CCL14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL14
Entrez Gene ID	6358
Full Name	C-C motif chemokine ligand 14
Synonyms	CC-1,CC-3,CKB1,HCC-1,HCC-1(1-74),HCC-1/HCC-3,HCC-3,MCIF,NCC-2,NCC2,SCYA14,SCYL2,SY14
General protein information	Preferred Names C-C motif chemokine ligand 14 Names C-C motif chemokine 14 chemokine (C-C motif) ligand 14 chemokine CC-1/CC-3 chemokine CC-3 hemofiltrate CC chemokine 1 new CC chemokine 2 small inducible cytokine subfamily A (Cys-Cys), member 14 small-inducible cytokine A14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009].
Disorder MIM:	601392

mRNA and Protein(s)

mRNA	Protein	Name
NM_032963.3	NP_116739.1	C-C motif chemokine 14 isoform 1 precursor
NM_032962.4	NP_116738.1	C-C motif chemokine 14 isoform 2 precursor
NM_032963.4	NP_116739.1	C-C motif chemokine 14 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCL14	XP_001173954.1
Homo sapiens (human)	CCL14	NP_116739.1
Canis lupus familiaris (dog)	CCL14	XP_537723.3
Bos taurus (cattle)	CCL14	NP_001040050.1

Gene Ontology
Bibliography

Related articles in PubMed

TMEM88, CCL14 and CLEC3B as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma.
Zhang X, Wan JX, Ke ZP, Wang F, Chai HX, Liu JQ
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317708900(2017 Jul)

Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma.
Li Y, Zheng Y, Li T, Wang Q, Qian J, Lu Y, Zhang M, Bi E, Yang M, Reu F, Yi Q, Cai Z
Oncotarget6(27)24218-29(2015 Sep)

Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.
Li Q, Shi L, Gui B, Yu W, Wang J, Zhang D, Han X, Yao Z, Shang Y
Cancer research71(21)6899-908(2011 Nov)

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
Mucosal immunology3(1)40-8(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival
Title: TMEM88, CCL14 and CLEC3B as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma.

CCL2, 3, 14 have roles in stimulating macrophage bone marrow homing, proliferation, and polarization in multiple myeloma
Title: Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma.

CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer.
Title: Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.

The following CCL14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05205	NM_032963.4 Latest version!	Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05204	NM_032962.4 Latest version!	Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu05205	NM_032963.3	Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL14 ( NM_032963.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116739.1 Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05205
Clone ID Related Accession (Same CDS sequence)	NM_032963.3 , NM_032963.4
Accession Version	NM_032963.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	C-C motif chemokine 14 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA821276.1. On Jan 24, 2009 this sequence version replaced NM_032963.2. Transcript Variant: This variant (3, CCL14a) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (1) lacks an alternate segment near the N-terminus, compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY071902.1, DA821276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCT CCGTGGCTGC CATTCCCTTC TTCCTCCTCA TCACCATCGC CCTAGGGACC 
AAGACTGAAT CCTCCTCACG GGGACCTTAC CACCCCTCAG AGTGCTGCTT CACCTACACT 
ACCTACAAGA TCCCGCGTCA GCGGATTATG GATTACTATG AGACCAACAG CCAGTGCTCC 
AAGCCCGGAA TTGTCTTCAT CACCAAAAGG GGCCATTCCG TCTGTACCAA CCCCAGTGAC 
AAGTGGGTCC AGGACTATAT CAAGGACATG AAGGAGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116739.1
CDS	80..361
Translation	MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN

Target ORF information:

RefSeq Version	NM_032963.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032963.3

ORF Insert Sequence:

ATGAAGATCT CCGTGGCTGC CATTCCCTTC TTCCTCCTCA TCACCATCGC CCTAGGGACC 
AAGACTGAAT CCTCCTCACG GGGACCTTAC CACCCCTCAG AGTGCTGCTT CACCTACACT 
ACCTACAAGA TCCCGCGTCA GCGGATTATG GATTACTATG AGACCAACAG CCAGTGCTCC 
AAGCCCGGAA TTGTCTTCAT CACCAAAAGG GGCCATTCCG TCTGTACCAA CCCCAGTGAC 
AAGTGGGTCC AGGACTATAT CAAGGACATG AAGGAGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL14 ( NM_032963.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116739.1 Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05205
Clone ID Related Accession (Same CDS sequence)	NM_032963.3 , NM_032963.4
Accession Version	NM_032963.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	C-C motif chemokine 14 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC244100.3 and DA821276.1. On Nov 23, 2018 this sequence version replaced NM_032963.3. Transcript Variant: This variant (3, CCL14a) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (1) lacks an alternate segment near the N-terminus, compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA821276.1, HY071902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000618404.5/ ENSP00000481023.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGATCT CCGTGGCTGC CATTCCCTTC TTCCTCCTCA TCACCATCGC CCTAGGGACC 
AAGACTGAAT CCTCCTCACG GGGACCTTAC CACCCCTCAG AGTGCTGCTT CACCTACACT 
ACCTACAAGA TCCCGCGTCA GCGGATTATG GATTACTATG AGACCAACAG CCAGTGCTCC 
AAGCCCGGAA TTGTCTTCAT CACCAAAAGG GGCCATTCCG TCTGTACCAA CCCCAGTGAC 
AAGTGGGTCC AGGACTATAT CAAGGACATG AAGGAGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116739.1
CDS	81..362
Translation	MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN

Target ORF information:

RefSeq Version	NM_032963.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032963.4

ORF Insert Sequence:

ATGAAGATCT CCGTGGCTGC CATTCCCTTC TTCCTCCTCA TCACCATCGC CCTAGGGACC 
AAGACTGAAT CCTCCTCACG GGGACCTTAC CACCCCTCAG AGTGCTGCTT CACCTACACT 
ACCTACAAGA TCCCGCGTCA GCGGATTATG GATTACTATG AGACCAACAG CCAGTGCTCC 
AAGCCCGGAA TTGTCTTCAT CACCAAAAGG GGCCATTCCG TCTGTACCAA CCCCAGTGAC 
AAGTGGGTCC AGGACTATAT CAAGGACATG AAGGAGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL14 ( NM_032962.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116738.1 Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05204
Clone ID Related Accession (Same CDS sequence)	NM_032962.4
Accession Version	NM_032962.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	C-C motif chemokine 14 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA821276.1, BC045165.1, AA612866.1 and BI496964.1. On Jun 27, 2009 this sequence version replaced NM_032962.3. Transcript Variant: This variant (2, also known as CCL14b) represents the longer transcript and encodes the longer isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA612866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCT CCGTGGCTGC CATTCCCTTC TTCCTCCTCA TCACCATCGC CCTAGGGACC 
AAGACTGAAT CCTCCTCACA AACTGGGGGG AAACCGAAGG TTGTTAAAAT ACAGCTAAAG 
TTGGTGGGGG GACCTTACCA CCCCTCAGAG TGCTGCTTCA CCTACACTAC CTACAAGATC 
CCGCGTCAGC GGATTATGGA TTACTATGAG ACCAACAGCC AGTGCTCCAA GCCCGGAATT 
GTCTTCATCA CCAAAAGGGG CCATTCCGTC TGTACCAACC CCAGTGACAA GTGGGTCCAG 
GACTATATCA AGGACATGAA GGAGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116738.1
CDS	80..409
Translation	MKISVAAIPFFLLITIALGTKTESSSQTGGKPKVVKIQLKLVGGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN

Target ORF information:

RefSeq Version	NM_032962.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032962.4

ORF Insert Sequence:

ATGAAGATCT CCGTGGCTGC CATTCCCTTC TTCCTCCTCA TCACCATCGC CCTAGGGACC 
AAGACTGAAT CCTCCTCACA AACTGGGGGG AAACCGAAGG TTGTTAAAAT ACAGCTAAAG 
TTGGTGGGGG GACCTTACCA CCCCTCAGAG TGCTGCTTCA CCTACACTAC CTACAAGATC 
CCGCGTCAGC GGATTATGGA TTACTATGAG ACCAACAGCC AGTGCTCCAA GCCCGGAATT 
GTCTTCATCA CCAAAAGGGG CCATTCCGTC TGTACCAACC CCAGTGACAA GTGGGTCCAG 
GACTATATCA AGGACATGAA GGAGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMEM88, CCL14 and CLEC3B as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317708900(2017 Jul)
Zhang X,Wan JX,Ke ZP,Wang F,Chai HX,Liu JQ

Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma.
Oncotarget6(27)24218-29(2015 Sep)
Li Y,Zheng Y,Li T,Wang Q,Qian J,Lu Y,Zhang M,Bi E,Yang M,Reu F,Yi Q,Cai Z

Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.
Cancer research71(21)6899-908(2011 Nov)
Li Q,Shi L,Gui B,Yu W,Wang J,Zhang D,Han X,Yao Z,Shang Y

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Mucosal immunology3(1)40-8(2010 Jan)
Kotarsky K,Sitnik KM,Stenstad H,Kotarsky H,Schmidtchen A,Koslowski M,Wehkamp J,Agace WW

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CCL14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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