S100A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100A1
Entrez Gene ID	6271
Full Name	S100 calcium binding protein A1
Synonyms	S100,S100-alpha,S100A
General protein information	Preferred Names S100 calcium binding protein A1 Names protein S100-A1 S-100 protein alpha chain S-100 protein subunit alpha S100 alpha S100 protein, alpha polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008].
Disorder MIM:	176940

mRNA and Protein(s)

mRNA	Protein	Name
NM_006271.1	NP_006262.1	protein S100-A1
NM_006271.2	NP_006262.1	protein S100-A1

Pathways from BioSystems

Homologies

Homo sapiens (human)	S100A1	NP_006262.1
	S100A1	XP_001111052.1
Canis lupus familiaris (dog)	S100A1	XP_005622873.1
Mus musculus (house mouse)	S100a1	NP_035439.1
Danio rerio (zebrafish)	s100a1	NP_001082820.1
Rattus norvegicus (Norway rat)	S100a1	NP_001007637.1
Gallus gallus (chicken)	S100A1	XP_003642677.1
Bos taurus (cattle)	S100A1	NP_001092512.1
Xenopus tropicalis (tropical clawed frog)	LOC101734724	XP_004920660.1
Pan troglodytes (chimpanzee)	S100A1	XP_513820.2

Gene Ontology
Bibliography

Related articles in PubMed

Long non-coding RNA FOXD2-AS1 aggravates nasopharyngeal carcinoma carcinogenesis by modulating miR-363-5p/S100A1 pathway.
Chen G, Sun W, Hua X, Zeng W, Yang L
Gene64576-84(2018 Mar)

Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus.
Bousova K, Herman P, Vecer J, Bednarova L, Monincova L, Majer P, Vyklicky L, Vondrasek J, Teisinger J
The FEBS journal(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that calcium signaling plays important role in prevention of protein misfolding; complexes of S100A1 and STIP1 are key players in this pathway; the stoichiometry of S100A1/STIP1 interaction appears to be three S100A1 dimers plus one STIP1 monomer; each S100A1-STIP1-binding interaction is entropically driven. (S100A1 = S100 calcium binding protein A1; STIP1 = stress-induced-phosphoprotein 1) [REVIEW]
Title: New insight on the S100A1-STIP1 complex highlights the important relationship between allostery and entropy in protein function.

a correlation between S100B + A1-positive Human Articular Chondrocytes in monolayer culture and their neochondrogenesis capacity in pellet culture, is reported.
Title: S100B?+?A1 CELISA: A Novel Potency Assay and Screening Tool for Redifferentiation Stimuli of Human Articular Chondrocytes.

Data suggest that three dimers of S100A1 (S100 calcium binding protein A1) associate with one molecule of STIP1 (stress-inducible phosphoprotein 1) in a calcium-dependent manner; individual STIP1 TPR (tetratricopeptide repeat) domains, TPR1, TPR2A and TPR2B, bind a single S100A1 dimer with significantly different affinities; TPR2B domain possesses highest affinity for S100A1.
Title: Molecular basis for the interaction between stress-inducible phosphoprotein 1 (STIP1) and S100A1.

X-ray crystal structure of human calcium-bound S100A1 has been reported.
Title: X-ray crystal structure of human calcium-bound S100A1.

Results identified amino acids motif in S100A1 for protein binding to 2-oxohistidine which appears to be an evolutionarily conserved capacity from bacteria to human.
Title: Identification of 2-oxohistidine Interacting Proteins Using E. coli Proteome Chips.

The following S100A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11487	NM_006271.2 Latest version!	Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11487	NM_006271.1	Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100A1 ( NM_006271.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_006262.1 Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.

Price & Availability↑

CloneID	OHu11487
Clone ID Related Accession (Same CDS sequence)	NM_006271.1 , NM_006271.2
Accession Version	NM_006271.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	protein S100-A1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X58079.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X58079.1, ERR279841.7456.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCTCTG AGCTGGAGAC GGCGATGGAG ACCCTCATCA ACGTGTTCCA CGCCCACTCG 
GGCAAAGAGG GGGACAAGTA CAAGCTGAGC AAGAAGGAGC TGAAAGAGCT GCTGCAGACG 
GAGCTCTCTG GCTTCCTGGA TGCCCAGAAG GATGTGGATG CTGTGGACAA GGTGATGAAG 
GAGCTAGACG AGAATGGAGA CGGGGAGGTG GACTTCCAGG AGTATGTGGT GCTTGTGGCT 
GCTCTCACAG TGGCCTGTAA CAATTTCTTC TGGGAGAACA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006262.1
CDS	114..398
Translation	MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS

Target ORF information:

RefSeq Version	NM_006271.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006271.1

ORF Insert Sequence:

ATGGGCTCTG AGCTGGAGAC GGCGATGGAG ACCCTCATCA ACGTGTTCCA CGCCCACTCG 
GGCAAAGAGG GGGACAAGTA CAAGCTGAGC AAGAAGGAGC TGAAAGAGCT GCTGCAGACG 
GAGCTCTCTG GCTTCCTGGA TGCCCAGAAG GATGTGGATG CTGTGGACAA GGTGATGAAG 
GAGCTAGACG AGAATGGAGA CGGGGAGGTG GACTTCCAGG AGTATGTGGT GCTTGTGGCT 
GCTCTCACAG TGGCCTGTAA CAATTTCTTC TGGGAGAACA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A1 ( NM_006271.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006262.1 Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.

Price & Availability↑

CloneID	OHu11487
Clone ID Related Accession (Same CDS sequence)	NM_006271.1 , NM_006271.2
Accession Version	NM_006271.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	protein S100-A1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X58079.1 and AL162258.12. On Jun 2, 2019 this sequence version replaced NM_006271.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014392.1, BX096164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCTCTG AGCTGGAGAC GGCGATGGAG ACCCTCATCA ACGTGTTCCA CGCCCACTCG 
GGCAAAGAGG GGGACAAGTA CAAGCTGAGC AAGAAGGAGC TGAAAGAGCT GCTGCAGACG 
GAGCTCTCTG GCTTCCTGGA TGCCCAGAAG GATGTGGATG CTGTGGACAA GGTGATGAAG 
GAGCTAGACG AGAATGGAGA CGGGGAGGTG GACTTCCAGG AGTATGTGGT GCTTGTGGCT 
GCTCTCACAG TGGCCTGTAA CAATTTCTTC TGGGAGAACA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006262.1
CDS	77..361
Translation	MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS

Target ORF information:

RefSeq Version	NM_006271.2
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A1 (S100A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006271.2

ORF Insert Sequence:

ATGGGCTCTG AGCTGGAGAC GGCGATGGAG ACCCTCATCA ACGTGTTCCA CGCCCACTCG 
GGCAAAGAGG GGGACAAGTA CAAGCTGAGC AAGAAGGAGC TGAAAGAGCT GCTGCAGACG 
GAGCTCTCTG GCTTCCTGGA TGCCCAGAAG GATGTGGATG CTGTGGACAA GGTGATGAAG 
GAGCTAGACG AGAATGGAGA CGGGGAGGTG GACTTCCAGG AGTATGTGGT GCTTGTGGCT 
GCTCTCACAG TGGCCTGTAA CAATTTCTTC TGGGAGAACA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long non-coding RNA FOXD2-AS1 aggravates nasopharyngeal carcinoma carcinogenesis by modulating miR-363-5p/S100A1 pathway.
Gene64576-84(2018 Mar)
Chen G,Sun W,Hua X,Zeng W,Yang L

Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus.
The FEBS journal(2017 Dec)
Bousova K,Herman P,Vecer J,Bednarova L,Monincova L,Majer P,Vyklicky L,Vondrasek J,Teisinger J

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S100A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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