CFB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CFB
Entrez Gene ID	629
Full Name	complement factor B
Synonyms	AHUS4,ARMD14,BF,BFD,CFAB,CFBD,FB,FBI12,GBG,H2-Bf,PBF2
General protein information	Preferred Names complement factor B Names complement factor B B-factor, properdin C3 proaccelerator C3 proactivator C3/C5 convertase glycine-rich beta-glycoprotein properdin factor B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008].
Disorder MIM:	138470
Disorder Html:	{Macular degeneration, age-related, 14, reduced risk of}, 615489 (3); {Hemolytic uremic syndrome, atypical, susceptibility to, 4}, 612924 (3); ?Complement factor B deficiency, 615561 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001710.5	NP_001701.2	complement factor B preproprotein
NM_001710.6	NP_001701.2	complement factor B preproprotein

Pathways from BioSystems

Homologies

	CFB	XP_001113553.2
Pan troglodytes (chimpanzee)	CFB	NP_001009169.1
Danio rerio (zebrafish)	zgc:158446	NP_001077327.1
Mus musculus (house mouse)	Cfb	NP_032224.2
Danio rerio (zebrafish)	bfb	NP_571316.1
Bos taurus (cattle)	CFB	NP_001035616.1
Rattus norvegicus (Norway rat)	Cfb	NP_997631.2
Danio rerio (zebrafish)	cfb	NP_571413.1
Xenopus tropicalis (tropical clawed frog)	LOC100491419	XP_002943021.2
Homo sapiens (human)	CFB	NP_001701.2
Canis lupus familiaris (dog)	CFB	XP_003431724.1

Gene Ontology
Bibliography

Related articles in PubMed

Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.
Urban A, Borowska A, Felberg A, van den Heuvel L, Stasi?oj? G, Volokhina E, Okr?j M
Autoimmunity1-7(2018 Jan)

Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab.
Alfakeeh K, Azar M, Alfadhel M, Abdullah AM, Aloudah N, Alsaad KO
Pediatric nephrology (Berlin, Germany)32(5)885-891(2017 May)

Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.
Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, Oshima Y, Mori R, Tanaka K, Mori K, Inoue S, Terasaki H, Yasuma T, Honda S, Miki A, Inoue M, Fujisawa K, Takahashi K, Yasukawa T, Yanagi Y, Kadonosono K, Sonoda KH, Ishibashi T, Takahashi A, Kubo M
Human molecular genetics25(22)5027-5034(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neutralization of the complement factor C3-dependent antichlamydial activity was dependent on the proteolytic activity of Chlamydia trachomatis CPAF and correlated with the CPAF-mediated degradation of complement factor C3 and factor B.
Title: Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF.

The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
Title: Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia.

Our results revealed a significant association of CFB with non-infectious uveitis, particularly predisposed to VKH disease. Genetic differences for uveitis could be gender-specific.
Title: Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease.

CFB is downregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease.
Title: Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

These results suggest (i) apparent allelic heterogeneity in CFB and genetic heterogeneity in SLC44A4 across different ethnic groups; (ii) shared ulcerative colitis genetic etiological factors among Asians
Title: A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility.

The following CFB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CFB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22310	NM_001710.6 Latest version!	Homo sapiens complement factor B (CFB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22310	NM_001710.5	Homo sapiens complement factor B (CFB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CFB ( NM_001710.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001701.2 Homo sapiens complement factor B (CFB), mRNA.

Price & Availability↑

CloneID	OHu22310
Clone ID Related Accession (Same CDS sequence)	NM_001710.5 , NM_001710.6
Accession Version	NM_001710.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2295bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	complement factor B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368322.1, BC004143.2 and CD689714.1. This sequence is a reference standard in the RefSeqGene project. On May 30, 2008 this sequence version replaced NM_001710.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004143.2, AK130533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGAGCA ATCTCAGCCC CCAACTCTGC CTGATGCCCT TTATCTTGGG CCTCTTGTCT 
GGAGGTGTGA CCACCACTCC ATGGTCTTTG GCCCGGCCCC AGGGATCCTG CTCTCTGGAG 
GGGGTAGAGA TCAAAGGCGG CTCCTTCCGA CTTCTCCAAG AGGGCCAGGC ACTGGAGTAC 
GTGTGTCCTT CTGGCTTCTA CCCGTACCCT GTGCAGACAC GTACCTGCAG ATCTACGGGG 
TCCTGGAGCA CCCTGAAGAC TCAAGACCAA AAGACTGTCA GGAAGGCAGA GTGCAGAGCA 
ATCCACTGTC CAAGACCACA CGACTTCGAG AACGGGGAAT ACTGGCCCCG GTCTCCCTAC 
TACAATGTGA GTGATGAGAT CTCTTTCCAC TGCTATGACG GTTACACTCT CCGGGGCTCT 
GCCAATCGCA CCTGCCAAGT GAATGGCCGA TGGAGTGGGC AGACAGCGAT CTGTGACAAC 
GGAGCGGGGT ACTGCTCCAA CCCGGGCATC CCCATTGGCA CAAGGAAGGT GGGCAGCCAG 
TACCGCCTTG AAGACAGCGT CACCTACCAC TGCAGCCGGG GGCTTACCCT GCGTGGCTCC 
CAGCGGCGAA CGTGTCAGGA AGGTGGCTCT TGGAGCGGGA CGGAGCCTTC CTGCCAAGAC 
TCCTTCATGT ACGACACCCC TCAAGAGGTG GCCGAAGCTT TCCTGTCTTC CCTGACAGAG 
ACCATAGAAG GAGTCGATGC TGAGGATGGG CACGGCCCAG GGGAACAACA GAAGCGGAAG 
ATCGTCCTGG ACCCTTCAGG CTCCATGAAC ATCTACCTGG TGCTAGATGG ATCAGACAGC 
ATTGGGGCCA GCAACTTCAC AGGAGCCAAA AAGTGTCTAG TCAACTTAAT TGAGAAGGTG 
GCAAGTTATG GTGTGAAGCC AAGATATGGT CTAGTGACAT ATGCCACATA CCCCAAAATT 
TGGGTCAAAG TGTCTGAAGC AGACAGCAGT AATGCAGACT GGGTCACGAA GCAGCTCAAT 
GAAATCAATT ATGAAGACCA CAAGTTGAAG TCAGGGACTA ACACCAAGAA GGCCCTCCAG 
GCAGTGTACA GCATGATGAG CTGGCCAGAT GACGTCCCTC CTGAAGGCTG GAACCGCACC 
CGCCATGTCA TCATCCTCAT GACTGATGGA TTGCACAACA TGGGCGGGGA CCCAATTACT 
GTCATTGATG AGATCCGGGA CTTGCTATAC ATTGGCAAGG ATCGCAAAAA CCCAAGGGAG 
GATTATCTGG ATGTCTATGT GTTTGGGGTC GGGCCTTTGG TGAACCAAGT GAACATCAAT 
GCTTTGGCTT CCAAGAAAGA CAATGAGCAA CATGTGTTCA AAGTCAAGGA TATGGAAAAC 
CTGGAAGATG TTTTCTACCA AATGATCGAT GAAAGCCAGT CTCTGAGTCT CTGTGGCATG 
GTTTGGGAAC ACAGGAAGGG TACCGATTAC CACAAGCAAC CATGGCAGGC CAAGATCTCA 
GTCATTCGCC CTTCAAAGGG ACACGAGAGC TGTATGGGGG CTGTGGTGTC TGAGTACTTT 
GTGCTGACAG CAGCACATTG TTTCACTGTG GATGACAAGG AACACTCAAT CAAGGTCAGC 
GTAGGAGGGG AGAAGCGGGA CCTGGAGATA GAAGTAGTCC TATTTCACCC CAACTACAAC 
ATTAATGGGA AAAAAGAAGC AGGAATTCCT GAATTTTATG ACTATGACGT TGCCCTGATC 
AAGCTCAAGA ATAAGCTGAA ATATGGCCAG ACTATCAGGC CCATTTGTCT CCCCTGCACC 
GAGGGAACAA CTCGAGCTTT GAGGCTTCCT CCAACTACCA CTTGCCAGCA ACAAAAGGAA 
GAGCTGCTCC CTGCACAGGA TATCAAAGCT CTGTTTGTGT CTGAGGAGGA GAAAAAGCTG 
ACTCGGAAGG AGGTCTACAT CAAGAATGGG GATAAGAAAG GCAGCTGTGA GAGAGATGCT 
CAATATGCCC CAGGCTATGA CAAAGTCAAG GACATCTCAG AGGTGGTCAC CCCTCGGTTC 
CTTTGTACTG GAGGAGTGAG TCCCTATGCT GACCCCAATA CTTGCAGAGG TGATTCTGGC 
GGCCCCTTGA TAGTTCACAA GAGAAGTCGT TTCATTCAAG TTGGTGTAAT CAGCTGGGGA 
GTAGTGGATG TCTGCAAAAA CCAGAAGCGG CAAAAGCAGG TACCTGCTCA CGCCCGAGAC 
TTTCACATCA ACCTCTTTCA AGTGCTGCCC TGGCTGAAGG AGAAACTCCA AGATGAGGAT 
TTGGGTTTTC TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001701.2
CDS	279..2573
Translation	MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL

Target ORF information:

RefSeq Version	NM_001710.5
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor B (CFB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001710.5

ORF Insert Sequence:

ATGGGGAGCA ATCTCAGCCC CCAACTCTGC CTGATGCCCT TTATCTTGGG CCTCTTGTCT 
GGAGGTGTGA CCACCACTCC ATGGTCTTTG GCCCGGCCCC AGGGATCCTG CTCTCTGGAG 
GGGGTAGAGA TCAAAGGCGG CTCCTTCCGA CTTCTCCAAG AGGGCCAGGC ACTGGAGTAC 
GTGTGTCCTT CTGGCTTCTA CCCGTACCCT GTGCAGACAC GTACCTGCAG ATCTACGGGG 
TCCTGGAGCA CCCTGAAGAC TCAAGACCAA AAGACTGTCA GGAAGGCAGA GTGCAGAGCA 
ATCCACTGTC CAAGACCACA CGACTTCGAG AACGGGGAAT ACTGGCCCCG GTCTCCCTAC 
TACAATGTGA GTGATGAGAT CTCTTTCCAC TGCTATGACG GTTACACTCT CCGGGGCTCT 
GCCAATCGCA CCTGCCAAGT GAATGGCCGA TGGAGTGGGC AGACAGCGAT CTGTGACAAC 
GGAGCGGGGT ACTGCTCCAA CCCGGGCATC CCCATTGGCA CAAGGAAGGT GGGCAGCCAG 
TACCGCCTTG AAGACAGCGT CACCTACCAC TGCAGCCGGG GGCTTACCCT GCGTGGCTCC 
CAGCGGCGAA CGTGTCAGGA AGGTGGCTCT TGGAGCGGGA CGGAGCCTTC CTGCCAAGAC 
TCCTTCATGT ACGACACCCC TCAAGAGGTG GCCGAAGCTT TCCTGTCTTC CCTGACAGAG 
ACCATAGAAG GAGTCGATGC TGAGGATGGG CACGGCCCAG GGGAACAACA GAAGCGGAAG 
ATCGTCCTGG ACCCTTCAGG CTCCATGAAC ATCTACCTGG TGCTAGATGG ATCAGACAGC 
ATTGGGGCCA GCAACTTCAC AGGAGCCAAA AAGTGTCTAG TCAACTTAAT TGAGAAGGTG 
GCAAGTTATG GTGTGAAGCC AAGATATGGT CTAGTGACAT ATGCCACATA CCCCAAAATT 
TGGGTCAAAG TGTCTGAAGC AGACAGCAGT AATGCAGACT GGGTCACGAA GCAGCTCAAT 
GAAATCAATT ATGAAGACCA CAAGTTGAAG TCAGGGACTA ACACCAAGAA GGCCCTCCAG 
GCAGTGTACA GCATGATGAG CTGGCCAGAT GACGTCCCTC CTGAAGGCTG GAACCGCACC 
CGCCATGTCA TCATCCTCAT GACTGATGGA TTGCACAACA TGGGCGGGGA CCCAATTACT 
GTCATTGATG AGATCCGGGA CTTGCTATAC ATTGGCAAGG ATCGCAAAAA CCCAAGGGAG 
GATTATCTGG ATGTCTATGT GTTTGGGGTC GGGCCTTTGG TGAACCAAGT GAACATCAAT 
GCTTTGGCTT CCAAGAAAGA CAATGAGCAA CATGTGTTCA AAGTCAAGGA TATGGAAAAC 
CTGGAAGATG TTTTCTACCA AATGATCGAT GAAAGCCAGT CTCTGAGTCT CTGTGGCATG 
GTTTGGGAAC ACAGGAAGGG TACCGATTAC CACAAGCAAC CATGGCAGGC CAAGATCTCA 
GTCATTCGCC CTTCAAAGGG ACACGAGAGC TGTATGGGGG CTGTGGTGTC TGAGTACTTT 
GTGCTGACAG CAGCACATTG TTTCACTGTG GATGACAAGG AACACTCAAT CAAGGTCAGC 
GTAGGAGGGG AGAAGCGGGA CCTGGAGATA GAAGTAGTCC TATTTCACCC CAACTACAAC 
ATTAATGGGA AAAAAGAAGC AGGAATTCCT GAATTTTATG ACTATGACGT TGCCCTGATC 
AAGCTCAAGA ATAAGCTGAA ATATGGCCAG ACTATCAGGC CCATTTGTCT CCCCTGCACC 
GAGGGAACAA CTCGAGCTTT GAGGCTTCCT CCAACTACCA CTTGCCAGCA ACAAAAGGAA 
GAGCTGCTCC CTGCACAGGA TATCAAAGCT CTGTTTGTGT CTGAGGAGGA GAAAAAGCTG 
ACTCGGAAGG AGGTCTACAT CAAGAATGGG GATAAGAAAG GCAGCTGTGA GAGAGATGCT 
CAATATGCCC CAGGCTATGA CAAAGTCAAG GACATCTCAG AGGTGGTCAC CCCTCGGTTC 
CTTTGTACTG GAGGAGTGAG TCCCTATGCT GACCCCAATA CTTGCAGAGG TGATTCTGGC 
GGCCCCTTGA TAGTTCACAA GAGAAGTCGT TTCATTCAAG TTGGTGTAAT CAGCTGGGGA 
GTAGTGGATG TCTGCAAAAA CCAGAAGCGG CAAAAGCAGG TACCTGCTCA CGCCCGAGAC 
TTTCACATCA ACCTCTTTCA AGTGCTGCCC TGGCTGAAGG AGAAACTCCA AGATGAGGAT 
TTGGGTTTTC TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFB ( NM_001710.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001701.2 Homo sapiens complement factor B (CFB), mRNA.

Price & Availability↑

CloneID	OHu22310
Clone ID Related Accession (Same CDS sequence)	NM_001710.5 , NM_001710.6
Accession Version	NM_001710.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2295bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	complement factor B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368322.1, BC004143.2 and CD689714.1. On Aug 31, 2019 this sequence version replaced NM_001710.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007990.2, AK130533.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGAGCA ATCTCAGCCC CCAACTCTGC CTGATGCCCT TTATCTTGGG CCTCTTGTCT 
GGAGGTGTGA CCACCACTCC ATGGTCTTTG GCCCGGCCCC AGGGATCCTG CTCTCTGGAG 
GGGGTAGAGA TCAAAGGCGG CTCCTTCCGA CTTCTCCAAG AGGGCCAGGC ACTGGAGTAC 
GTGTGTCCTT CTGGCTTCTA CCCGTACCCT GTGCAGACAC GTACCTGCAG ATCTACGGGG 
TCCTGGAGCA CCCTGAAGAC TCAAGACCAA AAGACTGTCA GGAAGGCAGA GTGCAGAGCA 
ATCCACTGTC CAAGACCACA CGACTTCGAG AACGGGGAAT ACTGGCCCCG GTCTCCCTAC 
TACAATGTGA GTGATGAGAT CTCTTTCCAC TGCTATGACG GTTACACTCT CCGGGGCTCT 
GCCAATCGCA CCTGCCAAGT GAATGGCCGA TGGAGTGGGC AGACAGCGAT CTGTGACAAC 
GGAGCGGGGT ACTGCTCCAA CCCGGGCATC CCCATTGGCA CAAGGAAGGT GGGCAGCCAG 
TACCGCCTTG AAGACAGCGT CACCTACCAC TGCAGCCGGG GGCTTACCCT GCGTGGCTCC 
CAGCGGCGAA CGTGTCAGGA AGGTGGCTCT TGGAGCGGGA CGGAGCCTTC CTGCCAAGAC 
TCCTTCATGT ACGACACCCC TCAAGAGGTG GCCGAAGCTT TCCTGTCTTC CCTGACAGAG 
ACCATAGAAG GAGTCGATGC TGAGGATGGG CACGGCCCAG GGGAACAACA GAAGCGGAAG 
ATCGTCCTGG ACCCTTCAGG CTCCATGAAC ATCTACCTGG TGCTAGATGG ATCAGACAGC 
ATTGGGGCCA GCAACTTCAC AGGAGCCAAA AAGTGTCTAG TCAACTTAAT TGAGAAGGTG 
GCAAGTTATG GTGTGAAGCC AAGATATGGT CTAGTGACAT ATGCCACATA CCCCAAAATT 
TGGGTCAAAG TGTCTGAAGC AGACAGCAGT AATGCAGACT GGGTCACGAA GCAGCTCAAT 
GAAATCAATT ATGAAGACCA CAAGTTGAAG TCAGGGACTA ACACCAAGAA GGCCCTCCAG 
GCAGTGTACA GCATGATGAG CTGGCCAGAT GACGTCCCTC CTGAAGGCTG GAACCGCACC 
CGCCATGTCA TCATCCTCAT GACTGATGGA TTGCACAACA TGGGCGGGGA CCCAATTACT 
GTCATTGATG AGATCCGGGA CTTGCTATAC ATTGGCAAGG ATCGCAAAAA CCCAAGGGAG 
GATTATCTGG ATGTCTATGT GTTTGGGGTC GGGCCTTTGG TGAACCAAGT GAACATCAAT 
GCTTTGGCTT CCAAGAAAGA CAATGAGCAA CATGTGTTCA AAGTCAAGGA TATGGAAAAC 
CTGGAAGATG TTTTCTACCA AATGATCGAT GAAAGCCAGT CTCTGAGTCT CTGTGGCATG 
GTTTGGGAAC ACAGGAAGGG TACCGATTAC CACAAGCAAC CATGGCAGGC CAAGATCTCA 
GTCATTCGCC CTTCAAAGGG ACACGAGAGC TGTATGGGGG CTGTGGTGTC TGAGTACTTT 
GTGCTGACAG CAGCACATTG TTTCACTGTG GATGACAAGG AACACTCAAT CAAGGTCAGC 
GTAGGAGGGG AGAAGCGGGA CCTGGAGATA GAAGTAGTCC TATTTCACCC CAACTACAAC 
ATTAATGGGA AAAAAGAAGC AGGAATTCCT GAATTTTATG ACTATGACGT TGCCCTGATC 
AAGCTCAAGA ATAAGCTGAA ATATGGCCAG ACTATCAGGC CCATTTGTCT CCCCTGCACC 
GAGGGAACAA CTCGAGCTTT GAGGCTTCCT CCAACTACCA CTTGCCAGCA ACAAAAGGAA 
GAGCTGCTCC CTGCACAGGA TATCAAAGCT CTGTTTGTGT CTGAGGAGGA GAAAAAGCTG 
ACTCGGAAGG AGGTCTACAT CAAGAATGGG GATAAGAAAG GCAGCTGTGA GAGAGATGCT 
CAATATGCCC CAGGCTATGA CAAAGTCAAG GACATCTCAG AGGTGGTCAC CCCTCGGTTC 
CTTTGTACTG GAGGAGTGAG TCCCTATGCT GACCCCAATA CTTGCAGAGG TGATTCTGGC 
GGCCCCTTGA TAGTTCACAA GAGAAGTCGT TTCATTCAAG TTGGTGTAAT CAGCTGGGGA 
GTAGTGGATG TCTGCAAAAA CCAGAAGCGG CAAAAGCAGG TACCTGCTCA CGCCCGAGAC 
TTTCACATCA ACCTCTTTCA AGTGCTGCCC TGGCTGAAGG AGAAACTCCA AGATGAGGAT 
TTGGGTTTTC TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001701.2
CDS	128..2422
Translation	MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL

Target ORF information:

RefSeq Version	NM_001710.6
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor B (CFB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001710.6

ORF Insert Sequence:

ATGGGGAGCA ATCTCAGCCC CCAACTCTGC CTGATGCCCT TTATCTTGGG CCTCTTGTCT 
GGAGGTGTGA CCACCACTCC ATGGTCTTTG GCCCGGCCCC AGGGATCCTG CTCTCTGGAG 
GGGGTAGAGA TCAAAGGCGG CTCCTTCCGA CTTCTCCAAG AGGGCCAGGC ACTGGAGTAC 
GTGTGTCCTT CTGGCTTCTA CCCGTACCCT GTGCAGACAC GTACCTGCAG ATCTACGGGG 
TCCTGGAGCA CCCTGAAGAC TCAAGACCAA AAGACTGTCA GGAAGGCAGA GTGCAGAGCA 
ATCCACTGTC CAAGACCACA CGACTTCGAG AACGGGGAAT ACTGGCCCCG GTCTCCCTAC 
TACAATGTGA GTGATGAGAT CTCTTTCCAC TGCTATGACG GTTACACTCT CCGGGGCTCT 
GCCAATCGCA CCTGCCAAGT GAATGGCCGA TGGAGTGGGC AGACAGCGAT CTGTGACAAC 
GGAGCGGGGT ACTGCTCCAA CCCGGGCATC CCCATTGGCA CAAGGAAGGT GGGCAGCCAG 
TACCGCCTTG AAGACAGCGT CACCTACCAC TGCAGCCGGG GGCTTACCCT GCGTGGCTCC 
CAGCGGCGAA CGTGTCAGGA AGGTGGCTCT TGGAGCGGGA CGGAGCCTTC CTGCCAAGAC 
TCCTTCATGT ACGACACCCC TCAAGAGGTG GCCGAAGCTT TCCTGTCTTC CCTGACAGAG 
ACCATAGAAG GAGTCGATGC TGAGGATGGG CACGGCCCAG GGGAACAACA GAAGCGGAAG 
ATCGTCCTGG ACCCTTCAGG CTCCATGAAC ATCTACCTGG TGCTAGATGG ATCAGACAGC 
ATTGGGGCCA GCAACTTCAC AGGAGCCAAA AAGTGTCTAG TCAACTTAAT TGAGAAGGTG 
GCAAGTTATG GTGTGAAGCC AAGATATGGT CTAGTGACAT ATGCCACATA CCCCAAAATT 
TGGGTCAAAG TGTCTGAAGC AGACAGCAGT AATGCAGACT GGGTCACGAA GCAGCTCAAT 
GAAATCAATT ATGAAGACCA CAAGTTGAAG TCAGGGACTA ACACCAAGAA GGCCCTCCAG 
GCAGTGTACA GCATGATGAG CTGGCCAGAT GACGTCCCTC CTGAAGGCTG GAACCGCACC 
CGCCATGTCA TCATCCTCAT GACTGATGGA TTGCACAACA TGGGCGGGGA CCCAATTACT 
GTCATTGATG AGATCCGGGA CTTGCTATAC ATTGGCAAGG ATCGCAAAAA CCCAAGGGAG 
GATTATCTGG ATGTCTATGT GTTTGGGGTC GGGCCTTTGG TGAACCAAGT GAACATCAAT 
GCTTTGGCTT CCAAGAAAGA CAATGAGCAA CATGTGTTCA AAGTCAAGGA TATGGAAAAC 
CTGGAAGATG TTTTCTACCA AATGATCGAT GAAAGCCAGT CTCTGAGTCT CTGTGGCATG 
GTTTGGGAAC ACAGGAAGGG TACCGATTAC CACAAGCAAC CATGGCAGGC CAAGATCTCA 
GTCATTCGCC CTTCAAAGGG ACACGAGAGC TGTATGGGGG CTGTGGTGTC TGAGTACTTT 
GTGCTGACAG CAGCACATTG TTTCACTGTG GATGACAAGG AACACTCAAT CAAGGTCAGC 
GTAGGAGGGG AGAAGCGGGA CCTGGAGATA GAAGTAGTCC TATTTCACCC CAACTACAAC 
ATTAATGGGA AAAAAGAAGC AGGAATTCCT GAATTTTATG ACTATGACGT TGCCCTGATC 
AAGCTCAAGA ATAAGCTGAA ATATGGCCAG ACTATCAGGC CCATTTGTCT CCCCTGCACC 
GAGGGAACAA CTCGAGCTTT GAGGCTTCCT CCAACTACCA CTTGCCAGCA ACAAAAGGAA 
GAGCTGCTCC CTGCACAGGA TATCAAAGCT CTGTTTGTGT CTGAGGAGGA GAAAAAGCTG 
ACTCGGAAGG AGGTCTACAT CAAGAATGGG GATAAGAAAG GCAGCTGTGA GAGAGATGCT 
CAATATGCCC CAGGCTATGA CAAAGTCAAG GACATCTCAG AGGTGGTCAC CCCTCGGTTC 
CTTTGTACTG GAGGAGTGAG TCCCTATGCT GACCCCAATA CTTGCAGAGG TGATTCTGGC 
GGCCCCTTGA TAGTTCACAA GAGAAGTCGT TTCATTCAAG TTGGTGTAAT CAGCTGGGGA 
GTAGTGGATG TCTGCAAAAA CCAGAAGCGG CAAAAGCAGG TACCTGCTCA CGCCCGAGAC 
TTTCACATCA ACCTCTTTCA AGTGCTGCCC TGGCTGAAGG AGAAACTCCA AGATGAGGAT 
TTGGGTTTTC TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.
Autoimmunity1-7(2018 Jan)
Urban A,Borowska A,Felberg A,van den Heuvel L,Stasi?oj? G,Volokhina E,Okr?j M

Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab.
Pediatric nephrology (Berlin, Germany)32(5)885-891(2017 May)
Alfakeeh K,Azar M,Alfadhel M,Abdullah AM,Aloudah N,Alsaad KO

Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.
Human molecular genetics25(22)5027-5034(2016 11)
Momozawa Y,Akiyama M,Kamatani Y,Arakawa S,Yasuda M,Yoshida S,Oshima Y,Mori R,Tanaka K,Mori K,Inoue S,Terasaki H,Yasuma T,Honda S,Miki A,Inoue M,Fujisawa K,Takahashi K,Yasukawa T,Yanagi Y,Kadonosono K,Sonoda KH,Ishibashi T,Takahashi A,Kubo M

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CFB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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