MRPL23 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL23
Entrez Gene ID	6150
Full Name	mitochondrial ribosomal protein L23
Synonyms	L23MRP,RPL23,RPL23L
General protein information	Preferred Names mitochondrial ribosomal protein L23 Names 39S ribosomal protein L23, mitochondrial L23 mitochondrial-related protein L23mt MRP-L23 mitochondrial large ribosomal subunit protein uL23m ribosomal protein related to L23 (mitochondrial)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008].
Disorder MIM:	600789

mRNA and Protein(s)

mRNA	Protein	Name
NM_021134.4	NP_066957.3	39S ribosomal protein L23, mitochondrial
XM_011520273.1	XP_011518575.1	39S ribosomal protein L23, mitochondrial isoform X1
XM_011520276.3	XP_011518578.1	39S ribosomal protein L23, mitochondrial isoform X3
XM_011520275.2	XP_011518577.1	39S ribosomal protein L23, mitochondrial isoform X2
XM_011520276.2	XP_011518578.1	39S ribosomal protein L23, mitochondrial isoform X3
XM_006718271.2	XP_006718334.1	39S ribosomal protein L23, mitochondrial isoform X4
NM_021134.3	NP_066957.3	39S ribosomal protein L23, mitochondrial

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mrpl23	NP_071974.1
Danio rerio (zebrafish)	mrpl23	NP_001002052.1
Homo sapiens (human)	LOC102724828	XP_006724959.1
Pan troglodytes (chimpanzee)	MRPL23	XP_508219.2
Bos taurus (cattle)	MRPL23	NP_001071352.1
Drosophila melanogaster (fruit fly)	mRpL23	NP_001137873.1
Homo sapiens (human)	MRPL23	NP_066957.3
	MRPL23	XP_001092196.1
Mus musculus (house mouse)	Mrpl23	NP_035418.1
Xenopus tropicalis (tropical clawed frog)	mrpl23	NP_001107679.1
Canis lupus familiaris (dog)	MRPL23	XP_540784.3
Gallus gallus (chicken)	MRPL23	NP_001186314.1
Anopheles gambiae (African malaria mosquito)	RM23_ANOGA	XP_559130.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
Renter?a ME, Coolen MW, Statham AL, Choi RS, Qu W, Campbell MJ, Smith S, Henders AK, Montgomery GW, Clark SJ, Martin NG, Medland SE
Twin research and human genetics : the official journal of the International Society for Twin Studies16(4)767-81(2013 Aug)

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
?stensson M, Mont?n C, Bacelis J, Gudjonsdottir AH, Adamovic S, Ek J, Ascher H, Pollak E, Arnell H, Browaldh L, Agardh D, Wahlstr?m J, Nilsson S, Torinsson-Naluai ?
PloS one8(8)e70174(2013)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

5-FU treatment triggers a ribosomal stress response so that ribosomal proteins L5, L11, and L23 are released from ribosome to activate p53 by ablating the MDM2-p53 feedback circuit
Title: 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction.

The following MRPL23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26202	NM_021134.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu44943	XM_006718271.2 Latest version!	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu60314	XM_011520273.1 Latest version!	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu60316	XM_011520275.2 Latest version!	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu60317	XM_011520276.3 Latest version!	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu60317	XM_011520276.2	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu26202	NM_021134.3	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL23 ( NM_021134.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066957.3 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), mRNA.

Price & Availability↑

CloneID	OHu26202
Clone ID Related Accession (Same CDS sequence)	NM_021134.4 , NM_021134.3
Accession Version	NM_021134.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN310387.1 and BC027710.2. On Nov 23, 2018 this sequence version replaced NM_021134.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD248886.1, U26596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000397298.8/ ENSP00000380466.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGGCC 
CATGGACAGA CCTTCACGTT CCCAGATCTG TTTCCCGAGA AAGACGAGAG CCCTGAAGGC 
AGCGCTGCCG ACGACCTCTA CAGCATGCTC GAGGAGGAGA GGCAGCAGAG GCAGAGCAGC 
GACCCGCGGC GGGGCGGCGT CCCCAGCTGG TTCGGGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066957.3
CDS	32..493
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLAHGQTFTFPDLFPEKDESPEGSAADDLYSMLEEERQQRQSSDPRRGGVPSWFGL

Target ORF information:

RefSeq Version	NM_021134.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021134.4

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGGCC 
CATGGACAGA CCTTCACGTT CCCAGATCTG TTTCCCGAGA AAGACGAGAG CCCTGAAGGC 
AGCGCTGCCG ACGACCTCTA CAGCATGCTC GAGGAGGAGA GGCAGCAGAG GCAGAGCAGC 
GACCCGCGGC GGGGCGGCGT CCCCAGCTGG TTCGGGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL23 ( NM_021134.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066957.3 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), mRNA.

Price & Availability↑

CloneID	OHu26202
Clone ID Related Accession (Same CDS sequence)	NM_021134.4 , NM_021134.3
Accession Version	NM_021134.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN310387.1, BC027710.2 and BM670857.1. On Feb 12, 2009 this sequence version replaced NM_021134.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.39578.1, ERR279834.8075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGGCC 
CATGGACAGA CCTTCACGTT CCCAGATCTG TTTCCCGAGA AAGACGAGAG CCCTGAAGGC 
AGCGCTGCCG ACGACCTCTA CAGCATGCTC GAGGAGGAGA GGCAGCAGAG GCAGAGCAGC 
GACCCGCGGC GGGGCGGCGT CCCCAGCTGG TTCGGGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066957.3
CDS	92..553
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLAHGQTFTFPDLFPEKDESPEGSAADDLYSMLEEERQQRQSSDPRRGGVPSWFGL

Target ORF information:

RefSeq Version	NM_021134.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021134.3

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGGCC 
CATGGACAGA CCTTCACGTT CCCAGATCTG TTTCCCGAGA AAGACGAGAG CCCTGAAGGC 
AGCGCTGCCG ACGACCTCTA CAGCATGCTC GAGGAGGAGA GGCAGCAGAG GCAGAGCAGC 
GACCCGCGGC GGGGCGGCGT CCCCAGCTGG TTCGGGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL23 ( XM_006718271.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006718334.1 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu44943
Clone ID Related Accession (Same CDS sequence)	XM_006718271.2
Accession Version	XM_006718271.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006718271.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGGTC 
CCCAAGGAGC AGTATCCCCT CCTTCTCGTG AACCCGAGCC ACATGCTGTG GCCTGGGCTG 
GGGCTTGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006718334.1
CDS	92..463
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLVPKEQYPLLLVNPSHMLWPGLGLG

Target ORF information:

RefSeq Version	XM_006718271.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718271.2

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGGTC 
CCCAAGGAGC AGTATCCCCT CCTTCTCGTG AACCCGAGCC ACATGCTGTG GCCTGGGCTG 
GGGCTTGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL23 ( XM_011520273.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518575.1 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60314
Clone ID Related Accession (Same CDS sequence)	XM_011520273.1
Accession Version	XM_011520273.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAACAG CTTCAGGAGT GCCGAGCCAC AAGGCTGCAG GAGCCTGGGT 
CCCCAGTCGC CTGGAGGAGA CCCTGCCCAC ACCATACTCA GACCACCCTC CCAGAATGGT 
GACTGTGCAG AGATGCACGC ATGTCGGCTG CACCCCGCCA TCTTGGGGGT ACATATTTCC 
AGAAAGAAAT CACTTCCAAT TCCAAGGGCT CCATGGAGGC GGATTTTTCC ATCTGGGCTT 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518575.1
CDS	92..817
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLPSQTPSKEQNGQGSTLCFRSSCSKGWSTWGTRDPRPAWSPVGGRIPRKAGSGGPANRIAQDGRLLLNSFRSAEPQGCRSLGPQSPGGDPAHTILRPPSQNGDCAEMHACRLHPAILGVHISRKKSLPIPRAPWRRIFPSGLF

Target ORF information:

RefSeq Version	XM_011520273.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520273.1

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAACAG CTTCAGGAGT GCCGAGCCAC AAGGCTGCAG GAGCCTGGGT 
CCCCAGTCGC CTGGAGGAGA CCCTGCCCAC ACCATACTCA GACCACCCTC CCAGAATGGT 
GACTGTGCAG AGATGCACGC ATGTCGGCTG CACCCCGCCA TCTTGGGGGT ACATATTTCC 
AGAAAGAAAT CACTTCCAAT TCCAAGGGCT CCATGGAGGC GGATTTTTCC ATCTGGGCTT 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL23 ( XM_011520275.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518577.1 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu60316
Clone ID Related Accession (Same CDS sequence)	XM_011520275.2
Accession Version	XM_011520275.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520275.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAACAG CTTCAGGAGT GCCGAGCCAC AAGGCTGCAG GAGCCTGGGT 
CCCCAGTCGC CTGGAGGAGA CCCTGCCCAC ACCATACTCA GACCACCCTC CCAGAATGGT 
GACTGTGCAG AGATGCACGC ATGTCGGCTG CACCCCGCCA TCTTGGGGCA CGGAAGTCCT 
GACCCCACAA CCTCAGAATG GGCCTGTCTA GAGGTGGATC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518577.1
CDS	92..796
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLPSQTPSKEQNGQGSTLCFRSSCSKGWSTWGTRDPRPAWSPVGGRIPRKAGSGGPANRIAQDGRLLLNSFRSAEPQGCRSLGPQSPGGDPAHTILRPPSQNGDCAEMHACRLHPAILGHGSPDPTTSEWACLEVDL

Target ORF information:

RefSeq Version	XM_011520275.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520275.2

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAACAG CTTCAGGAGT GCCGAGCCAC AAGGCTGCAG GAGCCTGGGT 
CCCCAGTCGC CTGGAGGAGA CCCTGCCCAC ACCATACTCA GACCACCCTC CCAGAATGGT 
GACTGTGCAG AGATGCACGC ATGTCGGCTG CACCCCGCCA TCTTGGGGCA CGGAAGTCCT 
GACCCCACAA CCTCAGAATG GGCCTGTCTA GAGGTGGATC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL23 ( XM_011520276.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518578.1 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu60317
Clone ID Related Accession (Same CDS sequence)	XM_011520276.3 , XM_011520276.2
Accession Version	XM_011520276.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011520276.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAAGAA CCTCAGGCCC AGAGTCCCCA GGAGGGAGCA GCCGGCAACA 
CGGTTTCCGC TGTGGAGACG GGGCGTCCTG GCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518578.1
CDS	92..667
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLPSQTPSKEQNGQGSTLCFRSSCSKGWSTWGTRDPRPAWSPVGGRIPRKAGSGGPANRIAQDGRLLLKNLRPRVPRREQPATRFPLWRRGVLA

Target ORF information:

RefSeq Version	XM_011520276.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520276.3

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAAGAA CCTCAGGCCC AGAGTCCCCA GGAGGGAGCA GCCGGCAACA 
CGGTTTCCGC TGTGGAGACG GGGCGTCCTG GCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL23 ( XM_011520276.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518578.1 Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu60317
Clone ID Related Accession (Same CDS sequence)	XM_011520276.3 , XM_011520276.2
Accession Version	XM_011520276.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	39S ribosomal protein L23, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520276.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAAGAA CCTCAGGCCC AGAGTCCCCA GGAGGGAGCA GCCGGCAACA 
CGGTTTCCGC TGTGGAGACG GGGCGTCCTG GCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518578.1
CDS	92..667
Translation	MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLPSQTPSKEQNGQGSTLCFRSSCSKGWSTWGTRDPRPAWSPVGGRIPRKAGSGGPANRIAQDGRLLLKNLRPRVPRREQPATRFPLWRRGVLA

Target ORF information:

RefSeq Version	XM_011520276.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L23 (MRPL23), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520276.2

ORF Insert Sequence:

ATGGCGCGGA ATGTGGTGTA CCCCCTGTAC CGGCTGGGTG GCCCACAACT TCGGGTGTTC 
CGAACCAACT TCTTCATTCA GCTGGTGCGG CCCGGTGTGG CCCAGCCCGA GGACACCGTG 
CAGTTCCGGA TCCCCATGGA AATGACAAGG GTGGACCTCA GGAATTACCT CGAGGGCATC 
TATAACGTGC CCGTGGCTGC TGTGCGGACA CGGGTGCAGC ATGGCTCTAA CAAGAGAAGA 
GATCACAGAA ACGTGAGGAT CAAGAAGCCG GACTACAAGG TCGCCTACGT GCAGCTGCCC 
TCCCAGACAC CCAGCAAGGA GCAAAATGGC CAGGGCAGCA CCCTCTGTTT CCGGAGCAGC 
TGCAGCAAGG GGTGGTCAAC CTGGGGGACC AGGGACCCCA GACCCGCTTG GAGTCCTGTG 
GGTGGCCGCA TTCCCAGGAA GGCTGGATCC GGAGGACCGG CCAACAGGAT CGCTCAGGAT 
GGACGTCTTC TACTCAAGAA CCTCAGGCCC AGAGTCCCCA GGAGGGAGCA GCCGGCAACA 
CGGTTTCCGC TGTGGAGACG GGGCGTCCTG GCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
Twin research and human genetics : the official journal of the International Society for Twin Studies16(4)767-81(2013 Aug)
Renter?a ME,Coolen MW,Statham AL,Choi RS,Qu W,Campbell MJ,Smith S,Henders AK,Montgomery GW,Clark SJ,Martin NG,Medland SE

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
PloS one8(8)e70174(2013)
?stensson M,Mont?n C,Bacelis J,Gudjonsdottir AH,Adamovic S,Ek J,Ascher H,Pollak E,Arnell H,Browaldh L,Agardh D,Wahlstr?m J,Nilsson S,Torinsson-Naluai ?

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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MRPL23 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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