RPL41 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPL41
Entrez Gene ID	6171
Full Name	ribosomal protein L41
Synonyms	L41
General protein information	Preferred Names ribosomal protein L41 Names 60S ribosomal protein L41 HG12 protein homologue of yeast ribosomal protein YL41 large ribosomal subunit protein eL41
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.2
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	613315

mRNA and Protein(s)

mRNA	Protein	Name
NM_021104.1	NP_066927.1	60S ribosomal protein L41
NM_021104.2	NP_066927.1	60S ribosomal protein L41
NM_001035267.1	NP_001030344.1	60S ribosomal protein L41
NM_001035267.2	NP_001030344.1	60S ribosomal protein L41

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.
Yang G, Zong H
Molecular medicine reports13(6)4786-90(2016 Jun)

Structural snapshots of actively translating human ribosomes.
Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, B?rger J, Mielke T, Scheerer P, Spahn CM
Cell161(4)845-57(2015 May)

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress.
Wang A, Xu S, Zhang X, He J, Yan D, Yang Z, Xiao S
The Journal of pathology225(2)285-92(2011 Oct)

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
Gorlova O, Martin JE, Rueda B, Koeleman BP, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJ, Voskuyl AE, Schuerwegh AJ, van Riel PL, Vanthuyne M, van 't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, Gonz?lez-Gay MA, Garc?a-Hern?ndez FJ, Gonz?lez-Escribano MF, Airo P, van Laar J, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels PG, Westhovens R, Kreuter A, de Baere E, Witte T, Padyukov L, Nordin A, Scorza R, Lunardi C, Lie BA, Hoffmann-Vold AM, Palm O, Garc?a de la Pe?a P, Carreira P, , Varga J, Hinchcliff M, Lee AT, Gourh P, Amos CI, Wigley FM, Hummers LK, Nelson JL, Riemekasten G, Herrick A, Beretta L, Fonseca C, Denton CP, Gregersen PK, Agarwal S, Assassi S, Tan FK, Arnett FC, Radstake TR, Mayes MD, Martin J
PLoS genetics7(7)e1002178(2011 Jul)

RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity.
Wang S, Huang J, He J, Wang A, Xu S, Huang SF, Xiao S
Neoplasia (New York, N.Y.)12(3)284-93(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.
Title: Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.

we show that RPL41 induces ATF4 phosphorylation and rapid degradation in the proteasome
Title: Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress.

RPL41 down-regulation is associated with breast neoplasms.
Title: RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity.

The following RPL41 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPL41 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29428	NM_021104.2 Latest version!	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29428	NM_001035267.2 Latest version!	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29428	NM_021104.1	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29428	NM_001035267.1	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPL41 ( NM_021104.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_066927.1 Homo sapiens ribosomal protein L41 (RPL41), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29428
Clone ID Related Accession (Same CDS sequence)	NM_021104.1 , NM_021104.2 , NM_001035267.1 , NM_001035267.2
Accession Version	NM_021104.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 78bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	60S ribosomal protein L41
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from Z12962.1. Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z12962.1, CR747070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066927.1
CDS	84..161
Translation	MRAKWRKKRMRRLKRKRRKMRQRSK

Target ORF information:

RefSeq Version	NM_021104.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021104.1

ORF Insert Sequence:

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL41 ( NM_021104.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066927.1 Homo sapiens ribosomal protein L41 (RPL41), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29428
Clone ID Related Accession (Same CDS sequence)	NM_021104.1 , NM_021104.2 , NM_001035267.1 , NM_001035267.2
Accession Version	NM_021104.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 78bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-17
Organism	Homo sapiens(human)
Product	60S ribosomal protein L41
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from Z12962.1 and AC034102.32. On May 31, 2019 this sequence version replaced NM_021104.1. Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM830448.1, BM765079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066927.1
CDS	41..118
Translation	MRAKWRKKRMRRLKRKRRKMRQRSK

Target ORF information:

RefSeq Version	NM_021104.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021104.2

ORF Insert Sequence:

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL41 ( NM_001035267.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030344.1 Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29428
Clone ID Related Accession (Same CDS sequence)	NM_021104.1 , NM_021104.2 , NM_001035267.1 , NM_001035267.2
Accession Version	NM_001035267.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 78bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	60S ribosomal protein L41
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF673574.1, BC082759.1 and BC064907.1. Transcript Variant: This variant (2) is the longer transcript, containing a unique segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.186641.1, CD638593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030344.1
CDS	199..276
Translation	MRAKWRKKRMRRLKRKRRKMRQRSK

Target ORF information:

RefSeq Version	NM_001035267.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001035267.1

ORF Insert Sequence:

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL41 ( NM_001035267.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030344.1 Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29428
Clone ID Related Accession (Same CDS sequence)	NM_021104.1 , NM_021104.2 , NM_001035267.1 , NM_001035267.2
Accession Version	NM_001035267.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 78bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	60S ribosomal protein L41
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF673574.1, BC082759.1, BC064907.1 and AC034102.32. On Nov 23, 2018 this sequence version replaced NM_001035267.1. Transcript Variant: This variant (2) is the longer transcript, containing a unique segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA604697.1, SRR1163658.187316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000546591.6/ ENSP00000449026.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030344.1
CDS	156..233
Translation	MRAKWRKKRMRRLKRKRRKMRQRSK

Target ORF information:

RefSeq Version	NM_001035267.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L41 (RPL41), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001035267.2

ORF Insert Sequence:

1 61	ATGAGAGCCA AGTGGAGGAA GAAGCGAATG CGCAGGCTGA AGCGCAAAAG AAGAAAGATG AGGCAGAGGT CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.
Molecular medicine reports13(6)4786-90(2016 Jun)
Yang G,Zong H

Structural snapshots of actively translating human ribosomes.
Cell161(4)845-57(2015 May)
Behrmann E,Loerke J,Budkevich TV,Yamamoto K,Schmidt A,Penczek PA,Vos MR,B?rger J,Mielke T,Scheerer P,Spahn CM

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress.
The Journal of pathology225(2)285-92(2011 Oct)
Wang A,Xu S,Zhang X,He J,Yan D,Yang Z,Xiao S

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
PLoS genetics7(7)e1002178(2011 Jul)
Gorlova O,Martin JE,Rueda B,Koeleman BP,Ying J,Teruel M,Diaz-Gallo LM,Broen JC,Vonk MC,Simeon CP,Alizadeh BZ,Coenen MJ,Voskuyl AE,Schuerwegh AJ,van Riel PL,Vanthuyne M,van 't Slot R,Italiaander A,Ophoff RA,Hunzelmann N,Fonollosa V,Ortego-Centeno N,Gonz?lez-Gay MA,Garc?a-Hern?ndez FJ,Gonz?lez-Escribano MF,Airo P,van Laar J,Worthington J,Hesselstrand R,Smith V,de Keyser F,Houssiau F,Chee MM,Madhok R,Shiels PG,Westhovens R,Kreuter A,de Baere E,Witte T,Padyukov L,Nordin A,Scorza R,Lunardi C,Lie BA,Hoffmann-Vold AM,Palm O,Garc?a de la Pe?a P,Carreira P,,Varga J,Hinchcliff M,Lee AT,Gourh P,Amos CI,Wigley FM,Hummers LK,Nelson JL,Riemekasten G,Herrick A,Beretta L,Fonseca C,Denton CP,Gregersen PK,Agarwal S,Assassi S,Tan FK,Arnett FC,Radstake TR,Mayes MD,Martin J

RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity.
Neoplasia (New York, N.Y.)12(3)284-93(2010 Mar)
Wang S,Huang J,He J,Wang A,Xu S,Huang SF,Xiao S

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RPL41 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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