S100A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100A2
Entrez Gene ID	6273
Full Name	S100 calcium binding protein A2
Synonyms	CAN19,S100L
General protein information	Preferred Names S100 calcium binding protein A2 Names protein S100-A2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008].
Disorder MIM:	176993

mRNA and Protein(s)

mRNA	Protein	Name
NM_001366406.1	NP_001353335.1	protein S100-A2 isoform 2
NM_005978.3	NP_005969.1	protein S100-A2
NM_001366407.1	NP_001353336.1	protein S100-A2 isoform 3
NM_005978.4	NP_005969.2	protein S100-A2 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	S100A2	XP_001139552.1
Canis lupus familiaris (dog)	S100A2	XP_005622879.1
	LOC715264	XP_001110911.1
Homo sapiens (human)	S100A2	NP_005969.1
Bos taurus (cattle)	S100A2	NP_001029539.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of S100A2 and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids.
Li H, Zhang M, Chen L, Zhang B, Zhang C
Journal of molecular histology48(3)219-223(2017 Jun)

Expression and clinicopathological significance of S100 calcium binding protein A2 in lung cancer patients of Chinese Han ethnicity.
Wang T, Liang Y, Thakur A, Zhang S, Liu F, Khan H, Shi P, Wang N, Chen M, Ren H
Clinica chimica acta; international journal of clinical chemistry464118-122(2017 Jan)

Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity.
Yamaguchi F, Tsuchiya M, Shimamoto S, Fujimoto T, Tokumitsu H, Tokuda M, Kobayashi R
The Tohoku journal of experimental medicine240(1)67-78(2016 09)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

high S100A2 expression and NSCLC
Title: Expression and clinicopathological significance of S100 calcium binding protein A2 in lung cancer patients of Chinese Han ethnicity.

These results indicate that oxidative stress impairs the ability of S100 proteins to bind and activate PP5, which in turn modulates the ASK1-mediated signaling cascades involved in apoptosis.
Title: Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity.

S100A2 could have a role in poor prognosis in stage II and III colorectal cancer recurrence
Title: Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer.

Our results indicate that serum levels of S100A2 and S100A6 are significantly elevated in early stage non-small cell lung cancer
Title: Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer.

Data show higher expression level of S100A2 in high-invasive cholangiocarcinoma Cell Line suggesting it as potential marker of tumor progression and novel therapeutic target.
Title: Comparative Proteomic Analysis of Human Cholangiocarcinoma Cell Lines: S100A2 as a Potential Candidate Protein Inducer of Invasion.

The following S100A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15057	NM_005978.3 Latest version!	Homo sapiens S100 calcium binding protein A2 (S100A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu106983	NM_001366407.1 Latest version!	Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu106984	NM_001366406.1 Latest version!	Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu107799	NM_005978.4 Latest version!	Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100A2 ( NM_005978.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005969.1 Homo sapiens S100 calcium binding protein A2 (S100A2), mRNA.

Price & Availability↑

CloneID	OHu15057
Clone ID Related Accession (Same CDS sequence)	NM_005978.3
Accession Version	NM_005978.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	protein S100-A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC002829.2, BQ953250.1 and AW195797.1. On Mar 9, 2004 this sequence version replaced NM_005978.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002829.2, BQ919168.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCAGTT CTCTGGAGCA GGCGCTGGCT GTGCTGGTCA CTACCTTCCA CAAGTACTCC 
TGCCAAGAGG GCGACAAGTT CAAGCTGAGT AAGGGGGAAA TGAAGGAACT TCTGCACAAG 
GAGCTGCCCA GCTTTGTGGG GGAGAAAGTG GATGAGGAGG GGCTGAAGAA GCTGATGGGC 
AGCCTGGATG AGAACAGTGA CCAGCAGGTG GACTTCCAGG AGTATGCTGT TTTCCTGGCA 
CTCATCACTG TCATGTGCAA TGACTTCTTC CAGGGCTGCC CAGACCGACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005969.1
CDS	339..632
Translation	MCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP

Target ORF information:

RefSeq Version	NM_005978.3
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A2 (S100A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005978.3

ORF Insert Sequence:

ATGTGCAGTT CTCTGGAGCA GGCGCTGGCT GTGCTGGTCA CTACCTTCCA CAAGTACTCC 
TGCCAAGAGG GCGACAAGTT CAAGCTGAGT AAGGGGGAAA TGAAGGAACT TCTGCACAAG 
GAGCTGCCCA GCTTTGTGGG GGAGAAAGTG GATGAGGAGG GGCTGAAGAA GCTGATGGGC 
AGCCTGGATG AGAACAGTGA CCAGCAGGTG GACTTCCAGG AGTATGCTGT TTTCCTGGCA 
CTCATCACTG TCATGTGCAA TGACTTCTTC CAGGGCTGCC CAGACCGACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A2 ( NM_001366407.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001353336.1 Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu106983
Clone ID Related Accession (Same CDS sequence)	NM_001366407.1
Accession Version	NM_001366407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	protein S100-A2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX470102.12. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD365047.1, CD364373.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGAAC TTCTGCACAA GGAGCTGCCC AGCTTTGTGG GGGAGAAAGT GGATGAGGAG 
GGGCTGAAGA AGCTGATGGG CAGCCTGGAT GAGAACAGTG ACCAGCAGGT GGACTTCCAG 
GAGTATGCTG TTTTCCTGGC ACTCATCACT GTCATGTGCA ATGACTTCTT CCAGGGCTGC 
CCAGACCGAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001353336.1
CDS	418..612
Translation	MKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP

Target ORF information:

RefSeq Version	NM_001366407.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001366407.1

ORF Insert Sequence:

ATGAAGGAAC TTCTGCACAA GGAGCTGCCC AGCTTTGTGG GGGAGAAAGT GGATGAGGAG 
GGGCTGAAGA AGCTGATGGG CAGCCTGGAT GAGAACAGTG ACCAGCAGGT GGACTTCCAG 
GAGTATGCTG TTTTCCTGGC ACTCATCACT GTCATGTGCA ATGACTTCTT CCAGGGCTGC 
CCAGACCGAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A2 ( NM_001366406.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001353335.1 Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu106984
Clone ID Related Accession (Same CDS sequence)	NM_001366406.1
Accession Version	NM_001366406.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	protein S100-A2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX470102.12. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.229836.1, DRR138524.576228.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTGCA GTTCTCTGGA GCAGGCGCTG GCTGTGCTGG TCACTACCTT CCACAAGTAC 
TCCTGCCAAG AGGGCGACAA GTTCAAGCTG AGTAAGGGGG AAATGAAGGA ACTTCTGCAC 
AAGGAGCTGC CCAGCTTTGT GGGGCATTCC AGAGAACCAT GTGCTGTGAG GGCCTTCCGA 
GTCCATCTGT TTAATCCTGT CATTGGAGAC TTGAGAAACC AGAGCCCAGA AGGGAAAAGT 
GATTGTCCCA AGATCACACA GCACTGGAGA AAGTGGATGA GGAGGGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001353335.1
CDS	11..301
Translation	MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGHSREPCAVRAFRVHLFNPVIGDLRNQSPEGKSDCPKITQHWRKWMRRG

Target ORF information:

RefSeq Version	NM_001366406.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001366406.1

ORF Insert Sequence:

ATGATGTGCA GTTCTCTGGA GCAGGCGCTG GCTGTGCTGG TCACTACCTT CCACAAGTAC 
TCCTGCCAAG AGGGCGACAA GTTCAAGCTG AGTAAGGGGG AAATGAAGGA ACTTCTGCAC 
AAGGAGCTGC CCAGCTTTGT GGGGCATTCC AGAGAACCAT GTGCTGTGAG GGCCTTCCGA 
GTCCATCTGT TTAATCCTGT CATTGGAGAC TTGAGAAACC AGAGCCCAGA AGGGAAAAGT 
GATTGTCCCA AGATCACACA GCACTGGAGA AAGTGGATGA GGAGGGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A2 ( NM_005978.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005969.2 Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107799
Clone ID Related Accession (Same CDS sequence)	NM_005978.4
Accession Version	NM_005978.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	protein S100-A2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX470102.12. On Oct 4, 2018 this sequence version replaced NM_005978.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: The coding region has been updated to extend the N-terminus to one that is more supported by available proteomics data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM557967.1, ERR279848.6495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368708.9/ ENSP00000357697.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGTGCA GTTCTCTGGA GCAGGCGCTG GCTGTGCTGG TCACTACCTT CCACAAGTAC 
TCCTGCCAAG AGGGCGACAA GTTCAAGCTG AGTAAGGGGG AAATGAAGGA ACTTCTGCAC 
AAGGAGCTGC CCAGCTTTGT GGGGGAGAAA GTGGATGAGG AGGGGCTGAA GAAGCTGATG 
GGCAGCCTGG ATGAGAACAG TGACCAGCAG GTGGACTTCC AGGAGTATGC TGTTTTCCTG 
GCACTCATCA CTGTCATGTG CAATGACTTC TTCCAGGGCT GCCCAGACCG ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005969.2
CDS	350..646
Translation	MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP

Target ORF information:

RefSeq Version	NM_005978.4
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A2 (S100A2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005978.4

ORF Insert Sequence:

ATGATGTGCA GTTCTCTGGA GCAGGCGCTG GCTGTGCTGG TCACTACCTT CCACAAGTAC 
TCCTGCCAAG AGGGCGACAA GTTCAAGCTG AGTAAGGGGG AAATGAAGGA ACTTCTGCAC 
AAGGAGCTGC CCAGCTTTGT GGGGGAGAAA GTGGATGAGG AGGGGCTGAA GAAGCTGATG 
GGCAGCCTGG ATGAGAACAG TGACCAGCAG GTGGACTTCC AGGAGTATGC TGTTTTCCTG 
GCACTCATCA CTGTCATGTG CAATGACTTC TTCCAGGGCT GCCCAGACCG ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of S100A2 and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids.
Journal of molecular histology48(3)219-223(2017 Jun)
Li H,Zhang M,Chen L,Zhang B,Zhang C

Expression and clinicopathological significance of S100 calcium binding protein A2 in lung cancer patients of Chinese Han ethnicity.
Clinica chimica acta; international journal of clinical chemistry464118-122(2017 Jan)
Wang T,Liang Y,Thakur A,Zhang S,Liu F,Khan H,Shi P,Wang N,Chen M,Ren H

Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity.
The Tohoku journal of experimental medicine240(1)67-78(2016 09)
Yamaguchi F,Tsuchiya M,Shimamoto S,Fujimoto T,Tokumitsu H,Tokuda M,Kobayashi R

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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S100A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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