CELA2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CELA2A
Entrez Gene ID	63036
Full Name	chymotrypsin like elastase family member 2A
Synonyms	ELA2A,PE-1
General protein information	Preferred Names chymotrypsin like elastase family member 2A Names chymotrypsin-like elastase family member 2A elastase 2A pancreatic elastase 2 pancreatic elastase IIA
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.21
Summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009].
Disorder MIM:	609443

mRNA and Protein(s)

mRNA	Protein	Name
NM_033440.2	NP_254275.1	chymotrypsin-like elastase family member 2A preproprotein
NM_033440.3	NP_254275.1	chymotrypsin-like elastase family member 2A preproprotein

Pathways from BioSystems

Homologies

	ELA2B	XP_001083219.1
Bos taurus (cattle)	CELA2A	NP_777139.1
Rattus norvegicus (Norway rat)	Cela2a	NP_036685.1
Danio rerio (zebrafish)	ela2	NP_001132936.1
Gallus gallus (chicken)	CELA2A	NP_001027562.2
Xenopus tropicalis (tropical clawed frog)	LOC100498609	XP_002944523.2
Xenopus tropicalis (tropical clawed frog)	LOC100488535	XP_002942694.2
Pan troglodytes (chimpanzee)	CELA2A	XP_001156270.2
Mus musculus (house mouse)	Cela2a	NP_031945.1
Homo sapiens (human)	CELA2A	NP_254275.1
Danio rerio (zebrafish)	ela2l	NP_956180.1

Gene Ontology
Bibliography

Related articles in PubMed

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
Szab? A, Pilsak C, Bence M, Witt H, Sahin-T?th M
The Journal of biological chemistry291(34)17706-16(2016 08)

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
Kerns SL, Ostrer H, Stock R, Li W, Moore J, Pearlman A, Campbell C, Shao Y, Stone N, Kusnetz L, Rosenstein BS
International journal of radiation oncology, biology, physics78(5)1292-300(2010 Dec)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, Briot A, Gonthier M, Lamant L, Dubus P, Monsarrat B, Hovnanian A
The Journal of clinical investigation120(3)871-82(2010 Mar)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
Title: Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

analysis of regulation of hELA2 gene expression suggests transcriptional effects of AML1-ETO are more complex than simple DNA binding and repression via recruitment of corepressors
Title: ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.

The following CELA2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CELA2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05455	NM_033440.3 Latest version!	Homo sapiens chymotrypsin like elastase 2A (CELA2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu05455	NM_033440.2	Homo sapiens chymotrypsin like elastase family member 2A (CELA2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CELA2A ( NM_033440.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_254275.1 Homo sapiens chymotrypsin like elastase family member 2A (CELA2A), mRNA.

Price & Availability↑

CloneID	OHu05455
Clone ID Related Accession (Same CDS sequence)	NM_033440.2 , NM_033440.3
Accession Version	NM_033440.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	chymotrypsin-like elastase family member 2A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP324428.1, BC007031.1 and BQ787677.1. On May 13, 2009 this sequence version replaced NM_033440.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007031.1, M16652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATAAGGA CGCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGACCCC 
ACTTACCCAC CTTATGTGAC TAGGGTGGTT GGCGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCAAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCAGGACC 
TACCGCGTGG GGCTGGGCCG GCACAACCTC TACGTTGCGG AGTCCGGCTC GCTGGCAGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCA ACCAAATCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTGTTCCT GATGTCCTGC AGCAGGGCCG GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGCC TGGTGGGGCA GCAGCGTGAA AACCAGTATG 
ATCTGTGCTG GGGGTGATGG CGTGATCTCC AGCTGCAACG GAGACTCTGG CGGGCCACTG 
AACTGTCAGG CGTCTGACGG CCGGTGGCAG GTGCACGGCA TCGTCAGCTT CGGGTCTCGC 
CTCGGCTGCA ACTACTACCA CAAGCCCTCC GTCTTCACGC GGGTCTCCAA TTACATCGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_254275.1
CDS	27..836
Translation	MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN

Target ORF information:

RefSeq Version	NM_033440.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chymotrypsin like elastase family member 2A (CELA2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033440.2

ORF Insert Sequence:

ATGATAAGGA CGCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGACCCC 
ACTTACCCAC CTTATGTGAC TAGGGTGGTT GGCGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCAAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCAGGACC 
TACCGCGTGG GGCTGGGCCG GCACAACCTC TACGTTGCGG AGTCCGGCTC GCTGGCAGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCA ACCAAATCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTGTTCCT GATGTCCTGC AGCAGGGCCG GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGCC TGGTGGGGCA GCAGCGTGAA AACCAGTATG 
ATCTGTGCTG GGGGTGATGG CGTGATCTCC AGCTGCAACG GAGACTCTGG CGGGCCACTG 
AACTGTCAGG CGTCTGACGG CCGGTGGCAG GTGCACGGCA TCGTCAGCTT CGGGTCTCGC 
CTCGGCTGCA ACTACTACCA CAAGCCCTCC GTCTTCACGC GGGTCTCCAA TTACATCGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CELA2A ( NM_033440.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_254275.1 Homo sapiens chymotrypsin like elastase 2A (CELA2A), mRNA.

Price & Availability↑

CloneID	OHu05455
Clone ID Related Accession (Same CDS sequence)	NM_033440.2 , NM_033440.3
Accession Version	NM_033440.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-12
Organism	Homo sapiens(human)
Product	chymotrypsin-like elastase family member 2A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007031.1 and BQ787677.1. On Nov 22, 2018 this sequence version replaced NM_033440.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312198.1, BC007031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359621.5/ ENSP00000352639.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATAAGGA CGCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGACCCC 
ACTTACCCAC CTTATGTGAC TAGGGTGGTT GGCGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCAAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCAGGACC 
TACCGCGTGG GGCTGGGCCG GCACAACCTC TACGTTGCGG AGTCCGGCTC GCTGGCAGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCA ACCAAATCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTGTTCCT GATGTCCTGC AGCAGGGCCG GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGCC TGGTGGGGCA GCAGCGTGAA AACCAGTATG 
ATCTGTGCTG GGGGTGATGG CGTGATCTCC AGCTGCAACG GAGACTCTGG CGGGCCACTG 
AACTGTCAGG CGTCTGACGG CCGGTGGCAG GTGCACGGCA TCGTCAGCTT CGGGTCTCGC 
CTCGGCTGCA ACTACTACCA CAAGCCCTCC GTCTTCACGC GGGTCTCCAA TTACATCGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_254275.1
CDS	23..832
Translation	MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN

Target ORF information:

RefSeq Version	NM_033440.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chymotrypsin like elastase 2A (CELA2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033440.3

ORF Insert Sequence:

ATGATAAGGA CGCTGCTGCT GTCCACTTTG GTGGCTGGAG CCCTCAGTTG TGGGGACCCC 
ACTTACCCAC CTTATGTGAC TAGGGTGGTT GGCGGTGAAG AAGCGAGGCC CAACAGCTGG 
CCCTGGCAGG TCTCCCTGCA GTACAGCTCC AATGGCAAGT GGTACCACAC CTGCGGAGGG 
TCCCTGATAG CCAACAGCTG GGTCCTGACG GCTGCCCACT GCATCAGCTC CTCCAGGACC 
TACCGCGTGG GGCTGGGCCG GCACAACCTC TACGTTGCGG AGTCCGGCTC GCTGGCAGTC 
AGTGTCTCTA AGATTGTGGT GCACAAGGAC TGGAACTCCA ACCAAATCTC CAAAGGGAAC 
GACATTGCCC TGCTCAAACT GGCTAACCCC GTCTCCCTCA CCGACAAGAT CCAGCTGGCC 
TGCCTCCCTC CTGCCGGCAC CATTCTACCC AACAACTACC CCTGCTACGT CACGGGCTGG 
GGAAGGCTGC AGACCAACGG GGCTGTTCCT GATGTCCTGC AGCAGGGCCG GTTGCTGGTT 
GTGGACTATG CCACCTGCTC CAGCTCTGCC TGGTGGGGCA GCAGCGTGAA AACCAGTATG 
ATCTGTGCTG GGGGTGATGG CGTGATCTCC AGCTGCAACG GAGACTCTGG CGGGCCACTG 
AACTGTCAGG CGTCTGACGG CCGGTGGCAG GTGCACGGCA TCGTCAGCTT CGGGTCTCGC 
CTCGGCTGCA ACTACTACCA CAAGCCCTCC GTCTTCACGC GGGTCTCCAA TTACATCGAC 
TGGATCAATT CGGTGATTGC AAATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
The Journal of biological chemistry291(34)17706-16(2016 08)
Szab? A,Pilsak C,Bence M,Witt H,Sahin-T?th M

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
International journal of radiation oncology, biology, physics78(5)1292-300(2010 Dec)
Kerns SL,Ostrer H,Stock R,Li W,Moore J,Pearlman A,Campbell C,Shao Y,Stone N,Kusnetz L,Rosenstein BS

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
The Journal of clinical investigation120(3)871-82(2010 Mar)
Bonnart C,Deraison C,Lacroix M,Uchida Y,Besson C,Robin A,Briot A,Gonthier M,Lamant L,Dubus P,Monsarrat B,Hovnanian A

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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CELA2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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