XPNPEP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XPNPEP3
Entrez Gene ID	63929
Full Name	X-prolyl aminopeptidase 3
Synonyms	APP3,ICP55,NPHPL1
General protein information	Preferred Names X-prolyl aminopeptidase 3 Names probable Xaa-Pro aminopeptidase 3 Intermediate Cleaving Peptidase 55 X-Pro aminopeptidase 3 X-prolyl aminopeptidase 3, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2
Summary	The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.[provided by RefSeq, Mar 2011].
Disorder MIM:	613553
Disorder Html:	Nephronophthisis-like nephropathy 1, 613159 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_022098.4	NP_071381.1	xaa-Pro aminopeptidase 3 isoform 1
NM_001204827.1	NP_001191756.1	xaa-Pro aminopeptidase 3 isoform 2
NM_022098.3	NP_071381.1	probable Xaa-Pro aminopeptidase 3 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	XPNPEP3	XP_538358.2
Rattus norvegicus (Norway rat)	Xpnpep3	NP_001124054.2
Gallus gallus (chicken)	XPNPEP3	XP_416240.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000887	XP_316864.4
Oryza sativa (rice)	Os12g0563500	NP_001067037.1
Homo sapiens (human)	XPNPEP3	NP_071381.1
Danio rerio (zebrafish)	xpnpep3	NP_996962.1
Drosophila melanogaster (fruit fly)	CG9581	NP_608376.1
Schizosaccharomyces pombe (fission yeast)	icp55	NP_594637.1
Neurospora crassa	NCU05971	XP_957892.1
Kluyveromyces lactis	KLLA0C07645g	XP_452540.1
Eremothecium gossypii	AGOS_ACL028W	NP_983376.2
Magnaporthe oryzae (rice blast fungus)	MGG_00596	XP_003718443.1
Arabidopsis thaliana (thale cress)	AT1G09300	NP_172401.2
Pan troglodytes (chimpanzee)	XPNPEP3	XP_515152.2
Bos taurus (cattle)	XPNPEP3	NP_001179123.1
Saccharomyces cerevisiae (baker's yeast)	ICP55	NP_011001.1
Xenopus tropicalis (tropical clawed frog)	xpnpep3	NP_001016515.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human aminopeptidase XPNPEP3 and comparison of its
Singh R, Jamdar SN, Goyal VD, Kumar A, Ghosh B, Makde RD
The Journal of biological chemistry292(24)10035-10047(2017 06)

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
Inoue M, Kamada H, Abe Y, Higashisaka K, Nagano K, Mukai Y, Yoshioka Y, Tsutsumi Y, Tsunoda S
Journal of cell science128(4)656-69(2015 Feb)

Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae.
Stames EM, O'Toole JF
PloS one8(10)e77234(2013)

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F,
Journal of medical genetics48(2)105-16(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that human XPNPEP3, Ashbya gossypii Icp55, and Fusarium graminearum Icp55 exhibit structural and functional properties of genuine Xaa-Pro specific aminopeptidases; these enzymes appear to function in the previously observed mitochondrial role of Icp55 in processing of Nfs1 (mitochondrial cysteine desulfurase) substrate. [Icp55 = intermediate-cleavage metalloexopeptidases 55]
Title: Structure of the human aminopeptidase XPNPEP3 and comparison of its

The findings reveal that APP3m is a new member of the TNF-TNFR2 signaling complex and characterize an APP3-mediated TNFR2 signal transduction mechanism that induces activation of JNK1 and JNK2.
Title: Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

Observational study of gene-disease association. (HuGE Navigator)
Title: Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
Title: Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.

The following XPNPEP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XPNPEP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09369	NM_001204827.1 Latest version!	Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu22210	NM_022098.4 Latest version!	Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu22210	NM_022098.3	Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XPNPEP3 ( NM_001204827.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191756.1 Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09369
Clone ID Related Accession (Same CDS sequence)	NM_001204827.1
Accession Version	NM_001204827.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 168bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-29
Organism	Homo sapiens(human)
Product	xaa-Pro aminopeptidase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP346902.1, BC053556.1 and BM980889.1. Transcript Variant: This variant (2) shares the first exon in common with variant 1 and contains two alternate exons at the 3' end. This results in a frame-shift and a very short isoform (2) with a distinct C-terminus compared to isoform 1. This variant is supported by transcript evidence, but the encoded isoform lacks experimental support. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.191724.1, BC005331.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 20179356 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGCCTTGGC TGCTCTCAGC CCCCAAGCTG GTTCCCGCTG TAGCAAACGT CCGCGGCCTC 
TCAGGGTCTT ACTTTGTCAC CCAAGCTGGA GTGCAGTGGC GTGATCCCAT TACACTGCAA 
CCTATGTCTT CCAGGCTCAA GCAGTCTTTC TACCAGCTTC CCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191756.1
CDS	102..269
Translation	MPWLLSAPKLVPAVANVRGLSGSYFVTQAGVQWRDPITLQPMSSRLKQSFYQLPE

Target ORF information:

RefSeq Version	NM_001204827.1
Organism	Homo sapiens(human)
Definition	Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204827.1

ORF Insert Sequence:

1
61
121

ATGCCTTGGC TGCTCTCAGC CCCCAAGCTG GTTCCCGCTG TAGCAAACGT CCGCGGCCTC 
TCAGGGTCTT ACTTTGTCAC CCAAGCTGGA GTGCAGTGGC GTGATCCCAT TACACTGCAA 
CCTATGTCTT CCAGGCTCAA GCAGTCTTTC TACCAGCTTC CCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XPNPEP3 ( NM_022098.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071381.1 Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22210
Clone ID Related Accession (Same CDS sequence)	NM_022098.4 , NM_022098.3
Accession Version	NM_022098.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	xaa-Pro aminopeptidase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP346902.1, BC004989.1, AL365514.1, AI446638.1, AL035450.1, AL080242.11 and BX648018.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_022098.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as APP3m). This isoform has been shown to be localized to the mitochondria (PMID:20179356). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.148658.1, SRR1803613.49857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 20179356 MANE Ensembl match :: ENST00000357137.9/ ENSP00000349658.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTTGGC TGCTCTCAGC CCCCAAGCTG GTTCCCGCTG TAGCAAACGT CCGCGGCCTC 
TCAGGATGTA TGTTGTGTTC ACAGCGAAGG TACTCCCTTC AGCCTGTCCC AGAAAGGAGG 
ATTCCAAACC GATACTTAGG CCAGCCCAGC CCCTTTACAC ACCCACACCT CCTCAGACCA 
GGGGAGGTAA CTCCAGGACT ATCTCAGGTG GAATATGCAC TTCGCAGACA CAAACTAATG 
TCTCTGATCC AGAAGGAAGC TCAAGGGCAG AGTGGGACAG ACCAGACAGT GGTTGTGCTC 
TCCAACCCTA CATACTACAT GAGCAACGAT ATTCCCTATA CTTTCCACCA AGACAACAAT 
TTCCTGTACC TATGTGGATT CCAAGAGCCT GATAGCATTC TTGTCCTTCA GAGCCTCCCT 
GGCAAACAAT TACCATCACA CAAAGCCATA CTTTTTGTGC CTCGGCGAGA TCCCAGTCGA 
GAACTTTGGG ATGGTCCGCG ATCTGGCACT GATGGAGCAA TAGCTCTAAC TGGAGTAGAC 
GAAGCCTATA CGCTAGAAGA ATTTCAACAT CTTCTACCAA AAATGAAAGC TGAGACGAAC 
ATGGTTTGGT ATGACTGGAT GAGGCCCTCA CATGCACAGC TTCACTCTGA CTATATGCAG 
CCCCTGACTG AGGCCAAAGC CAAGAGCAAG AACAAGGTTC GGGGTGTTCA GCAGCTGATA 
CAGCGCCTCC GGCTGATCAA GTCTCCTGCA GAAATTGAAC GAATGCAGAT TGCTGGGAAG 
CTGACATCAC AGGCTTTCAT AGAAACCATG TTCACCAGTA AAGCCCCTGT GGAAGAAGCC 
TTTCTTTATG CTAAGTTTGA ATTTGAATGC CGGGCTCGTG GCGCAGACAT TTTAGCCTAT 
CCACCTGTGG TGGCTGGTGG TAATCGGTCA AACACTTTGC ACTATGTGAA AAATAATCAA 
CTCATCAAGG ATGGGGAAAT GGTGCTTCTG GATGGAGGTT GTGAGTCTTC CTGCTATGTG 
AGTGACATCA CACGTACGTG GCCAGTCAAT GGCAGGTTCA CCGCACCTCA GGCAGAACTC 
TATGAAGCCG TTCTAGAGAT CCAAAGAGAT TGTTTGGCCC TCTGCTTCCC TGGGACAAGC 
TTGGAGAACA TCTACAGCAT GATGCTGACC CTGATAGGAC AGAAGCTTAA AGACTTGGGG 
ATCATGAAGA ACATTAAGGA AAATAATGCC TTCAAGGCTG CTCGAAAATA CTGTCCTCAT 
CATGTTGGCC ACTACCTCGG GATGGATGTC CATGACACTC CAGACATGCC CCGTTCCCTC 
CCTCTGCAGC CTGGGATGGT AATCACAATT GAGCCCGGCA TTTATATTCC AGAGGATGAC 
AAAGATGCCC CAGAGAAGTT TCGGGGTCTT GGTGTACGAA TTGAGGATGA TGTAGTGGTG 
ACTCAGGACT CACCTCTCAT CCTTTCTGCA GACTGTCCCA AAGAGATGAA TGACATTGAA 
CAGATATGCA GCCAGGCTTC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071381.1
CDS	35..1558
Translation	MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS

Target ORF information:

RefSeq Version	NM_022098.4
Organism	Homo sapiens(human)
Definition	Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022098.4

ORF Insert Sequence:

ATGCCTTGGC TGCTCTCAGC CCCCAAGCTG GTTCCCGCTG TAGCAAACGT CCGCGGCCTC 
TCAGGATGTA TGTTGTGTTC ACAGCGAAGG TACTCCCTTC AGCCTGTCCC AGAAAGGAGG 
ATTCCAAACC GATACTTAGG CCAGCCCAGC CCCTTTACAC ACCCACACCT CCTCAGACCA 
GGGGAGGTAA CTCCAGGACT ATCTCAGGTG GAATATGCAC TTCGCAGACA CAAACTAATG 
TCTCTGATCC AGAAGGAAGC TCAAGGGCAG AGTGGGACAG ACCAGACAGT GGTTGTGCTC 
TCCAACCCTA CATACTACAT GAGCAACGAT ATTCCCTATA CTTTCCACCA AGACAACAAT 
TTCCTGTACC TATGTGGATT CCAAGAGCCT GATAGCATTC TTGTCCTTCA GAGCCTCCCT 
GGCAAACAAT TACCATCACA CAAAGCCATA CTTTTTGTGC CTCGGCGAGA TCCCAGTCGA 
GAACTTTGGG ATGGTCCGCG ATCTGGCACT GATGGAGCAA TAGCTCTAAC TGGAGTAGAC 
GAAGCCTATA CGCTAGAAGA ATTTCAACAT CTTCTACCAA AAATGAAAGC TGAGACGAAC 
ATGGTTTGGT ATGACTGGAT GAGGCCCTCA CATGCACAGC TTCACTCTGA CTATATGCAG 
CCCCTGACTG AGGCCAAAGC CAAGAGCAAG AACAAGGTTC GGGGTGTTCA GCAGCTGATA 
CAGCGCCTCC GGCTGATCAA GTCTCCTGCA GAAATTGAAC GAATGCAGAT TGCTGGGAAG 
CTGACATCAC AGGCTTTCAT AGAAACCATG TTCACCAGTA AAGCCCCTGT GGAAGAAGCC 
TTTCTTTATG CTAAGTTTGA ATTTGAATGC CGGGCTCGTG GCGCAGACAT TTTAGCCTAT 
CCACCTGTGG TGGCTGGTGG TAATCGGTCA AACACTTTGC ACTATGTGAA AAATAATCAA 
CTCATCAAGG ATGGGGAAAT GGTGCTTCTG GATGGAGGTT GTGAGTCTTC CTGCTATGTG 
AGTGACATCA CACGTACGTG GCCAGTCAAT GGCAGGTTCA CCGCACCTCA GGCAGAACTC 
TATGAAGCCG TTCTAGAGAT CCAAAGAGAT TGTTTGGCCC TCTGCTTCCC TGGGACAAGC 
TTGGAGAACA TCTACAGCAT GATGCTGACC CTGATAGGAC AGAAGCTTAA AGACTTGGGG 
ATCATGAAGA ACATTAAGGA AAATAATGCC TTCAAGGCTG CTCGAAAATA CTGTCCTCAT 
CATGTTGGCC ACTACCTCGG GATGGATGTC CATGACACTC CAGACATGCC CCGTTCCCTC 
CCTCTGCAGC CTGGGATGGT AATCACAATT GAGCCCGGCA TTTATATTCC AGAGGATGAC 
AAAGATGCCC CAGAGAAGTT TCGGGGTCTT GGTGTACGAA TTGAGGATGA TGTAGTGGTG 
ACTCAGGACT CACCTCTCAT CCTTTCTGCA GACTGTCCCA AAGAGATGAA TGACATTGAA 
CAGATATGCA GCCAGGCTTC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XPNPEP3 ( NM_022098.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071381.1 Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22210
Clone ID Related Accession (Same CDS sequence)	NM_022098.4 , NM_022098.3
Accession Version	NM_022098.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	probable Xaa-Pro aminopeptidase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP346902.1, BC004989.1, AL365514.1, AI446638.1, AL035450.1, AL080242.11 and BX648018.1. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_022098.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as APP3m). This isoform has been shown to be localized to the mitochondria (PMID:20179356). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BX648018.1, SRR1803613.49857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 20179356 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTTGGC TGCTCTCAGC CCCCAAGCTG GTTCCCGCTG TAGCAAACGT CCGCGGCCTC 
TCAGGATGTA TGTTGTGTTC ACAGCGAAGG TACTCCCTTC AGCCTGTCCC AGAAAGGAGG 
ATTCCAAACC GATACTTAGG CCAGCCCAGC CCCTTTACAC ACCCACACCT CCTCAGACCA 
GGGGAGGTAA CTCCAGGACT ATCTCAGGTG GAATATGCAC TTCGCAGACA CAAACTAATG 
TCTCTGATCC AGAAGGAAGC TCAAGGGCAG AGTGGGACAG ACCAGACAGT GGTTGTGCTC 
TCCAACCCTA CATACTACAT GAGCAACGAT ATTCCCTATA CTTTCCACCA AGACAACAAT 
TTCCTGTACC TATGTGGATT CCAAGAGCCT GATAGCATTC TTGTCCTTCA GAGCCTCCCT 
GGCAAACAAT TACCATCACA CAAAGCCATA CTTTTTGTGC CTCGGCGAGA TCCCAGTCGA 
GAACTTTGGG ATGGTCCGCG ATCTGGCACT GATGGAGCAA TAGCTCTAAC TGGAGTAGAC 
GAAGCCTATA CGCTAGAAGA ATTTCAACAT CTTCTACCAA AAATGAAAGC TGAGACGAAC 
ATGGTTTGGT ATGACTGGAT GAGGCCCTCA CATGCACAGC TTCACTCTGA CTATATGCAG 
CCCCTGACTG AGGCCAAAGC CAAGAGCAAG AACAAGGTTC GGGGTGTTCA GCAGCTGATA 
CAGCGCCTCC GGCTGATCAA GTCTCCTGCA GAAATTGAAC GAATGCAGAT TGCTGGGAAG 
CTGACATCAC AGGCTTTCAT AGAAACCATG TTCACCAGTA AAGCCCCTGT GGAAGAAGCC 
TTTCTTTATG CTAAGTTTGA ATTTGAATGC CGGGCTCGTG GCGCAGACAT TTTAGCCTAT 
CCACCTGTGG TGGCTGGTGG TAATCGGTCA AACACTTTGC ACTATGTGAA AAATAATCAA 
CTCATCAAGG ATGGGGAAAT GGTGCTTCTG GATGGAGGTT GTGAGTCTTC CTGCTATGTG 
AGTGACATCA CACGTACGTG GCCAGTCAAT GGCAGGTTCA CCGCACCTCA GGCAGAACTC 
TATGAAGCCG TTCTAGAGAT CCAAAGAGAT TGTTTGGCCC TCTGCTTCCC TGGGACAAGC 
TTGGAGAACA TCTACAGCAT GATGCTGACC CTGATAGGAC AGAAGCTTAA AGACTTGGGG 
ATCATGAAGA ACATTAAGGA AAATAATGCC TTCAAGGCTG CTCGAAAATA CTGTCCTCAT 
CATGTTGGCC ACTACCTCGG GATGGATGTC CATGACACTC CAGACATGCC CCGTTCCCTC 
CCTCTGCAGC CTGGGATGGT AATCACAATT GAGCCCGGCA TTTATATTCC AGAGGATGAC 
AAAGATGCCC CAGAGAAGTT TCGGGGTCTT GGTGTACGAA TTGAGGATGA TGTAGTGGTG 
ACTCAGGACT CACCTCTCAT CCTTTCTGCA GACTGTCCCA AAGAGATGAA TGACATTGAA 
CAGATATGCA GCCAGGCTTC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071381.1
CDS	102..1625
Translation	MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS

Target ORF information:

RefSeq Version	NM_022098.3
Organism	Homo sapiens(human)
Definition	Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022098.3

ORF Insert Sequence:

ATGCCTTGGC TGCTCTCAGC CCCCAAGCTG GTTCCCGCTG TAGCAAACGT CCGCGGCCTC 
TCAGGATGTA TGTTGTGTTC ACAGCGAAGG TACTCCCTTC AGCCTGTCCC AGAAAGGAGG 
ATTCCAAACC GATACTTAGG CCAGCCCAGC CCCTTTACAC ACCCACACCT CCTCAGACCA 
GGGGAGGTAA CTCCAGGACT ATCTCAGGTG GAATATGCAC TTCGCAGACA CAAACTAATG 
TCTCTGATCC AGAAGGAAGC TCAAGGGCAG AGTGGGACAG ACCAGACAGT GGTTGTGCTC 
TCCAACCCTA CATACTACAT GAGCAACGAT ATTCCCTATA CTTTCCACCA AGACAACAAT 
TTCCTGTACC TATGTGGATT CCAAGAGCCT GATAGCATTC TTGTCCTTCA GAGCCTCCCT 
GGCAAACAAT TACCATCACA CAAAGCCATA CTTTTTGTGC CTCGGCGAGA TCCCAGTCGA 
GAACTTTGGG ATGGTCCGCG ATCTGGCACT GATGGAGCAA TAGCTCTAAC TGGAGTAGAC 
GAAGCCTATA CGCTAGAAGA ATTTCAACAT CTTCTACCAA AAATGAAAGC TGAGACGAAC 
ATGGTTTGGT ATGACTGGAT GAGGCCCTCA CATGCACAGC TTCACTCTGA CTATATGCAG 
CCCCTGACTG AGGCCAAAGC CAAGAGCAAG AACAAGGTTC GGGGTGTTCA GCAGCTGATA 
CAGCGCCTCC GGCTGATCAA GTCTCCTGCA GAAATTGAAC GAATGCAGAT TGCTGGGAAG 
CTGACATCAC AGGCTTTCAT AGAAACCATG TTCACCAGTA AAGCCCCTGT GGAAGAAGCC 
TTTCTTTATG CTAAGTTTGA ATTTGAATGC CGGGCTCGTG GCGCAGACAT TTTAGCCTAT 
CCACCTGTGG TGGCTGGTGG TAATCGGTCA AACACTTTGC ACTATGTGAA AAATAATCAA 
CTCATCAAGG ATGGGGAAAT GGTGCTTCTG GATGGAGGTT GTGAGTCTTC CTGCTATGTG 
AGTGACATCA CACGTACGTG GCCAGTCAAT GGCAGGTTCA CCGCACCTCA GGCAGAACTC 
TATGAAGCCG TTCTAGAGAT CCAAAGAGAT TGTTTGGCCC TCTGCTTCCC TGGGACAAGC 
TTGGAGAACA TCTACAGCAT GATGCTGACC CTGATAGGAC AGAAGCTTAA AGACTTGGGG 
ATCATGAAGA ACATTAAGGA AAATAATGCC TTCAAGGCTG CTCGAAAATA CTGTCCTCAT 
CATGTTGGCC ACTACCTCGG GATGGATGTC CATGACACTC CAGACATGCC CCGTTCCCTC 
CCTCTGCAGC CTGGGATGGT AATCACAATT GAGCCCGGCA TTTATATTCC AGAGGATGAC 
AAAGATGCCC CAGAGAAGTT TCGGGGTCTT GGTGTACGAA TTGAGGATGA TGTAGTGGTG 
ACTCAGGACT CACCTCTCAT CCTTTCTGCA GACTGTCCCA AAGAGATGAA TGACATTGAA 
CAGATATGCA GCCAGGCTTC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human aminopeptidase XPNPEP3 and comparison of its
The Journal of biological chemistry292(24)10035-10047(2017 06)
Singh R,Jamdar SN,Goyal VD,Kumar A,Ghosh B,Makde RD

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
Journal of cell science128(4)656-69(2015 Feb)
Inoue M,Kamada H,Abe Y,Higashisaka K,Nagano K,Mukai Y,Yoshioka Y,Tsutsumi Y,Tsunoda S

Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae.
PloS one8(10)e77234(2013)
Stames EM,O'Toole JF

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
Journal of medical genetics48(2)105-16(2011 Feb)
Otto EA,Ramaswami G,Janssen S,Chaki M,Allen SJ,Zhou W,Airik R,Hurd TW,Ghosh AK,Wolf MT,Hoppe B,Neuhaus TJ,Bockenhauer D,Milford DV,Soliman NA,Antignac C,Saunier S,Johnson CA,Hildebrandt F,

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XPNPEP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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