SELPLG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELPLG
Entrez Gene ID	6404
Full Name	selectin P ligand
Synonyms	CD162,CLA,PSGL-1,PSGL1
General protein information	Preferred Names selectin P ligand Names P-selectin glycoprotein ligand 1 cutaneous lymphocyte-associated associated antigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.11
Summary	This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].
Disorder MIM:	600738

mRNA and Protein(s)

mRNA	Protein	Name
NM_001206609.2	NP_001193538.1	P-selectin glycoprotein ligand 1 isoform 1 precursor
NM_003006.4	NP_002997.2	P-selectin glycoprotein ligand 1 isoform 2 precursor
NM_001206609.1	NP_001193538.1	P-selectin glycoprotein ligand 1 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SELPLG	XP_001164136.3
Mus musculus (house mouse)	Selplg	NP_033177.3
Rattus norvegicus (Norway rat)	Selplg	NP_001013248.1
Homo sapiens (human)	SELPLG	NP_001193538.1
	LOC706046	XP_002798810.1
Canis lupus familiaris (dog)	SELPLG	NP_001229648.1
Bos taurus (cattle)	SELPLG	NP_001032717.2

Gene Ontology
Bibliography

Related articles in PubMed

PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level.
Luo J
Inflammation(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.
Title: Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.

The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Title: Blood to skin recirculation of CD4

Studies indicate that P-selectin glycoprotein ligand-1 (PSGL-1) PSGL-1 can negatively regulate T cell function.
Title: PSGL-1: A New Player in the Immune Checkpoint Landscape.

Results suggest that PSGL-1 may play an oncogenic role in the development of intestinal tumors, and this is likely mediated through activation of NFkB signaling by MIP-1g.
Title: Inflammatory Molecule,

Platelet-leukocyte aggregations increased in acute ischemic stroke patients rapidly within 3h. The I allele of PSGL-1 M62I was associated with risk of developing acute ischemic stroke, especially large artery atherosclerosis stroke and small artery occlusion stroke. Small artery occlusion stroke patients with the II genotype of PSGL-1 M62I have the higher level of platelet-neutrophil aggregates.
Title: Correlations of platelet-leukocyte aggregates with P-selectin S290N and P-selectin glycoprotein ligand-1 M62I genetic polymorphisms in patients with acute ischemic stroke.

The following SELPLG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELPLG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20809	NM_001206609.2 Latest version!	Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu21116	NM_003006.4 Latest version!	Homo sapiens selectin P ligand (SELPLG), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu20809	NM_001206609.1	Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELPLG ( NM_001206609.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001193538.1 Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20809
Clone ID Related Accession (Same CDS sequence)	NM_001206609.2 , NM_001206609.1
Accession Version	NM_001206609.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	P-selectin glycoprotein ligand 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007569.22, DC339004.1, AK298742.1, AC008119.6, BC029782.1 and CA427270.1. On Jun 2, 2019 this sequence version replaced NM_001206609.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298742.1, DRR138517.123585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGTGG GGGCCAGTGG TCTAGAAGGA GATAAGATGG CTGGTGCCAT GCCTCTGCAA 
CTCCTCCTGT TGCTGATCCT ACTGGGCCCT GGCAACAGCT TGCAGCTGTG GGACACCTGG 
GCAGATGAAG CCGAGAAAGC CTTGGGTCCC CTGCTTGCCC GGGACCGGAG ACAGGCCACC 
GAATATGAGT ACCTAGATTA TGATTTCCTG CCAGAAACGG AGCCTCCAGA AATGCTGAGG 
AACAGCACTG ACACCACTCC TCTGACTGGG CCTGGAACCC CTGAGTCTAC CACTGTGGAG 
CCTGCTGCAA GGCGTTCTAC TGGCCTGGAT GCAGGAGGGG CAGTCACAGA GCTGACCACG 
GAGCTGGCCA ACATGGGGAA CCTGTCCACG GATTCAGCAG CTATGGAGAT ACAGACCACT 
CAACCAGCAG CCACGGAGGC ACAGACCACT CAACCAGTGC CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACAACT CGACTGACGG CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACCACT CCACCAGCAG CCACGGAAGC ACAGACCACT 
CAACCCACAG GCCTGGAGGC ACAGACCACT GCACCAGCAG CCATGGAGGC ACAGACCACT 
GCACCAGCAG CCATGGAAGC ACAGACCACT CCACCAGCAG CCATGGAGGC ACAGACCACT 
CAAACCACAG CCATGGAGGC ACAGACCACT GCACCAGAAG CCACGGAGGC ACAGACCACT 
CAACCCACAG CCACGGAGGC ACAGACCACT CCACTGGCAG CCATGGAGGC CCTGTCCACA 
GAACCCAGTG CCACAGAGGC CCTGTCCATG GAACCTACTA CCAAAAGAGG TCTGTTCATA 
CCCTTTTCTG TGTCCTCTGT TACTCACAAG GGCATTCCCA TGGCAGCCAG CAATTTGTCC 
GTCAACTACC CAGTGGGGGC CCCAGACCAC ATCTCTGTGA AGCAGTGCCT GCTGGCCATC 
CTAATCTTGG CGCTGGTGGC CACTATCTTC TTCGTGTGCA CTGTGGTGCT GGCGGTCCGC 
CTCTCCCGCA AGGGCCACAT GTACCCCGTG CGTAATTACT CCCCCACCGA GATGGTCTGC 
ATCTCATCCC TGTTGCCTGA TGGGGGTGAG GGGCCCTCTG CCACAGCCAA TGGGGGCCTG 
TCCAAGGCCA AGAGCCCGGG CCTGACGCCA GAGCCCAGGG AGGACCGTGA GGGGGATGAC 
CTCACCCTGC ACAGCTTCCT CCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001193538.1
CDS	181..1467
Translation	MAVGASGLEGDKMAGAMPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP

Target ORF information:

RefSeq Version	NM_001206609.2
Organism	Homo sapiens(human)
Definition	Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001206609.2

ORF Insert Sequence:

ATGGCAGTGG GGGCCAGTGG TCTAGAAGGA GATAAGATGG CTGGTGCCAT GCCTCTGCAA 
CTCCTCCTGT TGCTGATCCT ACTGGGCCCT GGCAACAGCT TGCAGCTGTG GGACACCTGG 
GCAGATGAAG CCGAGAAAGC CTTGGGTCCC CTGCTTGCCC GGGACCGGAG ACAGGCCACC 
GAATATGAGT ACCTAGATTA TGATTTCCTG CCAGAAACGG AGCCTCCAGA AATGCTGAGG 
AACAGCACTG ACACCACTCC TCTGACTGGG CCTGGAACCC CTGAGTCTAC CACTGTGGAG 
CCTGCTGCAA GGCGTTCTAC TGGCCTGGAT GCAGGAGGGG CAGTCACAGA GCTGACCACG 
GAGCTGGCCA ACATGGGGAA CCTGTCCACG GATTCAGCAG CTATGGAGAT ACAGACCACT 
CAACCAGCAG CCACGGAGGC ACAGACCACT CAACCAGTGC CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACAACT CGACTGACGG CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACCACT CCACCAGCAG CCACGGAAGC ACAGACCACT 
CAACCCACAG GCCTGGAGGC ACAGACCACT GCACCAGCAG CCATGGAGGC ACAGACCACT 
GCACCAGCAG CCATGGAAGC ACAGACCACT CCACCAGCAG CCATGGAGGC ACAGACCACT 
CAAACCACAG CCATGGAGGC ACAGACCACT GCACCAGAAG CCACGGAGGC ACAGACCACT 
CAACCCACAG CCACGGAGGC ACAGACCACT CCACTGGCAG CCATGGAGGC CCTGTCCACA 
GAACCCAGTG CCACAGAGGC CCTGTCCATG GAACCTACTA CCAAAAGAGG TCTGTTCATA 
CCCTTTTCTG TGTCCTCTGT TACTCACAAG GGCATTCCCA TGGCAGCCAG CAATTTGTCC 
GTCAACTACC CAGTGGGGGC CCCAGACCAC ATCTCTGTGA AGCAGTGCCT GCTGGCCATC 
CTAATCTTGG CGCTGGTGGC CACTATCTTC TTCGTGTGCA CTGTGGTGCT GGCGGTCCGC 
CTCTCCCGCA AGGGCCACAT GTACCCCGTG CGTAATTACT CCCCCACCGA GATGGTCTGC 
ATCTCATCCC TGTTGCCTGA TGGGGGTGAG GGGCCCTCTG CCACAGCCAA TGGGGGCCTG 
TCCAAGGCCA AGAGCCCGGG CCTGACGCCA GAGCCCAGGG AGGACCGTGA GGGGGATGAC 
CTCACCCTGC ACAGCTTCCT CCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELPLG ( NM_003006.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002997.2 Homo sapiens selectin P ligand (SELPLG), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21116
Clone ID Related Accession (Same CDS sequence)	NM_003006.4
Accession Version	NM_003006.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	P-selectin glycoprotein ligand 1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK098315.1, AK225644.1 and AC008119.6. On Apr 30, 2011 this sequence version replaced NM_003006.3. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.74400.1, SRR1660809.130254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCTGC AACTCCTCCT GTTGCTGATC CTACTGGGCC CTGGCAACAG CTTGCAGCTG 
TGGGACACCT GGGCAGATGA AGCCGAGAAA GCCTTGGGTC CCCTGCTTGC CCGGGACCGG 
AGACAGGCCA CCGAATATGA GTACCTAGAT TATGATTTCC TGCCAGAAAC GGAGCCTCCA 
GAAATGCTGA GGAACAGCAC TGACACCACT CCTCTGACTG GGCCTGGAAC CCCTGAGTCT 
ACCACTGTGG AGCCTGCTGC AAGGCGTTCT ACTGGCCTGG ATGCAGGAGG GGCAGTCACA 
GAGCTGACCA CGGAGCTGGC CAACATGGGG AACCTGTCCA CGGATTCAGC AGCTATGGAG 
ATACAGACCA CTCAACCAGC AGCCACGGAG GCACAGACCA CTCAACCAGT GCCCACGGAG 
GCACAGACCA CTCCACTGGC AGCCACAGAG GCACAGACAA CTCGACTGAC GGCCACGGAG 
GCACAGACCA CTCCACTGGC AGCCACAGAG GCACAGACCA CTCCACCAGC AGCCACGGAA 
GCACAGACCA CTCAACCCAC AGGCCTGGAG GCACAGACCA CTGCACCAGC AGCCATGGAG 
GCACAGACCA CTGCACCAGC AGCCATGGAA GCACAGACCA CTCCACCAGC AGCCATGGAG 
GCACAGACCA CTCAAACCAC AGCCATGGAG GCACAGACCA CTGCACCAGA AGCCACGGAG 
GCACAGACCA CTCAACCCAC AGCCACGGAG GCACAGACCA CTCCACTGGC AGCCATGGAG 
GCCCTGTCCA CAGAACCCAG TGCCACAGAG GCCCTGTCCA TGGAACCTAC TACCAAAAGA 
GGTCTGTTCA TACCCTTTTC TGTGTCCTCT GTTACTCACA AGGGCATTCC CATGGCAGCC 
AGCAATTTGT CCGTCAACTA CCCAGTGGGG GCCCCAGACC ACATCTCTGT GAAGCAGTGC 
CTGCTGGCCA TCCTAATCTT GGCGCTGGTG GCCACTATCT TCTTCGTGTG CACTGTGGTG 
CTGGCGGTCC GCCTCTCCCG CAAGGGCCAC ATGTACCCCG TGCGTAATTA CTCCCCCACC 
GAGATGGTCT GCATCTCATC CCTGTTGCCT GATGGGGGTG AGGGGCCCTC TGCCACAGCC 
AATGGGGGCC TGTCCAAGGC CAAGAGCCCG GGCCTGACGC CAGAGCCCAG GGAGGACCGT 
GAGGGGGATG ACCTCACCCT GCACAGCTTC CTCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002997.2
CDS	161..1399
Translation	MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP

Target ORF information:

RefSeq Version	NM_003006.4
Organism	Homo sapiens(human)
Definition	Homo sapiens selectin P ligand (SELPLG), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003006.4

ORF Insert Sequence:

ATGCCTCTGC AACTCCTCCT GTTGCTGATC CTACTGGGCC CTGGCAACAG CTTGCAGCTG 
TGGGACACCT GGGCAGATGA AGCCGAGAAA GCCTTGGGTC CCCTGCTTGC CCGGGACCGG 
AGACAGGCCA CCGAATATGA GTACCTAGAT TATGATTTCC TGCCAGAAAC GGAGCCTCCA 
GAAATGCTGA GGAACAGCAC TGACACCACT CCTCTGACTG GGCCTGGAAC CCCTGAGTCT 
ACCACTGTGG AGCCTGCTGC AAGGCGTTCT ACTGGCCTGG ATGCAGGAGG GGCAGTCACA 
GAGCTGACCA CGGAGCTGGC CAACATGGGG AACCTGTCCA CGGATTCAGC AGCTATGGAG 
ATACAGACCA CTCAACCAGC AGCCACGGAG GCACAGACCA CTCAACCAGT GCCCACGGAG 
GCACAGACCA CTCCACTGGC AGCCACAGAG GCACAGACAA CTCGACTGAC GGCCACGGAG 
GCACAGACCA CTCCACTGGC AGCCACAGAG GCACAGACCA CTCCACCAGC AGCCACGGAA 
GCACAGACCA CTCAACCCAC AGGCCTGGAG GCACAGACCA CTGCACCAGC AGCCATGGAG 
GCACAGACCA CTGCACCAGC AGCCATGGAA GCACAGACCA CTCCACCAGC AGCCATGGAG 
GCACAGACCA CTCAAACCAC AGCCATGGAG GCACAGACCA CTGCACCAGA AGCCACGGAG 
GCACAGACCA CTCAACCCAC AGCCACGGAG GCACAGACCA CTCCACTGGC AGCCATGGAG 
GCCCTGTCCA CAGAACCCAG TGCCACAGAG GCCCTGTCCA TGGAACCTAC TACCAAAAGA 
GGTCTGTTCA TACCCTTTTC TGTGTCCTCT GTTACTCACA AGGGCATTCC CATGGCAGCC 
AGCAATTTGT CCGTCAACTA CCCAGTGGGG GCCCCAGACC ACATCTCTGT GAAGCAGTGC 
CTGCTGGCCA TCCTAATCTT GGCGCTGGTG GCCACTATCT TCTTCGTGTG CACTGTGGTG 
CTGGCGGTCC GCCTCTCCCG CAAGGGCCAC ATGTACCCCG TGCGTAATTA CTCCCCCACC 
GAGATGGTCT GCATCTCATC CCTGTTGCCT GATGGGGGTG AGGGGCCCTC TGCCACAGCC 
AATGGGGGCC TGTCCAAGGC CAAGAGCCCG GGCCTGACGC CAGAGCCCAG GGAGGACCGT 
GAGGGGGATG ACCTCACCCT GCACAGCTTC CTCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELPLG ( NM_001206609.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001193538.1 Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20809
Clone ID Related Accession (Same CDS sequence)	NM_001206609.2 , NM_001206609.1
Accession Version	NM_001206609.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	P-selectin glycoprotein ligand 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC339004.1, AK298742.1, AC007569.22, AC008119.6, BC029782.1 and CA427270.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DC339004.1, AK298742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGTGG GGGCCAGTGG TCTAGAAGGA GATAAGATGG CTGGTGCCAT GCCTCTGCAA 
CTCCTCCTGT TGCTGATCCT ACTGGGCCCT GGCAACAGCT TGCAGCTGTG GGACACCTGG 
GCAGATGAAG CCGAGAAAGC CTTGGGTCCC CTGCTTGCCC GGGACCGGAG ACAGGCCACC 
GAATATGAGT ACCTAGATTA TGATTTCCTG CCAGAAACGG AGCCTCCAGA AATGCTGAGG 
AACAGCACTG ACACCACTCC TCTGACTGGG CCTGGAACCC CTGAGTCTAC CACTGTGGAG 
CCTGCTGCAA GGCGTTCTAC TGGCCTGGAT GCAGGAGGGG CAGTCACAGA GCTGACCACG 
GAGCTGGCCA ACATGGGGAA CCTGTCCACG GATTCAGCAG CTATGGAGAT ACAGACCACT 
CAACCAGCAG CCACGGAGGC ACAGACCACT CAACCAGTGC CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACAACT CGACTGACGG CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACCACT CCACCAGCAG CCACGGAAGC ACAGACCACT 
CAACCCACAG GCCTGGAGGC ACAGACCACT GCACCAGCAG CCATGGAGGC ACAGACCACT 
GCACCAGCAG CCATGGAAGC ACAGACCACT CCACCAGCAG CCATGGAGGC ACAGACCACT 
CAAACCACAG CCATGGAGGC ACAGACCACT GCACCAGAAG CCACGGAGGC ACAGACCACT 
CAACCCACAG CCACGGAGGC ACAGACCACT CCACTGGCAG CCATGGAGGC CCTGTCCACA 
GAACCCAGTG CCACAGAGGC CCTGTCCATG GAACCTACTA CCAAAAGAGG TCTGTTCATA 
CCCTTTTCTG TGTCCTCTGT TACTCACAAG GGCATTCCCA TGGCAGCCAG CAATTTGTCC 
GTCAACTACC CAGTGGGGGC CCCAGACCAC ATCTCTGTGA AGCAGTGCCT GCTGGCCATC 
CTAATCTTGG CGCTGGTGGC CACTATCTTC TTCGTGTGCA CTGTGGTGCT GGCGGTCCGC 
CTCTCCCGCA AGGGCCACAT GTACCCCGTG CGTAATTACT CCCCCACCGA GATGGTCTGC 
ATCTCATCCC TGTTGCCTGA TGGGGGTGAG GGGCCCTCTG CCACAGCCAA TGGGGGCCTG 
TCCAAGGCCA AGAGCCCGGG CCTGACGCCA GAGCCCAGGG AGGACCGTGA GGGGGATGAC 
CTCACCCTGC ACAGCTTCCT CCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001193538.1
CDS	178..1464
Translation	MAVGASGLEGDKMAGAMPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP

Target ORF information:

RefSeq Version	NM_001206609.1
Organism	Homo sapiens(human)
Definition	Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001206609.1

ORF Insert Sequence:

ATGGCAGTGG GGGCCAGTGG TCTAGAAGGA GATAAGATGG CTGGTGCCAT GCCTCTGCAA 
CTCCTCCTGT TGCTGATCCT ACTGGGCCCT GGCAACAGCT TGCAGCTGTG GGACACCTGG 
GCAGATGAAG CCGAGAAAGC CTTGGGTCCC CTGCTTGCCC GGGACCGGAG ACAGGCCACC 
GAATATGAGT ACCTAGATTA TGATTTCCTG CCAGAAACGG AGCCTCCAGA AATGCTGAGG 
AACAGCACTG ACACCACTCC TCTGACTGGG CCTGGAACCC CTGAGTCTAC CACTGTGGAG 
CCTGCTGCAA GGCGTTCTAC TGGCCTGGAT GCAGGAGGGG CAGTCACAGA GCTGACCACG 
GAGCTGGCCA ACATGGGGAA CCTGTCCACG GATTCAGCAG CTATGGAGAT ACAGACCACT 
CAACCAGCAG CCACGGAGGC ACAGACCACT CAACCAGTGC CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACAACT CGACTGACGG CCACGGAGGC ACAGACCACT 
CCACTGGCAG CCACAGAGGC ACAGACCACT CCACCAGCAG CCACGGAAGC ACAGACCACT 
CAACCCACAG GCCTGGAGGC ACAGACCACT GCACCAGCAG CCATGGAGGC ACAGACCACT 
GCACCAGCAG CCATGGAAGC ACAGACCACT CCACCAGCAG CCATGGAGGC ACAGACCACT 
CAAACCACAG CCATGGAGGC ACAGACCACT GCACCAGAAG CCACGGAGGC ACAGACCACT 
CAACCCACAG CCACGGAGGC ACAGACCACT CCACTGGCAG CCATGGAGGC CCTGTCCACA 
GAACCCAGTG CCACAGAGGC CCTGTCCATG GAACCTACTA CCAAAAGAGG TCTGTTCATA 
CCCTTTTCTG TGTCCTCTGT TACTCACAAG GGCATTCCCA TGGCAGCCAG CAATTTGTCC 
GTCAACTACC CAGTGGGGGC CCCAGACCAC ATCTCTGTGA AGCAGTGCCT GCTGGCCATC 
CTAATCTTGG CGCTGGTGGC CACTATCTTC TTCGTGTGCA CTGTGGTGCT GGCGGTCCGC 
CTCTCCCGCA AGGGCCACAT GTACCCCGTG CGTAATTACT CCCCCACCGA GATGGTCTGC 
ATCTCATCCC TGTTGCCTGA TGGGGGTGAG GGGCCCTCTG CCACAGCCAA TGGGGGCCTG 
TCCAAGGCCA AGAGCCCGGG CCTGACGCCA GAGCCCAGGG AGGACCGTGA GGGGGATGAC 
CTCACCCTGC ACAGCTTCCT CCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level.
Inflammation(2017 Dec)
Luo J

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SELPLG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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