CXCL5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL5
Entrez Gene ID	6374
Full Name	C-X-C motif chemokine ligand 5
Synonyms	ENA-78,SCYB5
General protein information	Preferred Names C-X-C motif chemokine ligand 5 Names C-X-C motif chemokine 5 chemokine (C-X-C motif) ligand 5 epithelial-derived neutrophil-activating protein 78 neutrophil-activating peptide ENA-78 neutrophil-activating protein 78 small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013].
Disorder MIM:	600324

mRNA and Protein(s)

mRNA	Protein	Name
NM_002994.4	NP_002985.1	C-X-C motif chemokine 5 precursor
NM_002994.5	NP_002985.1	C-X-C motif chemokine 5 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CXCL5	NP_002985.1
	CXCL5	XP_001091762.1
Bos taurus (cattle)	CXCL6	NP_776725.1
Pan troglodytes (chimpanzee)	CXCL5	XP_001155862.1

Gene Ontology
Bibliography

Related articles in PubMed

The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.
Shusterman A, Munz M, Richter G, Jepsen S, Lieb W, Krone B, Hoffman P, Laudes M, Wellmann J, Berger K, Kocher T, Offenbacher S, Divaris K, Franke A, Schreiber S, Dommisch H, Weiss E, Schaefer AS, Houri-Haddad Y, Iraqi FA
Journal of dental research96(8)945-952(2017 Jul)

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3?/?-catenin pathways.
Zhao J, Ou B, Han D, Wang P, Zong Y, Zhu C, Liu D, Zheng M, Sun J, Feng H, Lu A
Molecular cancer16(1)70(2017 03)

Down-regulation of CXCL5 inhibits squamous carcinogenesis.
Miyazaki H, Patel V, Wang H, Edmunds RK, Gutkind JS, Yeudall WA
Cancer research66(8)4279-84(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
Title: The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.

our findings support CXCL5 as a promoter of colorectal cancer metastasis and a predictor of poor clinical outcomes in colorectal cancer patients.
Title: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3?/?-catenin pathways.

CXCL5 levels were decreased in LSCC patient serum.
Title: Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance.

The expression of CXCL5 is up-regulated in osteosarcoma cells.
Title: CXCL5 Plays a Promoting Role in Osteosarcoma Cell Migration and Invasion in Autocrine- and Paracrine-Dependent Manners.

CXCL5 plays a promoting role in glioma in autocrine- and paracrine-dependent manners.
Title: CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners.

The following CXCL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03189	NM_002994.5 Latest version!	Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03189	NM_002994.4	Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL5 ( NM_002994.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002985.1 Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.

Price & Availability↑

CloneID	OHu03189
Clone ID Related Accession (Same CDS sequence)	NM_002994.4 , NM_002994.5
Accession Version	NM_002994.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN992282.1, BC008376.1, CB529782.1 and BU626570.1. On May 9, 2013 this sequence version replaced NM_002994.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP272634.1, SRR1660803.260744.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGCCTCC TGTCCAGCCG CGCGGCCCGT GTCCCCGGTC CTTCGAGCTC CTTGTGCGCG 
CTGTTGGTGC TGCTGCTGCT GCTGACGCAG CCAGGGCCCA TCGCCAGCGC TGGTCCTGCC 
GCTGCTGTGT TGAGAGAGCT GCGTTGCGTT TGTTTACAGA CCACGCAAGG AGTTCATCCC 
AAAATGATCA GTAATCTGCA AGTGTTCGCC ATAGGCCCAC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGGAAATT TGTCTTGATC CAGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACGGTGGA AACAAGGAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002985.1
CDS	149..493
Translation	MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIASAGPAAAVLRELRCVCLQTTQGVHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKILDGGNKEN

Target ORF information:

RefSeq Version	NM_002994.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002994.4

ORF Insert Sequence:

ATGAGCCTCC TGTCCAGCCG CGCGGCCCGT GTCCCCGGTC CTTCGAGCTC CTTGTGCGCG 
CTGTTGGTGC TGCTGCTGCT GCTGACGCAG CCAGGGCCCA TCGCCAGCGC TGGTCCTGCC 
GCTGCTGTGT TGAGAGAGCT GCGTTGCGTT TGTTTACAGA CCACGCAAGG AGTTCATCCC 
AAAATGATCA GTAATCTGCA AGTGTTCGCC ATAGGCCCAC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGGAAATT TGTCTTGATC CAGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACGGTGGA AACAAGGAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCL5 ( NM_002994.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002985.1 Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.

Price & Availability↑

CloneID	OHu03189
Clone ID Related Accession (Same CDS sequence)	NM_002994.4 , NM_002994.5
Accession Version	NM_002994.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097709.3. On Nov 23, 2018 this sequence version replaced NM_002994.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.147496.1, SRR1660809.183638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296027.5/ ENSP00000296027.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCTCC TGTCCAGCCG CGCGGCCCGT GTCCCCGGTC CTTCGAGCTC CTTGTGCGCG 
CTGTTGGTGC TGCTGCTGCT GCTGACGCAG CCAGGGCCCA TCGCCAGCGC TGGTCCTGCC 
GCTGCTGTGT TGAGAGAGCT GCGTTGCGTT TGTTTACAGA CCACGCAAGG AGTTCATCCC 
AAAATGATCA GTAATCTGCA AGTGTTCGCC ATAGGCCCAC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGGAAATT TGTCTTGATC CAGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACGGTGGA AACAAGGAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002985.1
CDS	97..441
Translation	MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIASAGPAAAVLRELRCVCLQTTQGVHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKILDGGNKEN

Target ORF information:

RefSeq Version	NM_002994.5
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002994.5

ORF Insert Sequence:

ATGAGCCTCC TGTCCAGCCG CGCGGCCCGT GTCCCCGGTC CTTCGAGCTC CTTGTGCGCG 
CTGTTGGTGC TGCTGCTGCT GCTGACGCAG CCAGGGCCCA TCGCCAGCGC TGGTCCTGCC 
GCTGCTGTGT TGAGAGAGCT GCGTTGCGTT TGTTTACAGA CCACGCAAGG AGTTCATCCC 
AAAATGATCA GTAATCTGCA AGTGTTCGCC ATAGGCCCAC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGGAAATT TGTCTTGATC CAGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACGGTGGA AACAAGGAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.
Journal of dental research96(8)945-952(2017 Jul)
Shusterman A,Munz M,Richter G,Jepsen S,Lieb W,Krone B,Hoffman P,Laudes M,Wellmann J,Berger K,Kocher T,Offenbacher S,Divaris K,Franke A,Schreiber S,Dommisch H,Weiss E,Schaefer AS,Houri-Haddad Y,Iraqi FA

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3?/?-catenin pathways.
Molecular cancer16(1)70(2017 03)
Zhao J,Ou B,Han D,Wang P,Zong Y,Zhu C,Liu D,Zheng M,Sun J,Feng H,Lu A

Down-regulation of CXCL5 inhibits squamous carcinogenesis.
Cancer research66(8)4279-84(2006 Apr)
Miyazaki H,Patel V,Wang H,Edmunds RK,Gutkind JS,Yeudall WA

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CXCL5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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