RPS18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS18
Entrez Gene ID	6222
Full Name	ribosomal protein S18
Synonyms	D6S218E,HKE3,KE-3,KE3,S18
General protein information	Preferred Names ribosomal protein S18 Names 40S ribosomal protein S18 rhabdomyosarcoma antigen MU-RMS-40.21 small ribosomal subunit protein uS13
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.32
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	180473

mRNA and Protein(s)

mRNA	Protein	Name
NM_022551.3	NP_072045.1	40S ribosomal protein S18
NM_022551.2	NP_072045.1	40S ribosomal protein S18

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RPS18	NP_001041547.1
Bos taurus (cattle)	RPS18	NP_001028786.1
Mus musculus (house mouse)	Rps18	NP_035426.1
Danio rerio (zebrafish)	rps18	NP_775341.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010375	XP_311570.4
Eremothecium gossypii	AGOS_AER315C	NP_985171.1
Magnaporthe oryzae (rice blast fungus)	MGG_05661	XP_003710559.1
	LOC706282	XP_001091975.1
Rattus norvegicus (Norway rat)	LOC100360679	XP_002727879.1
Schizosaccharomyces pombe (fission yeast)	rps1802	NP_588057.2
Drosophila melanogaster (fruit fly)	RpS18	NP_725943.1
Caenorhabditis elegans (roundworm)	rps-18	NP_502794.1
Saccharomyces cerevisiae (baker's yeast)	RPS18B	NP_013686.1
Schizosaccharomyces pombe (fission yeast)	rps1801	NP_596506.1
Arabidopsis thaliana (thale cress)	RPS18C	NP_192718.1
Arabidopsis thaliana (thale cress)	PFL	NP_173692.1
Homo sapiens (human)	RPS18	NP_072045.1
Rattus norvegicus (Norway rat)	Rps18	NP_998722.1
Saccharomyces cerevisiae (baker's yeast)	RPS18A	NP_010738.1
Kluyveromyces lactis	KLLA0B01562g	XP_451600.1
Neurospora crassa	NCU00475	XP_956794.2
Arabidopsis thaliana (thale cress)	AT1G34030	NP_564434.1
Oryza sativa (rice)	Os07g0173700	NP_001059007.2
Oryza sativa (rice)	Os03g0794700	NP_001051541.1
Xenopus tropicalis (tropical clawed frog)	rps18	NP_001016358.1

Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL
Cell157(2)472-485(2014 Apr)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.
Todd MA, Picketts DJ
Journal of proteome research11(8)4326-37(2012 Aug)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ribosomal protein S18e seems to act as a molecular staple fixing the 18S rRNA 3'-major domain core.
Title: Ribosomal protein S18e as a putative molecular staple for the 18S rRNA 3'-major domain core.

Observational study of gene-disease association. (HuGE Navigator)
Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

cofilin interacts with S18 protein at the actin-binding site
Title: Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library.

The following RPS18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02136	NM_022551.3 Latest version!	Homo sapiens ribosomal protein S18 (RPS18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu02136	NM_022551.2	Homo sapiens ribosomal protein S18 (RPS18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS18 ( NM_022551.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_072045.1 Homo sapiens ribosomal protein S18 (RPS18), mRNA.

Price & Availability↑

CloneID	OHu02136
Clone ID Related Accession (Same CDS sequence)	NM_022551.3 , NM_022551.2
Accession Version	NM_022551.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	40S ribosomal protein S18
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AL645940.4 and AL662820.6. On Nov 25, 2018 this sequence version replaced NM_022551.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189661.4343.1, CD173693.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000439602.7/ ENSP00000393241.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTCTAG TGATCCCTGA AAAGTTCCAG CATATTTTGC GAGTACTCAA CACCAACATC 
GATGGGCGGC GGAAAATAGC CTTTGCCATC ACTGCCATTA AGGGTGTGGG CCGAAGATAT 
GCTCATGTGG TGTTGAGGAA AGCAGACATT GACCTCACCA AGAGGGCGGG AGAACTCACT 
GAGGATGAGG TGGAACGTGT GATCACCATT ATGCAGAATC CACGCCAGTA CAAGATCCCA 
GACTGGTTCT TGAACAGACA GAAGGATGTA AAGGATGGAA AATACAGCCA GGTCCTAGCC 
AATGGTCTGG ACAACAAGCT CCGTGAAGAC CTGGAGCGAC TGAAGAAGAT TCGGGCCCAT 
AGAGGGCTGC GTCACTTCTG GGGCCTTCGT GTCCGAGGCC AGCACACCAA GACCACTGGC 
CGCCGTGGCC GCACCGTGGG TGTGTCCAAG AAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072045.1
CDS	46..504
Translation	MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

Target ORF information:

RefSeq Version	NM_022551.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S18 (RPS18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022551.3

ORF Insert Sequence:

ATGTCTCTAG TGATCCCTGA AAAGTTCCAG CATATTTTGC GAGTACTCAA CACCAACATC 
GATGGGCGGC GGAAAATAGC CTTTGCCATC ACTGCCATTA AGGGTGTGGG CCGAAGATAT 
GCTCATGTGG TGTTGAGGAA AGCAGACATT GACCTCACCA AGAGGGCGGG AGAACTCACT 
GAGGATGAGG TGGAACGTGT GATCACCATT ATGCAGAATC CACGCCAGTA CAAGATCCCA 
GACTGGTTCT TGAACAGACA GAAGGATGTA AAGGATGGAA AATACAGCCA GGTCCTAGCC 
AATGGTCTGG ACAACAAGCT CCGTGAAGAC CTGGAGCGAC TGAAGAAGAT TCGGGCCCAT 
AGAGGGCTGC GTCACTTCTG GGGCCTTCGT GTCCGAGGCC AGCACACCAA GACCACTGGC 
CGCCGTGGCC GCACCGTGGG TGTGTCCAAG AAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS18 ( NM_022551.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_072045.1 Homo sapiens ribosomal protein S18 (RPS18), mRNA.

Price & Availability↑

CloneID	OHu02136
Clone ID Related Accession (Same CDS sequence)	NM_022551.3 , NM_022551.2
Accession Version	NM_022551.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	40S ribosomal protein S18
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from X69150.1. On May 22, 2001 this sequence version replaced NM_022551.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106063.1, BG706853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCTCTAG TGATCCCTGA AAAGTTCCAG CATATTTTGC GAGTACTCAA CACCAACATC 
GATGGGCGGC GGAAAATAGC CTTTGCCATC ACTGCCATTA AGGGTGTGGG CCGAAGATAT 
GCTCATGTGG TGTTGAGGAA AGCAGACATT GACCTCACCA AGAGGGCGGG AGAACTCACT 
GAGGATGAGG TGGAACGTGT GATCACCATT ATGCAGAATC CACGCCAGTA CAAGATCCCA 
GACTGGTTCT TGAACAGACA GAAGGATGTA AAGGATGGAA AATACAGCCA GGTCCTAGCC 
AATGGTCTGG ACAACAAGCT CCGTGAAGAC CTGGAGCGAC TGAAGAAGAT TCGGGCCCAT 
AGAGGGCTGC GTCACTTCTG GGGCCTTCGT GTCCGAGGCC AGCACACCAA GACCACTGGC 
CGCCGTGGCC GCACCGTGGG TGTGTCCAAG AAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072045.1
CDS	46..504
Translation	MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

Target ORF information:

RefSeq Version	NM_022551.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S18 (RPS18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022551.2

ORF Insert Sequence:

ATGTCTCTAG TGATCCCTGA AAAGTTCCAG CATATTTTGC GAGTACTCAA CACCAACATC 
GATGGGCGGC GGAAAATAGC CTTTGCCATC ACTGCCATTA AGGGTGTGGG CCGAAGATAT 
GCTCATGTGG TGTTGAGGAA AGCAGACATT GACCTCACCA AGAGGGCGGG AGAACTCACT 
GAGGATGAGG TGGAACGTGT GATCACCATT ATGCAGAATC CACGCCAGTA CAAGATCCCA 
GACTGGTTCT TGAACAGACA GAAGGATGTA AAGGATGGAA AATACAGCCA GGTCCTAGCC 
AATGGTCTGG ACAACAAGCT CCGTGAAGAC CTGGAGCGAC TGAAGAAGAT TCGGGCCCAT 
AGAGGGCTGC GTCACTTCTG GGGCCTTCGT GTCCGAGGCC AGCACACCAA GACCACTGGC 
CGCCGTGGCC GCACCGTGGG TGTGTCCAAG AAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Cell157(2)472-485(2014 Apr)
Martin I,Kim JW,Lee BD,Kang HC,Xu JC,Jia H,Stankowski J,Kim MS,Zhong J,Kumar M,Andrabi SA,Xiong Y,Dickson DW,Wszolek ZK,Pandey A,Dawson TM,Dawson VL

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.
Journal of proteome research11(8)4326-37(2012 Aug)
Todd MA,Picketts DJ

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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RPS18 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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