CCL7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL7
Entrez Gene ID	6354
Full Name	C-C motif chemokine ligand 7
Synonyms	FIC,MARC,MCP-3,MCP3,NC28,SCYA6,SCYA7
General protein information	Preferred Names C-C motif chemokine ligand 7 Names C-C motif chemokine 7 chemokine (C-C motif) ligand 7 monocyte chemoattractant protein 3 monocyte chemotactic protein 3 small inducible cytokine A7 (monocyte chemotactic protein 3) small-inducible cytokine A7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008].
Disorder MIM:	158106

mRNA and Protein(s)

mRNA	Protein	Name
NM_006273.3	NP_006264.2	C-C motif chemokine 7 precursor
NM_006273.4	NP_006264.2	C-C motif chemokine 7 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CCL7	NP_006264.2
Canis lupus familiaris (dog)	CCL7	NP_001010960.1
Pan troglodytes (chimpanzee)	CCL7	XP_511407.2
	LOC714751	XP_001113381.1

Gene Ontology
Bibliography

Related articles in PubMed

The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone.
Wang M, Wu C, Guo Y, Cao X, Zheng W, Fan GK
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(5)1010428317705512(2017 May)

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.
Laurent V, Gu?rard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D, Socrier Y, Golzio M, Cadoudal T, Chaoui K, Dray C, Monsarrat B, Schiltz O, Wang YY, Couderc B, Valet P, Malavaud B, Muller C
Nature communications710230(2016 Jan)

Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity.
Cou?ago RM, Knapp KM, Nakatani Y, Fleming SB, Corbett M, Wise LM, Mercer AA, Krause KL
Structure (London, England : 1993)23(7)1199-213(2015 Jul)

Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.
van den Kieboom CH, Ahout IM, Zomer A, Brand KH, de Groot R, Ferwerda G, de Jonge MI
The European respiratory journal45(3)718-25(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Enzyme-linked immunosorbent assay was used to detect the levels of chemokine (C-X-C motif) ligand 12, chemokine (C-X-C motif) ligand 7, hepatocyte growth factor, and fibroblast growth factor 1 in the supernatants of the laryngeal squamous cell carcinoma and control cells.
Title: The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone.

Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells.
Title: Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.

Based on nasopharyngeal CCL7 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
Title: Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.

These results suggest that let-7d may suppress renal cell carcinoma growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7.
Title: Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.

Data indicate that different glycosaminoglycan-binding properties of monocyte chemoattractant protein-3/CCL7 and monocyte chemoattractant protein (MCP)-1/CCL2 suggest non-redundant functions and regulation.
Title: Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine.

The following CCL7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15963	NM_006273.4 Latest version!	Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15963	NM_006273.3	Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL7 ( NM_006273.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006264.2 Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.

Price & Availability↑

CloneID	OHu15963
Clone ID Related Accession (Same CDS sequence)	NM_006273.3 , NM_006273.4
Accession Version	NM_006273.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	C-C motif chemokine 7 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD523198.1, X71087.1 and AC005549.1. On Dec 7, 2012 this sequence version replaced NM_006273.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. There is an upstream in-frame AUG at nt 46-48. This AUG was not annotated as the translation start baecuase it has a weak Kozak signal and is not conserved in vertebrates. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092436.1, CD523198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGCCT CTGCAGCACT TCTGTGTCTG CTGCTCACAG CAGCTGCTTT CAGCCCCCAG 
GGGCTTGCTC AGCCAGTTGG GATTAATACT TCAACTACCT GCTGCTACAG ATTTATCAAT 
AAGAAAATCC CTAAGCAGAG GCTGGAGAGC TACAGAAGGA CCACCAGTAG CCACTGTCCC 
CGGGAAGCTG TAATCTTCAA GACCAAACTG GACAAGGAGA TCTGTGCTGA CCCCACACAG 
AAGTGGGTCC AGGACTTTAT GAAGCACCTG GACAAGAAAA CCCAAACTCC AAAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006264.2
CDS	76..375
Translation	MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL

Target ORF information:

RefSeq Version	NM_006273.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006273.3

ORF Insert Sequence:

ATGAAAGCCT CTGCAGCACT TCTGTGTCTG CTGCTCACAG CAGCTGCTTT CAGCCCCCAG 
GGGCTTGCTC AGCCAGTTGG GATTAATACT TCAACTACCT GCTGCTACAG ATTTATCAAT 
AAGAAAATCC CTAAGCAGAG GCTGGAGAGC TACAGAAGGA CCACCAGTAG CCACTGTCCC 
CGGGAAGCTG TAATCTTCAA GACCAAACTG GACAAGGAGA TCTGTGCTGA CCCCACACAG 
AAGTGGGTCC AGGACTTTAT GAAGCACCTG GACAAGAAAA CCCAAACTCC AAAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL7 ( NM_006273.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006264.2 Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.

Price & Availability↑

CloneID	OHu15963
Clone ID Related Accession (Same CDS sequence)	NM_006273.3 , NM_006273.4
Accession Version	NM_006273.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	C-C motif chemokine 7 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X71087.1 and AC005549.1. On May 17, 2019 this sequence version replaced NM_006273.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. There is an upstream in-frame AUG at nt 46-48. This AUG was not annotated as the translation start baecuase it has a weak Kozak signal and is not conserved in vertebrates. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X71087.1, BC092436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000378569.2/ ENSP00000367832.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAAGCCT CTGCAGCACT TCTGTGTCTG CTGCTCACAG CAGCTGCTTT CAGCCCCCAG 
GGGCTTGCTC AGCCAGTTGG GATTAATACT TCAACTACCT GCTGCTACAG ATTTATCAAT 
AAGAAAATCC CTAAGCAGAG GCTGGAGAGC TACAGAAGGA CCACCAGTAG CCACTGTCCC 
CGGGAAGCTG TAATCTTCAA GACCAAACTG GACAAGGAGA TCTGTGCTGA CCCCACACAG 
AAGTGGGTCC AGGACTTTAT GAAGCACCTG GACAAGAAAA CCCAAACTCC AAAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006264.2
CDS	71..370
Translation	MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL

Target ORF information:

RefSeq Version	NM_006273.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006273.4

ORF Insert Sequence:

ATGAAAGCCT CTGCAGCACT TCTGTGTCTG CTGCTCACAG CAGCTGCTTT CAGCCCCCAG 
GGGCTTGCTC AGCCAGTTGG GATTAATACT TCAACTACCT GCTGCTACAG ATTTATCAAT 
AAGAAAATCC CTAAGCAGAG GCTGGAGAGC TACAGAAGGA CCACCAGTAG CCACTGTCCC 
CGGGAAGCTG TAATCTTCAA GACCAAACTG GACAAGGAGA TCTGTGCTGA CCCCACACAG 
AAGTGGGTCC AGGACTTTAT GAAGCACCTG GACAAGAAAA CCCAAACTCC AAAGCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(5)1010428317705512(2017 May)
Wang M,Wu C,Guo Y,Cao X,Zheng W,Fan GK

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.
Nature communications710230(2016 Jan)
Laurent V,Gu?rard A,Mazerolles C,Le Gonidec S,Toulet A,Nieto L,Zaidi F,Majed B,Garandeau D,Socrier Y,Golzio M,Cadoudal T,Chaoui K,Dray C,Monsarrat B,Schiltz O,Wang YY,Couderc B,Valet P,Malavaud B,Muller C

Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity.
Structure (London, England : 1993)23(7)1199-213(2015 Jul)
Cou?ago RM,Knapp KM,Nakatani Y,Fleming SB,Corbett M,Wise LM,Mercer AA,Krause KL

Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.
The European respiratory journal45(3)718-25(2015 Mar)
van den Kieboom CH,Ahout IM,Zomer A,Brand KH,de Groot R,Ferwerda G,de Jonge MI

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CCL7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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