CCL3L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL3L1
Entrez Gene ID	6349
Full Name	C-C motif chemokine ligand 3 like 1
Synonyms	464.2,D17S1718,G0S19-2,LD78,LD78-beta(1-70),LD78BETA,MIP1AP,SCYA3L,SCYA3L1
General protein information	Preferred Names C-C motif chemokine ligand 3 like 1 Names C-C motif chemokine 3-like 1 G0/G1 switch regulatory protein 19-2 chemokine (C-C motif) ligand 3-like 1 small inducible cytokine A3-like 1 tonsillar lymphocyte LD78 beta protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.1
Summary	This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Disorder MIM:	601395
Disorder Html:	{HIV/AIDS, susceptibility to}, 609423 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021006.5	NP_066286.1	C-C motif chemokine 3-like 1 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Characterization of copy number variants for CCL3L1 gene in rheumatoid arthritis for French trio families and Tunisian cases and controls.
Ben Kilani MS, Achour Y, Perea J, Cornelis F, Bardin T, Chaudru V, Maalej A, Petit-Teixeira E
Clinical rheumatology35(8)1917-1922(2016 Aug)

CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis.
Carpenter D, Taype C, Goulding J, Levin M, Eley B, Anderson S, Shaw MA, Armour JA
BMC medical genetics155(2014 Jan)

CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.
Aklillu E, Odenthal-Hesse L, Bowdrey J, Habtewold A, Ngaimisi E, Yimer G, Amogne W, Mugusi S, Minzi O, Makonnen E, Janabi M, Mugusi F, Aderaye G, Hardwick R, Fu B, Viskaduraki M, Yang F, Hollox EJ
BMC infectious diseases13536(2013 Nov)

A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2.
Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, Ledbetter DH, Coillie EV, Opdenakker G, Gunge N, Sakaki Y, Iio M, Miura R
Genomics34(2)236-40(1996 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Characterization of CCL3L1 CNVs with droplet digital PCR methodology highlighted specific CN genotypes in a French family sample. A copy number polymorphism of a rheumatoid arthritis (RA) candidate gene was quantified, and its significant association with RA was revealed in a Tunisian sample.
Title: Characterization of copy number variants for CCL3L1 gene in rheumatoid arthritis for French trio families and Tunisian cases and controls.

no evidence for an influence of variation in genes coding for MIP-1alpha or CCR5 individually or together in susceptibility to clinically active TB
Title: CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis.

Studied copy number variation of the CCL3L1 gene in contributing to the host variation in susceptibility and response to HIV infection by analyzing a sub-Saharan African cohort.
Title: CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.

Studies indicate beta-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4) for copy number variation in disease association.
Title: Correlating multiallelic copy number polymorphisms with disease susceptibility.

The results do not support involvement of the CCL3L1 copy number variants in rheumatoid arthritis susceptibility.
Title: Association analysis of the CCL3L1 copy number locus by paralogue ratio test in Norwegian rheumatoid arthritis patients and healthy controls.

The following CCL3L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL3L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27976	NM_021006.5 Latest version!	Homo sapiens C-C motif chemokine ligand 3 like 1 (CCL3L1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL3L1 ( NM_021006.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_066286.1 Homo sapiens C-C motif chemokine ligand 3 like 1 (CCL3L1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27976
Clone ID Related Accession (Same CDS sequence)	NM_021006.5
Accession Version	NM_021006.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	C-C motif chemokine 3-like 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC107710.1 and BC027888.1. This sequence is a reference standard in the RefSeqGene project. On Apr 15, 2014 this sequence version replaced NM_021006.4. Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.520414.1, BC107710.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGGTCT CCACTGCTGC CCTTGCCGTC CTCCTCTGCA CCATGGCTCT CTGCAACCAG 
GTCCTCTCTG CACCACTTGC TGCTGACACG CCGACCGCCT GCTGCTTCAG CTACACCTCC 
CGACAGATTC CACAGAATTT CATAGCTGAC TACTTTGAGA CGAGCAGCCA GTGCTCCAAG 
CCCAGTGTCA TCTTCCTAAC CAAGAGAGGC CGGCAGGTCT GTGCTGACCC CAGTGAGGAG 
TGGGTCCAGA AATACGTCAG TGACCTGGAG CTGAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066286.1
CDS	86..367
Translation	MQVSTAALAVLLCTMALCNQVLSAPLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPSVIFLTKRGRQVCADPSEEWVQKYVSDLELSA

Target ORF information:

RefSeq Version	NM_021006.5
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 3 like 1 (CCL3L1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021006.5

ORF Insert Sequence:

ATGCAGGTCT CCACTGCTGC CCTTGCCGTC CTCCTCTGCA CCATGGCTCT CTGCAACCAG 
GTCCTCTCTG CACCACTTGC TGCTGACACG CCGACCGCCT GCTGCTTCAG CTACACCTCC 
CGACAGATTC CACAGAATTT CATAGCTGAC TACTTTGAGA CGAGCAGCCA GTGCTCCAAG 
CCCAGTGTCA TCTTCCTAAC CAAGAGAGGC CGGCAGGTCT GTGCTGACCC CAGTGAGGAG 
TGGGTCCAGA AATACGTCAG TGACCTGGAG CTGAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of copy number variants for CCL3L1 gene in rheumatoid arthritis for French trio families and Tunisian cases and controls.
Clinical rheumatology35(8)1917-1922(2016 Aug)
Ben Kilani MS,Achour Y,Perea J,Cornelis F,Bardin T,Chaudru V,Maalej A,Petit-Teixeira E

CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis.
BMC medical genetics155(2014 Jan)
Carpenter D,Taype C,Goulding J,Levin M,Eley B,Anderson S,Shaw MA,Armour JA

CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.
BMC infectious diseases13536(2013 Nov)
Aklillu E,Odenthal-Hesse L,Bowdrey J,Habtewold A,Ngaimisi E,Yimer G,Amogne W,Mugusi S,Minzi O,Makonnen E,Janabi M,Mugusi F,Aderaye G,Hardwick R,Fu B,Viskaduraki M,Yang F,Hollox EJ

A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2.
Genomics34(2)236-40(1996 Jun)
Naruse K,Ueno M,Satoh T,Nomiyama H,Tei H,Takeda M,Ledbetter DH,Coillie EV,Opdenakker G,Gunge N,Sakaki Y,Iio M,Miura R

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CCL3L1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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