CCL13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL13
Entrez Gene ID	6357
Full Name	C-C motif chemokine ligand 13
Synonyms	CKb10,MCP-4,NCC-1,NCC1,SCYA13,SCYL1
General protein information	Preferred Names C-C motif chemokine ligand 13 Names C-C motif chemokine 13 CK-beta-10 chemokine (C-C motif) ligand 13 monocyte chemoattractant protein 4 monocyte chemotactic protein 4 new CC chemokine 1 small inducible cytokine subfamily A (Cys-Cys), member 13 small-inducible cytokine A13
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014].
Disorder MIM:	601391

mRNA and Protein(s)

mRNA	Protein	Name
NM_005408.3	NP_005399.1	C-C motif chemokine 13 precursor
NM_005408.2	NP_005399.1	C-C motif chemokine 13 precursor

Pathways from BioSystems

Homologies

	CCL13	XP_001113462.1
Homo sapiens (human)	CCL13	NP_005399.1
Pan troglodytes (chimpanzee)	CCL13	XP_001174525.3
Mus musculus (house mouse)	Ccl2	NP_035463.1
Rattus norvegicus (Norway rat)	Ccl2	NP_113718.1

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, D?ring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C
Science translational medicine9(384)(2017 Apr)

The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder.
Dalgard C, Eidelman O, Jozwik C, Olsen CH, Srivastava M, Biswas R, Eudy Y, Rothwell SW, Mueller GP, Yuan P, Drevets WC, Manji HK, Vythlingam M, Charney DS, Neumeister A, Ursano RJ, Jacobowitz DM, Pollard HB, Bonne O
Translational psychiatry7(2)e1025(2017 02)

Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1? (MIP-1?), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.
Gentili A, Zaibi MS, Alomar SY, De Vuono S, Ricci MA, Alaeddin A, Siepi D, Boni M, Vaudo G, Trayhurn P, Lupattelli G
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme48(12)847-853(2016 Dec)

Association of CCL13 levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis.
Gao F, Tian J, Pan H, Gao J, Yao M
Journal of investigative medicine : the official publication of the American Federation for Clinical Research63(3)545-7(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

In plasma, but not CSF, the bivariate MCP4 (CCL13)/ MCP1(CCL2) ratio is ca. twofold elevated in PTSD patients compared with healthy controls.
Title: The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder.

The reduction of circulating levels of MCP-4, eotaxin-3, and MIP-1beta could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.
Title: Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1? (MIP-1?), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.

CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis.
Title: Association of CCL13 levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis.

identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies
Title: Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.

The following CCL13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29848	NM_005408.3 Latest version!	Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29848	NM_005408.2	Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL13 ( NM_005408.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005399.1 Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA.

Price & Availability↑

CloneID	OHu29848
Clone ID Related Accession (Same CDS sequence)	NM_005408.3 , NM_005408.2
Accession Version	NM_005408.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-08
Organism	Homo sapiens(human)
Product	C-C motif chemokine 13 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011193.3. On Nov 26, 2018 this sequence version replaced NM_005408.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ001634.1, U59808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225844.7/ ENSP00000225844.2 Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT 
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG 
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG 
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005399.1
CDS	48..344
Translation	MKVSAVLLCLLLMTAAFNPQGLAQPDALNVPSTCCFTFSSKKISLQRLKSYVITTSRCPQKAVIFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT

Target ORF information:

RefSeq Version	NM_005408.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005408.3

ORF Insert Sequence:

ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT 
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG 
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG 
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL13 ( NM_005408.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005399.1 Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA.

Price & Availability↑

CloneID	OHu29848
Clone ID Related Accession (Same CDS sequence)	NM_005408.3 , NM_005408.2
Accession Version	NM_005408.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	C-C motif chemokine 13 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U59808.1. On Aug 29, 2002 this sequence version replaced NM_005408.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U59808.1, BG620880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT 
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG 
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG 
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005399.1
CDS	76..372
Translation	MKVSAVLLCLLLMTAAFNPQGLAQPDALNVPSTCCFTFSSKKISLQRLKSYVITTSRCPQKAVIFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT

Target ORF information:

RefSeq Version	NM_005408.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005408.2

ORF Insert Sequence:

ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT 
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG 
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG 
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Science translational medicine9(384)(2017 Apr)
von Hundelshausen P,Agten SM,Eckardt V,Blanchet X,Schmitt MM,Ippel H,Neideck C,Bidzhekov K,Leberzammer J,Wichapong K,Faussner A,Drechsler M,Grommes J,van Geffen JP,Li H,Ortega-Gomez A,Megens RT,Naumann R,Dijkgraaf I,Nicolaes GA,D?ring Y,Soehnlein O,Lutgens E,Heemskerk JW,Koenen RR,Mayo KH,Hackeng TM,Weber C

The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder.
Translational psychiatry7(2)e1025(2017 02)
Dalgard C,Eidelman O,Jozwik C,Olsen CH,Srivastava M,Biswas R,Eudy Y,Rothwell SW,Mueller GP,Yuan P,Drevets WC,Manji HK,Vythlingam M,Charney DS,Neumeister A,Ursano RJ,Jacobowitz DM,Pollard HB,Bonne O

Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1? (MIP-1?), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme48(12)847-853(2016 Dec)
Gentili A,Zaibi MS,Alomar SY,De Vuono S,Ricci MA,Alaeddin A,Siepi D,Boni M,Vaudo G,Trayhurn P,Lupattelli G

Association of CCL13 levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research63(3)545-7(2015 Mar)
Gao F,Tian J,Pan H,Gao J,Yao M

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CCL13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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