MRPL17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL17
Entrez Gene ID	63875
Full Name	mitochondrial ribosomal protein L17
Synonyms	L17mt,LIP2,MRP-L17,MRP-L26,RPL17L,RPML26
General protein information	Preferred Names mitochondrial ribosomal protein L17 Names 39S ribosomal protein L17, mitochondrial LYST-interacting protein 2 LYST-interacting protein LIP2 mitochondrial large ribosomal subunit protein bL17m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	611830

mRNA and Protein(s)

mRNA	Protein	Name
NM_022061.4	NP_071344.1	39S ribosomal protein L17, mitochondrial
NM_022061.3	NP_071344.1	39S ribosomal protein L17, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPL17	NP_071344.1
Pan troglodytes (chimpanzee)	MRPL17	XP_001166071.1
	MRPL17	XP_001084385.1
Bos taurus (cattle)	MRPL17	NP_001029446.1
Mus musculus (house mouse)	Mrpl17	NP_079577.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001865	XP_321202.3
Canis lupus familiaris (dog)	MRPL17	XP_851127.1
Drosophila melanogaster (fruit fly)	mRpL17	NP_523870.2
Xenopus tropicalis (tropical clawed frog)	mrpl17	NP_001165747.1
Gallus gallus (chicken)	MRPL17	XP_001232123.1
Danio rerio (zebrafish)	mrpl17	NP_001004683.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

High levels of the proNGF peptides LIP1 and LIP2 in the serum and synovial fluid of rheumatoid arthritis patients: evidence for two new cytokines.
Dicou E
Journal of neuroimmunology194(1-2)143-6(2008 Feb)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

High levels of LIP2 were found in serum and synovial fluid of rheumatoid arthritis patients, providing evidence for a cytokine-like role.
Title: High levels of the proNGF peptides LIP1 and LIP2 in the serum and synovial fluid of rheumatoid arthritis patients: evidence for two new cytokines.

The following MRPL17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08923	NM_022061.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu08923	NM_022061.3	Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL17 ( NM_022061.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071344.1 Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.

Price & Availability↑

CloneID	OHu08923
Clone ID Related Accession (Same CDS sequence)	NM_022061.4 , NM_022061.3
Accession Version	NM_022061.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	39S ribosomal protein L17, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB228622.1, AF164797.1, BF513148.1, AL572779.3, BM725086.1 and DA876701.1. On May 17, 2019 this sequence version replaced NM_022061.3. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.251574.1, SRR1803615.87288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000288937.7/ ENSP00000288937.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTGT CGGTCGCTGC AGCGATCTCC CATGGCCGCG TATTTCGCCG TATGGGCCTC 
GGTCCCGAGT CCCGCATCCA TCTGTTGCGG AACTTGCTCA CAGGGCTGGT GCGGCACGAA 
CGCATCGAGG CACCATGGGC GCGTGTGGAC GAAATGAGGG GCTACGCGGA GAAGCTCATC 
GACTATGGGA AGCTGGGAGA CACTAACGAA CGAGCCATGC GCATGGCTGA CTTCTGGCTC 
ACAGAGAAGG ATTTGATCCC AAAGCTGTTT CAAGTACTGG CCCCTCGGTA CAAAGATCAA 
ACTGGGGGCT ACACAAGAAT GCTGCAGATC CCAAATCGGA GTTTGGATCG GGCCAAGATG 
GCAGTGATCG AGTATAAAGG GAATTGCCTC CCACCCCTGC CTCTGCCTCG CAGAGACAGC 
CACCTTACAC TCCTAAACCA GCTGCTGCAG GGTTTGCGGC AGGACCTCAG GCAAAGCCAG 
GAAGCAAGCA ACCACAGCTC CCACACAGCT CAAACACCAG GGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071344.1
CDS	45..572
Translation	MRLSVAAAISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRMLQIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQSQEASNHSSHTAQTPGI

Target ORF information:

RefSeq Version	NM_022061.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022061.4

ORF Insert Sequence:

ATGCGGCTGT CGGTCGCTGC AGCGATCTCC CATGGCCGCG TATTTCGCCG TATGGGCCTC 
GGTCCCGAGT CCCGCATCCA TCTGTTGCGG AACTTGCTCA CAGGGCTGGT GCGGCACGAA 
CGCATCGAGG CACCATGGGC GCGTGTGGAC GAAATGAGGG GCTACGCGGA GAAGCTCATC 
GACTATGGGA AGCTGGGAGA CACTAACGAA CGAGCCATGC GCATGGCTGA CTTCTGGCTC 
ACAGAGAAGG ATTTGATCCC AAAGCTGTTT CAAGTACTGG CCCCTCGGTA CAAAGATCAA 
ACTGGGGGCT ACACAAGAAT GCTGCAGATC CCAAATCGGA GTTTGGATCG GGCCAAGATG 
GCAGTGATCG AGTATAAAGG GAATTGCCTC CCACCCCTGC CTCTGCCTCG CAGAGACAGC 
CACCTTACAC TCCTAAACCA GCTGCTGCAG GGTTTGCGGC AGGACCTCAG GCAAAGCCAG 
GAAGCAAGCA ACCACAGCTC CCACACAGCT CAAACACCAG GGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL17 ( NM_022061.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071344.1 Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.

Price & Availability↑

CloneID	OHu08923
Clone ID Related Accession (Same CDS sequence)	NM_022061.4 , NM_022061.3
Accession Version	NM_022061.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-10
Organism	Homo sapiens(human)
Product	39S ribosomal protein L17, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB228622.1, AF164797.1, BF513148.1, AL572779.3, BM725086.1 and DA876701.1. On Mar 5, 2008 this sequence version replaced NM_022061.2. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.393602.1, SRR1803615.87288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTGT CGGTCGCTGC AGCGATCTCC CATGGCCGCG TATTTCGCCG TATGGGCCTC 
GGTCCCGAGT CCCGCATCCA TCTGTTGCGG AACTTGCTCA CAGGGCTGGT GCGGCACGAA 
CGCATCGAGG CACCATGGGC GCGTGTGGAC GAAATGAGGG GCTACGCGGA GAAGCTCATC 
GACTATGGGA AGCTGGGAGA CACTAACGAA CGAGCCATGC GCATGGCTGA CTTCTGGCTC 
ACAGAGAAGG ATTTGATCCC AAAGCTGTTT CAAGTACTGG CCCCTCGGTA CAAAGATCAA 
ACTGGGGGCT ACACAAGAAT GCTGCAGATC CCAAATCGGA GTTTGGATCG GGCCAAGATG 
GCAGTGATCG AGTATAAAGG GAATTGCCTC CCACCCCTGC CTCTGCCTCG CAGAGACAGC 
CACCTTACAC TCCTAAACCA GCTGCTGCAG GGTTTGCGGC AGGACCTCAG GCAAAGCCAG 
GAAGCAAGCA ACCACAGCTC CCACACAGCT CAAACACCAG GGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071344.1
CDS	106..633
Translation	MRLSVAAAISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRMLQIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQSQEASNHSSHTAQTPGI

Target ORF information:

RefSeq Version	NM_022061.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022061.3

ORF Insert Sequence:

ATGCGGCTGT CGGTCGCTGC AGCGATCTCC CATGGCCGCG TATTTCGCCG TATGGGCCTC 
GGTCCCGAGT CCCGCATCCA TCTGTTGCGG AACTTGCTCA CAGGGCTGGT GCGGCACGAA 
CGCATCGAGG CACCATGGGC GCGTGTGGAC GAAATGAGGG GCTACGCGGA GAAGCTCATC 
GACTATGGGA AGCTGGGAGA CACTAACGAA CGAGCCATGC GCATGGCTGA CTTCTGGCTC 
ACAGAGAAGG ATTTGATCCC AAAGCTGTTT CAAGTACTGG CCCCTCGGTA CAAAGATCAA 
ACTGGGGGCT ACACAAGAAT GCTGCAGATC CCAAATCGGA GTTTGGATCG GGCCAAGATG 
GCAGTGATCG AGTATAAAGG GAATTGCCTC CCACCCCTGC CTCTGCCTCG CAGAGACAGC 
CACCTTACAC TCCTAAACCA GCTGCTGCAG GGTTTGCGGC AGGACCTCAG GCAAAGCCAG 
GAAGCAAGCA ACCACAGCTC CCACACAGCT CAAACACCAG GGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

High levels of the proNGF peptides LIP1 and LIP2 in the serum and synovial fluid of rheumatoid arthritis patients: evidence for two new cytokines.
Journal of neuroimmunology194(1-2)143-6(2008 Feb)
Dicou E

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

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MRPL17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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