RPS6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS6
Entrez Gene ID	6194
Full Name	ribosomal protein S6
Synonyms	S6
General protein information	Preferred Names ribosomal protein S6 Names 40S ribosomal protein S6 phosphoprotein NP33 small ribosomal subunit protein eS6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p22.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	180460

mRNA and Protein(s)

mRNA	Protein	Name
NM_001010.3	NP_001001.2	40S ribosomal protein S6
NM_001010.2	NP_001001.2	40S ribosomal protein S6

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPS6	NP_001001.2
Rattus norvegicus (Norway rat)	Rps6	NP_058856.1
Kluyveromyces lactis	KLLA0E24047g	XP_455035.1
Eremothecium gossypii	AGOS_AGR197C	NP_986863.1
Magnaporthe oryzae (rice blast fungus)	MGG_03236	XP_003716740.1
Neurospora crassa	NCU08502	XP_963431.1
	RPS6	XP_001109421.1
Rattus norvegicus (Norway rat)	LOC100911372	XP_003750019.1
Danio rerio (zebrafish)	rps6	NP_001003728.1
Drosophila melanogaster (fruit fly)	RpS6	NP_511073.1
Schizosaccharomyces pombe (fission yeast)	rps601	NP_592833.1
Gallus gallus (chicken)	RPS6	NP_990556.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002919	XP_001237411.2
Saccharomyces cerevisiae (baker's yeast)	RPS6B	NP_009740.3
Saccharomyces cerevisiae (baker's yeast)	RPS6A	NP_015235.1
Schizosaccharomyces pombe (fission yeast)	rps602	NP_594138.1
Arabidopsis thaliana (thale cress)	EMB3010	NP_196598.1
Oryza sativa (rice)	Os03g0390000	NP_001050273.1
Oryza sativa (rice)	Os07g0622100	NP_001060313.1
Xenopus tropicalis (tropical clawed frog)	rps6	NP_989152.1
Pan troglodytes (chimpanzee)	RPS6	XP_003951447.1
Bos taurus (cattle)	RPS6	NP_001015548.1
Mus musculus (house mouse)	Rps6	NP_033122.1
Arabidopsis thaliana (thale cress)	RPS6	NP_194898.1
	LOC718556	XP_001111414.2
Canis lupus familiaris (dog)	RPS6	NP_001239099.1
Caenorhabditis elegans (roundworm)	rps-6	NP_493435.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.
Machado LE, Alvarenga AW, da Silva FF, Roff? M, Begnami MD, Torres LFB, da Cunha IW, Martins VR, Hajj GNM
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society22155417750838(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study examined baseline levels of S6 phosphorylated at Ser235/236 (pS6Ser235/236) or Ser240/244 (pS6Ser240/244)and a possible effect of tau pathology. Findings argue against the idea that high levels of pS6Ser235/236 in neurons are a consequence of a higher expression of S6 protein and speak for an increased phosphorylation of S6 in intensely pS6Ser235/236-labeled neurons.
Title: Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus.

the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase.
Title: Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent.

this study unveils an unprecedented correlation of mTOR activation with improved clinical outcome in patients with laryngeal carcinomas and uncovers the potential of p-S6 expression as a good prognostic biomarker and an inverse predictor of lymph node and distant metastases.
Title: Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas.

reciprocal expression of p-AMPKa and p-S6 may be promising prognostic biomarkers in patients with gastric cancer
Title: Reciprocal expression of p-AMPKa and p-S6 is strongly associated with the prognosis of gastric cancer.

Data suggest ribosomal protein S6 (rpS6) as tumor marker for renal cell carcinoma.
Title: The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker.

The following RPS6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02539	NM_001010.3 Latest version!	Homo sapiens ribosomal protein S6 (RPS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu02539	NM_001010.2	Homo sapiens ribosomal protein S6 (RPS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS6 ( NM_001010.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001.2 Homo sapiens ribosomal protein S6 (RPS6), mRNA.

Price & Availability↑

CloneID	OHu02539
Clone ID Related Accession (Same CDS sequence)	NM_001010.3 , NM_001010.2
Accession Version	NM_001010.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	40S ribosomal protein S6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AL391834.8. On May 17, 2019 this sequence version replaced NM_001010.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.41015.1, AK291517.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380394.9/ ENSP00000369757.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTGA ACATCTCCTT CCCAGCCACT GGCTGCCAGA AACTCATTGA AGTGGACGAT 
GAACGCAAAC TTCGTACTTT CTATGAGAAG CGTATGGCCA CAGAAGTTGC TGCTGACGCT 
CTGGGTGAAG AATGGAAGGG TTATGTGGTC CGAATCAGTG GTGGGAACGA CAAACAAGGT 
TTCCCCATGA AGCAGGGTGT CTTGACCCAT GGCCGTGTCC GCCTGCTACT GAGTAAGGGG 
CATTCCTGTT ACAGACCAAG GAGAACTGGA GAAAGAAAGA GAAAATCAGT TCGTGGTTGC 
ATTGTGGATG CAAATCTGAG CGTTCTCAAC TTGGTTATTG TAAAAAAAGG AGAGAAGGAT 
ATTCCTGGAC TGACTGATAC TACAGTGCCT CGCCGCCTGG GCCCCAAAAG AGCTAGCAGA 
ATCCGCAAAC TTTTCAATCT CTCTAAAGAA GATGATGTCC GCCAGTATGT TGTAAGAAAG 
CCCTTAAATA AAGAAGGTAA GAAACCTAGG ACCAAAGCAC CCAAGATTCA GCGTCTTGTT 
ACTCCACGTG TCCTGCAGCA CAAACGGCGG CGTATTGCTC TGAAGAAGCA GCGTACCAAG 
AAAAATAAAG AAGAGGCTGC AGAATATGCT AAACTTTTGG CCAAGAGAAT GAAGGAGGCT 
AAGGAGAAGC GCCAGGAACA AATTGCGAAG AGACGCAGAC TTTCCTCTCT GCGAGCTTCT 
ACTTCTAAGT CTGAATCCAG TCAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001.2
CDS	42..791
Translation	MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

Target ORF information:

RefSeq Version	NM_001010.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S6 (RPS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010.3

ORF Insert Sequence:

ATGAAGCTGA ACATCTCCTT CCCAGCCACT GGCTGCCAGA AACTCATTGA AGTGGACGAT 
GAACGCAAAC TTCGTACTTT CTATGAGAAG CGTATGGCCA CAGAAGTTGC TGCTGACGCT 
CTGGGTGAAG AATGGAAGGG TTATGTGGTC CGAATCAGTG GTGGGAACGA CAAACAAGGT 
TTCCCCATGA AGCAGGGTGT CTTGACCCAT GGCCGTGTCC GCCTGCTACT GAGTAAGGGG 
CATTCCTGTT ACAGACCAAG GAGAACTGGA GAAAGAAAGA GAAAATCAGT TCGTGGTTGC 
ATTGTGGATG CAAATCTGAG CGTTCTCAAC TTGGTTATTG TAAAAAAAGG AGAGAAGGAT 
ATTCCTGGAC TGACTGATAC TACAGTGCCT CGCCGCCTGG GCCCCAAAAG AGCTAGCAGA 
ATCCGCAAAC TTTTCAATCT CTCTAAAGAA GATGATGTCC GCCAGTATGT TGTAAGAAAG 
CCCTTAAATA AAGAAGGTAA GAAACCTAGG ACCAAAGCAC CCAAGATTCA GCGTCTTGTT 
ACTCCACGTG TCCTGCAGCA CAAACGGCGG CGTATTGCTC TGAAGAAGCA GCGTACCAAG 
AAAAATAAAG AAGAGGCTGC AGAATATGCT AAACTTTTGG CCAAGAGAAT GAAGGAGGCT 
AAGGAGAAGC GCCAGGAACA AATTGCGAAG AGACGCAGAC TTTCCTCTCT GCGAGCTTCT 
ACTTCTAAGT CTGAATCCAG TCAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS6 ( NM_001010.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001.2 Homo sapiens ribosomal protein S6 (RPS6), mRNA.

Price & Availability↑

CloneID	OHu02539
Clone ID Related Accession (Same CDS sequence)	NM_001010.3 , NM_001010.2
Accession Version	NM_001010.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	40S ribosomal protein S6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from X67309.1. On Nov 30, 2001 this sequence version replaced NM_001010.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.394462.1, SRR1163657.146427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAGCTGA ACATCTCCTT CCCAGCCACT GGCTGCCAGA AACTCATTGA AGTGGACGAT 
GAACGCAAAC TTCGTACTTT CTATGAGAAG CGTATGGCCA CAGAAGTTGC TGCTGACGCT 
CTGGGTGAAG AATGGAAGGG TTATGTGGTC CGAATCAGTG GTGGGAACGA CAAACAAGGT 
TTCCCCATGA AGCAGGGTGT CTTGACCCAT GGCCGTGTCC GCCTGCTACT GAGTAAGGGG 
CATTCCTGTT ACAGACCAAG GAGAACTGGA GAAAGAAAGA GAAAATCAGT TCGTGGTTGC 
ATTGTGGATG CAAATCTGAG CGTTCTCAAC TTGGTTATTG TAAAAAAAGG AGAGAAGGAT 
ATTCCTGGAC TGACTGATAC TACAGTGCCT CGCCGCCTGG GCCCCAAAAG AGCTAGCAGA 
ATCCGCAAAC TTTTCAATCT CTCTAAAGAA GATGATGTCC GCCAGTATGT TGTAAGAAAG 
CCCTTAAATA AAGAAGGTAA GAAACCTAGG ACCAAAGCAC CCAAGATTCA GCGTCTTGTT 
ACTCCACGTG TCCTGCAGCA CAAACGGCGG CGTATTGCTC TGAAGAAGCA GCGTACCAAG 
AAAAATAAAG AAGAGGCTGC AGAATATGCT AAACTTTTGG CCAAGAGAAT GAAGGAGGCT 
AAGGAGAAGC GCCAGGAACA AATTGCGAAG AGACGCAGAC TTTCCTCTCT GCGAGCTTCT 
ACTTCTAAGT CTGAATCCAG TCAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001.2
CDS	43..792
Translation	MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

Target ORF information:

RefSeq Version	NM_001010.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S6 (RPS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010.2

ORF Insert Sequence:

ATGAAGCTGA ACATCTCCTT CCCAGCCACT GGCTGCCAGA AACTCATTGA AGTGGACGAT 
GAACGCAAAC TTCGTACTTT CTATGAGAAG CGTATGGCCA CAGAAGTTGC TGCTGACGCT 
CTGGGTGAAG AATGGAAGGG TTATGTGGTC CGAATCAGTG GTGGGAACGA CAAACAAGGT 
TTCCCCATGA AGCAGGGTGT CTTGACCCAT GGCCGTGTCC GCCTGCTACT GAGTAAGGGG 
CATTCCTGTT ACAGACCAAG GAGAACTGGA GAAAGAAAGA GAAAATCAGT TCGTGGTTGC 
ATTGTGGATG CAAATCTGAG CGTTCTCAAC TTGGTTATTG TAAAAAAAGG AGAGAAGGAT 
ATTCCTGGAC TGACTGATAC TACAGTGCCT CGCCGCCTGG GCCCCAAAAG AGCTAGCAGA 
ATCCGCAAAC TTTTCAATCT CTCTAAAGAA GATGATGTCC GCCAGTATGT TGTAAGAAAG 
CCCTTAAATA AAGAAGGTAA GAAACCTAGG ACCAAAGCAC CCAAGATTCA GCGTCTTGTT 
ACTCCACGTG TCCTGCAGCA CAAACGGCGG CGTATTGCTC TGAAGAAGCA GCGTACCAAG 
AAAAATAAAG AAGAGGCTGC AGAATATGCT AAACTTTTGG CCAAGAGAAT GAAGGAGGCT 
AAGGAGAAGC GCCAGGAACA AATTGCGAAG AGACGCAGAC TTTCCTCTCT GCGAGCTTCT 
ACTTCTAAGT CTGAATCCAG TCAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society22155417750838(2018 Jan)
Machado LE,Alvarenga AW,da Silva FF,Roff? M,Begnami MD,Torres LFB,da Cunha IW,Martins VR,Hajj GNM

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RPS6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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