law J, Salla M, Zare A, Wong Y, Luong L, Volodko N, Svystun O, Flood K, Lim J, Sung M, Dyck JR, Tan CT, Su YC, Yu VC, Mackey J, Baksh S
The Journal of biological chemistry290(40)24100-18(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UBR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.
Title: Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.

These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria.
Title: MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.

PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction
Title: PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.

MOAP-1 is a tumor suppressor protein linked to the RASSF1A protein
Title: Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.

miR-25 promotes cell proliferation and inhibits apoptosis in non-small cell lung cancer cells by negatively regulating MOAP1 expression.
Title: miR-25 targets the modulator of apoptosis 1 gene in lung cancer.

The following MOAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13816	NM_022151.5 Latest version!	Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu13816	NM_022151.4	Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MOAP1 ( NM_022151.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_071434.2 Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.

Price & Availability↑

CloneID	OHu13816
Clone ID Related Accession (Same CDS sequence)	NM_022151.5 , NM_022151.4
Accession Version	NM_022151.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	modulator of apoptosis 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG699993.1 and BC015044.1. On Nov 22, 2018 this sequence version replaced NM_022151.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.963213.1, SRR3476690.306588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151358, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298894.5/ ENSP00000298894.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTTTGA GGCTTTTAGA AGACTGGTGC AGGGGGATGG ACATGAACCC TCGGAAAGCG 
CTATTGATTG CCGGCATCTC CCAGAGCTGC AGTGTGGCAG AAATCGAGGA GGCTCTGCAG 
GCTGGTTTAG CTCCCTTGGG GGAGTACAGA CTGCTTGGAA GGATGTTCAG GAGGGATGAG 
AACAGGAAAG TAGCCTTAGT AGGGCTTACT GCGGAGACTA GTCACGCCCT GGTCCCTAAG 
GAGATACCGG GAAAAGGGGG TATCTGGAGA GTGATCTTTA AGCCCCCTGA CCCAGATAAT 
ACATTTTTAA GCAGATTAAA TGAATTTTTA GCGGGAGAGG GCATGACAGT GGGTGAGTTG 
AGCAGAGCTC TTGGACATGA AAATGGCTCC TTAGACCCAG AGCAGGGCAT GATCCCGGAA 
ATGTGGGCCC CTATGTTGGC ACAGGCATTA GAGGCTCTTC AGCCTGCCCT GCAATGCTTG 
AAGTATAAAA AGCTGAGAGT GTTCTCGGGC AGGGAGTCTC CAGAACCAGG AGAAGAAGAA 
TTTGGACGCT GGATGTTTCA TACTACTCAG ATGATAAAGG CGTGGCAGGT GCCAGATGTA 
GAGAAGAGAA GGCGATTGCT AGAGAGCCTT CGAGGCCCAG CACTTGATGT TATTCGTGTC 
CTCAAGATAA ACAATCCTTT AATTACTGTC GATGAATGTC TGCAGGCTCT TGAGGAGGTA 
TTTGGGGTTA CAGATAATCC TAGGGAGTTG CAGGTCAAAT ATCTAACCAC TTACCAGAAG 
GATGAGGAAA AGTTGTCGGC TTATGTACTA AGGCTGGAGC CTTTGTTACA GAAGCTGGTA 
CAGAGAGGAG CAATTGAGAG AGATGCTGTG AATCAGGCCC GCCTAGACCA AGTCATTGCT 
GGGGCAGTCC ACAAAACAAT TCGCAGAGAG CTTAATCTGC CAGAGGATGG CCCAGCCCCT 
GGTTTCTTGC AGTTATTGGT ACTAATAAAG GATTATGAGG CAGCTGAGGA GGAGGAGGCC 
CTTCTCCAGG CAATATTGGA AGGTAATTTC ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071434.2
CDS	364..1419
Translation	MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT

Target ORF information:

RefSeq Version	NM_022151.5
Organism	Homo sapiens(human)
Definition	Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022151.5

ORF Insert Sequence:

ATGACTTTGA GGCTTTTAGA AGACTGGTGC AGGGGGATGG ACATGAACCC TCGGAAAGCG 
CTATTGATTG CCGGCATCTC CCAGAGCTGC AGTGTGGCAG AAATCGAGGA GGCTCTGCAG 
GCTGGTTTAG CTCCCTTGGG GGAGTACAGA CTGCTTGGAA GGATGTTCAG GAGGGATGAG 
AACAGGAAAG TAGCCTTAGT AGGGCTTACT GCGGAGACTA GTCACGCCCT GGTCCCTAAG 
GAGATACCGG GAAAAGGGGG TATCTGGAGA GTGATCTTTA AGCCCCCTGA CCCAGATAAT 
ACATTTTTAA GCAGATTAAA TGAATTTTTA GCGGGAGAGG GCATGACAGT GGGTGAGTTG 
AGCAGAGCTC TTGGACATGA AAATGGCTCC TTAGACCCAG AGCAGGGCAT GATCCCGGAA 
ATGTGGGCCC CTATGTTGGC ACAGGCATTA GAGGCTCTTC AGCCTGCCCT GCAATGCTTG 
AAGTATAAAA AGCTGAGAGT GTTCTCGGGC AGGGAGTCTC CAGAACCAGG AGAAGAAGAA 
TTTGGACGCT GGATGTTTCA TACTACTCAG ATGATAAAGG CGTGGCAGGT GCCAGATGTA 
GAGAAGAGAA GGCGATTGCT AGAGAGCCTT CGAGGCCCAG CACTTGATGT TATTCGTGTC 
CTCAAGATAA ACAATCCTTT AATTACTGTC GATGAATGTC TGCAGGCTCT TGAGGAGGTA 
TTTGGGGTTA CAGATAATCC TAGGGAGTTG CAGGTCAAAT ATCTAACCAC TTACCAGAAG 
GATGAGGAAA AGTTGTCGGC TTATGTACTA AGGCTGGAGC CTTTGTTACA GAAGCTGGTA 
CAGAGAGGAG CAATTGAGAG AGATGCTGTG AATCAGGCCC GCCTAGACCA AGTCATTGCT 
GGGGCAGTCC ACAAAACAAT TCGCAGAGAG CTTAATCTGC CAGAGGATGG CCCAGCCCCT 
GGTTTCTTGC AGTTATTGGT ACTAATAAAG GATTATGAGG CAGCTGAGGA GGAGGAGGCC 
CTTCTCCAGG CAATATTGGA AGGTAATTTC ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOAP1 ( NM_022151.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071434.2 Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.

Price & Availability↑

CloneID	OHu13816
Clone ID Related Accession (Same CDS sequence)	NM_022151.5 , NM_022151.4
Accession Version	NM_022151.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	modulator of apoptosis 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG699993.1, BC015044.1 and BG475323.1. On Aug 24, 2005 this sequence version replaced NM_022151.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.109114.1, SRR1660803.88983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151358, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTTGA GGCTTTTAGA AGACTGGTGC AGGGGGATGG ACATGAACCC TCGGAAAGCG 
CTATTGATTG CCGGCATCTC CCAGAGCTGC AGTGTGGCAG AAATCGAGGA GGCTCTGCAG 
GCTGGTTTAG CTCCCTTGGG GGAGTACAGA CTGCTTGGAA GGATGTTCAG GAGGGATGAG 
AACAGGAAAG TAGCCTTAGT AGGGCTTACT GCGGAGACTA GTCACGCCCT GGTCCCTAAG 
GAGATACCGG GAAAAGGGGG TATCTGGAGA GTGATCTTTA AGCCCCCTGA CCCAGATAAT 
ACATTTTTAA GCAGATTAAA TGAATTTTTA GCGGGAGAGG GCATGACAGT GGGTGAGTTG 
AGCAGAGCTC TTGGACATGA AAATGGCTCC TTAGACCCAG AGCAGGGCAT GATCCCGGAA 
ATGTGGGCCC CTATGTTGGC ACAGGCATTA GAGGCTCTTC AGCCTGCCCT GCAATGCTTG 
AAGTATAAAA AGCTGAGAGT GTTCTCGGGC AGGGAGTCTC CAGAACCAGG AGAAGAAGAA 
TTTGGACGCT GGATGTTTCA TACTACTCAG ATGATAAAGG CGTGGCAGGT GCCAGATGTA 
GAGAAGAGAA GGCGATTGCT AGAGAGCCTT CGAGGCCCAG CACTTGATGT TATTCGTGTC 
CTCAAGATAA ACAATCCTTT AATTACTGTC GATGAATGTC TGCAGGCTCT TGAGGAGGTA 
TTTGGGGTTA CAGATAATCC TAGGGAGTTG CAGGTCAAAT ATCTAACCAC TTACCAGAAG 
GATGAGGAAA AGTTGTCGGC TTATGTACTA AGGCTGGAGC CTTTGTTACA GAAGCTGGTA 
CAGAGAGGAG CAATTGAGAG AGATGCTGTG AATCAGGCCC GCCTAGACCA AGTCATTGCT 
GGGGCAGTCC ACAAAACAAT TCGCAGAGAG CTTAATCTGC CAGAGGATGG CCCAGCCCCT 
GGTTTCTTGC AGTTATTGGT ACTAATAAAG GATTATGAGG CAGCTGAGGA GGAGGAGGCC 
CTTCTCCAGG CAATATTGGA AGGTAATTTC ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071434.2
CDS	371..1426
Translation	MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT

Target ORF information:

RefSeq Version	NM_022151.4
Organism	Homo sapiens(human)
Definition	Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022151.4

ORF Insert Sequence:

ATGACTTTGA GGCTTTTAGA AGACTGGTGC AGGGGGATGG ACATGAACCC TCGGAAAGCG 
CTATTGATTG CCGGCATCTC CCAGAGCTGC AGTGTGGCAG AAATCGAGGA GGCTCTGCAG 
GCTGGTTTAG CTCCCTTGGG GGAGTACAGA CTGCTTGGAA GGATGTTCAG GAGGGATGAG 
AACAGGAAAG TAGCCTTAGT AGGGCTTACT GCGGAGACTA GTCACGCCCT GGTCCCTAAG 
GAGATACCGG GAAAAGGGGG TATCTGGAGA GTGATCTTTA AGCCCCCTGA CCCAGATAAT 
ACATTTTTAA GCAGATTAAA TGAATTTTTA GCGGGAGAGG GCATGACAGT GGGTGAGTTG 
AGCAGAGCTC TTGGACATGA AAATGGCTCC TTAGACCCAG AGCAGGGCAT GATCCCGGAA 
ATGTGGGCCC CTATGTTGGC ACAGGCATTA GAGGCTCTTC AGCCTGCCCT GCAATGCTTG 
AAGTATAAAA AGCTGAGAGT GTTCTCGGGC AGGGAGTCTC CAGAACCAGG AGAAGAAGAA 
TTTGGACGCT GGATGTTTCA TACTACTCAG ATGATAAAGG CGTGGCAGGT GCCAGATGTA 
GAGAAGAGAA GGCGATTGCT AGAGAGCCTT CGAGGCCCAG CACTTGATGT TATTCGTGTC 
CTCAAGATAA ACAATCCTTT AATTACTGTC GATGAATGTC TGCAGGCTCT TGAGGAGGTA 
TTTGGGGTTA CAGATAATCC TAGGGAGTTG CAGGTCAAAT ATCTAACCAC TTACCAGAAG 
GATGAGGAAA AGTTGTCGGC TTATGTACTA AGGCTGGAGC CTTTGTTACA GAAGCTGGTA 
CAGAGAGGAG CAATTGAGAG AGATGCTGTG AATCAGGCCC GCCTAGACCA AGTCATTGCT 
GGGGCAGTCC ACAAAACAAT TCGCAGAGAG CTTAATCTGC CAGAGGATGG CCCAGCCCCT 
GGTTTCTTGC AGTTATTGGT ACTAATAAAG GATTATGAGG CAGCTGAGGA GGAGGAGGCC 
CTTCTCCAGG CAATATTGGA AGGTAATTTC ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.
Oncogene36(12)1698-1706(2017 Mar)
Matsuura K,Huang NJ,Cocce K,Zhang L,Kornbluth S

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.
Cell reports16(1)174-185(2016 06)
Tan CT,Zhou QL,Su YC,Fu NY,Chang HC,Tao RN,Sukumaran SK,Baksh S,Tan YJ,Sabapathy K,Yu CD,Yu VC

PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.
Biochemical and biophysical research communications473(1)224-229(2016 Apr)
Lee YH,Pang SW,Tan KO

Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.
The Journal of biological chemistry290(40)24100-18(2015 Oct)
Law J,Salla M,Zare A,Wong Y,Luong L,Volodko N,Svystun O,Flood K,Lim J,Sung M,Dyck JR,Tan CT,Su YC,Yu VC,Mackey J,Baksh S

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MOAP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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