RPS15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS15
Entrez Gene ID	6209
Full Name	ribosomal protein S15
Synonyms	RIG,S15
General protein information	Preferred Names ribosomal protein S15 Names 40S ribosomal protein S15 homolog of rat insulinoma insulinoma protein small ribosomal subunit protein uS19
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Disorder MIM:	180535

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308226.1	NP_001295155.1	40S ribosomal protein S15 isoform 1
NM_001018.4	NP_001009.1	40S ribosomal protein S15 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rps15	NP_058847.1
Saccharomyces cerevisiae (baker's yeast)	RPS15	NP_014602.1
Schizosaccharomyces pombe (fission yeast)	rps1501	NP_587961.1
Magnaporthe oryzae (rice blast fungus)	MGG_10370	XP_003713417.1
	RPS15	XP_001095102.1
Canis lupus familiaris (dog)	RPS15	XP_005633186.1
Bos taurus (cattle)	RPS15	NP_001019712.1
Eremothecium gossypii	AGOS_AEL343C	NP_984517.1
Arabidopsis thaliana (thale cress)	AT5G09510	NP_196513.1
Arabidopsis thaliana (thale cress)	AT5G09490	NP_196511.1
Oryza sativa (rice)	Os03g0798600	NP_001051572.1
Pan troglodytes (chimpanzee)	RPS15	XP_003953356.1
Gallus gallus (chicken)	RPS15	NP_990793.1
Homo sapiens (human)	RPS15	NP_001009.1
Mus musculus (house mouse)	Rps15	NP_033117.1
Kluyveromyces lactis	KLLA0F07843g	XP_455435.1
Neurospora crassa	NCU00971	XP_965164.1
Arabidopsis thaliana (thale cress)	RPS15	NP_171923.1
Arabidopsis thaliana (thale cress)	AT5G09500	NP_196512.1
Arabidopsis thaliana (thale cress)	AT5G43640	NP_199177.1
Schizosaccharomyces pombe (fission yeast)	rps1502	NP_594357.1

Gene Ontology
Bibliography

Related articles in PubMed

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.
Ljungstr?m V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford R, Sutton LA, Blakemore SJ, Stavroyianni N, Agathangelidis A, Rossi D, H?glund M, Kotaskova J, Juliusson G, Belessi C, Chiorazzi N, Panagiotidis P, Langerak AW, Smedby KE, Oscier D, Gaidano G, Schuh A, Davi F, Pott C, Strefford JC, Trentin L, Pospisilova S, Ghia P, Stamatopoulos K, Sj?blom T, Rosenquist R
Blood127(8)1007-16(2016 Feb)

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M
eLife5(2016 Jan)

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM
Journal of neurochemistry131(2)239-50(2014 Oct)

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL
Cell157(2)472-485(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we provide novel insights into the heterogeneous genomic landscape of relapsing chronic lymphocytic leukemia and report recurrent mutations in a "hotspot" region of RPS15
Title: Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.

Study shows that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron Parkinson's disease models.
Title: Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.

RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network but employ different mechanisms to do so.
Title: Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.

The following RPS15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25028	NM_001018.4 Latest version!	Homo sapiens ribosomal protein S15 (RPS15), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu60327	NM_001308226.1 Latest version!	Homo sapiens ribosomal protein S15 (RPS15), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS15 ( NM_001018.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001009.1 Homo sapiens ribosomal protein S15 (RPS15), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25028
Clone ID Related Accession (Same CDS sequence)	NM_001018.4
Accession Version	NM_001018.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	40S ribosomal protein S15 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BU602036.1, J02984.1 and BG253776.1. This sequence is a reference standard in the RefSeqGene project. On Apr 28, 2015 this sequence version replaced NM_001018.3. Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU598756.1, CD249770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAAG TAGAGCAGAA GAAGAAGCGG ACCTTCCGCA AGTTCACCTA CCGCGGCGTG 
GACCTCGACC AGCTGCTGGA CATGTCCTAC GAGCAGCTGA TGCAGCTGTA CAGTGCGCGC 
CAGCGGCGGC GGCTGAACCG GGGCCTGCGG CGGAAGCAGC ACTCCCTGCT GAAGCGCCTG 
CGCAAGGCCA AGAAGGAGGC GCCGCCCATG GAGAAGCCGG AAGTGGTGAA GACGCACCTG 
CGGGACATGA TCATCCTACC CGAGATGGTG GGCAGCATGG TGGGCGTCTA CAACGGCAAG 
ACCTTCAACC AGGTGGAGAT CAAGCCCGAG ATGATCGGCC ACTACCTGGG CGAGTTCTCC 
ATCACCTACA AGCCCGTAAA GCATGGCCGG CCCGGCATCG GGGCCACCCA CTCCTCCCGC 
TTCATCCCTC TCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009.1
CDS	63..500
Translation	MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK

Target ORF information:

RefSeq Version	NM_001018.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S15 (RPS15), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018.4

ORF Insert Sequence:

ATGGCAGAAG TAGAGCAGAA GAAGAAGCGG ACCTTCCGCA AGTTCACCTA CCGCGGCGTG 
GACCTCGACC AGCTGCTGGA CATGTCCTAC GAGCAGCTGA TGCAGCTGTA CAGTGCGCGC 
CAGCGGCGGC GGCTGAACCG GGGCCTGCGG CGGAAGCAGC ACTCCCTGCT GAAGCGCCTG 
CGCAAGGCCA AGAAGGAGGC GCCGCCCATG GAGAAGCCGG AAGTGGTGAA GACGCACCTG 
CGGGACATGA TCATCCTACC CGAGATGGTG GGCAGCATGG TGGGCGTCTA CAACGGCAAG 
ACCTTCAACC AGGTGGAGAT CAAGCCCGAG ATGATCGGCC ACTACCTGGG CGAGTTCTCC 
ATCACCTACA AGCCCGTAAA GCATGGCCGG CCCGGCATCG GGGCCACCCA CTCCTCCCGC 
TTCATCCCTC TCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS15 ( NM_001308226.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295155.1 Homo sapiens ribosomal protein S15 (RPS15), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu60327
Clone ID Related Accession (Same CDS sequence)	NM_001308226.1
Accession Version	NM_001308226.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	40S ribosomal protein S15 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG705752.1, BM558707.1, BE798984.1 and BG253776.1. On Apr 28, 2015 this sequence version replaced XM_011528176.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD249042.1, CA426260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGGGC GAGGGGCGGA CTTGGCAGAA GTAGAGCAGA AGAAGAAGCG GACCTTCCGC 
AAGTTCACCT ACCGCGGCGT GGACCTCGAC CAGCTGCTGG ACATGTCCTA CGAGCAGCTG 
ATGCAGCTGT ACAGTGCGCG CCAGCGGCGG CGGCTGAACC GGGGCCTGCG GCGGAAGCAG 
CACTCCCTGC TGAAGCGCCT GCGCAAGGCC AAGAAGGAGG CGCCGCCCAT GGAGAAGCCG 
GAAGTGGTGA AGACGCACCT GCGGGACATG ATCATCCTAC CCGAGATGGT GGGCAGCATG 
GTGGGCGTCT ACAACGGCAA GACCTTCAAC CAGGTGGAGA TCAAGCCCGA GATGATCGGC 
CACTACCTGG GCGAGTTCTC CATCACCTAC AAGCCCGTAA AGCATGGCCG GCCCGGCATC 
GGGGCCACCC ACTCCTCCCG CTTCATCCCT CTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295155.1
CDS	133..591
Translation	MLGRGADLAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK

Target ORF information:

RefSeq Version	NM_001308226.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S15 (RPS15), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308226.1

ORF Insert Sequence:

ATGTTGGGGC GAGGGGCGGA CTTGGCAGAA GTAGAGCAGA AGAAGAAGCG GACCTTCCGC 
AAGTTCACCT ACCGCGGCGT GGACCTCGAC CAGCTGCTGG ACATGTCCTA CGAGCAGCTG 
ATGCAGCTGT ACAGTGCGCG CCAGCGGCGG CGGCTGAACC GGGGCCTGCG GCGGAAGCAG 
CACTCCCTGC TGAAGCGCCT GCGCAAGGCC AAGAAGGAGG CGCCGCCCAT GGAGAAGCCG 
GAAGTGGTGA AGACGCACCT GCGGGACATG ATCATCCTAC CCGAGATGGT GGGCAGCATG 
GTGGGCGTCT ACAACGGCAA GACCTTCAAC CAGGTGGAGA TCAAGCCCGA GATGATCGGC 
CACTACCTGG GCGAGTTCTC CATCACCTAC AAGCCCGTAA AGCATGGCCG GCCCGGCATC 
GGGGCCACCC ACTCCTCCCG CTTCATCCCT CTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.
Blood127(8)1007-16(2016 Feb)
Ljungstr?m V,Cortese D,Young E,Pandzic T,Mansouri L,Plevova K,Ntoufa S,Baliakas P,Clifford R,Sutton LA,Blakemore SJ,Stavroyianni N,Agathangelidis A,Rossi D,H?glund M,Kotaskova J,Juliusson G,Belessi C,Chiorazzi N,Panagiotidis P,Langerak AW,Smedby KE,Oscier D,Gaidano G,Schuh A,Davi F,Pott C,Strefford JC,Trentin L,Pospisilova S,Ghia P,Stamatopoulos K,Sj?blom T,Rosenquist R

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
eLife5(2016 Jan)
Steger M,Tonelli F,Ito G,Davies P,Trost M,Vetter M,Wachter S,Lorentzen E,Duddy G,Wilson S,Baptista MA,Fiske BK,Fell MJ,Morrow JA,Reith AD,Alessi DR,Mann M

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Journal of neurochemistry131(2)239-50(2014 Oct)
Reyniers L,Del Giudice MG,Civiero L,Belluzzi E,Lobbestael E,Beilina A,Arrigoni G,Derua R,Waelkens E,Li Y,Crosio C,Iaccarino C,Cookson MR,Baekelandt V,Greggio E,Taymans JM

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Cell157(2)472-485(2014 Apr)
Martin I,Kim JW,Lee BD,Kang HC,Xu JC,Jia H,Stankowski J,Kim MS,Zhong J,Kumar M,Andrabi SA,Xiong Y,Dickson DW,Wszolek ZK,Pandey A,Dawson TM,Dawson VL

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RPS15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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