RPL29 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPL29
Entrez Gene ID	6159
Full Name	ribosomal protein L29
Synonyms	HIP,HUMRPL29,L29,RPL29P10,RPL29_3_370
General protein information	Preferred Names ribosomal protein L29 Names 60S ribosomal protein L29 HP/HS-interacting protein cell surface heparin-binding protein HIP heparin/heparan sulfate-binding protein heparin/heparan sulfate-interacting protein large ribosomal subunit protein eL29 ribosomal protein YL43 homologue
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.2
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	601832

mRNA and Protein(s)

mRNA	Protein	Name
XM_024453698.1	XP_024309466.1	60S ribosomal protein L29 isoform X1
NM_000992.2	NP_000983.1	60S ribosomal protein L29
NM_000992.3	NP_000983.1	60S ribosomal protein L29

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPL29	NP_000983.1
Pan troglodytes (chimpanzee)	RPL29	NP_001238868.1
	LOC704510	XP_001092860.2
	LOC708074	XP_001096515.1
Gallus gallus (chicken)	RPL29	NP_001165148.1
	RPL29	XP_001091393.1
	LOC698791	XP_001087279.1
Xenopus tropicalis (tropical clawed frog)	rpl29	NP_001165147.1
Canis lupus familiaris (dog)	LOC102154836	XP_005615933.1
Canis lupus familiaris (dog)	RPL29	XP_005632523.1
Bos taurus (cattle)	RPL29	NP_001014862.1

Gene Ontology
Bibliography

Related articles in PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells.
Li C, Ge M, Yin Y, Luo M, Chen D
Molecular and cellular biochemistry370(1-2)127-39(2012 Nov)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.
Sun XX, Wang YG, Xirodimas DP, Dai MS
The Journal of biological chemistry285(33)25812-21(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results showed that knockdown of RPL26 or RPL29 expression significantly suppressed cell proliferation, induced cell arrest at G0/G1 phase and enhanced cell apoptosis
Title: Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells.

Knockdown of L29 or L30 enhanced the interaction of MDM2 with L11 and L5 and markedly inhibited MDM2-mediated p53 ubiquitination, suggesting that direct perturbation of 60 S ribosomal biogenesis activates p53 via L11- and L5-mediated MDM2 suppression.
Title: Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.

HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses
Title: HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses.

Hip is a pro-survival substrate of granzyme B
Title: Hip is a pro-survival substrate of granzyme B.

HIP/RPL29 plays a role in the cellular differentiation process in colon cancer cells.
Title: Repression of HIP/RPL29 expression induces differentiation in colon cancer cells.

The following RPL29 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPL29 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02553	NM_000992.3 Latest version!	Homo sapiens ribosomal protein L29 (RPL29), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu105423	XM_024453698.1 Latest version!	Homo sapiens ribosomal protein L29 (RPL29), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu02553	NM_000992.2	Homo sapiens ribosomal protein L29 (RPL29), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPL29 ( NM_000992.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000983.1 Homo sapiens ribosomal protein L29 (RPL29), mRNA.

Price & Availability↑

CloneID	OHu02553
Clone ID Related Accession (Same CDS sequence)	NM_000992.2 , NM_000992.3
Accession Version	NM_000992.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	60S ribosomal protein L29
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC008926.2. On Nov 27, 2001 this sequence version replaced NM_000992.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008926.2, CD389036.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCAAGT CCAAGAACCA CACCACACAC AACCAGTCCC GAAAATGGCA CAGAAATGGT 
ATCAAGAAAC CCCGATCACA AAGATACGAA TCTCTTAAGG GGGTGGACCC CAAGTTCCTG 
AGGAACATGC GCTTTGCCAA GAAGCACAAC AAAAAGGGCC TAAAGAAGAT GCAGGCCAAC 
AATGCCAAGG CCATGAGTGC ACGTGCCGAG GCTATCAAGG CCCTCGTAAA GCCCAAGGAG 
GTTAAGCCCA AGATCCCAAA GGGTGTCAGC CGCAAGCTCG ATCGACTTGC CTACATTGCC 
CACCCCAAGC TTGGGAAGCG TGCTCGTGCC CGTATTGCCA AGGGGCTCAG GCTGTGCCGG 
CCAAAGGCCA AGGCCAAGGC CAAGGCCAAG GATCAAACCA AGGCCCAGGC TGCAGCCCCA 
GCTTCAGTTC CAGCTCAGGC TCCCAAACGT ACCCAGGCCC CTACAAAGGC TTCAGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000983.1
CDS	95..574
Translation	MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE

Target ORF information:

RefSeq Version	NM_000992.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L29 (RPL29), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000992.2

ORF Insert Sequence:

ATGGCCAAGT CCAAGAACCA CACCACACAC AACCAGTCCC GAAAATGGCA CAGAAATGGT 
ATCAAGAAAC CCCGATCACA AAGATACGAA TCTCTTAAGG GGGTGGACCC CAAGTTCCTG 
AGGAACATGC GCTTTGCCAA GAAGCACAAC AAAAAGGGCC TAAAGAAGAT GCAGGCCAAC 
AATGCCAAGG CCATGAGTGC ACGTGCCGAG GCTATCAAGG CCCTCGTAAA GCCCAAGGAG 
GTTAAGCCCA AGATCCCAAA GGGTGTCAGC CGCAAGCTCG ATCGACTTGC CTACATTGCC 
CACCCCAAGC TTGGGAAGCG TGCTCGTGCC CGTATTGCCA AGGGGCTCAG GCTGTGCCGG 
CCAAAGGCCA AGGCCAAGGC CAAGGCCAAG GATCAAACCA AGGCCCAGGC TGCAGCCCCA 
GCTTCAGTTC CAGCTCAGGC TCCCAAACGT ACCCAGGCCC CTACAAAGGC TTCAGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL29 ( NM_000992.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000983.1 Homo sapiens ribosomal protein L29 (RPL29), mRNA.

Price & Availability↑

CloneID	OHu02553
Clone ID Related Accession (Same CDS sequence)	NM_000992.2 , NM_000992.3
Accession Version	NM_000992.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	60S ribosomal protein L29
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC008926.2 and AC115284.4. On May 17, 2019 this sequence version replaced NM_000992.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD249111.1, CD247488.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000294189.11/ ENSP00000294189.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAGT CCAAGAACCA CACCACACAC AACCAGTCCC GAAAATGGCA CAGAAATGGT 
ATCAAGAAAC CCCGATCACA AAGATACGAA TCTCTTAAGG GGGTGGACCC CAAGTTCCTG 
AGGAACATGC GCTTTGCCAA GAAGCACAAC AAAAAGGGCC TAAAGAAGAT GCAGGCCAAC 
AATGCCAAGG CCATGAGTGC ACGTGCCGAG GCTATCAAGG CCCTCGTAAA GCCCAAGGAG 
GTTAAGCCCA AGATCCCAAA GGGTGTCAGC CGCAAGCTCG ATCGACTTGC CTACATTGCC 
CACCCCAAGC TTGGGAAGCG TGCTCGTGCC CGTATTGCCA AGGGGCTCAG GCTGTGCCGG 
CCAAAGGCCA AGGCCAAGGC CAAGGCCAAG GATCAAACCA AGGCCCAGGC TGCAGCCCCA 
GCTTCAGTTC CAGCTCAGGC TCCCAAACGT ACCCAGGCCC CTACAAAGGC TTCAGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000983.1
CDS	48..527
Translation	MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE

Target ORF information:

RefSeq Version	NM_000992.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L29 (RPL29), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000992.3

ORF Insert Sequence:

ATGGCCAAGT CCAAGAACCA CACCACACAC AACCAGTCCC GAAAATGGCA CAGAAATGGT 
ATCAAGAAAC CCCGATCACA AAGATACGAA TCTCTTAAGG GGGTGGACCC CAAGTTCCTG 
AGGAACATGC GCTTTGCCAA GAAGCACAAC AAAAAGGGCC TAAAGAAGAT GCAGGCCAAC 
AATGCCAAGG CCATGAGTGC ACGTGCCGAG GCTATCAAGG CCCTCGTAAA GCCCAAGGAG 
GTTAAGCCCA AGATCCCAAA GGGTGTCAGC CGCAAGCTCG ATCGACTTGC CTACATTGCC 
CACCCCAAGC TTGGGAAGCG TGCTCGTGCC CGTATTGCCA AGGGGCTCAG GCTGTGCCGG 
CCAAAGGCCA AGGCCAAGGC CAAGGCCAAG GATCAAACCA AGGCCCAGGC TGCAGCCCCA 
GCTTCAGTTC CAGCTCAGGC TCCCAAACGT ACCCAGGCCC CTACAAAGGC TTCAGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL29 ( XM_024453698.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024309466.1 Homo sapiens ribosomal protein L29 (RPL29), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu105423
Clone ID Related Accession (Same CDS sequence)	XM_024453698.1
Accession Version	XM_024453698.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	60S ribosomal protein L29 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGGGTG GTCTTATTAG AGGAAAGTTC TTTGTTGGCT TAATTCCCTT TTTTTCTCCC 
ACAGCCCGAA AATGGCACAG AAATGGTATC AAGAAACCCC GATCACAAAG ATACGAATCT 
CTTAAGGGGG TGGACCCCAA GTTCCTGAGG AACATGCGCT TTGCCAAGAA GCACAACAAA 
AAGGGCCTAA AGAAGATGCA GGCCAACAAT GCCAAGGCCA TGAGTGCACG TGCCGAGGCT 
ATCAAGGCCC TCGTAAAGCC CAAGGAGGTT AAGCCCAAGA TCCCAAAGGG TGTCAGCCGC 
AAGCTCGATC GACTTGCCTA CATTGCCCAC CCCAAGCTTG GGAAGCGTGC TCGTGCCCGT 
ATTGCCAAGG GGCTCAGGCT GTGCCGGCCA AAGGCCAAGG CCAAGGCCAA GGCCAAGGAT 
CAAACCAAGG CCCAGGCTGC AGCCCCAGCT TCAGTTCCAG CTCAGGCTCC CAAACGTACC 
CAGGCCCCTA CAAAGGCTTC AGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024309466.1
CDS	316..822
Translation	MLGGLIRGKFFVGLIPFFSPTARKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE

Target ORF information:

RefSeq Version	XM_024453698.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L29 (RPL29), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024453698.1

ORF Insert Sequence:

ATGTTGGGTG GTCTTATTAG AGGAAAGTTC TTTGTTGGCT TAATTCCCTT TTTTTCTCCC 
ACAGCCCGAA AATGGCACAG AAATGGTATC AAGAAACCCC GATCACAAAG ATACGAATCT 
CTTAAGGGGG TGGACCCCAA GTTCCTGAGG AACATGCGCT TTGCCAAGAA GCACAACAAA 
AAGGGCCTAA AGAAGATGCA GGCCAACAAT GCCAAGGCCA TGAGTGCACG TGCCGAGGCT 
ATCAAGGCCC TCGTAAAGCC CAAGGAGGTT AAGCCCAAGA TCCCAAAGGG TGTCAGCCGC 
AAGCTCGATC GACTTGCCTA CATTGCCCAC CCCAAGCTTG GGAAGCGTGC TCGTGCCCGT 
ATTGCCAAGG GGCTCAGGCT GTGCCGGCCA AAGGCCAAGG CCAAGGCCAA GGCCAAGGAT 
CAAACCAAGG CCCAGGCTGC AGCCCCAGCT TCAGTTCCAG CTCAGGCTCC CAAACGTACC 
CAGGCCCCTA CAAAGGCTTC AGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells.
Molecular and cellular biochemistry370(1-2)127-39(2012 Nov)
Li C,Ge M,Yin Y,Luo M,Chen D

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.
The Journal of biological chemistry285(33)25812-21(2010 Aug)
Sun XX,Wang YG,Xirodimas DP,Dai MS

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RPL29 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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