CCL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL1
Entrez Gene ID	6346
Full Name	C-C motif chemokine ligand 1
Synonyms	I-309,P500,SCYA1,SISe,TCA3
General protein information	Preferred Names C-C motif chemokine ligand 1 Names C-C motif chemokine 1 T lymphocyte-secreted protein I-309 chemokine (C-C motif) ligand 1 inflammatory cytokine I-309 small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014].
Disorder MIM:	182281

mRNA and Protein(s)

mRNA	Protein	Name
NM_002981.2	NP_002972.1	C-C motif chemokine 1 precursor

Pathways from BioSystems

Homologies

	CCL1	NP_001028021.1
Bos taurus (cattle)	CCL1	XP_002695678.1
Pan troglodytes (chimpanzee)	CCL1	XP_003315573.1
Canis lupus familiaris (dog)	CCL1	NP_001005252.1
Homo sapiens (human)	CCL1	NP_002972.1
Mus musculus (house mouse)	Ccl1	NP_035459.1
Rattus norvegicus (Norway rat)	Ccl1	NP_001178021.1

Gene Ontology
Bibliography

Related articles in PubMed

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.
Saito M, Sejima H, Naito T, Ushirogawa H, Matsuzaki T, Matsuura E, Tanaka Y, Nakamura T, Takashima H
Virology journal14(1)234(2017 Dec)

MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease.
Chang R, Yi S, Tan X, Huang Y, Wang Q, Su G, Zhou C, Cao Q, Yuan G, Kijlstra A, Yang P
The British journal of ophthalmology(2017 Sep)

Genetic polymorphisms of CCL1 rs2072069 G/A and TLR2 rs3804099 T/C in pulmonary or meningeal tuberculosis patients.
Zhao Y, Bu H, Hong K, Yin H, Zou YL, Geng SJ, Zheng MM, He JY
International journal of clinical and experimental pathology8(10)12608-20(2015)

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ
Journal of leukocyte biology74(3)448-55(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of the present study demonstrated that GAS5 was able to suppress bladder cancer cell proliferation, at least partially, by suppressing the expression of CCL1.
Title: Long non?coding RNA?GAS5 acts as a tumor suppressor in bladder transitional cell carcinoma via regulation of chemokine (C?C motif) ligand 1 expression.

was to evaluate the possible association between CCL1 rs2072069 G/A or/and TLR2 rs3804099 T/C (T597C) polymorphisms and pulmonary tuberculosis (PTB) or/and tuberculous meningitis (TBM) in a sample of the Chinese adult population
Title: Genetic polymorphisms of CCL1 rs2072069 G/A and TLR2 rs3804099 T/C in pulmonary or meningeal tuberculosis patients.

CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.
Title: Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis.

These data identify a novel function for CCL1-CCR8 in metastasis and lymph node LECs as a critical checkpoint for the entry of metastases into the lymph nodes.
Title: Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses.

CCL1, CCL26, and IgE may be associated with pruritus in cutaneous T-cell lymphoma.
Title: Association of nerve growth factor, chemokine (C-C motif) ligands and immunoglobulin E with pruritus in cutaneous T-cell lymphoma.

The following CCL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11523	NM_002981.2 Latest version!	Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL1 ( NM_002981.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002972.1 Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA.

Price & Availability↑

CloneID	OHu11523
Clone ID Related Accession (Same CDS sequence)	NM_002981.2
Accession Version	NM_002981.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	C-C motif chemokine 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011193.3, M57502.1 and DA620119.1. On Jul 12, 2013 this sequence version replaced NM_002981.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA620119.1, BX093610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225842.4/ ENSP00000225842.3 Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGATCA TCACCACAGC CCTGGTGTGC TTGCTGCTAG CTGGGATGTG GCCGGAAGAT 
GTGGACAGCA AGAGCATGCA GGTACCCTTC TCCAGATGTT GCTTCTCATT TGCGGAGCAA 
GAGATTCCCC TGAGGGCAAT CCTGTGTTAC AGAAATACCA GCTCCATCTG CTCCAATGAG 
GGCTTAATAT TCAAGCTGAA GAGAGGCAAA GAGGCCTGCG CCTTGGACAC AGTTGGATGG 
GTTCAGAGGC ACAGAAAAAT GCTGAGGCAC TGCCCGTCAA AAAGAAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002972.1
CDS	73..363
Translation	MQIITTALVCLLLAGMWPEDVDSKSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNEGLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK

Target ORF information:

RefSeq Version	NM_002981.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002981.2

ORF Insert Sequence:

ATGCAGATCA TCACCACAGC CCTGGTGTGC TTGCTGCTAG CTGGGATGTG GCCGGAAGAT 
GTGGACAGCA AGAGCATGCA GGTACCCTTC TCCAGATGTT GCTTCTCATT TGCGGAGCAA 
GAGATTCCCC TGAGGGCAAT CCTGTGTTAC AGAAATACCA GCTCCATCTG CTCCAATGAG 
GGCTTAATAT TCAAGCTGAA GAGAGGCAAA GAGGCCTGCG CCTTGGACAC AGTTGGATGG 
GTTCAGAGGC ACAGAAAAAT GCTGAGGCAC TGCCCGTCAA AAAGAAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.
Virology journal14(1)234(2017 Dec)
Saito M,Sejima H,Naito T,Ushirogawa H,Matsuzaki T,Matsuura E,Tanaka Y,Nakamura T,Takashima H

MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease.
The British journal of ophthalmology(2017 Sep)
Chang R,Yi S,Tan X,Huang Y,Wang Q,Su G,Zhou C,Cao Q,Yuan G,Kijlstra A,Yang P

Genetic polymorphisms of CCL1 rs2072069 G/A and TLR2 rs3804099 T/C in pulmonary or meningeal tuberculosis patients.
International journal of clinical and experimental pathology8(10)12608-20(2015)
Zhao Y,Bu H,Hong K,Yin H,Zou YL,Geng SJ,Zheng MM,He JY

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
Journal of leukocyte biology74(3)448-55(2003 Sep)
Yang D,Chen Q,Hoover DM,Staley P,Tucker KD,Lubkowski J,Oppenheim JJ

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CCL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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