PRSS22 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRSS22
Entrez Gene ID	64063
Full Name	serine protease 22
Synonyms	BSSP-4,SP001LA,hBSSP-4
General protein information	Preferred Names serine protease 22 Names brain-specific serine protease 4 prosemin protease, serine 22 protease, serine S1 family member 22 serine protease 26 tryptase epsilon
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008].
Disorder MIM:	609343

mRNA and Protein(s)

mRNA	Protein	Name
XM_005255473.3	XP_005255530.1	brain-specific serine protease 4 isoform X1
NM_022119.4	NP_071402.1	brain-specific serine protease 4 precursor
NM_022119.3	NP_071402.1	brain-specific serine protease 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PRSS22	NP_071402.1
Mus musculus (house mouse)	Prss22	NP_598492.2
Pan troglodytes (chimpanzee)	PRSS22	XP_510756.3
Rattus norvegicus (Norway rat)	Prss22	NP_001100454.1
Drosophila melanogaster (fruit fly)	CG8170	NP_001036533.1
Canis lupus familiaris (dog)	PRSS22	XP_005622142.1
Bos taurus (cattle)	PRSS22	XP_002697973.2

Gene Ontology
Bibliography

Related articles in PubMed

Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling.
Chen CY, Chung IH, Tsai MM, Tseng YH, Chi HC, Tsai CY, Lin YH, Wang YC, Chen CP, Wu TI, Yeh CT, Tai DI, Lin KH
Molecular cancer13162(2014 Jul)

A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.
Mitsui S, Okui A, Kominami K, Konishi E, Uemura H, Yamaguchi N
The FEBS journal272(19)4911-23(2005 Oct)

Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL
Blood105(10)3893-901(2005 May)

The sequence and analysis of duplication-rich human chromosome 16.
Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA
Nature432(7020)988-94(2004 Dec)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings collectively support a potential role of T3 in cancer cell progression through regulation of the BSSP4 protease via the ERK 1/2-C/EBPbeta-VEGF cascade
Title: Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling.

prosemin is a novel serine protease of the chromosome 16 cluster that is highly expressed in the pancreas.
Title: A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.

Tryptase epsilon also was able to induce pro-uPA-expressing smooth muscle cells to increase their migration
Title: Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.

The following PRSS22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03810	NM_022119.4 Latest version!	Homo sapiens serine protease 22 (PRSS22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03810	XM_005255473.3 Latest version!	Homo sapiens serine protease 22 (PRSS22), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu03810	NM_022119.3	Homo sapiens protease, serine 22 (PRSS22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRSS22 ( NM_022119.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071402.1 Homo sapiens serine protease 22 (PRSS22), mRNA.

Price & Availability↑

CloneID	OHu03810
Clone ID Related Accession (Same CDS sequence)	XM_005255473.3 , NM_022119.4 , NM_022119.3
Accession Version	NM_022119.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	brain-specific serine protease 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ893064.1, AF321182.1 and AW083723.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_022119.3. ##Evidence-Data-START## Transcript exon combination :: AY358396.1, ERR279835.322.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000161006.8/ ENSP00000161006.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGTTT CTGGAGCGCC CCCAGCCCTG GGTGGGGGCT GTCTCGGCAC CTTCACCTCC 
CTGCTGCTGC TGGCGTCGAC AGCCATCCTC AATGCGGCCA GGATACCTGT TCCCCCAGCC 
TGTGGGAAGC CCCAGCAGCT GAACCGGGTT GTGGGCGGCG AGGACAGCAC TGACAGCGAG 
TGGCCCTGGA TCGTGAGCAT CCAGAAGAAT GGGACCCACC ACTGCGCAGG TTCTCTGCTC 
ACCAGCCGCT GGGTGATCAC TGCTGCCCAC TGTTTCAAGG ACAACCTGAA CAAACCATAC 
CTGTTCTCTG TGCTGCTGGG GGCCTGGCAG CTGGGGAACC CTGGCTCTCG GTCCCAGAAG 
GTGGGTGTTG CCTGGGTGGA GCCCCACCCT GTGTATTCCT GGAAGGAAGG TGCCTGTGCA 
GACATTGCCC TGGTGCGTCT CGAGCGCTCC ATACAGTTCT CAGAGCGGGT CCTGCCCATC 
TGCCTACCTG ATGCCTCTAT CCACCTCCCT CCAAACACCC ACTGCTGGAT CTCAGGCTGG 
GGGAGCATCC AAGATGGAGT TCCCTTGCCC CACCCTCAGA CCCTGCAGAA GCTGAAGGTT 
CCTATCATCG ACTCGGAAGT CTGCAGCCAT CTGTACTGGC GGGGAGCAGG ACAGGGACCC 
ATCACTGAGG ACATGCTGTG TGCCGGCTAC TTGGAGGGGG AGCGGGATGC TTGTCTGGGC 
GACTCCGGGG GCCCCCTCAT GTGCCAGGTG GACGGCGCCT GGCTGCTGGC CGGCATCATC 
AGCTGGGGCG AGGGCTGTGC CGAGCGCAAC AGGCCCGGGG TCTACATCAG CCTCTCTGCG 
CACCGCTCCT GGGTGGAGAA GATCGTGCAA GGGGTGCAGC TCCGCGGGCG CGCTCAGGGG 
GGTGGGGCCC TCAGGGCACC GAGCCAGGGC TCTGGGGCCG CCGCGCGCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071402.1
CDS	67..1020
Translation	MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGGGALRAPSQGSGAAARS

Target ORF information:

RefSeq Version	NM_022119.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 22 (PRSS22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022119.4

ORF Insert Sequence:

ATGGTGGTTT CTGGAGCGCC CCCAGCCCTG GGTGGGGGCT GTCTCGGCAC CTTCACCTCC 
CTGCTGCTGC TGGCGTCGAC AGCCATCCTC AATGCGGCCA GGATACCTGT TCCCCCAGCC 
TGTGGGAAGC CCCAGCAGCT GAACCGGGTT GTGGGCGGCG AGGACAGCAC TGACAGCGAG 
TGGCCCTGGA TCGTGAGCAT CCAGAAGAAT GGGACCCACC ACTGCGCAGG TTCTCTGCTC 
ACCAGCCGCT GGGTGATCAC TGCTGCCCAC TGTTTCAAGG ACAACCTGAA CAAACCATAC 
CTGTTCTCTG TGCTGCTGGG GGCCTGGCAG CTGGGGAACC CTGGCTCTCG GTCCCAGAAG 
GTGGGTGTTG CCTGGGTGGA GCCCCACCCT GTGTATTCCT GGAAGGAAGG TGCCTGTGCA 
GACATTGCCC TGGTGCGTCT CGAGCGCTCC ATACAGTTCT CAGAGCGGGT CCTGCCCATC 
TGCCTACCTG ATGCCTCTAT CCACCTCCCT CCAAACACCC ACTGCTGGAT CTCAGGCTGG 
GGGAGCATCC AAGATGGAGT TCCCTTGCCC CACCCTCAGA CCCTGCAGAA GCTGAAGGTT 
CCTATCATCG ACTCGGAAGT CTGCAGCCAT CTGTACTGGC GGGGAGCAGG ACAGGGACCC 
ATCACTGAGG ACATGCTGTG TGCCGGCTAC TTGGAGGGGG AGCGGGATGC TTGTCTGGGC 
GACTCCGGGG GCCCCCTCAT GTGCCAGGTG GACGGCGCCT GGCTGCTGGC CGGCATCATC 
AGCTGGGGCG AGGGCTGTGC CGAGCGCAAC AGGCCCGGGG TCTACATCAG CCTCTCTGCG 
CACCGCTCCT GGGTGGAGAA GATCGTGCAA GGGGTGCAGC TCCGCGGGCG CGCTCAGGGG 
GGTGGGGCCC TCAGGGCACC GAGCCAGGGC TCTGGGGCCG CCGCGCGCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS22 ( NM_022119.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071402.1 Homo sapiens protease, serine 22 (PRSS22), mRNA.

Price & Availability↑

CloneID	OHu03810
Clone ID Related Accession (Same CDS sequence)	XM_005255473.3 , NM_022119.4 , NM_022119.3
Accession Version	NM_022119.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	brain-specific serine protease 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ893064.1, AF321182.1 and AW083723.1. This sequence is a reference standard in the RefSeqGene project. On May 6, 2005 this sequence version replaced NM_022119.2. ##Evidence-Data-START## Transcript exon combination :: AY358396.1, BC009726.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGTTT CTGGAGCGCC CCCAGCCCTG GGTGGGGGCT GTCTCGGCAC CTTCACCTCC 
CTGCTGCTGC TGGCGTCGAC AGCCATCCTC AATGCGGCCA GGATACCTGT TCCCCCAGCC 
TGTGGGAAGC CCCAGCAGCT GAACCGGGTT GTGGGCGGCG AGGACAGCAC TGACAGCGAG 
TGGCCCTGGA TCGTGAGCAT CCAGAAGAAT GGGACCCACC ACTGCGCAGG TTCTCTGCTC 
ACCAGCCGCT GGGTGATCAC TGCTGCCCAC TGTTTCAAGG ACAACCTGAA CAAACCATAC 
CTGTTCTCTG TGCTGCTGGG GGCCTGGCAG CTGGGGAACC CTGGCTCTCG GTCCCAGAAG 
GTGGGTGTTG CCTGGGTGGA GCCCCACCCT GTGTATTCCT GGAAGGAAGG TGCCTGTGCA 
GACATTGCCC TGGTGCGTCT CGAGCGCTCC ATACAGTTCT CAGAGCGGGT CCTGCCCATC 
TGCCTACCTG ATGCCTCTAT CCACCTCCCT CCAAACACCC ACTGCTGGAT CTCAGGCTGG 
GGGAGCATCC AAGATGGAGT TCCCTTGCCC CACCCTCAGA CCCTGCAGAA GCTGAAGGTT 
CCTATCATCG ACTCGGAAGT CTGCAGCCAT CTGTACTGGC GGGGAGCAGG ACAGGGACCC 
ATCACTGAGG ACATGCTGTG TGCCGGCTAC TTGGAGGGGG AGCGGGATGC TTGTCTGGGC 
GACTCCGGGG GCCCCCTCAT GTGCCAGGTG GACGGCGCCT GGCTGCTGGC CGGCATCATC 
AGCTGGGGCG AGGGCTGTGC CGAGCGCAAC AGGCCCGGGG TCTACATCAG CCTCTCTGCG 
CACCGCTCCT GGGTGGAGAA GATCGTGCAA GGGGTGCAGC TCCGCGGGCG CGCTCAGGGG 
GGTGGGGCCC TCAGGGCACC GAGCCAGGGC TCTGGGGCCG CCGCGCGCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071402.1
CDS	67..1020
Translation	MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGGGALRAPSQGSGAAARS

Target ORF information:

RefSeq Version	NM_022119.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protease, serine 22 (PRSS22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022119.3

ORF Insert Sequence:

ATGGTGGTTT CTGGAGCGCC CCCAGCCCTG GGTGGGGGCT GTCTCGGCAC CTTCACCTCC 
CTGCTGCTGC TGGCGTCGAC AGCCATCCTC AATGCGGCCA GGATACCTGT TCCCCCAGCC 
TGTGGGAAGC CCCAGCAGCT GAACCGGGTT GTGGGCGGCG AGGACAGCAC TGACAGCGAG 
TGGCCCTGGA TCGTGAGCAT CCAGAAGAAT GGGACCCACC ACTGCGCAGG TTCTCTGCTC 
ACCAGCCGCT GGGTGATCAC TGCTGCCCAC TGTTTCAAGG ACAACCTGAA CAAACCATAC 
CTGTTCTCTG TGCTGCTGGG GGCCTGGCAG CTGGGGAACC CTGGCTCTCG GTCCCAGAAG 
GTGGGTGTTG CCTGGGTGGA GCCCCACCCT GTGTATTCCT GGAAGGAAGG TGCCTGTGCA 
GACATTGCCC TGGTGCGTCT CGAGCGCTCC ATACAGTTCT CAGAGCGGGT CCTGCCCATC 
TGCCTACCTG ATGCCTCTAT CCACCTCCCT CCAAACACCC ACTGCTGGAT CTCAGGCTGG 
GGGAGCATCC AAGATGGAGT TCCCTTGCCC CACCCTCAGA CCCTGCAGAA GCTGAAGGTT 
CCTATCATCG ACTCGGAAGT CTGCAGCCAT CTGTACTGGC GGGGAGCAGG ACAGGGACCC 
ATCACTGAGG ACATGCTGTG TGCCGGCTAC TTGGAGGGGG AGCGGGATGC TTGTCTGGGC 
GACTCCGGGG GCCCCCTCAT GTGCCAGGTG GACGGCGCCT GGCTGCTGGC CGGCATCATC 
AGCTGGGGCG AGGGCTGTGC CGAGCGCAAC AGGCCCGGGG TCTACATCAG CCTCTCTGCG 
CACCGCTCCT GGGTGGAGAA GATCGTGCAA GGGGTGCAGC TCCGCGGGCG CGCTCAGGGG 
GGTGGGGCCC TCAGGGCACC GAGCCAGGGC TCTGGGGCCG CCGCGCGCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS22 ( XM_005255473.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255530.1 Homo sapiens serine protease 22 (PRSS22), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03810
Clone ID Related Accession (Same CDS sequence)	XM_005255473.3 , NM_022119.4 , NM_022119.3
Accession Version	XM_005255473.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	brain-specific serine protease 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005255473.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGTTT CTGGAGCGCC CCCAGCCCTG GGTGGGGGCT GTCTCGGCAC CTTCACCTCC 
CTGCTGCTGC TGGCGTCGAC AGCCATCCTC AATGCGGCCA GGATACCTGT TCCCCCAGCC 
TGTGGGAAGC CCCAGCAGCT GAACCGGGTT GTGGGCGGCG AGGACAGCAC TGACAGCGAG 
TGGCCCTGGA TCGTGAGCAT CCAGAAGAAT GGGACCCACC ACTGCGCAGG TTCTCTGCTC 
ACCAGCCGCT GGGTGATCAC TGCTGCCCAC TGTTTCAAGG ACAACCTGAA CAAACCATAC 
CTGTTCTCTG TGCTGCTGGG GGCCTGGCAG CTGGGGAACC CTGGCTCTCG GTCCCAGAAG 
GTGGGTGTTG CCTGGGTGGA GCCCCACCCT GTGTATTCCT GGAAGGAAGG TGCCTGTGCA 
GACATTGCCC TGGTGCGTCT CGAGCGCTCC ATACAGTTCT CAGAGCGGGT CCTGCCCATC 
TGCCTACCTG ATGCCTCTAT CCACCTCCCT CCAAACACCC ACTGCTGGAT CTCAGGCTGG 
GGGAGCATCC AAGATGGAGT TCCCTTGCCC CACCCTCAGA CCCTGCAGAA GCTGAAGGTT 
CCTATCATCG ACTCGGAAGT CTGCAGCCAT CTGTACTGGC GGGGAGCAGG ACAGGGACCC 
ATCACTGAGG ACATGCTGTG TGCCGGCTAC TTGGAGGGGG AGCGGGATGC TTGTCTGGGC 
GACTCCGGGG GCCCCCTCAT GTGCCAGGTG GACGGCGCCT GGCTGCTGGC CGGCATCATC 
AGCTGGGGCG AGGGCTGTGC CGAGCGCAAC AGGCCCGGGG TCTACATCAG CCTCTCTGCG 
CACCGCTCCT GGGTGGAGAA GATCGTGCAA GGGGTGCAGC TCCGCGGGCG CGCTCAGGGG 
GGTGGGGCCC TCAGGGCACC GAGCCAGGGC TCTGGGGCCG CCGCGCGCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255530.1
CDS	166..1119
Translation	MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGGGALRAPSQGSGAAARS

Target ORF information:

RefSeq Version	XM_005255473.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 22 (PRSS22), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005255473.3

ORF Insert Sequence:

ATGGTGGTTT CTGGAGCGCC CCCAGCCCTG GGTGGGGGCT GTCTCGGCAC CTTCACCTCC 
CTGCTGCTGC TGGCGTCGAC AGCCATCCTC AATGCGGCCA GGATACCTGT TCCCCCAGCC 
TGTGGGAAGC CCCAGCAGCT GAACCGGGTT GTGGGCGGCG AGGACAGCAC TGACAGCGAG 
TGGCCCTGGA TCGTGAGCAT CCAGAAGAAT GGGACCCACC ACTGCGCAGG TTCTCTGCTC 
ACCAGCCGCT GGGTGATCAC TGCTGCCCAC TGTTTCAAGG ACAACCTGAA CAAACCATAC 
CTGTTCTCTG TGCTGCTGGG GGCCTGGCAG CTGGGGAACC CTGGCTCTCG GTCCCAGAAG 
GTGGGTGTTG CCTGGGTGGA GCCCCACCCT GTGTATTCCT GGAAGGAAGG TGCCTGTGCA 
GACATTGCCC TGGTGCGTCT CGAGCGCTCC ATACAGTTCT CAGAGCGGGT CCTGCCCATC 
TGCCTACCTG ATGCCTCTAT CCACCTCCCT CCAAACACCC ACTGCTGGAT CTCAGGCTGG 
GGGAGCATCC AAGATGGAGT TCCCTTGCCC CACCCTCAGA CCCTGCAGAA GCTGAAGGTT 
CCTATCATCG ACTCGGAAGT CTGCAGCCAT CTGTACTGGC GGGGAGCAGG ACAGGGACCC 
ATCACTGAGG ACATGCTGTG TGCCGGCTAC TTGGAGGGGG AGCGGGATGC TTGTCTGGGC 
GACTCCGGGG GCCCCCTCAT GTGCCAGGTG GACGGCGCCT GGCTGCTGGC CGGCATCATC 
AGCTGGGGCG AGGGCTGTGC CGAGCGCAAC AGGCCCGGGG TCTACATCAG CCTCTCTGCG 
CACCGCTCCT GGGTGGAGAA GATCGTGCAA GGGGTGCAGC TCCGCGGGCG CGCTCAGGGG 
GGTGGGGCCC TCAGGGCACC GAGCCAGGGC TCTGGGGCCG CCGCGCGCTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling.
Molecular cancer13162(2014 Jul)
Chen CY,Chung IH,Tsai MM,Tseng YH,Chi HC,Tsai CY,Lin YH,Wang YC,Chen CP,Wu TI,Yeh CT,Tai DI,Lin KH

A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.
The FEBS journal272(19)4911-23(2005 Oct)
Mitsui S,Okui A,Kominami K,Konishi E,Uemura H,Yamaguchi N

Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Blood105(10)3893-901(2005 May)
Yasuda S,Morokawa N,Wong GW,Rossi A,Madhusudhan MS,Sali A,Askew YS,Adachi R,Silverman GA,Krilis SA,Stevens RL

The sequence and analysis of duplication-rich human chromosome 16.
Nature432(7020)988-94(2004 Dec)
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PRSS22 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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