S100A7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100A7
Entrez Gene ID	6278
Full Name	S100 calcium binding protein A7
Synonyms	PSOR1,S100A7c
General protein information	Preferred Names S100 calcium binding protein A7 Names protein S100-A7 psoriasin 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014].
Disorder MIM:	600353

mRNA and Protein(s)

mRNA	Protein	Name
NM_002963.4	NP_002954.2	protein S100-A7
NM_002963.3	NP_002954.2	protein S100-A7

Pathways from BioSystems

Homologies

Homo sapiens (human)	S100A7	NP_002954.2
	S100A7	XP_001102452.1
Pan troglodytes (chimpanzee)	S100A7A	XP_003949608.1
Bos taurus (cattle)	S100A7	XP_002686048.1
Pan troglodytes (chimpanzee)	S100A7	XP_001138487.1

Gene Ontology
Bibliography

Related articles in PubMed

Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin).
Cunden LS, Brophy MB, Rodriguez GE, Flaxman HA, Nolan EM
Biochemistry56(43)5726-5738(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The promigratory function of S100A7 on tumor cells was confirmed in A431 cells where neutralizing monoclonal antibodies were able to block this effect.
Title: S100A7: from mechanism to cancer therapy.

only S100A7ox exhibits antibacterial activity against select bacterial species. Metal substitution experiments suggest that the disulfide bonds in S100A7 may enhance metal sequestration by the His3Asp sites and thereby confer growth inhibitory properties to S100A7ox.
Title: Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin).

higher expression of Psoriasin was associated with local invasion in pancreatic cancers. Psoriasin expression is associated with pancreatic cancer cell growth, migration, cell-matrix adhesion, and invasion via regulation of MMPs
Title: Psoriasin promotes invasion, aggregation and survival of pancreatic cancer cells; association with disease progression.

Psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis.
Title: Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis.

our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis.
Title: Human S100A7 Induces Mature Interleukin1? Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.

The following S100A7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100A7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14119	NM_002963.4 Latest version!	Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14119	NM_002963.3	Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100A7 ( NM_002963.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002954.2 Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.

Price & Availability↑

CloneID	OHu14119
Clone ID Related Accession (Same CDS sequence)	NM_002963.4 , NM_002963.3
Accession Version	NM_002963.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	protein S100-A7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF090388.1, AW238300.1 and BX476368.1. On Nov 23, 2018 this sequence version replaced NM_002963.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW237898.1, ERR279832.7723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368723.4/ ENSP00000357712.3 Protein has antimicrobial activity :: PMID: 24842328 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAACA CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC 
ACCAGACGTG ATGACAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC 
CCCAACTTCC TTAGTGCCTG TGACAAAAAG GGCACAAATT ACCTCGCCGA TGTCTTTGAG 
AAAAAGGACA AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA 
GACATAGCCA CAGACTACCA CAAGCAGAGC CATGGAGCAG CGCCCTGTTC CGGGGGCAGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002954.2
CDS	62..367
Translation	MSNTQAERSIIGMIDMFHKYTRRDDKIEKPSLLTMMKENFPNFLSACDKKGTNYLADVFEKKDKNEDKKIDFSEFLSLLGDIATDYHKQSHGAAPCSGGSQ

Target ORF information:

RefSeq Version	NM_002963.4
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002963.4

ORF Insert Sequence:

ATGAGCAACA CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC 
ACCAGACGTG ATGACAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC 
CCCAACTTCC TTAGTGCCTG TGACAAAAAG GGCACAAATT ACCTCGCCGA TGTCTTTGAG 
AAAAAGGACA AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA 
GACATAGCCA CAGACTACCA CAAGCAGAGC CATGGAGCAG CGCCCTGTTC CGGGGGCAGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A7 ( NM_002963.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002954.2 Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.

Price & Availability↑

CloneID	OHu14119
Clone ID Related Accession (Same CDS sequence)	NM_002963.4 , NM_002963.3
Accession Version	NM_002963.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	protein S100-A7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF090388.1, AW238300.1 and BX476368.1. On Sep 22, 2006 this sequence version replaced NM_002963.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX280362.1, ERR279832.7723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 24842328 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAACA CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC 
ACCAGACGTG ATGACAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC 
CCCAACTTCC TTAGTGCCTG TGACAAAAAG GGCACAAATT ACCTCGCCGA TGTCTTTGAG 
AAAAAGGACA AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA 
GACATAGCCA CAGACTACCA CAAGCAGAGC CATGGAGCAG CGCCCTGTTC CGGGGGCAGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002954.2
CDS	72..377
Translation	MSNTQAERSIIGMIDMFHKYTRRDDKIEKPSLLTMMKENFPNFLSACDKKGTNYLADVFEKKDKNEDKKIDFSEFLSLLGDIATDYHKQSHGAAPCSGGSQ

Target ORF information:

RefSeq Version	NM_002963.3
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002963.3

ORF Insert Sequence:

ATGAGCAACA CTCAAGCTGA GAGGTCCATA ATAGGCATGA TCGACATGTT TCACAAATAC 
ACCAGACGTG ATGACAAGAT TGAGAAGCCA AGCCTGCTGA CGATGATGAA GGAGAACTTC 
CCCAACTTCC TTAGTGCCTG TGACAAAAAG GGCACAAATT ACCTCGCCGA TGTCTTTGAG 
AAAAAGGACA AGAATGAGGA TAAGAAGATT GATTTTTCTG AGTTTCTGTC CTTGCTGGGA 
GACATAGCCA CAGACTACCA CAAGCAGAGC CATGGAGCAG CGCCCTGTTC CGGGGGCAGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin).
Biochemistry56(43)5726-5738(2017 10)
Cunden LS,Brophy MB,Rodriguez GE,Flaxman HA,Nolan EM

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S100A7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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