PERP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PERP
Entrez Gene ID	64065
Full Name	PERP, TP53 apoptosis effector
Synonyms	KCP1,KRTCAP1,PIGPC1,THW,dJ496H19.1
General protein information	Preferred Names PERP, TP53 apoptosis effector Names p53 apoptosis effector related to PMP-22 1110017A08Rik KCP-1 keratinocyte-associated protein 1 keratinocytes associated protein 1 p53 apoptosis effector related to PMP22 p53-induced protein PIGPC1 transmembrane protein THW
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q23.3
Disorder MIM:	609301

mRNA and Protein(s)

mRNA	Protein	Name
NM_022121.4	NP_071404.2	p53 apoptosis effector related to PMP-22
NM_022121.5	NP_071404.2	p53 apoptosis effector related to PMP-22
XM_024446520.1	XP_024302288.1	p53 apoptosis effector related to PMP-22 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC421682	NP_001264633.1
Gallus gallus (chicken)	PERP	NP_001264632.1
Homo sapiens (human)	PERP	NP_071404.2
Mus musculus (house mouse)	Perp	NP_071315.1
Canis lupus familiaris (dog)	PERP	XP_533423.1
Rattus norvegicus (Norway rat)	Perp	NP_001099735.1
Xenopus tropicalis (tropical clawed frog)	perp	NP_001165005.1
Bos taurus (cattle)	PERP	NP_001029522.1
	PERP	XP_001095578.1
Danio rerio (zebrafish)	perp	NP_001243136.1

Gene Ontology
Bibliography

Related articles in PubMed

Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors.
Kiseljak-Vassiliades K, Mills TS, Zhang Y, Xu M, Lillehei KO, Kleinschmidt-DeMasters BK, Wierman ME
Endocrinology158(5)1450-1460(2017 May)

p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma.
Awais R, Spiller DG, White MR, Paraoan L
British journal of cancer115(8)983-992(2016 Oct)

The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.
Hallstrom KN, McCormick BA
Gut microbes7(2)136-45(2016)

PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation.
Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA
Cellular microbiology17(6)843-59(2015 Jun)

Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.
Du Y, Deng L, Li Y, Gan L, Wang Y, Shi G
Clinical & developmental immunology2013256462(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of desmosomal formation transcripts including PERP may contribute to the aggressive phenotype seen in sparsely granulated GH pituitary tumors and their behavior in response to surgery and medical therapy.
Title: Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors.

Expression of p63-tGFP induces apoptosis with marked increase in PERP expression and associated p53 accumulation. Lack of p63 contributes to reduced PERP levels and impaired p53-mediated apoptosis in UM.
Title: p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma.

Salmonella Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface.
Title: The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.

The authors identified the tetraspanning membrane protein, p53 effector related to PMP-22 (PERP), as a Salmonella typhimurium SipA binding partner.
Title: PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation.

Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.
Title: Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.

The following PERP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PERP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17725	NM_022121.5 Latest version!	Homo sapiens p53 apoptosis effector related to PMP22 (PERP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu105826	XM_024446520.1 Latest version!	Homo sapiens p53 apoptosis effector related to PMP22 (PERP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu17725	NM_022121.4	Homo sapiens PERP, TP53 apoptosis effector (PERP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PERP ( NM_022121.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071404.2 Homo sapiens PERP, TP53 apoptosis effector (PERP), mRNA.

Price & Availability↑

CloneID	OHu17725
Clone ID Related Accession (Same CDS sequence)	NM_022121.4 , NM_022121.5
Accession Version	NM_022121.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	p53 apoptosis effector related to PMP-22
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX784592.1, BC010163.2, AL023582.1 and BU674771.1. On Jan 28, 2009 this sequence version replaced NM_022121.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CX784592.1, SRR1660803.32793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCGCT GCGGCCTGGC CTGCGAGCGC TGCCGCTGGA TCCTGCCCCT GCTCCTACTC 
AGCGCCATCG CCTTCGACAT CATCGCGCTG GCCGGCCGCG GCTGGTTGCA GTCTAGCGAC 
CACGGCCAGA CGTCCTCGCT GTGGTGGAAA TGCTCCCAAG AGGGCGGCGG CAGCGGGTCC 
TACGAGGAGG GCTGTCAGAG CCTCATGGAG TACGCGTGGG GTAGAGCAGC GGCTGCCATG 
CTCTTCTGTG GCTTCATCAT CCTGGTGATC TGTTTCATCC TCTCCTTCTT CGCCCTCTGT 
GGACCCCAGA TGCTTGTCTT CCTGAGAGTG ATTGGAGGTC TCCTTGCCTT GGCTGCTGTG 
TTCCAGATCA TCTCCCTGGT AATTTACCCC GTGAAGTACA CCCAGACCTT CACCCTTCAT 
GCCAACCCTG CTGTCACTTA CATCTATAAC TGGGCCTACG GCTTTGGGTG GGCAGCCACG 
ATTATCCTGA TTGGCTGTGC CTTCTTCTTC TGCTGCCTCC CCAACTACGA AGATGACCTT 
CTGGGCAATG CCAAGCCCAG GTACTTCTAC ACATCTGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071404.2
CDS	184..765
Translation	MIRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSDHGQTSSLWWKCSQEGGGSGSYEEGCQSLMEYAWGRAAAAMLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGWAATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA

Target ORF information:

RefSeq Version	NM_022121.4
Organism	Homo sapiens(human)
Definition	Homo sapiens PERP, TP53 apoptosis effector (PERP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022121.4

ORF Insert Sequence:

ATGATCCGCT GCGGCCTGGC CTGCGAGCGC TGCCGCTGGA TCCTGCCCCT GCTCCTACTC 
AGCGCCATCG CCTTCGACAT CATCGCGCTG GCCGGCCGCG GCTGGTTGCA GTCTAGCGAC 
CACGGCCAGA CGTCCTCGCT GTGGTGGAAA TGCTCCCAAG AGGGCGGCGG CAGCGGGTCC 
TACGAGGAGG GCTGTCAGAG CCTCATGGAG TACGCGTGGG GTAGAGCAGC GGCTGCCATG 
CTCTTCTGTG GCTTCATCAT CCTGGTGATC TGTTTCATCC TCTCCTTCTT CGCCCTCTGT 
GGACCCCAGA TGCTTGTCTT CCTGAGAGTG ATTGGAGGTC TCCTTGCCTT GGCTGCTGTG 
TTCCAGATCA TCTCCCTGGT AATTTACCCC GTGAAGTACA CCCAGACCTT CACCCTTCAT 
GCCAACCCTG CTGTCACTTA CATCTATAAC TGGGCCTACG GCTTTGGGTG GGCAGCCACG 
ATTATCCTGA TTGGCTGTGC CTTCTTCTTC TGCTGCCTCC CCAACTACGA AGATGACCTT 
CTGGGCAATG CCAAGCCCAG GTACTTCTAC ACATCTGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PERP ( NM_022121.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_071404.2 Homo sapiens p53 apoptosis effector related to PMP22 (PERP), mRNA.

Price & Availability↑

CloneID	OHu17725
Clone ID Related Accession (Same CDS sequence)	NM_022121.4 , NM_022121.5
Accession Version	NM_022121.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	p53 apoptosis effector related to PMP-22
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX784592.1, BC010163.2, AL023582.1 and BU674771.1. On Nov 22, 2018 this sequence version replaced NM_022121.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075082.1, SRR1660803.32793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000421351.4/ ENSP00000397157.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATCCGCT GCGGCCTGGC CTGCGAGCGC TGCCGCTGGA TCCTGCCCCT GCTCCTACTC 
AGCGCCATCG CCTTCGACAT CATCGCGCTG GCCGGCCGCG GCTGGTTGCA GTCTAGCGAC 
CACGGCCAGA CGTCCTCGCT GTGGTGGAAA TGCTCCCAAG AGGGCGGCGG CAGCGGGTCC 
TACGAGGAGG GCTGTCAGAG CCTCATGGAG TACGCGTGGG GTAGAGCAGC GGCTGCCATG 
CTCTTCTGTG GCTTCATCAT CCTGGTGATC TGTTTCATCC TCTCCTTCTT CGCCCTCTGT 
GGACCCCAGA TGCTTGTCTT CCTGAGAGTG ATTGGAGGTC TCCTTGCCTT GGCTGCTGTG 
TTCCAGATCA TCTCCCTGGT AATTTACCCC GTGAAGTACA CCCAGACCTT CACCCTTCAT 
GCCAACCCTG CTGTCACTTA CATCTATAAC TGGGCCTACG GCTTTGGGTG GGCAGCCACG 
ATTATCCTGA TTGGCTGTGC CTTCTTCTTC TGCTGCCTCC CCAACTACGA AGATGACCTT 
CTGGGCAATG CCAAGCCCAG GTACTTCTAC ACATCTGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071404.2
CDS	80..661
Translation	MIRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSDHGQTSSLWWKCSQEGGGSGSYEEGCQSLMEYAWGRAAAAMLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGWAATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA

Target ORF information:

RefSeq Version	NM_022121.5
Organism	Homo sapiens(human)
Definition	Homo sapiens p53 apoptosis effector related to PMP22 (PERP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022121.5

ORF Insert Sequence:

ATGATCCGCT GCGGCCTGGC CTGCGAGCGC TGCCGCTGGA TCCTGCCCCT GCTCCTACTC 
AGCGCCATCG CCTTCGACAT CATCGCGCTG GCCGGCCGCG GCTGGTTGCA GTCTAGCGAC 
CACGGCCAGA CGTCCTCGCT GTGGTGGAAA TGCTCCCAAG AGGGCGGCGG CAGCGGGTCC 
TACGAGGAGG GCTGTCAGAG CCTCATGGAG TACGCGTGGG GTAGAGCAGC GGCTGCCATG 
CTCTTCTGTG GCTTCATCAT CCTGGTGATC TGTTTCATCC TCTCCTTCTT CGCCCTCTGT 
GGACCCCAGA TGCTTGTCTT CCTGAGAGTG ATTGGAGGTC TCCTTGCCTT GGCTGCTGTG 
TTCCAGATCA TCTCCCTGGT AATTTACCCC GTGAAGTACA CCCAGACCTT CACCCTTCAT 
GCCAACCCTG CTGTCACTTA CATCTATAAC TGGGCCTACG GCTTTGGGTG GGCAGCCACG 
ATTATCCTGA TTGGCTGTGC CTTCTTCTTC TGCTGCCTCC CCAACTACGA AGATGACCTT 
CTGGGCAATG CCAAGCCCAG GTACTTCTAC ACATCTGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PERP ( XM_024446520.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302288.1 Homo sapiens p53 apoptosis effector related to PMP22 (PERP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu105826
Clone ID Related Accession (Same CDS sequence)	XM_024446520.1
Accession Version	XM_024446520.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	p53 apoptosis effector related to PMP-22 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCTTCT GTGGCTTCAT CATCCTGGTG ATCTGTTTCA TCCTCTCCTT CTTCGCCCTC 
TGTGGACCCC AGATGCTTGT CTTCCTGAGA GTGATTGGAG GTCTCCTTGC CTTGGCTGCT 
GTGTTCCAGA TCATCTCCCT GGTAATTTAC CCCGTGAAGT ACACCCAGAC CTTCACCCTT 
CATGCCAACC CTGCTGTCAC TTACATCTAT AACTGGGCCT ACGGCTTTGG GTGGGCAGCC 
ACGATTATCC TGATTGGCTG TGCCTTCTTC TTCTGCTGCC TCCCCAACTA CGAAGATGAC 
CTTCTGGGCA ATGCCAAGCC CAGGTACTTC TACACATCTG CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302288.1
CDS	657..1001
Translation	MLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGWAATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA

Target ORF information:

RefSeq Version	XM_024446520.1
Organism	Homo sapiens(human)
Definition	Homo sapiens p53 apoptosis effector related to PMP22 (PERP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446520.1

ORF Insert Sequence:

ATGCTCTTCT GTGGCTTCAT CATCCTGGTG ATCTGTTTCA TCCTCTCCTT CTTCGCCCTC 
TGTGGACCCC AGATGCTTGT CTTCCTGAGA GTGATTGGAG GTCTCCTTGC CTTGGCTGCT 
GTGTTCCAGA TCATCTCCCT GGTAATTTAC CCCGTGAAGT ACACCCAGAC CTTCACCCTT 
CATGCCAACC CTGCTGTCAC TTACATCTAT AACTGGGCCT ACGGCTTTGG GTGGGCAGCC 
ACGATTATCC TGATTGGCTG TGCCTTCTTC TTCTGCTGCC TCCCCAACTA CGAAGATGAC 
CTTCTGGGCA ATGCCAAGCC CAGGTACTTC TACACATCTG CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors.
Endocrinology158(5)1450-1460(2017 May)
Kiseljak-Vassiliades K,Mills TS,Zhang Y,Xu M,Lillehei KO,Kleinschmidt-DeMasters BK,Wierman ME

p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma.
British journal of cancer115(8)983-992(2016 Oct)
Awais R,Spiller DG,White MR,Paraoan L

The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.
Gut microbes7(2)136-45(2016)
Hallstrom KN,McCormick BA

PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation.
Cellular microbiology17(6)843-59(2015 Jun)
Hallstrom KN,Srikanth CV,Agbor TA,Dumont CM,Peters KN,Paraoan L,Casanova JE,Boll EJ,McCormick BA

Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.
Clinical & developmental immunology2013256462(2013)
Du Y,Deng L,Li Y,Gan L,Wang Y,Shi G

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PERP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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