CCL21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL21
Entrez Gene ID	6366
Full Name	C-C motif chemokine ligand 21
Synonyms	6Ckine,CKb9,ECL,SCYA21,SLC,TCA4
General protein information	Preferred Names C-C motif chemokine ligand 21 Names C-C motif chemokine 21 Efficient Chemoattractant for Lymphocytes beta chemokine exodus-2 chemokine (C-C motif) ligand 21 secondary lymphoid tissue chemokine small inducible cytokine subfamily A (Cys-Cys), member 21
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.3
Summary	This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014].
Disorder MIM:	602737

mRNA and Protein(s)

mRNA	Protein	Name
XM_011518004.2	XP_011516306.1	C-C motif chemokine 21 isoform X1
NM_002989.3	NP_002980.1	C-C motif chemokine 21 precursor
NM_002989.4	NP_002980.1	C-C motif chemokine 21 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ccl21c	NP_075539.1
Pan troglodytes (chimpanzee)	CCL21	XP_001164162.1
Mus musculus (house mouse)	Gm13304	NP_001180595.1
Mus musculus (house mouse)	LOC100041593	XP_001473444.1
Mus musculus (house mouse)	Gm10591	NP_001180597.1
	CCL21	NP_001028027.1
Canis lupus familiaris (dog)	CCL21	NP_001005258.1
Mus musculus (house mouse)	Ccl21b	NP_035465.2
Mus musculus (house mouse)	Gm21541	NP_001257289.1
Mus musculus (house mouse)	Ccl21a	NP_035254.1
Homo sapiens (human)	CCL21	NP_002980.1
Bos taurus (cattle)	CCL21	NP_001033165.2
Mus musculus (house mouse)	LOC100041504	XP_001473308.1
Mus musculus (house mouse)	Gm1987	NP_001180596.1
Rattus norvegicus (Norway rat)	Ccl21	NP_001008513.1

Gene Ontology
Bibliography

Related articles in PubMed

Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration.
Karlsen TV, Reikvam T, Tofteberg A, Nikpey E, Skogstrand T, Wagner M, Tenstad O, Wiig H
Arteriosclerosis, thrombosis, and vascular biology37(11)2128-2135(2017 Nov)

Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
Li G, Zhao J, Li B, Ma J, Zhao Q, Wang X, Lv Z, Li K, Du Z, Ma X, Liu J
Rheumatology international37(10)1673-1681(2017 Oct)

Stimulation of osteoclast migration and bone resorption by C-C chemokine ligands 19 and 21.
Lee J, Park C, Kim HJ, Lee YD, Lee ZH, Song YW, Kim HH
Experimental & molecular medicine49(7)e358(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An expanded lymphatic network is capable of enhanced chemoattractant CCL21 production, and lymphangiogenesis will facilitate initial lymph formation favoring increased clearance of fluid in situations of augmented fluid filtration.
Title: Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration.

Results provide evidence for an association between an increase level of CCL21 and IP-10 in the blood and pulmonary involvement in systemic lupus erythematosus patients.
Title: CCL21 and IP-10 as blood biomarkers for pulmonary involvement in systemic lupus erythematosus patients.

CCL21 and CXCL13 levels are increased in the minor salivary glands of patients with Sjogren's syndrome.
Title: Predictive significance of CCL21 and CXCL13 levels in the minor salivary glands of patients with Sj?gren's syndrome.

Gata1-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21.
Title: GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid.

CCL21/CCR7 interaction contributes to the time-dependent proliferation of PTC cells by upregulating cyclin A, cyclin B1 and cyclin-dependent kinase 1 (CDK1) expression via the extracellular signal-regulated kinase (ERK) pathway associated with iodine.
Title: Iodine regulates G2/M progression induced by CCL21/CCR7 interaction in primary cultures of papillary thyroid cancer cells with RET/PTC expression.

The following CCL21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27534	NM_002989.4 Latest version!	Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu60431	XM_011518004.2 Latest version!	Homo sapiens C-C motif chemokine ligand 21 (CCL21), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu27534	NM_002989.3	Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL21 ( NM_002989.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002980.1 Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.

Price & Availability↑

CloneID	OHu27534
Clone ID Related Accession (Same CDS sequence)	NM_002989.3 , NM_002989.4
Accession Version	NM_002989.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	C-C motif chemokine 21 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP331359.1, BI833188.1 and BC027918.1. On May 16, 2013 this sequence version replaced NM_002989.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279875.1698.1, BI834167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAGT CACTGGCTCT GAGCCTCCTT ATCCTGGTTC TGGCCTTTGG CATCCCCAGG 
ACCCAAGGCA GTGATGGAGG GGCTCAGGAC TGTTGCCTCA AGTACAGCCA AAGGAAGATT 
CCCGCCAAGG TTGTCCGCAG CTACCGGAAG CAGGAACCAA GCTTAGGCTG CTCCATCCCA 
GCTATCCTGT TCTTGCCCCG CAAGCGCTCT CAGGCAGAGC TATGTGCAGA CCCAAAGGAG 
CTCTGGGTGC AGCAGCTGAT GCAGCATCTG GACAAGACAC CATCCCCACA GAAACCAGCC 
CAGGGCTGCA GGAAGGACAG GGGGGCCTCC AAGACTGGCA AGAAAGGAAA GGGCTCCAAA 
GGCTGCAAGA GGACTGAGCG GTCACAGACC CCTAAAGGGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002980.1
CDS	102..506
Translation	MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP

Target ORF information:

RefSeq Version	NM_002989.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002989.3

ORF Insert Sequence:

ATGGCTCAGT CACTGGCTCT GAGCCTCCTT ATCCTGGTTC TGGCCTTTGG CATCCCCAGG 
ACCCAAGGCA GTGATGGAGG GGCTCAGGAC TGTTGCCTCA AGTACAGCCA AAGGAAGATT 
CCCGCCAAGG TTGTCCGCAG CTACCGGAAG CAGGAACCAA GCTTAGGCTG CTCCATCCCA 
GCTATCCTGT TCTTGCCCCG CAAGCGCTCT CAGGCAGAGC TATGTGCAGA CCCAAAGGAG 
CTCTGGGTGC AGCAGCTGAT GCAGCATCTG GACAAGACAC CATCCCCACA GAAACCAGCC 
CAGGGCTGCA GGAAGGACAG GGGGGCCTCC AAGACTGGCA AGAAAGGAAA GGGCTCCAAA 
GGCTGCAAGA GGACTGAGCG GTCACAGACC CCTAAAGGGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL21 ( NM_002989.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002980.1 Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.

Price & Availability↑

CloneID	OHu27534
Clone ID Related Accession (Same CDS sequence)	NM_002989.3 , NM_002989.4
Accession Version	NM_002989.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	C-C motif chemokine 21 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI833188.1 and BC027918.1. On Nov 23, 2018 this sequence version replaced NM_002989.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.188399.1, SRR5189667.380449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259607.7/ ENSP00000259607.2 Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCAGT CACTGGCTCT GAGCCTCCTT ATCCTGGTTC TGGCCTTTGG CATCCCCAGG 
ACCCAAGGCA GTGATGGAGG GGCTCAGGAC TGTTGCCTCA AGTACAGCCA AAGGAAGATT 
CCCGCCAAGG TTGTCCGCAG CTACCGGAAG CAGGAACCAA GCTTAGGCTG CTCCATCCCA 
GCTATCCTGT TCTTGCCCCG CAAGCGCTCT CAGGCAGAGC TATGTGCAGA CCCAAAGGAG 
CTCTGGGTGC AGCAGCTGAT GCAGCATCTG GACAAGACAC CATCCCCACA GAAACCAGCC 
CAGGGCTGCA GGAAGGACAG GGGGGCCTCC AAGACTGGCA AGAAAGGAAA GGGCTCCAAA 
GGCTGCAAGA GGACTGAGCG GTCACAGACC CCTAAAGGGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002980.1
CDS	71..475
Translation	MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP

Target ORF information:

RefSeq Version	NM_002989.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002989.4

ORF Insert Sequence:

ATGGCTCAGT CACTGGCTCT GAGCCTCCTT ATCCTGGTTC TGGCCTTTGG CATCCCCAGG 
ACCCAAGGCA GTGATGGAGG GGCTCAGGAC TGTTGCCTCA AGTACAGCCA AAGGAAGATT 
CCCGCCAAGG TTGTCCGCAG CTACCGGAAG CAGGAACCAA GCTTAGGCTG CTCCATCCCA 
GCTATCCTGT TCTTGCCCCG CAAGCGCTCT CAGGCAGAGC TATGTGCAGA CCCAAAGGAG 
CTCTGGGTGC AGCAGCTGAT GCAGCATCTG GACAAGACAC CATCCCCACA GAAACCAGCC 
CAGGGCTGCA GGAAGGACAG GGGGGCCTCC AAGACTGGCA AGAAAGGAAA GGGCTCCAAA 
GGCTGCAAGA GGACTGAGCG GTCACAGACC CCTAAAGGGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL21 ( XM_011518004.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011516306.1 Homo sapiens C-C motif chemokine ligand 21 (CCL21), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60431
Clone ID Related Accession (Same CDS sequence)	XM_011518004.2
Accession Version	XM_011518004.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	C-C motif chemokine 21 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011518004.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCAGT CACTGGCTCT GAGCCTCCTT ATCCTGGTTC TGGCCTTTGG CATCCCCAGG 
ACCCAAGGCA GTGATGGAGG GGCTCAGGAC TGTTGCCTCA AGTACAGCCA AAGGAAGATT 
CCCGCCAAGG TTGTCCGCAG CTACCGGAAG CAGGAACCAA GCTTAGGCTG CTCCATCCCA 
GCTATCCTGT TCTTGCCCCG CAAGCGCTCT CAGGCAGAGC TATGTGCAGA CCCAAAGGAG 
CTCTGGGTGC AGCAGCTGAT GCAGCATCTG GACAAGACAC CATCCCCACA GAAACCAGCC 
CAGGGCTGCA GGAAGGACAG GGGGGCCTCC AAGACTGGCA AGAAAGGAAA GGGCTCCAAA 
GGCTGCAAGA GTCAGCCCCT CACACCCCTC TTCTGCCCTC ACAGGACTGA GCGGTCACAG 
ACCCCTAAAG GGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011516306.1
CDS	89..526
Translation	MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKSQPLTPLFCPHRTERSQTPKGP

Target ORF information:

RefSeq Version	XM_011518004.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 21 (CCL21), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518004.2

ORF Insert Sequence:

ATGGCTCAGT CACTGGCTCT GAGCCTCCTT ATCCTGGTTC TGGCCTTTGG CATCCCCAGG 
ACCCAAGGCA GTGATGGAGG GGCTCAGGAC TGTTGCCTCA AGTACAGCCA AAGGAAGATT 
CCCGCCAAGG TTGTCCGCAG CTACCGGAAG CAGGAACCAA GCTTAGGCTG CTCCATCCCA 
GCTATCCTGT TCTTGCCCCG CAAGCGCTCT CAGGCAGAGC TATGTGCAGA CCCAAAGGAG 
CTCTGGGTGC AGCAGCTGAT GCAGCATCTG GACAAGACAC CATCCCCACA GAAACCAGCC 
CAGGGCTGCA GGAAGGACAG GGGGGCCTCC AAGACTGGCA AGAAAGGAAA GGGCTCCAAA 
GGCTGCAAGA GTCAGCCCCT CACACCCCTC TTCTGCCCTC ACAGGACTGA GCGGTCACAG 
ACCCCTAAAG GGCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration.
Arteriosclerosis, thrombosis, and vascular biology37(11)2128-2135(2017 Nov)
Karlsen TV,Reikvam T,Tofteberg A,Nikpey E,Skogstrand T,Wagner M,Tenstad O,Wiig H

Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
Rheumatology international37(10)1673-1681(2017 Oct)
Li G,Zhao J,Li B,Ma J,Zhao Q,Wang X,Lv Z,Li K,Du Z,Ma X,Liu J

Stimulation of osteoclast migration and bone resorption by C-C chemokine ligands 19 and 21.
Experimental & molecular medicine49(7)e358(2017 Jul)
Lee J,Park C,Kim HJ,Lee YD,Lee ZH,Song YW,Kim HH

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CCL21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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