RPS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPS2
Entrez Gene ID	6187
Full Name	ribosomal protein S2
Synonyms	LLREP3,S2
General protein information	Preferred Names ribosomal protein S2 Names 40S ribosomal protein S2 40S ribosomal protein S4 OK/KNS-cl.6 protein LLRep3 small ribosomal subunit protein uS5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	603624

mRNA and Protein(s)

mRNA	Protein	Name
NM_002952.3	NP_002943.2	40S ribosomal protein S2
NM_002952.4	NP_002943.2	40S ribosomal protein S2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RPS2	NP_001028785.1
Drosophila melanogaster (fruit fly)	RpS2	NP_001260303.1
Schizosaccharomyces pombe (fission yeast)	rps2	NP_588435.1
Arabidopsis thaliana (thale cress)	AT2G41840	NP_181715.1
Arabidopsis thaliana (thale cress)	AT1G59359	NP_564740.1
Oryza sativa (rice)	Os03g0807800	NP_001051645.1
Pan troglodytes (chimpanzee)	RPS2	XP_511195.1
Mus musculus (house mouse)	Rps2	NP_032529.2
Rattus norvegicus (Norway rat)	Rps2	NP_114026.3
Gallus gallus (chicken)	RPS2	NP_001264093.1
Danio rerio (zebrafish)	rps2	NP_998444.1
Neurospora crassa	NCU06047	XP_959810.1
Arabidopsis thaliana (thale cress)	XW6	NP_176134.1
Arabidopsis thaliana (thale cress)	AT1G58983	NP_564737.1
Xenopus tropicalis (tropical clawed frog)	rps2	NP_001007869.1
Pan troglodytes (chimpanzee)	LOC743929	XP_001161545.1
	LOC700955	XP_001095648.1
Caenorhabditis elegans (roundworm)	rps-2	NP_501322.1
Saccharomyces cerevisiae (baker's yeast)	RPS2	NP_011392.1
Kluyveromyces lactis	KLLA0F09812g	XP_455527.1
Arabidopsis thaliana (thale cress)	AT1G58684	NP_683443.1
Arabidopsis thaliana (thale cress)	AT3G57490	NP_191308.1
Homo sapiens (human)	RPS2	NP_002943.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003768	XP_310307.5
Eremothecium gossypii	AGOS_AAR177W	NP_982720.1
Magnaporthe oryzae (rice blast fungus)	MGG_16248	XP_003709842.1
Canis lupus familiaris (dog)	RPS2	XP_005621761.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.
Landry-Voyer AM, Bilodeau S, Bergeron D, Dionne KL, Port SA, Rouleau C, Boisvert FM, Kehlenbach RH, Bachand F
Molecular and cellular biology36(24)3019-3032(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings uncover the existence of an extra-ribosomal complex consisting of PDCD2L, RPS2, and PRMT3 and support a role for PDCD2L in the late maturation of 40S ribosomal subunits.
Title: Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.

PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).
Title: Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.

RPS2 or other aberrantly over-expressed ribosomal proteins might promote cancer and be excellent therapeutic targets for treatment of the disease
Title: RPS2: a novel therapeutic target in prostate cancer.

These results suggest that in addition to its catalytic function, PRMT3 may control the level of rpS2 protein in cells by inhibiting ubiquitin-mediated proteolysis of rpS2.
Title: PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex.

These findings suggest that the nuclear form of FGF3 inhibits cell proliferation by interfering with ribosomal biogenesis.
Title: Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2.

The following RPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03177	NM_002952.4 Latest version!	Homo sapiens ribosomal protein S2 (RPS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu03177	NM_002952.3	Homo sapiens ribosomal protein S2 (RPS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPS2 ( NM_002952.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002943.2 Homo sapiens ribosomal protein S2 (RPS2), mRNA.

Price & Availability↑

CloneID	OHu03177
Clone ID Related Accession (Same CDS sequence)	NM_002952.3 , NM_002952.4
Accession Version	NM_002952.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	40S ribosomal protein S2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC066321.1 and BC068051.1. On Jul 8, 2005 this sequence version replaced NM_002952.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.78149.1, SRR1163657.465938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474, SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGATG ACGCCGGTGC AGCGGGGGGG CCCGGGGGCC CTGGTGGCCC TGGGATGGGG 
AACCGCGGTG GCTTCCGCGG AGGTTTCGGC AGTGGCATCC GGGGCCGGGG TCGCGGCCGT 
GGACGGGGCC GGGGCCGAGG CCGCGGAGCT CGCGGAGGCA AGGCCGAGGA TAAGGAGTGG 
ATGCCCGTCA CCAAGTTGGG CCGCTTGGTC AAGGACATGA AGATCAAGTC CCTGGAGGAG 
ATCTATCTCT TCTCCCTGCC TATTAAGGAA TCAGAGATCA TTGATTTCTT CCTGGGGGCC 
TCTCTCAAGG ATGAGGTTTT GAAGATTATG CCAGTGCAGA AGCAGACCCG TGCCGGCCAG 
CGCACCAGGT TCAAGGCATT TGTTGCTATC GGGGACTACA ATGGCCACGT CGGTCTGGGT 
GTTAAGTGCT CCAAGGAGGT GGCCACCGCC ATCCGTGGGG CCATCATCCT GGCCAAGCTC 
TCCATCGTCC CCGTGCGCAG AGGCTACTGG GGGAACAAGA TCGGCAAGCC CCACACTGTC 
CCTTGCAAGG TGACAGGCCG CTGCGGCTCT GTGCTGGTAC GCCTCATCCC TGCACCCAGG 
GGCACTGGCA TCGTCTCCGC ACCTGTGCCT AAGAAGCTGC TCATGATGGC TGGTATCGAT 
GACTGCTACA CCTCAGCCCG GGGCTGCACT GCCACCCTGG GCAACTTCGC CAAGGCCACC 
TTTGATGCCA TTTCTAAGAC CTACAGCTAC CTGACCCCCG ACCTCTGGAA GGAGACTGTA 
TTCACCAAGT CTCCCTATCA GGAGTTCACT GACCACCTCG TCAAGACCCA CACCAGAGTC 
TCCGTGCAGC GGACTCAGGC TCCAGCTGTG GCTACAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002943.2
CDS	24..905
Translation	MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT

Target ORF information:

RefSeq Version	NM_002952.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S2 (RPS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002952.3

ORF Insert Sequence:

ATGGCGGATG ACGCCGGTGC AGCGGGGGGG CCCGGGGGCC CTGGTGGCCC TGGGATGGGG 
AACCGCGGTG GCTTCCGCGG AGGTTTCGGC AGTGGCATCC GGGGCCGGGG TCGCGGCCGT 
GGACGGGGCC GGGGCCGAGG CCGCGGAGCT CGCGGAGGCA AGGCCGAGGA TAAGGAGTGG 
ATGCCCGTCA CCAAGTTGGG CCGCTTGGTC AAGGACATGA AGATCAAGTC CCTGGAGGAG 
ATCTATCTCT TCTCCCTGCC TATTAAGGAA TCAGAGATCA TTGATTTCTT CCTGGGGGCC 
TCTCTCAAGG ATGAGGTTTT GAAGATTATG CCAGTGCAGA AGCAGACCCG TGCCGGCCAG 
CGCACCAGGT TCAAGGCATT TGTTGCTATC GGGGACTACA ATGGCCACGT CGGTCTGGGT 
GTTAAGTGCT CCAAGGAGGT GGCCACCGCC ATCCGTGGGG CCATCATCCT GGCCAAGCTC 
TCCATCGTCC CCGTGCGCAG AGGCTACTGG GGGAACAAGA TCGGCAAGCC CCACACTGTC 
CCTTGCAAGG TGACAGGCCG CTGCGGCTCT GTGCTGGTAC GCCTCATCCC TGCACCCAGG 
GGCACTGGCA TCGTCTCCGC ACCTGTGCCT AAGAAGCTGC TCATGATGGC TGGTATCGAT 
GACTGCTACA CCTCAGCCCG GGGCTGCACT GCCACCCTGG GCAACTTCGC CAAGGCCACC 
TTTGATGCCA TTTCTAAGAC CTACAGCTAC CTGACCCCCG ACCTCTGGAA GGAGACTGTA 
TTCACCAAGT CTCCCTATCA GGAGTTCACT GACCACCTCG TCAAGACCCA CACCAGAGTC 
TCCGTGCAGC GGACTCAGGC TCCAGCTGTG GCTACAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPS2 ( NM_002952.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002943.2 Homo sapiens ribosomal protein S2 (RPS2), mRNA.

Price & Availability↑

CloneID	OHu03177
Clone ID Related Accession (Same CDS sequence)	NM_002952.3 , NM_002952.4
Accession Version	NM_002952.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	40S ribosomal protein S2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC066321.1, BC068051.1 and AC005363.1. On Nov 22, 2018 this sequence version replaced NM_002952.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.465938.1, SRR1163655.432815.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474, SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000343262.9/ ENSP00000341885.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGATG ACGCCGGTGC AGCGGGGGGG CCCGGGGGCC CTGGTGGCCC TGGGATGGGG 
AACCGCGGTG GCTTCCGCGG AGGTTTCGGC AGTGGCATCC GGGGCCGGGG TCGCGGCCGT 
GGACGGGGCC GGGGCCGAGG CCGCGGAGCT CGCGGAGGCA AGGCCGAGGA TAAGGAGTGG 
ATGCCCGTCA CCAAGTTGGG CCGCTTGGTC AAGGACATGA AGATCAAGTC CCTGGAGGAG 
ATCTATCTCT TCTCCCTGCC TATTAAGGAA TCAGAGATCA TTGATTTCTT CCTGGGGGCC 
TCTCTCAAGG ATGAGGTTTT GAAGATTATG CCAGTGCAGA AGCAGACCCG TGCCGGCCAG 
CGCACCAGGT TCAAGGCATT TGTTGCTATC GGGGACTACA ATGGCCACGT CGGTCTGGGT 
GTTAAGTGCT CCAAGGAGGT GGCCACCGCC ATCCGTGGGG CCATCATCCT GGCCAAGCTC 
TCCATCGTCC CCGTGCGCAG AGGCTACTGG GGGAACAAGA TCGGCAAGCC CCACACTGTC 
CCTTGCAAGG TGACAGGCCG CTGCGGCTCT GTGCTGGTAC GCCTCATCCC TGCACCCAGG 
GGCACTGGCA TCGTCTCCGC ACCTGTGCCT AAGAAGCTGC TCATGATGGC TGGTATCGAT 
GACTGCTACA CCTCAGCCCG GGGCTGCACT GCCACCCTGG GCAACTTCGC CAAGGCCACC 
TTTGATGCCA TTTCTAAGAC CTACAGCTAC CTGACCCCCG ACCTCTGGAA GGAGACTGTA 
TTCACCAAGT CTCCCTATCA GGAGTTCACT GACCACCTCG TCAAGACCCA CACCAGAGTC 
TCCGTGCAGC GGACTCAGGC TCCAGCTGTG GCTACAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002943.2
CDS	24..905
Translation	MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT

Target ORF information:

RefSeq Version	NM_002952.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein S2 (RPS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002952.4

ORF Insert Sequence:

ATGGCGGATG ACGCCGGTGC AGCGGGGGGG CCCGGGGGCC CTGGTGGCCC TGGGATGGGG 
AACCGCGGTG GCTTCCGCGG AGGTTTCGGC AGTGGCATCC GGGGCCGGGG TCGCGGCCGT 
GGACGGGGCC GGGGCCGAGG CCGCGGAGCT CGCGGAGGCA AGGCCGAGGA TAAGGAGTGG 
ATGCCCGTCA CCAAGTTGGG CCGCTTGGTC AAGGACATGA AGATCAAGTC CCTGGAGGAG 
ATCTATCTCT TCTCCCTGCC TATTAAGGAA TCAGAGATCA TTGATTTCTT CCTGGGGGCC 
TCTCTCAAGG ATGAGGTTTT GAAGATTATG CCAGTGCAGA AGCAGACCCG TGCCGGCCAG 
CGCACCAGGT TCAAGGCATT TGTTGCTATC GGGGACTACA ATGGCCACGT CGGTCTGGGT 
GTTAAGTGCT CCAAGGAGGT GGCCACCGCC ATCCGTGGGG CCATCATCCT GGCCAAGCTC 
TCCATCGTCC CCGTGCGCAG AGGCTACTGG GGGAACAAGA TCGGCAAGCC CCACACTGTC 
CCTTGCAAGG TGACAGGCCG CTGCGGCTCT GTGCTGGTAC GCCTCATCCC TGCACCCAGG 
GGCACTGGCA TCGTCTCCGC ACCTGTGCCT AAGAAGCTGC TCATGATGGC TGGTATCGAT 
GACTGCTACA CCTCAGCCCG GGGCTGCACT GCCACCCTGG GCAACTTCGC CAAGGCCACC 
TTTGATGCCA TTTCTAAGAC CTACAGCTAC CTGACCCCCG ACCTCTGGAA GGAGACTGTA 
TTCACCAAGT CTCCCTATCA GGAGTTCACT GACCACCTCG TCAAGACCCA CACCAGAGTC 
TCCGTGCAGC GGACTCAGGC TCCAGCTGTG GCTACAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.
Molecular and cellular biology36(24)3019-3032(2016 Dec)
Landry-Voyer AM,Bilodeau S,Bergeron D,Dionne KL,Port SA,Rouleau C,Boisvert FM,Kehlenbach RH,Bachand F

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RPS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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