RPL39 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPL39
Entrez Gene ID	6170
Full Name	ribosomal protein L39
Synonyms	L39,RPL39P42,RPL39_23_1806
General protein information	Preferred Names ribosomal protein L39 Names 60S ribosomal protein L39 large ribosomal subunit protein eL39
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq24
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	300899

mRNA and Protein(s)

mRNA	Protein	Name
NM_001000.4	NP_000991.1	60S ribosomal protein L39
NM_001000.3	NP_000991.1	60S ribosomal protein L39

Pathways from BioSystems

Homologies

	LOC100423472	XP_002806420.1
	LOC100430755	XP_002803435.1
Bos taurus (cattle)	RPL39	NP_001098925.1
Gallus gallus (chicken)	RPL39	NP_989603.1
Mus musculus (house mouse)	Rpl39	NP_080331.1
Rattus norvegicus (Norway rat)	Rpl39	NP_037007.1
Pan troglodytes (chimpanzee)	LOC100614664	XP_003950924.1
Canis lupus familiaris (dog)	RPL39	XP_005641800.1
Xenopus tropicalis (tropical clawed frog)	rpl39	NP_001165135.1
Homo sapiens (human)	RPL39	NP_000991.1
Danio rerio (zebrafish)	rpl39	NP_001002078.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of RPL39 in Metaplastic Breast Cancer.
Dave B, Gonzalez DD, Liu ZB, Li X, Wong H, Granados S, Ezzedine NE, Sieglaff DH, Ensor JE, Miller KD, Radovich M, KarinaEtrovic A, Gross SS, Elemento O, Mills GB, Gilcrease MZ, Chang JC
Journal of the National Cancer Institute109(6)(2017 06)

Structural snapshots of actively translating human ribosomes.
Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, B?rger J, Mielke T, Scheerer P, Spahn CM
Cell161(4)845-57(2015 May)

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Dave B, Granados-Principal S, Zhu R, Benz S, Rabizadeh S, Soon-Shiong P, Yu KD, Shao Z, Li X, Gilcrease M, Lai Z, Chen Y, Huang TH, Shen H, Liu X, Ferrari M, Zhan M, Wong ST, Kumaraswami M, Mittal V, Chen X, Gross SS, Chang JC
Proceedings of the National Academy of Sciences of the United States of America111(24)8838-43(2014 Jun)

Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo.
Li C, Chen D, Luo M, Ge M, Zhu J
Biotechnology journal9(5)652-63(2014 May)

Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes.
Balasubramanian S, Zheng D, Liu YJ, Fang G, Frankish A, Carriero N, Robilotto R, Cayting P, Gerstein M
Genome biology10(1)R2(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RPL39 mediated its cancer-promoting actions through iNOS signaling, which was driven by the RNA editing enzyme adenosine deaminase acting on RNA 1.
Title: Role of RPL39 in Metaplastic Breast Cancer.

RPL39 and MLF2 have roles in tumor initiation and metastasis in breast cancer that involve nitric oxide synthase signaling
Title: Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.

Small interfering RNA (siRNA) targeting of the RPL39 gene was done to determine the effects of the RPL39 gene on growth of pancreatic cancer PANC-1 and BxPC-3 cells in vitro and in vivo.
Title: Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo.

The following RPL39 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPL39 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21256	NM_001000.4 Latest version!	Homo sapiens ribosomal protein L39 (RPL39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21256	NM_001000.3	Homo sapiens ribosomal protein L39 (RPL39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPL39 ( NM_001000.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000991.1 Homo sapiens ribosomal protein L39 (RPL39), mRNA.

Price & Availability↑

CloneID	OHu21256
Clone ID Related Accession (Same CDS sequence)	NM_001000.4 , NM_001000.3
Accession Version	NM_001000.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 156bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	60S ribosomal protein L39
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BX476041.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001000.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.98803.1, SRR5189661.155159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361575.4/ ENSP00000355315.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121

ATGTCTTCTC ACAAGACTTT CAGGATTAAG CGATTCCTGG CCAAGAAACA AAAGCAAAAT 
CGTCCCATTC CCCAGTGGAT TCGGATGAAA ACTGGAAATA AAATCAGGTA CAACTCCAAA 
AGGAGACATT GGAGAAGAAC CAAGCTGGGT CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000991.1
CDS	55..210
Translation	MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL

Target ORF information:

RefSeq Version	NM_001000.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L39 (RPL39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001000.4

ORF Insert Sequence:

1
61
121

ATGTCTTCTC ACAAGACTTT CAGGATTAAG CGATTCCTGG CCAAGAAACA AAAGCAAAAT 
CGTCCCATTC CCCAGTGGAT TCGGATGAAA ACTGGAAATA AAATCAGGTA CAACTCCAAA 
AGGAGACATT GGAGAAGAAC CAAGCTGGGT CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL39 ( NM_001000.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000991.1 Homo sapiens ribosomal protein L39 (RPL39), mRNA.

Price & Availability↑

CloneID	OHu21256
Clone ID Related Accession (Same CDS sequence)	NM_001000.4 , NM_001000.3
Accession Version	NM_001000.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 156bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	60S ribosomal protein L39
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BX476041.1. This sequence is a reference standard in the RefSeqGene project. On Mar 8, 2013 this sequence version replaced NM_001000.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX476041.1, BF977216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121

ATGTCTTCTC ACAAGACTTT CAGGATTAAG CGATTCCTGG CCAAGAAACA AAAGCAAAAT 
CGTCCCATTC CCCAGTGGAT TCGGATGAAA ACTGGAAATA AAATCAGGTA CAACTCCAAA 
AGGAGACATT GGAGAAGAAC CAAGCTGGGT CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000991.1
CDS	84..239
Translation	MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL

Target ORF information:

RefSeq Version	NM_001000.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L39 (RPL39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001000.3

ORF Insert Sequence:

1
61
121

ATGTCTTCTC ACAAGACTTT CAGGATTAAG CGATTCCTGG CCAAGAAACA AAAGCAAAAT 
CGTCCCATTC CCCAGTGGAT TCGGATGAAA ACTGGAAATA AAATCAGGTA CAACTCCAAA 
AGGAGACATT GGAGAAGAAC CAAGCTGGGT CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of RPL39 in Metaplastic Breast Cancer.
Journal of the National Cancer Institute109(6)(2017 06)
Dave B,Gonzalez DD,Liu ZB,Li X,Wong H,Granados S,Ezzedine NE,Sieglaff DH,Ensor JE,Miller KD,Radovich M,KarinaEtrovic A,Gross SS,Elemento O,Mills GB,Gilcrease MZ,Chang JC

Structural snapshots of actively translating human ribosomes.
Cell161(4)845-57(2015 May)
Behrmann E,Loerke J,Budkevich TV,Yamamoto K,Schmidt A,Penczek PA,Vos MR,B?rger J,Mielke T,Scheerer P,Spahn CM

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Proceedings of the National Academy of Sciences of the United States of America111(24)8838-43(2014 Jun)
Dave B,Granados-Principal S,Zhu R,Benz S,Rabizadeh S,Soon-Shiong P,Yu KD,Shao Z,Li X,Gilcrease M,Lai Z,Chen Y,Huang TH,Shen H,Liu X,Ferrari M,Zhan M,Wong ST,Kumaraswami M,Mittal V,Chen X,Gross SS,Chang JC

Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo.
Biotechnology journal9(5)652-63(2014 May)
Li C,Chen D,Luo M,Ge M,Zhu J

Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes.
Genome biology10(1)R2(2009)
Balasubramanian S,Zheng D,Liu YJ,Fang G,Frankish A,Carriero N,Robilotto R,Cayting P,Gerstein M

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RPL39 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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