RPL11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPL11
Entrez Gene ID	6135
Full Name	ribosomal protein L11
Synonyms	DBA7,GIG34,L11
General protein information	Preferred Names ribosomal protein L11 Names 60S ribosomal protein L11 CLL-associated antigen KW-12 cell growth-inhibiting protein 34 large ribosomal subunit protein uL5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010].
Disorder MIM:	604175
Disorder Html:	Diamond-Blackfan anemia 7, 612562 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000975.4	NP_000966.2	60S ribosomal protein L11 isoform 1
NM_000975.3	NP_000966.2	60S ribosomal protein L11 isoform 1
NM_000975.5	NP_000966.2	60S ribosomal protein L11 isoform 1
NM_001199802.1	NP_001186731.1	60S ribosomal protein L11 isoform 2

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	RpL11	NP_477054.1
Caenorhabditis elegans (roundworm)	rpl-11.1	NP_504008.1
Caenorhabditis elegans (roundworm)	rpl-11.2	NP_508413.1
Arabidopsis thaliana (thale cress)	AT5G45775	NP_568649.2
Canis lupus familiaris (dog)	RPL11	NP_001240835.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011173	XP_309477.3
Kluyveromyces lactis	KLLA0F08261g	XP_455455.1
Schizosaccharomyces pombe (fission yeast)	rpl1101	NP_594150.1
Schizosaccharomyces pombe (fission yeast)	rpl1102	NP_595899.1
Arabidopsis thaliana (thale cress)	RPL16A	NP_850376.2
Arabidopsis thaliana (thale cress)	AT3G58700	NP_191429.1
Oryza sativa (rice)	Os05g0207300	NP_001054899.1
Rattus norvegicus (Norway rat)	Rpl11	NP_001020910.1
Saccharomyces cerevisiae (baker's yeast)	RPL11A	NP_015427.1
Eremothecium gossypii	AGOS_AEL325W	NP_984535.1
Arabidopsis thaliana (thale cress)	RPL16B	NP_567563.1
Oryza sativa (rice)	Os02g0235600	NP_001046386.1
Bos taurus (cattle)	RPL11	NP_001069049.1
Mus musculus (house mouse)	Rpl11	NP_080195.1
Magnaporthe oryzae (rice blast fungus)	MGG_07753	XP_003712966.1
Neurospora crassa	NCU02509	XP_965640.2
Homo sapiens (human)	RPL11	NP_000966.2
Gallus gallus (chicken)	RPL11	NP_001026075.1
Danio rerio (zebrafish)	rpl11	NP_001002139.1
Saccharomyces cerevisiae (baker's yeast)	RPL11B	NP_011599.1
Oryza sativa (rice)	Os06g0550000	NP_001057834.2
Oryza sativa (rice)	Os01g0205500	NP_001042339.1
Xenopus tropicalis (tropical clawed frog)	rpl11	NP_001016640.1

Gene Ontology
Bibliography

Related articles in PubMed

Variable expressivity and incomplete penetrance in a large family with non-classical Diamond-Blackfan anemia associated with ribosomal protein L11 splicing variant.
Carlston CM, Afify ZA, Palumbos JC, Bagley H, Barbagelata C, Wooderchak-Donahue WL, Mao R, Carey JC
American journal of medical genetics. Part A173(10)2622-2627(2017 Oct)

Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia.
Arbiv OA, Cuvelier G, Klaassen RJ, Fernandez CV, Robitaille N, Steele M, Breakey V, Abish S, Wu J, Sinha R, Silva M, Goodyear L, Jardine L, Lipton JH, Corriveau-Bourque C, Brossard J, Michon B, Ghemlas I, Waespe N, Zlateska B, Sung L, Cada M, Dror Y
Clinical genetics(2017 Oct)

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, Cao W, Chen L, Tan Z, Xu N, Huang X, Zhuang J, Huang L
Oncotarget7(50)83241-83257(2016 Dec)

A novel pathogenic mutation in RPL11 identified in a patient diagnosed with diamond Blackfan anemia as a young adult.
Narla A, Yuan D, Kazerounian S, LaVasseur C, Ulirsch JC, Narla J, Glader B, Sankaran VG, Gazda H
Blood cells, molecules & diseases6146-7(2016 Oct)

HEY1 functions are regulated by its phosphorylation at Ser-68.
L?pez-Mateo I, Arruabarrena-Aristorena A, Artaza-Irigaray C, L?pez JA, Calvo E, Belandia B
Bioscience reports36(3)(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Simulation of HEY1 Ser-68 phosphorylation prevents its interaction with p53, RPL11 and MDM2 and abolishes HEY1 migration to nucleolar caps upon ribosomal stress. Our findings uncover a novel mechanism for cross-talk between Notch signalling and nucleolar stress
Title: HEY1 functions are regulated by its phosphorylation at Ser-68.

Data suggest 5S ribosomal RNA is a direct target of miR-150 and miR-383 in esophageal squamous cell carcinoma (ESCC); overexpression of miR-150 and miR-383 inhibits ESCC cell proliferation in vitro and in vivo and intensifies RPL11/c-Myc interaction.
Title: Down-regulation of 5S rRNA by miR-150 and miR-383 enhances c-Myc-rpL11 interaction and inhibits proliferation of esophageal squamous carcinoma cells.

Data indicate that ribosomal protein L11 (RPL11)-expressing cells proliferated more rapidly than the ribosomal protein L11 (RPL11)-expressing cells.
Title: Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells.

Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
Title: Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.

Data indicate that ribosomal protein (L11) promotes the recruitment of microRNA-130a (miR-130a) to oncoprotein c-Myc in response to UV irradiation treatment.
Title: MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation.

The following RPL11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPL11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16862	NM_001199802.1 Latest version!	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18188	NM_000975.5 Latest version!	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18188	NM_000975.3	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18188	NM_000975.4	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPL11 ( NM_001199802.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186731.1 Homo sapiens ribosomal protein L11 (RPL11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16862
Clone ID Related Accession (Same CDS sequence)	NM_001199802.1
Accession Version	NM_001199802.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	60S ribosomal protein L11 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF240826.1, BU954396.1, BC018970.2 and CA335141.1. Transcript Variant: This variant (2) lacks 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) lacks an internal aa in the N-terminal region, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.466961.1, CD176921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGATC AAGGTGAAAA GGAGAACCCC ATGCGGGAAC TTCGCATCCG CAAACTCTGT 
CTCAACATCT GTGTTGGGGA GAGTGGAGAC AGACTGACGC GAGCAGCCAA GGTGTTGGAG 
CAGCTCACAG GGCAGACCCC TGTGTTTTCC AAAGCTAGAT ACACTGTCAG ATCCTTTGGC 
ATCCGGAGAA ATGAAAAGAT TGCTGTCCAC TGCACAGTTC GAGGGGCCAA GGCAGAAGAA 
ATCTTGGAGA AGGGTCTAAA GGTGCGGGAG TATGAGTTAA GAAAAAACAA CTTCTCAGAT 
ACTGGAAACT TTGGTTTTGG GATCCAGGAA CACATCGATC TGGGTATCAA ATATGACCCA 
AGCATTGGTA TCTACGGCCT GGACTTCTAT GTGGTGCTGG GTAGGCCAGG TTTCAGCATC 
GCAGACAAGA AGCGCAGGAC AGGCTGCATT GGGGCCAAAC ACAGAATCAG CAAAGAGGAG 
GCCATGCGCT GGTTCCAGCA GAAGTATGAT GGGATCATCC TTCCTGGCAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186731.1
CDS	46..579
Translation	MADQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK

Target ORF information:

RefSeq Version	NM_001199802.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199802.1

ORF Insert Sequence:

ATGGCGGATC AAGGTGAAAA GGAGAACCCC ATGCGGGAAC TTCGCATCCG CAAACTCTGT 
CTCAACATCT GTGTTGGGGA GAGTGGAGAC AGACTGACGC GAGCAGCCAA GGTGTTGGAG 
CAGCTCACAG GGCAGACCCC TGTGTTTTCC AAAGCTAGAT ACACTGTCAG ATCCTTTGGC 
ATCCGGAGAA ATGAAAAGAT TGCTGTCCAC TGCACAGTTC GAGGGGCCAA GGCAGAAGAA 
ATCTTGGAGA AGGGTCTAAA GGTGCGGGAG TATGAGTTAA GAAAAAACAA CTTCTCAGAT 
ACTGGAAACT TTGGTTTTGG GATCCAGGAA CACATCGATC TGGGTATCAA ATATGACCCA 
AGCATTGGTA TCTACGGCCT GGACTTCTAT GTGGTGCTGG GTAGGCCAGG TTTCAGCATC 
GCAGACAAGA AGCGCAGGAC AGGCTGCATT GGGGCCAAAC ACAGAATCAG CAAAGAGGAG 
GCCATGCGCT GGTTCCAGCA GAAGTATGAT GGGATCATCC TTCCTGGCAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL11 ( NM_000975.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000966.2 Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18188
Clone ID Related Accession (Same CDS sequence)	NM_000975.4 , NM_000975.3 , NM_000975.5
Accession Version	NM_000975.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	60S ribosomal protein L11 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BF240826.1, BU954396.1, CA335141.1, BX118515.1, AL451000.16 and AA748897.1. This sequence is a reference standard in the RefSeqGene project. On Aug 30, 2017 this sequence version replaced NM_000975.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.90758.1, BU598750.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC 
TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG 
GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT 
GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA 
GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA 
GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC 
CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC 
ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG 
GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000966.2
CDS	46..582
Translation	MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK

Target ORF information:

RefSeq Version	NM_000975.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000975.4

ORF Insert Sequence:

ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC 
TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG 
GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT 
GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA 
GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA 
GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC 
CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC 
ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG 
GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL11 ( NM_000975.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000966.2 Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18188
Clone ID Related Accession (Same CDS sequence)	NM_000975.4 , NM_000975.3 , NM_000975.5
Accession Version	NM_000975.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-03-26
Organism	Homo sapiens(Human)
Product	60S ribosomal protein L11 isoform 1
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BF240826.1, BU954396.1 and CA335141.1. This sequence is a reference standard in the RefSeqGene project. On Dec 18, 2010 this sequence version replaced NM_000975.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD176330.1, BU954396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC 
TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG 
GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT 
GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA 
GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA 
GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC 
CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC 
ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG 
GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000966.2
CDS	46..582
Translation	MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK

Target ORF information:

RefSeq Version	NM_000975.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000975.3

ORF Insert Sequence:

ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC 
TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG 
GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT 
GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA 
GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA 
GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC 
CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC 
ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG 
GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPL11 ( NM_000975.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000966.2 Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18188
Clone ID Related Accession (Same CDS sequence)	NM_000975.4 , NM_000975.3 , NM_000975.5
Accession Version	NM_000975.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	60S ribosomal protein L11 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BU954396.1, CA335141.1, BX118515.1, AL451000.16 and AA748897.1. This sequence is a reference standard in the RefSeqGene project. On May 8, 2018 this sequence version replaced NM_000975.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.43615.1, BG700016.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000643754.2/ ENSP00000496250.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC 
TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG 
GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT 
GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA 
GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA 
GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC 
CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC 
ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG 
GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000966.2
CDS	19..555
Translation	MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK

Target ORF information:

RefSeq Version	NM_000975.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000975.5

ORF Insert Sequence:

ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC 
TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG 
GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT 
GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA 
GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA 
GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC 
CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC 
ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG 
GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variable expressivity and incomplete penetrance in a large family with non-classical Diamond-Blackfan anemia associated with ribosomal protein L11 splicing variant.
American journal of medical genetics. Part A173(10)2622-2627(2017 Oct)
Carlston CM,Afify ZA,Palumbos JC,Bagley H,Barbagelata C,Wooderchak-Donahue WL,Mao R,Carey JC

Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia.
Clinical genetics(2017 Oct)
Arbiv OA,Cuvelier G,Klaassen RJ,Fernandez CV,Robitaille N,Steele M,Breakey V,Abish S,Wu J,Sinha R,Silva M,Goodyear L,Jardine L,Lipton JH,Corriveau-Bourque C,Brossard J,Michon B,Ghemlas I,Waespe N,Zlateska B,Sung L,Cada M,Dror Y

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Oncotarget7(50)83241-83257(2016 Dec)
Chen H,Han L,Tsai H,Wang Z,Wu Y,Duo Y,Cao W,Chen L,Tan Z,Xu N,Huang X,Zhuang J,Huang L

A novel pathogenic mutation in RPL11 identified in a patient diagnosed with diamond Blackfan anemia as a young adult.
Blood cells, molecules & diseases6146-7(2016 Oct)
Narla A,Yuan D,Kazerounian S,LaVasseur C,Ulirsch JC,Narla J,Glader B,Sankaran VG,Gazda H

HEY1 functions are regulated by its phosphorylation at Ser-68.
Bioscience reports36(3)(2016 Jul)
L?pez-Mateo I,Arruabarrena-Aristorena A,Artaza-Irigaray C,L?pez JA,Calvo E,Belandia B

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RPL11 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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