CCL25 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL25
Entrez Gene ID	6370
Full Name	C-C motif chemokine ligand 25
Synonyms	Ckb15,SCYA25,TECK
General protein information	Preferred Names C-C motif chemokine ligand 25 Names C-C motif chemokine 25 Ck beta-15 TECKvar chemokine (C-C motif) ligand 25 chemokine TECK small inducible cytokine subfamily A (Cys-Cys), member 25 small-inducible cytokine A25 thymus expressed chemokine
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Disorder MIM:	602565

mRNA and Protein(s)

mRNA	Protein	Name
XM_017027119.1	XP_016882608.1	C-C motif chemokine 25 isoform X1
XM_017027120.1	XP_016882609.1	C-C motif chemokine 25 isoform X2
XM_017027121.1	XP_016882610.1	C-C motif chemokine 25 isoform X2
NM_001201359.1	NP_001188288.1	C-C motif chemokine 25 isoform 2 precursor
XM_011528177.2	XP_011526479.1	C-C motif chemokine 25 isoform X2
XM_017027122.1	XP_016882611.1	C-C motif chemokine 25 isoform X3
NM_005624.3	NP_005615.2	C-C motif chemokine 25 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCL25	XP_001156693.1
	CCL25	NP_001028047.1
Homo sapiens (human)	CCL25	NP_005615.2
Canis lupus familiaris (dog)	CCL25	NP_001005259.1
Bos taurus (cattle)	CCL25	NP_001040034.2
Rattus norvegicus (Norway rat)	Ccl25	NP_001032280.1
Mus musculus (house mouse)	Ccl25	NP_033164.1

Gene Ontology
Bibliography

Related articles in PubMed

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, D?ring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C
Science translational medicine9(384)(2017 Apr)

CCL25/CCR9 Signal Promotes Migration and Invasion in Hepatocellular and Breast Cancer Cell Lines.
Zhang Z, Sun T, Chen Y, Gong S, Sun X, Zou F, Peng R
DNA and cell biology35(7)348-57(2016 Jul)

Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation.
Usui M, Okamatsu Y, Sato T, Hanatani T, Moritani Y, Sano K, Yamamoto M, Nakashima K
Archives of oral biology6677-85(2016 Jun)

Role of inflammatory macrophages and CCR9/CCL25 chemokine axis in the pathogenesis of liver injury as a therapeutic target.
Nakamoto N
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology39(5)460-467(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that CCL25/CCR9 signal may provide cancer cells with chemotactic abilities through influencing several epithelial-mesenchymal transitionmarkers
Title: CCL25/CCR9 Signal Promotes Migration and Invasion in Hepatocellular and Breast Cancer Cell Lines.

TECK was shown to be expressed by osteoblasts, and its receptor, CCR9, by osteoclast precursors. TECK increased P. gingivalis LPS-induced osteoclast numbers in an in vitro osteoclast formation assay using osteoclast precursors. T
Title: Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation.

CCR9/CCL25 interactions are not only involved in colitis pathogenesis but also correlate with colonic inflammatory burden; further supporting the existence of overlapping mucosal lymphocyte recruitment pathways between the inflamed colon and liver.
Title: Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity.

Studies indicate important roles played by chemokine ligand 25 (CCL25)/chemokine receptor 9 (CCR9) in tumorigenesis, tumor chemoresistance and metastasis.
Title: CCR9 in cancer: oncogenic role and therapeutic targeting.

It plays a pathogenic role in liver diseases and it will be a therapeutic target of the diseases.
Title: Role of inflammatory macrophages and CCR9/CCL25 chemokine axis in the pathogenesis of liver injury as a therapeutic target.

The following CCL25 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL25 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01803	NM_005624.3 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01613	NM_001201359.1 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu01613	XM_017027122.1 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu01803	XM_011528177.2 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu01803	XM_017027120.1 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu01803	XM_017027121.1 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu88652	XM_017027119.1 Latest version!	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL25 ( NM_005624.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005615.2 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01803
Clone ID Related Accession (Same CDS sequence)	XM_017027120.1 , XM_017027121.1 , XM_011528177.2 , NM_005624.3
Accession Version	NM_005624.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008946.7, BC130561.1 and AI313430.1. On Feb 10, 2011 this sequence version replaced NM_005624.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.315.1, ERR279828.1575.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005615.2
CDS	112..564
Translation	MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	NM_005624.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005624.3

ORF Insert Sequence:

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL25 ( NM_001201359.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001188288.1 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01613
Clone ID Related Accession (Same CDS sequence)	NM_001201359.1 , XM_017027122.1
Accession Version	NM_001201359.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-17
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292662.1, AC008946.7 and AI313430.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292662.1, ERR279834.7957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGGCCCT CATGCTGTAA AGAAGTTGAG TTCTGGAAAC 
TCCAAGTTAT CATCGTCCAA GTTTAGCAAT CCCATCAGCA GCAGTAAGAG GAATGTCTCC 
CTCCTGATAT CAGCTAATTC AGGACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001188288.1
CDS	112..561
Translation	MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	NM_001201359.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201359.1

ORF Insert Sequence:

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGGCCCT CATGCTGTAA AGAAGTTGAG TTCTGGAAAC 
TCCAAGTTAT CATCGTCCAA GTTTAGCAAT CCCATCAGCA GCAGTAAGAG GAATGTCTCC 
CTCCTGATAT CAGCTAATTC AGGACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL25 ( XM_017027122.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882611.1 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu01613
Clone ID Related Accession (Same CDS sequence)	NM_001201359.1 , XM_017027122.1
Accession Version	XM_017027122.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGGCCCT CATGCTGTAA AGAAGTTGAG TTCTGGAAAC 
TCCAAGTTAT CATCGTCCAA GTTTAGCAAT CCCATCAGCA GCAGTAAGAG GAATGTCTCC 
CTCCTGATAT CAGCTAATTC AGGACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882611.1
CDS	291..740
Translation	MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	XM_017027122.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027122.1

ORF Insert Sequence:

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGGCCCT CATGCTGTAA AGAAGTTGAG TTCTGGAAAC 
TCCAAGTTAT CATCGTCCAA GTTTAGCAAT CCCATCAGCA GCAGTAAGAG GAATGTCTCC 
CTCCTGATAT CAGCTAATTC AGGACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL25 ( XM_017027120.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882609.1 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu01803
Clone ID Related Accession (Same CDS sequence)	XM_017027120.1 , XM_017027121.1 , XM_011528177.2 , NM_005624.3
Accession Version	XM_017027120.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882609.1
CDS	208..660
Translation	MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	XM_017027120.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027120.1

ORF Insert Sequence:

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL25 ( XM_017027121.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882610.1 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu01803
Clone ID Related Accession (Same CDS sequence)	XM_017027120.1 , XM_017027121.1 , XM_011528177.2 , NM_005624.3
Accession Version	XM_017027121.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882610.1
CDS	154..606
Translation	MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	XM_017027121.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027121.1

ORF Insert Sequence:

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL25 ( XM_011528177.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526479.1 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X2, mRNA.

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CloneID	OHu01803
Clone ID Related Accession (Same CDS sequence)	XM_017027120.1 , XM_017027121.1 , XM_011528177.2 , NM_005624.3
Accession Version	XM_011528177.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528177.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526479.1
CDS	313..765
Translation	MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	XM_011528177.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528177.2

ORF Insert Sequence:

ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL25 ( XM_017027119.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882608.1 Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88652
Clone ID Related Accession (Same CDS sequence)	XM_017027119.1
Accession Version	XM_017027119.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	C-C motif chemokine 25 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGTAA GGGCTTGTTT GGGGGCTCAA GGCAGTCTGA GCCTTGTTCG CAGGCAGCCA 
GTGTCCACCA GATGGGACAG CTTGGCCTAC AGCCCGGCGG GCATCAGCTC CCTTGACCCA 
GTGGATATCG GTGGCCCCGT TATTCGTCCA GGTGCCCAGG GAGGAGGACC CGCCTGCAGC 
ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882608.1
CDS	99..731
Translation	MKVRACLGAQGSLSLVRRQPVSTRWDSLAYSPAGISSLDPVDIGGPVIRPGAQGGGPACSMNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL

Target ORF information:

RefSeq Version	XM_017027119.1
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027119.1

ORF Insert Sequence:

ATGAAGGTAA GGGCTTGTTT GGGGGCTCAA GGCAGTCTGA GCCTTGTTCG CAGGCAGCCA 
GTGTCCACCA GATGGGACAG CTTGGCCTAC AGCCCGGCGG GCATCAGCTC CCTTGACCCA 
GTGGATATCG GTGGCCCCGT TATTCGTCCA GGTGCCCAGG GAGGAGGACC CGCCTGCAGC 
ATGAACCTGT GGCTCCTGGC CTGCCTGGTG GCCGGCTTCC TGGGAGCCTG GGCCCCCGCT 
GTCCACACCC AAGGTGTCTT TGAGGACTGC TGCCTGGCCT ACCACTACCC CATTGGGTGG 
GCTGTGCTCC GGCGCGCCTG GACTTACCGG ATCCAGGAGG TGAGCGGGAG CTGCAATCTG 
CCTGCTGCGA TATTCTACCT CCCCAAGAGA CACAGGAAGG TGTGTGGGAA CCCCAAAAGC 
AGGGAGGTGC AGAGAGCCAT GAAGCTCCTG GATGCTCGAA ATAAGGTTTT TGCAAAGCTC 
CACCACAACA CGCAGACCTT CCAAGCAGGC CCTCATGCTG TAAAGAAGTT GAGTTCTGGA 
AACTCCAAGT TATCATCGTC CAAGTTTAGC AATCCCATCA GCAGCAGTAA GAGGAATGTC 
TCCCTCCTGA TATCAGCTAA TTCAGGACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Science translational medicine9(384)(2017 Apr)
von Hundelshausen P,Agten SM,Eckardt V,Blanchet X,Schmitt MM,Ippel H,Neideck C,Bidzhekov K,Leberzammer J,Wichapong K,Faussner A,Drechsler M,Grommes J,van Geffen JP,Li H,Ortega-Gomez A,Megens RT,Naumann R,Dijkgraaf I,Nicolaes GA,D?ring Y,Soehnlein O,Lutgens E,Heemskerk JW,Koenen RR,Mayo KH,Hackeng TM,Weber C

CCL25/CCR9 Signal Promotes Migration and Invasion in Hepatocellular and Breast Cancer Cell Lines.
DNA and cell biology35(7)348-57(2016 Jul)
Zhang Z,Sun T,Chen Y,Gong S,Sun X,Zou F,Peng R

Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation.
Archives of oral biology6677-85(2016 Jun)
Usui M,Okamatsu Y,Sato T,Hanatani T,Moritani Y,Sano K,Yamamoto M,Nakashima K

Role of inflammatory macrophages and CCR9/CCL25 chemokine axis in the pathogenesis of liver injury as a therapeutic target.
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology39(5)460-467(2016)
Nakamoto N

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CCL25 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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