RRAS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RRAS
Entrez Gene ID	6237
Full Name	RAS related
Synonyms	R-Ras
General protein information	Preferred Names RAS related Names ras-related protein R-Ras oncogene RRAS p23 ras family small GTP binding protein R-Ras related RAS viral (r-ras) oncogene homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015].
Disorder MIM:	165090

mRNA and Protein(s)

mRNA	Protein	Name
NM_006270.4	NP_006261.1	ras-related protein R-Ras
NM_006270.5	NP_006261.1	ras-related protein R-Ras

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RRAS	XP_524339.1
Canis lupus familiaris (dog)	RRAS	XP_533617.1
Bos taurus (cattle)	RRAS	NP_001033777.1
Danio rerio (zebrafish)	rras	NP_001005931.2
	RRAS	XP_001115362.1
Homo sapiens (human)	RRAS	NP_006261.1
Mus musculus (house mouse)	Rras	NP_033127.1
Rattus norvegicus (Norway rat)	Rras	NP_001101951.1
Xenopus tropicalis (tropical clawed frog)	rras	NP_001107720.1

Gene Ontology
Bibliography

Related articles in PubMed

SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.
Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J
Nature cell biology19(4)292-305(2017 Apr)

Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.
Xu L, Gao Y, Chen Y, Xiao Y, He Q, Qiu H, Ge W
Oncotarget7(28)43868-43893(2016 Jul)

Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.
Sung H, Kanchi KL, Wang X, Hill KS, Messina JL, Lee JH, Kim Y, Dees ND, Ding L, Teer JK, Yang S, Sarnaik AA, Sondak VK, Mul? JJ, Wilson RK, Weber JS, Kim M
Oncotarget7(17)23885-96(2016 Apr)

miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.
Chevalier B, Adamiok A, Mercey O, Revinski DR, Zaragosi LE, Pasini A, Kodjabachian L, Barbry P, Marcet B
Nature communications68386(2015 Sep)

R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.
Sawada J, Li F, Komatsu M
Journal of vascular research52(5)347-59(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane.
Title: SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.

this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer
Title: Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.

RRAS is a key regulator of miR-34/449 promotion of actin network formation during multiciliogenesis.
Title: miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.

Girdin regulates the trafficking of VE-cadherin in synergy with R-Ras.
Title: Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.

Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
Title: R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.

The following RRAS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRAS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25972	NM_006270.5 Latest version!	Homo sapiens RAS related (RRAS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu25972	NM_006270.4	Homo sapiens RAS related (RRAS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RRAS ( NM_006270.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006261.1 Homo sapiens RAS related (RRAS), mRNA.

Price & Availability↑

CloneID	OHu25972
Clone ID Related Accession (Same CDS sequence)	NM_006270.4 , NM_006270.5
Accession Version	NM_006270.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-08-04
Organism	Homo sapiens(human)
Product	ras-related protein R-Ras
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016318.1 and BC016286.1. This sequence is a reference standard in the RefSeqGene project. On Jul 8, 2015 this sequence version replaced NM_006270.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016286.1, BC016318.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG 
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG 
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC 
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC 
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT 
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC 
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC 
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC 
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC 
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG 
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006261.1
CDS	46..702
Translation	MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

Target ORF information:

RefSeq Version	NM_006270.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAS related (RRAS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006270.4

ORF Insert Sequence:

ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG 
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG 
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC 
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC 
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT 
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC 
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC 
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC 
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC 
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG 
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRAS ( NM_006270.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006261.1 Homo sapiens RAS related (RRAS), mRNA.

Price & Availability↑

CloneID	OHu25972
Clone ID Related Accession (Same CDS sequence)	NM_006270.4 , NM_006270.5
Accession Version	NM_006270.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	ras-related protein R-Ras
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016318.1 and BC016286.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006270.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016286.1, BC016318.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246792.4/ ENSP00000246792.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG 
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG 
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC 
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC 
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT 
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC 
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC 
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC 
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC 
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG 
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006261.1
CDS	46..702
Translation	MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

Target ORF information:

RefSeq Version	NM_006270.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAS related (RRAS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006270.5

ORF Insert Sequence:

ATGAGCAGCG GGGCGGCGTC CGGGACAGGG CGGGGGCGGC CCCGGGGCGG GGGACCTGGG 
CCCGGGGACC CCCCGCCCAG CGAGACACAC AAGCTGGTGG TCGTGGGCGG CGGCGGCGTG 
GGCAAGAGCG CGCTGACCAT CCAGTTCATC CAGTCCTACT TCGTGTCTGA CTACGACCCC 
ACTATTGAGG ACTCCTACAC GAAGATCTGC AGTGTGGATG GCATCCCAGC CCGGCTGGAC 
ATCCTGGACA CCGCGGGCCA GGAAGAGTTC GGGGCCATGA GAGAGCAGTA CATGCGTGCT 
GGCCACGGCT TCCTGCTGGT GTTCGCCATT AACGACCGGC AGAGTTTCAA CGAGGTGGGC 
AAGCTCTTCA CGCAGATTCT GCGGGTCAAG GACCGCGACG ACTTCCCCGT TGTGTTGGTC 
GGGAACAAGG CAGATCTGGA GTCACAGCGC CAGGTCCCCC GATCAGAAGC CTCTGCCTTC 
GGCGCCTCCC ACCACGTGGC CTACTTTGAG GCCTCGGCCA AACTGCGTCT CAACGTGGAC 
GAGGCTTTTG AGCAGCTGGT GCGGGCTGTC CGGAAATACC AGGAACAAGA GCTCCCACCG 
AGCCCTCCCA GTGCCCCCAG GAAGAAGGGC GGGGGCTGCC CCTGCGTCCT CCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.
Nature cell biology19(4)292-305(2017 Apr)
Lilja J,Zacharchenko T,Georgiadou M,Jacquemet G,De Franceschi N,Peuhu E,Hamidi H,Pouwels J,Martens V,Nia FH,Beifuss M,Boeckers T,Kreienkamp HJ,Barsukov IL,Ivaska J

Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.
Oncotarget7(28)43868-43893(2016 Jul)
Xu L,Gao Y,Chen Y,Xiao Y,He Q,Qiu H,Ge W

Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.
Oncotarget7(17)23885-96(2016 Apr)
Sung H,Kanchi KL,Wang X,Hill KS,Messina JL,Lee JH,Kim Y,Dees ND,Ding L,Teer JK,Yang S,Sarnaik AA,Sondak VK,Mul? JJ,Wilson RK,Weber JS,Kim M

miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.
Nature communications68386(2015 Sep)
Chevalier B,Adamiok A,Mercey O,Revinski DR,Zaragosi LE,Pasini A,Kodjabachian L,Barbry P,Marcet B

R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.
Journal of vascular research52(5)347-59(2015)
Sawada J,Li F,Komatsu M

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RRAS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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