RPLP0 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPLP0
Entrez Gene ID	6175
Full Name	ribosomal protein lateral stalk subunit P0
Synonyms	L10E,LP0,P0,PRLP0,RPP0
General protein information	Preferred Names ribosomal protein lateral stalk subunit P0 Names 60S acidic ribosomal protein P0 60S ribosomal protein L10E acidic ribosomal phosphoprotein P0 large ribosomal subunit protein uL10 neutral ribosomal phosphoprotein P0 ribosomal protein, large, P0
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.23
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	180510

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002.4	NP_000993.1	60S acidic ribosomal protein P0
NM_001002.3	NP_000993.1	60S acidic ribosomal protein P0
NM_053275.3	NP_444505.1	60S acidic ribosomal protein P0

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003592	XP_003436533.1
Neurospora crassa	NCU07408	XP_958183.1
Arabidopsis thaliana (thale cress)	AT3G11250	NP_187734.1
Arabidopsis thaliana (thale cress)	AT3G09200	NP_187531.1
Xenopus tropicalis (tropical clawed frog)	rplp0	NP_989067.1
Homo sapiens (human)	RPLP0	NP_444505.1
Rattus norvegicus (Norway rat)	Rplp0	NP_071797.1
Gallus gallus (chicken)	RPLP0	NP_990318.1
Caenorhabditis elegans (roundworm)	rla-0	NP_492766.1
Saccharomyces cerevisiae (baker's yeast)	RPP0	NP_013444.1
Magnaporthe oryzae (rice blast fungus)	MGG_04467	XP_003710994.1
Canis lupus familiaris (dog)	RPLP0	NP_001239066.1
Bos taurus (cattle)	RPLP0	NP_001012700.1
Mus musculus (house mouse)	Rplp0	NP_031501.1
Kluyveromyces lactis	KLLA0B05918g	XP_451800.1
Eremothecium gossypii	AGOS_ACL178C	NP_983226.2
Schizosaccharomyces pombe (fission yeast)	rpp0	NP_588393.1
Oryza sativa (rice)	Os08g0130500	NP_001060923.1
Pan troglodytes (chimpanzee)	RPLP0	XP_509423.1
Danio rerio (zebrafish)	rplp0	NP_571655.2
Drosophila melanogaster (fruit fly)	RpLP0	NP_001262202.1
Arabidopsis thaliana (thale cress)	AT2G40010	NP_181530.1

Gene Ontology
Bibliography

Related articles in PubMed

The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.
Dery?o K, Michalec-Wawi?rka B, Krokowski D, Wawi?rka L, Hatzoglou M, Tch?rzewski M
Biochimica et biophysica acta1865(1)34-47(2018 Jan)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.
Benvenuto M, Sileri P, Rossi P, Masuelli L, Fantini M, Nanni M, Franceschilli L, Sconocchia G, Lanzilli G, Arriga R, Faggioni G, Lista F, Orlandi A, Manzari V, Gaspari AL, Modesti A, Bei R
Journal of translational medicine13101(2015 Mar)

Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
Teller A, Jechorek D, Hartig R, Adolf D, Rei?ig K, Roessner A, Franke S
Pathology, research and practice211(1)62-70(2015 Jan)

Disruption of the ribosomal P complex leads to stress-induced autophagy.
Artero-Castro A, Perez-Alea M, Feliciano A, Leal JA, Genestar M, Castellvi J, Peg V, Ram?n Y Cajal S, Lleonart ME
Autophagy11(9)1499-519(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study shows a spontaneous humoral immune response to ribosomal P0 protein in colorectal cancer patients.
Title: Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.

Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells
Title: Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.

the immune response mediated by serum anti-RPLP0 and anti-galectin 3 antibodies plays a key role in the pathogenesis of SLE skin lesions. These findings provide new insights into the mechanism of SLE-related organ disorders.
Title: Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus.

absence of RPLP0, RPLP1, or RPLP2 resulted in reactive oxygen species (ROS) accumulation and MAPK1/ERK2 signaling pathway activation.
Title: Disruption of the ribosomal P complex leads to stress-induced autophagy.

Evaluated autoantibodies against native ribosomal P complex and recombinant ribosomal P proteins (anti-Rib-P0, anti-Rib-P1, anti-Rib-P2) for prevalence, diagnostic relevance&clinical associations in a Chinese cohort with systemic lupus erythematosus.
Title: Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.

The following RPLP0 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPLP0 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02559	NM_001002.4 Latest version!	Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu02559	NM_053275.3 Latest version!	Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu02559	NM_001002.3	Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPLP0 ( NM_001002.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000993.1 Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02559
Clone ID Related Accession (Same CDS sequence)	NM_001002.4 , NM_001002.3 , NM_053275.3
Accession Version	NM_001002.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P0
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BF131912.1, BC000087.2, BC019014.2 and AC004263.1. On Nov 23, 2018 this sequence version replaced NM_001002.3. Transcript Variant: This variant (1) is the predominant transcript. It has a different 5' UTR than variant 2. They encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189661.187834.1, SRR5189664.41454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000392514.9/ ENSP00000376299.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAGGG AAGACAGGGC GACCTGGAAG TCCAACTACT TCCTTAAGAT CATCCAACTA 
TTGGATGATT ATCCGAAATG TTTCATTGTG GGAGCAGACA ATGTGGGCTC CAAGCAGATG 
CAGCAGATCC GCATGTCCCT TCGCGGGAAG GCTGTGGTGC TGATGGGCAA GAACACCATG 
ATGCGCAAGG CCATCCGAGG GCACCTGGAA AACAACCCAG CTCTGGAGAA ACTGCTGCCT 
CATATCCGGG GGAATGTGGG CTTTGTGTTC ACCAAGGAGG ACCTCACTGA GATCAGGGAC 
ATGTTGCTGG CCAATAAGGT GCCAGCTGCT GCCCGTGCTG GTGCCATTGC CCCATGTGAA 
GTCACTGTGC CAGCCCAGAA CACTGGTCTC GGGCCCGAGA AGACCTCCTT TTTCCAGGCT 
TTAGGTATCA CCACTAAAAT CTCCAGGGGC ACCATTGAAA TCCTGAGTGA TGTGCAGCTG 
ATCAAGACTG GAGACAAAGT GGGAGCCAGC GAAGCCACGC TGCTGAACAT GCTCAACATC 
TCCCCCTTCT CCTTTGGGCT GGTCATCCAG CAGGTGTTCG ACAATGGCAG CATCTACAAC 
CCTGAAGTGC TTGATATCAC AGAGGAAACT CTGCATTCTC GCTTCCTGGA GGGTGTCCGC 
AATGTTGCCA GTGTCTGTCT GCAGATTGGC TACCCAACTG TTGCATCAGT ACCCCATTCT 
ATCATCAACG GGTACAAACG AGTCCTGGCC TTGTCTGTGG AGACGGATTA CACCTTCCCA 
CTTGCTGAAA AGGTCAAGGC CTTCTTGGCT GATCCATCTG CCTTTGTGGC TGCTGCCCCT 
GTGGCTGCTG CCACCACAGC TGCTCCTGCT GCTGCTGCAG CCCCAGCTAA GGTTGAAGCC 
AAGGAAGAGT CGGAGGAGTC GGACGAGGAT ATGGGATTTG GTCTCTTTGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000993.1
CDS	78..1031
Translation	MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD

Target ORF information:

RefSeq Version	NM_001002.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002.4

ORF Insert Sequence:

ATGCCCAGGG AAGACAGGGC GACCTGGAAG TCCAACTACT TCCTTAAGAT CATCCAACTA 
TTGGATGATT ATCCGAAATG TTTCATTGTG GGAGCAGACA ATGTGGGCTC CAAGCAGATG 
CAGCAGATCC GCATGTCCCT TCGCGGGAAG GCTGTGGTGC TGATGGGCAA GAACACCATG 
ATGCGCAAGG CCATCCGAGG GCACCTGGAA AACAACCCAG CTCTGGAGAA ACTGCTGCCT 
CATATCCGGG GGAATGTGGG CTTTGTGTTC ACCAAGGAGG ACCTCACTGA GATCAGGGAC 
ATGTTGCTGG CCAATAAGGT GCCAGCTGCT GCCCGTGCTG GTGCCATTGC CCCATGTGAA 
GTCACTGTGC CAGCCCAGAA CACTGGTCTC GGGCCCGAGA AGACCTCCTT TTTCCAGGCT 
TTAGGTATCA CCACTAAAAT CTCCAGGGGC ACCATTGAAA TCCTGAGTGA TGTGCAGCTG 
ATCAAGACTG GAGACAAAGT GGGAGCCAGC GAAGCCACGC TGCTGAACAT GCTCAACATC 
TCCCCCTTCT CCTTTGGGCT GGTCATCCAG CAGGTGTTCG ACAATGGCAG CATCTACAAC 
CCTGAAGTGC TTGATATCAC AGAGGAAACT CTGCATTCTC GCTTCCTGGA GGGTGTCCGC 
AATGTTGCCA GTGTCTGTCT GCAGATTGGC TACCCAACTG TTGCATCAGT ACCCCATTCT 
ATCATCAACG GGTACAAACG AGTCCTGGCC TTGTCTGTGG AGACGGATTA CACCTTCCCA 
CTTGCTGAAA AGGTCAAGGC CTTCTTGGCT GATCCATCTG CCTTTGTGGC TGCTGCCCCT 
GTGGCTGCTG CCACCACAGC TGCTCCTGCT GCTGCTGCAG CCCCAGCTAA GGTTGAAGCC 
AAGGAAGAGT CGGAGGAGTC GGACGAGGAT ATGGGATTTG GTCTCTTTGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPLP0 ( NM_001002.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000993.1 Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02559
Clone ID Related Accession (Same CDS sequence)	NM_001002.4 , NM_001002.3 , NM_053275.3
Accession Version	NM_001002.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P0
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BF131912.1, BC000087.2 and BC019014.2. On Jun 23, 2004 this sequence version replaced NM_001002.2. Transcript Variant: This variant (1) is the predominant transcript. It has a different 5' UTR than variant 2. They encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.424535.1, SRR1163658.145861.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCCAGGG AAGACAGGGC GACCTGGAAG TCCAACTACT TCCTTAAGAT CATCCAACTA 
TTGGATGATT ATCCGAAATG TTTCATTGTG GGAGCAGACA ATGTGGGCTC CAAGCAGATG 
CAGCAGATCC GCATGTCCCT TCGCGGGAAG GCTGTGGTGC TGATGGGCAA GAACACCATG 
ATGCGCAAGG CCATCCGAGG GCACCTGGAA AACAACCCAG CTCTGGAGAA ACTGCTGCCT 
CATATCCGGG GGAATGTGGG CTTTGTGTTC ACCAAGGAGG ACCTCACTGA GATCAGGGAC 
ATGTTGCTGG CCAATAAGGT GCCAGCTGCT GCCCGTGCTG GTGCCATTGC CCCATGTGAA 
GTCACTGTGC CAGCCCAGAA CACTGGTCTC GGGCCCGAGA AGACCTCCTT TTTCCAGGCT 
TTAGGTATCA CCACTAAAAT CTCCAGGGGC ACCATTGAAA TCCTGAGTGA TGTGCAGCTG 
ATCAAGACTG GAGACAAAGT GGGAGCCAGC GAAGCCACGC TGCTGAACAT GCTCAACATC 
TCCCCCTTCT CCTTTGGGCT GGTCATCCAG CAGGTGTTCG ACAATGGCAG CATCTACAAC 
CCTGAAGTGC TTGATATCAC AGAGGAAACT CTGCATTCTC GCTTCCTGGA GGGTGTCCGC 
AATGTTGCCA GTGTCTGTCT GCAGATTGGC TACCCAACTG TTGCATCAGT ACCCCATTCT 
ATCATCAACG GGTACAAACG AGTCCTGGCC TTGTCTGTGG AGACGGATTA CACCTTCCCA 
CTTGCTGAAA AGGTCAAGGC CTTCTTGGCT GATCCATCTG CCTTTGTGGC TGCTGCCCCT 
GTGGCTGCTG CCACCACAGC TGCTCCTGCT GCTGCTGCAG CCCCAGCTAA GGTTGAAGCC 
AAGGAAGAGT CGGAGGAGTC GGACGAGGAT ATGGGATTTG GTCTCTTTGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000993.1
CDS	178..1131
Translation	MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD

Target ORF information:

RefSeq Version	NM_001002.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002.3

ORF Insert Sequence:

ATGCCCAGGG AAGACAGGGC GACCTGGAAG TCCAACTACT TCCTTAAGAT CATCCAACTA 
TTGGATGATT ATCCGAAATG TTTCATTGTG GGAGCAGACA ATGTGGGCTC CAAGCAGATG 
CAGCAGATCC GCATGTCCCT TCGCGGGAAG GCTGTGGTGC TGATGGGCAA GAACACCATG 
ATGCGCAAGG CCATCCGAGG GCACCTGGAA AACAACCCAG CTCTGGAGAA ACTGCTGCCT 
CATATCCGGG GGAATGTGGG CTTTGTGTTC ACCAAGGAGG ACCTCACTGA GATCAGGGAC 
ATGTTGCTGG CCAATAAGGT GCCAGCTGCT GCCCGTGCTG GTGCCATTGC CCCATGTGAA 
GTCACTGTGC CAGCCCAGAA CACTGGTCTC GGGCCCGAGA AGACCTCCTT TTTCCAGGCT 
TTAGGTATCA CCACTAAAAT CTCCAGGGGC ACCATTGAAA TCCTGAGTGA TGTGCAGCTG 
ATCAAGACTG GAGACAAAGT GGGAGCCAGC GAAGCCACGC TGCTGAACAT GCTCAACATC 
TCCCCCTTCT CCTTTGGGCT GGTCATCCAG CAGGTGTTCG ACAATGGCAG CATCTACAAC 
CCTGAAGTGC TTGATATCAC AGAGGAAACT CTGCATTCTC GCTTCCTGGA GGGTGTCCGC 
AATGTTGCCA GTGTCTGTCT GCAGATTGGC TACCCAACTG TTGCATCAGT ACCCCATTCT 
ATCATCAACG GGTACAAACG AGTCCTGGCC TTGTCTGTGG AGACGGATTA CACCTTCCCA 
CTTGCTGAAA AGGTCAAGGC CTTCTTGGCT GATCCATCTG CCTTTGTGGC TGCTGCCCCT 
GTGGCTGCTG CCACCACAGC TGCTCCTGCT GCTGCTGCAG CCCCAGCTAA GGTTGAAGCC 
AAGGAAGAGT CGGAGGAGTC GGACGAGGAT ATGGGATTTG GTCTCTTTGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPLP0 ( NM_053275.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_444505.1 Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02559
Clone ID Related Accession (Same CDS sequence)	NM_001002.4 , NM_001002.3 , NM_053275.3
Accession Version	NM_053275.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P0
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF131912.1 and BC019014.2. On Jun 23, 2004 this sequence version replaced NM_053275.2. Transcript Variant: This variant (2) has a different 5' UTR than variant 1. They encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019014.2, SRR1163658.496302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149876 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCCAGGG AAGACAGGGC GACCTGGAAG TCCAACTACT TCCTTAAGAT CATCCAACTA 
TTGGATGATT ATCCGAAATG TTTCATTGTG GGAGCAGACA ATGTGGGCTC CAAGCAGATG 
CAGCAGATCC GCATGTCCCT TCGCGGGAAG GCTGTGGTGC TGATGGGCAA GAACACCATG 
ATGCGCAAGG CCATCCGAGG GCACCTGGAA AACAACCCAG CTCTGGAGAA ACTGCTGCCT 
CATATCCGGG GGAATGTGGG CTTTGTGTTC ACCAAGGAGG ACCTCACTGA GATCAGGGAC 
ATGTTGCTGG CCAATAAGGT GCCAGCTGCT GCCCGTGCTG GTGCCATTGC CCCATGTGAA 
GTCACTGTGC CAGCCCAGAA CACTGGTCTC GGGCCCGAGA AGACCTCCTT TTTCCAGGCT 
TTAGGTATCA CCACTAAAAT CTCCAGGGGC ACCATTGAAA TCCTGAGTGA TGTGCAGCTG 
ATCAAGACTG GAGACAAAGT GGGAGCCAGC GAAGCCACGC TGCTGAACAT GCTCAACATC 
TCCCCCTTCT CCTTTGGGCT GGTCATCCAG CAGGTGTTCG ACAATGGCAG CATCTACAAC 
CCTGAAGTGC TTGATATCAC AGAGGAAACT CTGCATTCTC GCTTCCTGGA GGGTGTCCGC 
AATGTTGCCA GTGTCTGTCT GCAGATTGGC TACCCAACTG TTGCATCAGT ACCCCATTCT 
ATCATCAACG GGTACAAACG AGTCCTGGCC TTGTCTGTGG AGACGGATTA CACCTTCCCA 
CTTGCTGAAA AGGTCAAGGC CTTCTTGGCT GATCCATCTG CCTTTGTGGC TGCTGCCCCT 
GTGGCTGCTG CCACCACAGC TGCTCCTGCT GCTGCTGCAG CCCCAGCTAA GGTTGAAGCC 
AAGGAAGAGT CGGAGGAGTC GGACGAGGAT ATGGGATTTG GTCTCTTTGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444505.1
CDS	238..1191
Translation	MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD

Target ORF information:

RefSeq Version	NM_053275.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P0 (RPLP0), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053275.3

ORF Insert Sequence:

ATGCCCAGGG AAGACAGGGC GACCTGGAAG TCCAACTACT TCCTTAAGAT CATCCAACTA 
TTGGATGATT ATCCGAAATG TTTCATTGTG GGAGCAGACA ATGTGGGCTC CAAGCAGATG 
CAGCAGATCC GCATGTCCCT TCGCGGGAAG GCTGTGGTGC TGATGGGCAA GAACACCATG 
ATGCGCAAGG CCATCCGAGG GCACCTGGAA AACAACCCAG CTCTGGAGAA ACTGCTGCCT 
CATATCCGGG GGAATGTGGG CTTTGTGTTC ACCAAGGAGG ACCTCACTGA GATCAGGGAC 
ATGTTGCTGG CCAATAAGGT GCCAGCTGCT GCCCGTGCTG GTGCCATTGC CCCATGTGAA 
GTCACTGTGC CAGCCCAGAA CACTGGTCTC GGGCCCGAGA AGACCTCCTT TTTCCAGGCT 
TTAGGTATCA CCACTAAAAT CTCCAGGGGC ACCATTGAAA TCCTGAGTGA TGTGCAGCTG 
ATCAAGACTG GAGACAAAGT GGGAGCCAGC GAAGCCACGC TGCTGAACAT GCTCAACATC 
TCCCCCTTCT CCTTTGGGCT GGTCATCCAG CAGGTGTTCG ACAATGGCAG CATCTACAAC 
CCTGAAGTGC TTGATATCAC AGAGGAAACT CTGCATTCTC GCTTCCTGGA GGGTGTCCGC 
AATGTTGCCA GTGTCTGTCT GCAGATTGGC TACCCAACTG TTGCATCAGT ACCCCATTCT 
ATCATCAACG GGTACAAACG AGTCCTGGCC TTGTCTGTGG AGACGGATTA CACCTTCCCA 
CTTGCTGAAA AGGTCAAGGC CTTCTTGGCT GATCCATCTG CCTTTGTGGC TGCTGCCCCT 
GTGGCTGCTG CCACCACAGC TGCTCCTGCT GCTGCTGCAG CCCCAGCTAA GGTTGAAGCC 
AAGGAAGAGT CGGAGGAGTC GGACGAGGAT ATGGGATTTG GTCTCTTTGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.
Biochimica et biophysica acta1865(1)34-47(2018 Jan)
Dery?o K,Michalec-Wawi?rka B,Krokowski D,Wawi?rka L,Hatzoglou M,Tch?rzewski M

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.
Journal of translational medicine13101(2015 Mar)
Benvenuto M,Sileri P,Rossi P,Masuelli L,Fantini M,Nanni M,Franceschilli L,Sconocchia G,Lanzilli G,Arriga R,Faggioni G,Lista F,Orlandi A,Manzari V,Gaspari AL,Modesti A,Bei R

Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
Pathology, research and practice211(1)62-70(2015 Jan)
Teller A,Jechorek D,Hartig R,Adolf D,Rei?ig K,Roessner A,Franke S

Disruption of the ribosomal P complex leads to stress-induced autophagy.
Autophagy11(9)1499-519(2015)
Artero-Castro A,Perez-Alea M,Feliciano A,Leal JA,Genestar M,Castellvi J,Peg V,Ram?n Y Cajal S,Lleonart ME

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RPLP0 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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ORF Insert Sequence:

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