SCNN1G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCNN1G
Entrez Gene ID	6340
Full Name	sodium channel epithelial 1 gamma subunit
Synonyms	BESC3,ENaCg,ENaCgamma,PHA1,SCNEG
General protein information	Preferred Names sodium channel epithelial 1 gamma subunit Names amiloride-sensitive sodium channel subunit gamma ENaC gamma subunit amiloride-sensitive epithelial sodium channel gamma subunit amiloride-sensitive sodium channel gamma-subunit epithelial Na(+) channel subunit gamma gamma-ENaC gamma-NaCH nonvoltage-gated sodium channel 1 subunit gamma sodium channe epithelial 1 gamma subunit sodium channel, non-voltage-gated 1, gamma subunit sodium channel, nonvoltage-gated 1, gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p12.2
Summary	Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009].
Disorder MIM:	600761
Disorder Html:	Liddle syndrome, 177200 (3); Pseudohypoaldosteronism, type I, 264350 (3); Bronchiectasis with or without elevated sweat chloride 3, 613071 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039.4	NP_001030.2	amiloride-sensitive sodium channel subunit gamma
NM_001039.3	NP_001030.2	amiloride-sensitive sodium channel subunit gamma

Pathways from BioSystems

Homologies

	SCNN1G	XP_001093466.1
Mus musculus (house mouse)	Scnn1g	NP_035456.1
Caenorhabditis elegans (roundworm)	asic-1	NP_491214.3
Caenorhabditis elegans (roundworm)	mec-4	NP_510712.2
Caenorhabditis elegans (roundworm)	del-1	NP_510380.1
Caenorhabditis elegans (roundworm)	unc-8	NP_501138.1
Xenopus tropicalis (tropical clawed frog)	scnn1g	XP_004918046.1
Pan troglodytes (chimpanzee)	SCNN1G	XP_003315070.1
Caenorhabditis elegans (roundworm)	unc-105	NP_001254142.1
Caenorhabditis elegans (roundworm)	asic-2	NP_492099.1
Caenorhabditis elegans (roundworm)	mec-10	NP_509438.1
Bos taurus (cattle)	SCNN1G	NP_001180103.1
Gallus gallus (chicken)	SCNN1G	XP_414880.2
Homo sapiens (human)	SCNN1G	NP_001030.2
Rattus norvegicus (Norway rat)	Scnn1g	NP_058742.1
Canis lupus familiaris (dog)	SCNN1G	XP_547093.2
Caenorhabditis elegans (roundworm)	deg-1	NP_509311.1
Caenorhabditis elegans (roundworm)	del-4	NP_492230.2

Gene Ontology
Bibliography

Related articles in PubMed

Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
Gu X, Gu D, He J, Rao DC, Hixson JE, Chen J, Li J, Huang J, Wu X, Rice TK, Shimmin LC, Kelly TN
American journal of hypertension31(2)205-211(2018 Jan)

Mapping allosteric linkage to channel gating of extracellular domains in the human epithelial sodium channel.
Shobair M, Popov KI, Dang YL, He H, Stutts MJ, Dokholyan NV
The Journal of biological chemistry(2018 Jan)

Derlin-1 promotes ubiquitylation and degradation of the epithelial Na
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X
Journal of cell science130(6)1027-1036(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.
Title: Derlin-1 promotes ubiquitylation and degradation of the epithelial Na

deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.
Title: ???-ENaC is inhibited by CFTR but stimulated by cAMP in

hENaC incorporating the Liddle-mutated beta-subunit lacks one or more PKC phosphorylation sites, thereby significantly reducing the inhibitory effect of PKC on Na(+) channel activity, whereas hENaC incorporating Liddle-mutated gamma-subunits remains as susceptible to PKC as wild-type hENaC.
Title: Liddle-Mutation of the ?-Subunit, but not the ?-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).

One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified.
Title: Assessment of epithelial sodium channel variants in nonwhite cystic fibrosis patients with non-diagnostic CFTR genotypes.

Both vascular smooth muscle cell and bronchial gamma-ENaC downregulation may explain pulmonary fluid disturbances and participate in pulmonary edema pathogenesis.
Title: A potential role for interleukin-33 and ?-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.

The following SCNN1G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCNN1G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17893	NM_001039.4 Latest version!	Homo sapiens sodium channel epithelial 1 subunit gamma (SCNN1G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu17893	NM_001039.3	Homo sapiens sodium channel epithelial 1 gamma subunit (SCNN1G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCNN1G ( NM_001039.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030.2 Homo sapiens sodium channel epithelial 1 subunit gamma (SCNN1G), mRNA.

Price & Availability↑

CloneID	OHu17893
Clone ID Related Accession (Same CDS sequence)	NM_001039.4 , NM_001039.3
Accession Version	NM_001039.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Homo sapiens(human)
Product	amiloride-sensitive sodium channel subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC059391.1, X87160.1 and AC099482.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001039.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059391.1, SRR1660805.207998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300061.3/ ENSP00000300061.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC 
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA 
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT 
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC 
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG 
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG 
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG 
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG 
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA 
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC 
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG 
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC 
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT 
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG 
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC 
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC 
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA 
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA 
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG 
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC 
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA 
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA 
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG 
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC 
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA 
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC 
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC 
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA 
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT 
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC 
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC 
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030.2
CDS	114..2063
Translation	MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL

Target ORF information:

RefSeq Version	NM_001039.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium channel epithelial 1 subunit gamma (SCNN1G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039.4

ORF Insert Sequence:

ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC 
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA 
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT 
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC 
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG 
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG 
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG 
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG 
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA 
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC 
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG 
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC 
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT 
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG 
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC 
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC 
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA 
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA 
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG 
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC 
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA 
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA 
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG 
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC 
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA 
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC 
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC 
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA 
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT 
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC 
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC 
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCNN1G ( NM_001039.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030.2 Homo sapiens sodium channel epithelial 1 gamma subunit (SCNN1G), mRNA.

Price & Availability↑

CloneID	OHu17893
Clone ID Related Accession (Same CDS sequence)	NM_001039.4 , NM_001039.3
Accession Version	NM_001039.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	amiloride-sensitive sodium channel subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC059391.1 and X87160.1. This sequence is a reference standard in the RefSeqGene project. On Jun 15, 2007 this sequence version replaced NM_001039.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059391.1, SRR1660805.207998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC 
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA 
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT 
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC 
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG 
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG 
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG 
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG 
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA 
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC 
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG 
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC 
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT 
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG 
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC 
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC 
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA 
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA 
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG 
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC 
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA 
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA 
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG 
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC 
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA 
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC 
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC 
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA 
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT 
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC 
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC 
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030.2
CDS	140..2089
Translation	MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL

Target ORF information:

RefSeq Version	NM_001039.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium channel epithelial 1 gamma subunit (SCNN1G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039.3

ORF Insert Sequence:

ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC 
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA 
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT 
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC 
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG 
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG 
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG 
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG 
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA 
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC 
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG 
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC 
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT 
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG 
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC 
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC 
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA 
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA 
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG 
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC 
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA 
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA 
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG 
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC 
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA 
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC 
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC 
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA 
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT 
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC 
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC 
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
American journal of hypertension31(2)205-211(2018 Jan)
Gu X,Gu D,He J,Rao DC,Hixson JE,Chen J,Li J,Huang J,Wu X,Rice TK,Shimmin LC,Kelly TN

Mapping allosteric linkage to channel gating of extracellular domains in the human epithelial sodium channel.
The Journal of biological chemistry(2018 Jan)
Shobair M,Popov KI,Dang YL,He H,Stutts MJ,Dokholyan NV

Derlin-1 promotes ubiquitylation and degradation of the epithelial Na
Journal of cell science130(6)1027-1036(2017 03)
You H,Ge Y,Zhang J,Cao Y,Xing J,Su D,Huang Y,Li M,Qu S,Sun F,Liang X

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SCNN1G cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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