CTXN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTXN3
Entrez Gene ID	613212
Full Name	cortexin 3
Synonyms	KABE
General protein information	Preferred Names cortexin 3 Names cortexin-3 kidney and brain-expressed protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q23.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001127385.1	NP_001120857.1	cortexin-3
NM_001048252.2	NP_001041717.1	cortexin-3

Pathways from BioSystems

Homologies

Homo sapiens (human)	CTXN3	NP_001041717.1
Bos taurus (cattle)	CTXN3	NP_001098956.1
Danio rerio (zebrafish)	LOC100331302	XP_002663549.1
Gallus gallus (chicken)	LOC100859328	XP_004949433.1
Pan troglodytes (chimpanzee)	CTXN3	XP_001159340.1
	CTXN3	XP_001098120.1
Canis lupus familiaris (dog)	CTXN3	XP_005626539.1
Mus musculus (house mouse)	Ctxn3	NP_001128169.1
Rattus norvegicus (Norway rat)	Ctxn3	NP_001128168.1
Xenopus tropicalis (tropical clawed frog)	ctxn3	NP_001165159.2

Gene Ontology
Bibliography

Related articles in PubMed

Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia.
?er? O, Lochman J, Povov? J, Janout V, Plesn?k J, Balcar VJ
Behavioral and brain functions : BBF1110(2015 Mar)

A genome-wide association meta-analysis of plasma A? peptides concentrations in the elderly.
Chouraki V, De Bruijn RF, Chapuis J, Bis JC, Reitz C, Schraen S, Ibrahim-Verbaas CA, Grenier-Boley B, Delay C, Rogers R, Demiautte F, Mounier A, Fitzpatrick AL, , Berr C, Dartigues JF, Uitterlinden AG, Hofman A, Breteler M, Becker JT, Lathrop M, Schupf N, Alp?rovitch A, Mayeux R, van Duijn CM, Bu?e L, Amouyel P, Lopez OL, Ikram MA, Tzourio C, Lambert JC
Molecular psychiatry19(12)1326-35(2014 Dec)

Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population.
Panichareon B, Nakayama K, Iwamoto S, Thurakitwannakarn W, Sukhumsirichart W
Behavioral and brain functions : BBF827(2012 May)

A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
Potkin SG, Turner JA, Guffanti G, Lakatos A, Fallon JH, Nguyen DD, Mathalon D, Ford J, Lauriello J, Macciardi F,
Schizophrenia bulletin35(1)96-108(2009 Jan)

In silico-initiated cloning and molecular characterization of cortexin 3, a novel human gene specifically expressed in the kidney and brain, and well conserved in vertebrates.
Wang HT, Chang JW, Guo Z, Li BG
International journal of molecular medicine20(4)501-10(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

altered expression of cortexin 3, either alone, or in parallel with changes in disrupted-in-schizophrenia 1, could subtly perturb GABAergic neurotransmission
Title: Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia.

Two single nucleotide polymophisms of the CTXN3 and SLC12A2 genes are associated with risk of schizophrenia in a Thai population.
Title: Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.

Selective expression of CTXN3 in the kidney and brain, the amino acid identity to cortexin, and its high conservation among different species indicate that CTXN3 may be involved in a process specifically restricted to kidney and brain tissue function.
Title: In silico-initiated cloning and molecular characterization of cortexin 3, a novel human gene specifically expressed in the kidney and brain, and well conserved in vertebrates.

The following CTXN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTXN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu06717	NM_001127385.1 Latest version!	Homo sapiens cortexin 3 (CTXN3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06717	NM_001048252.2 Latest version!	Homo sapiens cortexin 3 (CTXN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTXN3 ( NM_001127385.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001120857.1 Homo sapiens cortexin 3 (CTXN3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06717
Clone ID Related Accession (Same CDS sequence)	NM_001127385.1 , NM_001048252.2
Accession Version	NM_001127385.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	cortexin-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA623980.1 and AB219832.1. Transcript Variant: This variant (2) utilizes an alternate first exon. Transcript variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB219832.1, BG429351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGATGGAG GACAGCCCAT CCCCTCATCC CTAGTGCCCC TTGGGAACGA ATCAGCAGAT 
TCTAGCATGT CCCTGGAGCA GAAAATGACA TTTGTTTTTG TGATTCTGTT GTTTATTTTC 
TTGGGCATTC TCATTGTCCG GTGCTTCCGG ATTCTTTTGG ATCCATATCG AAGCATGCCA 
ACCTCTACCT GGGCTGATGG ACTTGAAGGC CTGGAGAAAG GGCAGTTCGA CCATGCCCTT 
GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120857.1
CDS	384..629
Translation	MDGGQPIPSSLVPLGNESADSSMSLEQKMTFVFVILLFIFLGILIVRCFRILLDPYRSMPTSTWADGLEGLEKGQFDHALA

Target ORF information:

RefSeq Version	NM_001127385.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cortexin 3 (CTXN3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127385.1

ORF Insert Sequence:

ATGGATGGAG GACAGCCCAT CCCCTCATCC CTAGTGCCCC TTGGGAACGA ATCAGCAGAT 
TCTAGCATGT CCCTGGAGCA GAAAATGACA TTTGTTTTTG TGATTCTGTT GTTTATTTTC 
TTGGGCATTC TCATTGTCCG GTGCTTCCGG ATTCTTTTGG ATCCATATCG AAGCATGCCA 
ACCTCTACCT GGGCTGATGG ACTTGAAGGC CTGGAGAAAG GGCAGTTCGA CCATGCCCTT 
GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTXN3 ( NM_001048252.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001041717.1 Homo sapiens cortexin 3 (CTXN3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06717
Clone ID Related Accession (Same CDS sequence)	NM_001127385.1 , NM_001048252.2
Accession Version	NM_001048252.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	cortexin-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA131605.1 and AB219764.1. On May 16, 2008 this sequence version replaced NM_001048252.1. Transcript Variant: This variant (1) utilizes an alternate first exon. Transcript variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB219764.1, SRR1660803.24806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END##

ATGGATGGAG GACAGCCCAT CCCCTCATCC CTAGTGCCCC TTGGGAACGA ATCAGCAGAT 
TCTAGCATGT CCCTGGAGCA GAAAATGACA TTTGTTTTTG TGATTCTGTT GTTTATTTTC 
TTGGGCATTC TCATTGTCCG GTGCTTCCGG ATTCTTTTGG ATCCATATCG AAGCATGCCA 
ACCTCTACCT GGGCTGATGG ACTTGAAGGC CTGGAGAAAG GGCAGTTCGA CCATGCCCTT 
GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041717.1
CDS	575..820
Translation	MDGGQPIPSSLVPLGNESADSSMSLEQKMTFVFVILLFIFLGILIVRCFRILLDPYRSMPTSTWADGLEGLEKGQFDHALA

Target ORF information:

RefSeq Version	NM_001048252.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cortexin 3 (CTXN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048252.2

ORF Insert Sequence:

ATGGATGGAG GACAGCCCAT CCCCTCATCC CTAGTGCCCC TTGGGAACGA ATCAGCAGAT 
TCTAGCATGT CCCTGGAGCA GAAAATGACA TTTGTTTTTG TGATTCTGTT GTTTATTTTC 
TTGGGCATTC TCATTGTCCG GTGCTTCCGG ATTCTTTTGG ATCCATATCG AAGCATGCCA 
ACCTCTACCT GGGCTGATGG ACTTGAAGGC CTGGAGAAAG GGCAGTTCGA CCATGCCCTT 
GCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia.
Behavioral and brain functions : BBF1110(2015 Mar)
?er? O,Lochman J,Povov? J,Janout V,Plesn?k J,Balcar VJ

A genome-wide association meta-analysis of plasma A? peptides concentrations in the elderly.
Molecular psychiatry19(12)1326-35(2014 Dec)
Chouraki V,De Bruijn RF,Chapuis J,Bis JC,Reitz C,Schraen S,Ibrahim-Verbaas CA,Grenier-Boley B,Delay C,Rogers R,Demiautte F,Mounier A,Fitzpatrick AL,,Berr C,Dartigues JF,Uitterlinden AG,Hofman A,Breteler M,Becker JT,Lathrop M,Schupf N,Alp?rovitch A,Mayeux R,van Duijn CM,Bu?e L,Amouyel P,Lopez OL,Ikram MA,Tzourio C,Lambert JC

Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population.
Behavioral and brain functions : BBF827(2012 May)
Panichareon B,Nakayama K,Iwamoto S,Thurakitwannakarn W,Sukhumsirichart W

A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
Schizophrenia bulletin35(1)96-108(2009 Jan)
Potkin SG,Turner JA,Guffanti G,Lakatos A,Fallon JH,Nguyen DD,Mathalon D,Ford J,Lauriello J,Macciardi F,

In silico-initiated cloning and molecular characterization of cortexin 3, a novel human gene specifically expressed in the kidney and brain, and well conserved in vertebrates.
International journal of molecular medicine20(4)501-10(2007 Oct)
Wang HT,Chang JW,Guo Z,Li BG

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CTXN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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