CHP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHP2
Entrez Gene ID	63928
Full Name	calcineurin like EF-hand protein 2
General protein information	Preferred Names calcineurin like EF-hand protein 2 Names calcineurin B homologous protein 2 hepatocellular carcinoma antigen gene 520 hepatocellular carcinoma-associated antigen 520
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p12.2
Summary	This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022097.4	NP_071380.1	calcineurin B homologous protein 2
NM_022097.3	NP_071380.1	calcineurin B homologous protein 2

Pathways from BioSystems

Homologies

	CHP2	XP_001095666.1
Bos taurus (cattle)	CHP2	NP_001179334.1
Pan troglodytes (chimpanzee)	CHP2	XP_523319.3
Mus musculus (house mouse)	Chp2	NP_081639.1
Caenorhabditis elegans (roundworm)	pbo-1	NP_497601.1
Homo sapiens (human)	CHP2	NP_071380.1
Danio rerio (zebrafish)	chp2	NP_956130.1
Rattus norvegicus (Norway rat)	Chp2	NP_877402.1

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Calcineurin homologous protein: a multifunctional Ca2+-binding protein family.
Di Sole F, Vadnagara K, Moe OW, Babich V
American journal of physiology. Renal physiology303(2)F165-79(2012 Jul)

Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
Ramsuran V, Kulkarni H, He W, Mlisana K, Wright EJ, Werner L, Castiblanco J, Dhanda R, Le T, Dolan MJ, Guan W, Weiss RA, Clark RA, Karim SS, Ahuja SK, Ndung'u T
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America52(10)1248-56(2011 May)

Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Li QH, Wang LH, Lin YN, Chang GQ, Li HW, Jin WN, Hu RH, Pang TX
Genes to cells : devoted to molecular & cellular mechanisms16(4)416-26(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CHP2 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

chp2 expression in leukemia primary cells and leukemia cell lines is significantly increased.
Title: [Expression of a tumor related gene chp2 in leukemia cells].

overexpression of the CHP2 gene affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression
Title: Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.

These findings suggest that CHP serves as an obligatory subunit that is required both for supporting the basic activity and regulating the pH-sensing of NHE1 via interactions between distinct parts of these proteins.
Title: Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.

The following CHP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03803	NM_022097.4 Latest version!	Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03803	NM_022097.3	Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHP2 ( NM_022097.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071380.1 Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.

Price & Availability↑

CloneID	OHu03803
Clone ID Related Accession (Same CDS sequence)	NM_022097.4 , NM_022097.3
Accession Version	NM_022097.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	calcineurin B homologous protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF146019.1 and BF197519.1. On Nov 23, 2018 this sequence version replaced NM_022097.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF146019.1, SRR1803612.214828.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300113.3/ ENSP00000300113.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGTCGC GCAGCTCCCA CGCCGCGGTC ATTCCCGACG GGGACAGTAT TCGGCGAGAG 
ACCGGCTTCT CCCAAGCCAG CCTGCTCCGC CTGCACCACC GGTTCCGGGC ACTGGACAGG 
AATAAGAAGG GCTACCTGAG CCGCATGGAT CTCCAGCAGA TAGGGGCGCT CGCCGTGAAC 
CCCCTGGGAG ACCGAATTAT AGAAAGCTTC TTCCCCGATG GGAGCCAGCG AGTGGATTTC 
CCAGGCTTTG TCAGGGTCTT GGCTCATTTT CGCCCTGTAG AAGATGAGGA CACAGAAACC 
CAAGACCCCA AGAAACCTGA ACCTCTCAAC AGCAGAAGGA ACAAACTTCA CTATGCATTT 
CAGCTCTATG ACCTGGATCG CGATGGGAAG ATCTCCAGGC ATGAGATGCT GCAGGTTCTC 
CGTCTGATGG TTGGGGTACA GGTGACAGAA GAGCAGCTGG AGAACATCGC TGACCGCACG 
GTGCAGGAGG CTGATGAAGA TGGGGATGGG GCTGTGTCCT TCGTGGAGTT CACCAAGTCC 
TTAGAGAAGA TGGACGTTGA GCAAAAAATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071380.1
CDS	25..615
Translation	MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK

Target ORF information:

RefSeq Version	NM_022097.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022097.4

ORF Insert Sequence:

ATGGGGTCGC GCAGCTCCCA CGCCGCGGTC ATTCCCGACG GGGACAGTAT TCGGCGAGAG 
ACCGGCTTCT CCCAAGCCAG CCTGCTCCGC CTGCACCACC GGTTCCGGGC ACTGGACAGG 
AATAAGAAGG GCTACCTGAG CCGCATGGAT CTCCAGCAGA TAGGGGCGCT CGCCGTGAAC 
CCCCTGGGAG ACCGAATTAT AGAAAGCTTC TTCCCCGATG GGAGCCAGCG AGTGGATTTC 
CCAGGCTTTG TCAGGGTCTT GGCTCATTTT CGCCCTGTAG AAGATGAGGA CACAGAAACC 
CAAGACCCCA AGAAACCTGA ACCTCTCAAC AGCAGAAGGA ACAAACTTCA CTATGCATTT 
CAGCTCTATG ACCTGGATCG CGATGGGAAG ATCTCCAGGC ATGAGATGCT GCAGGTTCTC 
CGTCTGATGG TTGGGGTACA GGTGACAGAA GAGCAGCTGG AGAACATCGC TGACCGCACG 
GTGCAGGAGG CTGATGAAGA TGGGGATGGG GCTGTGTCCT TCGTGGAGTT CACCAAGTCC 
TTAGAGAAGA TGGACGTTGA GCAAAAAATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHP2 ( NM_022097.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071380.1 Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.

Price & Availability↑

CloneID	OHu03803
Clone ID Related Accession (Same CDS sequence)	NM_022097.4 , NM_022097.3
Accession Version	NM_022097.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	calcineurin B homologous protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF146019.1 and BF197519.1. On Jul 16, 2013 this sequence version replaced NM_022097.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF146019.1, ERR279842.5809.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTCGC GCAGCTCCCA CGCCGCGGTC ATTCCCGACG GGGACAGTAT TCGGCGAGAG 
ACCGGCTTCT CCCAAGCCAG CCTGCTCCGC CTGCACCACC GGTTCCGGGC ACTGGACAGG 
AATAAGAAGG GCTACCTGAG CCGCATGGAT CTCCAGCAGA TAGGGGCGCT CGCCGTGAAC 
CCCCTGGGAG ACCGAATTAT AGAAAGCTTC TTCCCCGATG GGAGCCAGCG AGTGGATTTC 
CCAGGCTTTG TCAGGGTCTT GGCTCATTTT CGCCCTGTAG AAGATGAGGA CACAGAAACC 
CAAGACCCCA AGAAACCTGA ACCTCTCAAC AGCAGAAGGA ACAAACTTCA CTATGCATTT 
CAGCTCTATG ACCTGGATCG CGATGGGAAG ATCTCCAGGC ATGAGATGCT GCAGGTTCTC 
CGTCTGATGG TTGGGGTACA GGTGACAGAA GAGCAGCTGG AGAACATCGC TGACCGCACG 
GTGCAGGAGG CTGATGAAGA TGGGGATGGG GCTGTGTCCT TCGTGGAGTT CACCAAGTCC 
TTAGAGAAGA TGGACGTTGA GCAAAAAATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071380.1
CDS	424..1014
Translation	MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK

Target ORF information:

RefSeq Version	NM_022097.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022097.3

ORF Insert Sequence:

ATGGGGTCGC GCAGCTCCCA CGCCGCGGTC ATTCCCGACG GGGACAGTAT TCGGCGAGAG 
ACCGGCTTCT CCCAAGCCAG CCTGCTCCGC CTGCACCACC GGTTCCGGGC ACTGGACAGG 
AATAAGAAGG GCTACCTGAG CCGCATGGAT CTCCAGCAGA TAGGGGCGCT CGCCGTGAAC 
CCCCTGGGAG ACCGAATTAT AGAAAGCTTC TTCCCCGATG GGAGCCAGCG AGTGGATTTC 
CCAGGCTTTG TCAGGGTCTT GGCTCATTTT CGCCCTGTAG AAGATGAGGA CACAGAAACC 
CAAGACCCCA AGAAACCTGA ACCTCTCAAC AGCAGAAGGA ACAAACTTCA CTATGCATTT 
CAGCTCTATG ACCTGGATCG CGATGGGAAG ATCTCCAGGC ATGAGATGCT GCAGGTTCTC 
CGTCTGATGG TTGGGGTACA GGTGACAGAA GAGCAGCTGG AGAACATCGC TGACCGCACG 
GTGCAGGAGG CTGATGAAGA TGGGGATGGG GCTGTGTCCT TCGTGGAGTT CACCAAGTCC 
TTAGAGAAGA TGGACGTTGA GCAAAAAATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Calcineurin homologous protein: a multifunctional Ca2+-binding protein family.
American journal of physiology. Renal physiology303(2)F165-79(2012 Jul)
Di Sole F,Vadnagara K,Moe OW,Babich V

Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America52(10)1248-56(2011 May)
Ramsuran V,Kulkarni H,He W,Mlisana K,Wright EJ,Werner L,Castiblanco J,Dhanda R,Le T,Dolan MJ,Guan W,Weiss RA,Clark RA,Karim SS,Ahuja SK,Ndung'u T

Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Genes to cells : devoted to molecular & cellular mechanisms16(4)416-26(2011 Apr)
Li QH,Wang LH,Lin YN,Chang GQ,Li HW,Jin WN,Hu RH,Pang TX

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CHP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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