S100B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100B
Entrez Gene ID	6285
Full Name	S100 calcium binding protein B
Synonyms	NEF,S100,S100-B,S100beta
General protein information	Preferred Names S100 calcium binding protein B Names protein S100-B S-100 calcium-binding protein, beta chain S-100 protein subunit beta S100 calcium-binding protein, beta (neural)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008].
Disorder MIM:	176990

mRNA and Protein(s)

mRNA	Protein	Name
XM_017028424.2	XP_016883913.1	protein S100-B isoform X1
XM_017028424.1	XP_016883913.1	protein S100-B isoform X1
NM_006272.2	NP_006263.1	protein S100-B
NM_006272.3	NP_006263.1	protein S100-B

Pathways from BioSystems

Homologies

Homo sapiens (human)	S100B	NP_006263.1
Bos taurus (cattle)	S100B	NP_001029727.1
Pan troglodytes (chimpanzee)	S100B	XP_531586.1
Canis lupus familiaris (dog)	S100B	XP_548737.3
Rattus norvegicus (Norway rat)	S100b	NP_037323.1
Gallus gallus (chicken)	S100B	XP_001233035.1
	S100B	XP_001098016.1
Mus musculus (house mouse)	S100b	NP_033141.1
Danio rerio (zebrafish)	s100b	NP_001002552.1

Gene Ontology

The following S100B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25501	NM_006272.3 Latest version!	Homo sapiens S100 calcium binding protein B (S100B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25501	XM_017028424.2 Latest version!	Homo sapiens S100 calcium binding protein B (S100B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25501	XM_017028424.1	Homo sapiens S100 calcium binding protein B (S100B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25501	NM_006272.2	Homo sapiens S100 calcium binding protein B (S100B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100B ( NM_006272.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006263.1 Homo sapiens S100 calcium binding protein B (S100B), mRNA.

Price & Availability↑

CloneID	OHu25501
Clone ID Related Accession (Same CDS sequence)	XM_017028424.2 , XM_017028424.1 , NM_006272.2 , NM_006272.3
Accession Version	NM_006272.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	protein S100-B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA310307.1, BC001766.1, EB386131.1 and AP000339.2. On Sep 15, 2006 this sequence version replaced NM_006272.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.308821.1, SRR1660809.323703.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006263.1
CDS	112..390
Translation	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE

Target ORF information:

RefSeq Version	NM_006272.2
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein B (S100B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006272.2

ORF Insert Sequence:

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100B ( NM_006272.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006263.1 Homo sapiens S100 calcium binding protein B (S100B), mRNA.

Price & Availability↑

CloneID	OHu25501
Clone ID Related Accession (Same CDS sequence)	XM_017028424.2 , XM_017028424.1 , NM_006272.2 , NM_006272.3
Accession Version	NM_006272.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	protein S100-B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA310307.1, BC001766.1, EB386131.1 and AP000339.2. On Nov 23, 2018 this sequence version replaced NM_006272.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.311408.1, SRR1660807.308821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291700.9/ ENSP00000291700.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006263.1
CDS	72..350
Translation	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE

Target ORF information:

RefSeq Version	NM_006272.3
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein B (S100B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006272.3

ORF Insert Sequence:

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100B ( XM_017028424.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883913.1 Homo sapiens S100 calcium binding protein B (S100B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu25501
Clone ID Related Accession (Same CDS sequence)	XM_017028424.2 , XM_017028424.1 , NM_006272.2 , NM_006272.3
Accession Version	XM_017028424.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein S100-B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000021.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017028424.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883913.1
CDS	240..518
Translation	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE

Target ORF information:

RefSeq Version	XM_017028424.2
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein B (S100B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028424.2

ORF Insert Sequence:

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100B ( XM_017028424.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883913.1 Homo sapiens S100 calcium binding protein B (S100B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu25501
Clone ID Related Accession (Same CDS sequence)	XM_017028424.2 , XM_017028424.1 , NM_006272.2 , NM_006272.3
Accession Version	XM_017028424.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein S100-B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000021.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883913.1
CDS	239..517
Translation	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE

Target ORF information:

RefSeq Version	XM_017028424.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein B (S100B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028424.1

ORF Insert Sequence:

ATGTCTGAGC TGGAGAAGGC CATGGTGGCC CTCATCGACG TTTTCCACCA ATATTCTGGA 
AGGGAGGGAG ACAAGCACAA GCTGAAGAAA TCCGAACTGA AGGAGCTCAT CAACAATGAG 
CTTTCCCATT TCTTAGAGGA AATCAAAGAG CAGGAGGTTG TGGACAAAGT CATGGAAACA 
CTGGACAATG ATGGAGACGG CGAATGTGAC TTCCAGGAAT TCATGGCCTT TGTTGCCATG 
GTTACTACTG CCTGCCACGA GTTCTTTGAA CATGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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S100B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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