FKBPL cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FKBPL
Entrez Gene ID	63943
Full Name	FK506 binding protein like
Synonyms	DIR1,FKBP4,NG7,WISP39
General protein information	Preferred Names FK506 binding protein like Names FK506-binding protein-like WAF-1/CIP1 stabilizing protein 39 peptidyl-prolyl cis-trans isomerase
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 6 Map Location: 6p21.32
Summary	The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008].
Disorder MIM:	617076

mRNA and Protein(s)

mRNA	Protein	Name
NM_022110.3	NP_071393.2	FK506-binding protein-like
XM_011514803.1	XP_011513105.1	FK506-binding protein-like isoform X1
NM_022110.4	NP_071393.2	FK506-binding protein-like
XM_011547274.1	XP_011545576.1	FK506-binding protein-like isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FKBPL	XP_538845.1
Mus musculus (house mouse)	Fkbpl	NP_063926.1
Rattus norvegicus (Norway rat)	Fkbpl	NP_001002818.1
Xenopus tropicalis (tropical clawed frog)	fkbpl	XP_002941306.1
	FKBPL	XP_001114301.1
Homo sapiens (human)	FKBPL	NP_071393.2
Pan troglodytes (chimpanzee)	FKBPL	XP_001162639.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Low-frequency nonsynonymous variants in FKBPL and ARPC1B genes are associated with breast cancer risk in Chinese women.
Zhou W, Jiang Y, Zhu M, Hang D, Chen J, Zhou J, Dai J, Ma H, Hu Z, Jin G, Sha J, Shen H
Molecular carcinogenesis56(2)774-780(2017 Feb)

FKBPL: a marker of good prognosis in breast cancer.
Nelson L, McKeen HD, Marshall A, Mulrane L, Starczynski J, Storr SJ, Lanigan F, Byrne C, Arthur K, Hegarty S, Ali AA, Furlong F, McCarthy HO, Ellis IO, Green AR, Rakha E, Young L, Kunkler I, Thomas J, Jack W, Cameron D, Jirstr?m K, Yakkundi A, McClements L, Martin SG, Gallagher WM, Dunn J, Bartlett J, O'Connor D, Robson T
Oncotarget6(14)12209-23(2015 May)

FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.
Yakkundi A, Bennett R, Hern?ndez-Negrete I, Delalande JM, Hanna M, Lyubomska O, Arthur K, Short A, McKeen H, Nelson L, McCrudden CM, McNally R, McClements L, McCarthy HO, Burns AJ, Bicknell R, Kissenpfennig A, Robson T
Arteriosclerosis, thrombosis, and vascular biology35(4)845-54(2015 Apr)

WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility.
Howell M, Brickner H, Delorme-Walker VD, Choi J, Saffin JM, Miller D, Panopoulos A, DerMardirossian C, Fotedar A, Margolis RL, Fotedar R
The Journal of cell biology208(7)961-74(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk.
Title: Low-frequency nonsynonymous variants in FKBPL and ARPC1B genes are associated with breast cancer risk in Chinese women.

The data suggests a role for FKBPL as a prognostic factor for BCSS, with the potential to be routinely evaluated within the clinic.
Title: FKBPL: a marker of good prognosis in breast cancer.

FKBPL is an important regulator of developmental and pathological angiogenesis.
Title: FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.

WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase to dephosphorylate and activate Cofilin.
Title: WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility.

high levels of FKBPL and RBCK1 correlated with increased patient survival, whereas high RBCK1 predicted for a poor response to tamoxifen.
Title: Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen.

The following FKBPL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FKBPL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30506	NM_022110.4 Latest version!	Homo sapiens FKBP prolyl isomerase like (FKBPL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30506	XM_011547274.1 Latest version!	Homo sapiens FK506 binding protein like (FKBPL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30506	XM_011514803.1 Latest version!	Homo sapiens FK506 binding protein like (FKBPL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu30506	NM_022110.3	Homo sapiens FK506 binding protein like (FKBPL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FKBPL ( NM_022110.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_071393.2 Homo sapiens FK506 binding protein like (FKBPL), mRNA.

Price & Availability↑

CloneID	OHu30506
Clone ID Related Accession (Same CDS sequence)	NM_022110.3 , XM_011514803.1 , NM_022110.4 , XM_011547274.1
Accession Version	NM_022110.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	FK506-binding protein-like
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC011966.1. On Aug 27, 2003 this sequence version replaced NM_022110.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011966.1, AK291418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071393.2
CDS	271..1320
Translation	METPPVNTIGEKDTSQPQQEWEKNLRENLDSVIQIRQQPRDPPTETLELEVSPDPASQILEHTQGAEKLVAELEGDSHKSHGSTSQMPEALQASDLWYCPDGSFVKKIVIRGHGLDKPKLGSCCRVLALGFPFGSGPPEGWTELTMGVGPWREETWGELIEKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQGLRKMFG

Target ORF information:

RefSeq Version	NM_022110.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FK506 binding protein like (FKBPL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022110.3

ORF Insert Sequence:

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBPL ( NM_022110.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_071393.2 Homo sapiens FKBP prolyl isomerase like (FKBPL), mRNA.

Price & Availability↑

CloneID	OHu30506
Clone ID Related Accession (Same CDS sequence)	NM_022110.3 , XM_011514803.1 , NM_022110.4 , XM_011547274.1
Accession Version	NM_022110.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	FK506-binding protein-like
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662884.11. On Nov 25, 2018 this sequence version replaced NM_022110.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK027119.1, BC011966.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375156.4/ ENSP00000364298.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071393.2
CDS	269..1318
Translation	METPPVNTIGEKDTSQPQQEWEKNLRENLDSVIQIRQQPRDPPTETLELEVSPDPASQILEHTQGAEKLVAELEGDSHKSHGSTSQMPEALQASDLWYCPDGSFVKKIVIRGHGLDKPKLGSCCRVLALGFPFGSGPPEGWTELTMGVGPWREETWGELIEKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQGLRKMFG

Target ORF information:

RefSeq Version	NM_022110.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FKBP prolyl isomerase like (FKBPL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022110.4

ORF Insert Sequence:

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBPL ( XM_011514803.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011513105.1 Homo sapiens FK506 binding protein like (FKBPL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30506
Clone ID Related Accession (Same CDS sequence)	NM_022110.3 , XM_011514803.1 , NM_022110.4 , XM_011547274.1
Accession Version	XM_011514803.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	FK506-binding protein-like isoform X1
Comment

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513105.1
Translation	METPPVNTIGEKDTSQPQQEWEKNLRENLDSVIQIRQQPRDPPTETLELEVSPDPASQILEHTQGAEKLVAELEGDSHKSHGSTSQMPEALQASDLWYCPDGSFVKKIVIRGHGLDKPKLGSCCRVLALGFPFGSGPPEGWTELTMGVGPWREETWGELIEKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQGLRKMFG

Target ORF information:

RefSeq Version	XM_011514803.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens FK506 binding protein like (FKBPL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514803.1

ORF Insert Sequence:

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FKBPL ( XM_011547274.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011545576.1 Homo sapiens FK506 binding protein like (FKBPL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30506
Clone ID Related Accession (Same CDS sequence)	NM_022110.3 , XM_011514803.1 , NM_022110.4 , XM_011547274.1
Accession Version	XM_011547274.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	FK506-binding protein-like isoform X1
Comment

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011545576.1
Translation	METPPVNTIGEKDTSQPQQEWEKNLRENLDSVIQIRQQPRDPPTETLELEVSPDPASQILEHTQGAEKLVAELEGDSHKSHGSTSQMPEALQASDLWYCPDGSFVKKIVIRGHGLDKPKLGSCCRVLALGFPFGSGPPEGWTELTMGVGPWREETWGELIEKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQGLRKMFG

Target ORF information:

RefSeq Version	XM_011547274.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens FK506 binding protein like (FKBPL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011547274.1

ORF Insert Sequence:

ATGGAGACGC CACCAGTCAA TACAATTGGA GAAAAGGACA CCTCTCAGCC GCAACAAGAG 
TGGGAAAAGA ACCTTCGGGA GAACCTTGAT TCAGTTATTC AGATTAGGCA GCAGCCCCGA 
GACCCTCCTA CCGAAACGCT TGAGCTGGAA GTAAGCCCAG ATCCAGCCAG CCAAATTCTA 
GAGCATACTC AAGGAGCTGA AAAACTGGTT GCTGAACTTG AAGGAGACTC TCATAAGTCT 
CATGGATCAA CCAGTCAGAT GCCAGAGGCC CTTCAAGCTT CTGATCTCTG GTACTGCCCC 
GATGGGAGCT TTGTCAAGAA GATCGTAATC CGTGGCCATG GCTTGGACAA ACCCAAACTA 
GGCTCCTGCT GCCGGGTACT GGCTTTGGGG TTTCCTTTCG GATCAGGGCC GCCAGAGGGC 
TGGACAGAGC TAACTATGGG CGTAGGGCCA TGGAGGGAGG AAACTTGGGG GGAGCTCATA 
GAGAAATGCT TGGAGTCCAT GTGTCAAGGT GAGGAAGCAG AGCTTCAGCT GCCTGGGCAC 
TCTGGACCTC CTGTCAGGCT CACACTGGCA TCCTTCACTC AAGGCCGAGA CTCCTGGGAG 
CTGGAGACTA GCGAGAAGGA AGCCCTGGCC AGGGAAGAAC GTGCAAGGGG CACAGAACTA 
TTTCGAGCTG GGAACCCTGA AGGAGCTGCC CGATGCTATG GACGGGCTCT TCGGCTGCTC 
CTGACTTTAC CCCCACCTGG CCCTCCAGAA CGAACTGTCC TTCATGCCAA TCTGGCTGCC 
TGTCAGTTGT TGCTAGGGCA GCCTCAGTTG GCAGCCCAGA GCTGTGACCG GGTGTTGGAG 
CGGGAGCCTG GCCATTTAAA GGCCTTATAC CGAAGGGGGG TTGCCCAGGC TGCCCTTGGG 
AACCTGGAAA AAGCAACTGC TGACCTCAAG AAGGTGCTGG CGATAGATCC CAAAAACCGG 
GCAGCCCAGG AGGAACTGGG GAAGGTGGTC ATTCAGGGGA AGAACCAGGA TGCAGGGCTG 
GCTCAGGGTC TGCGCAAGAT GTTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Low-frequency nonsynonymous variants in FKBPL and ARPC1B genes are associated with breast cancer risk in Chinese women.
Molecular carcinogenesis56(2)774-780(2017 Feb)
Zhou W,Jiang Y,Zhu M,Hang D,Chen J,Zhou J,Dai J,Ma H,Hu Z,Jin G,Sha J,Shen H

FKBPL: a marker of good prognosis in breast cancer.
Oncotarget6(14)12209-23(2015 May)
Nelson L,McKeen HD,Marshall A,Mulrane L,Starczynski J,Storr SJ,Lanigan F,Byrne C,Arthur K,Hegarty S,Ali AA,Furlong F,McCarthy HO,Ellis IO,Green AR,Rakha E,Young L,Kunkler I,Thomas J,Jack W,Cameron D,Jirstr?m K,Yakkundi A,McClements L,Martin SG,Gallagher WM,Dunn J,Bartlett J,O'Connor D,Robson T

FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.
Arteriosclerosis, thrombosis, and vascular biology35(4)845-54(2015 Apr)
Yakkundi A,Bennett R,Hern?ndez-Negrete I,Delalande JM,Hanna M,Lyubomska O,Arthur K,Short A,McKeen H,Nelson L,McCrudden CM,McNally R,McClements L,McCarthy HO,Burns AJ,Bicknell R,Kissenpfennig A,Robson T

WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility.
The Journal of cell biology208(7)961-74(2015 Mar)
Howell M,Brickner H,Delorme-Walker VD,Choi J,Saffin JM,Miller D,Panopoulos A,DerMardirossian C,Fotedar A,Margolis RL,Fotedar R

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FKBPL cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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