DEFB136 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB136
Entrez Gene ID	613210
Full Name	defensin beta 136
Synonyms	DEFB137
General protein information	Preferred Names defensin beta 136 Names beta-defensin 136 beta-defensin 137
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033018.2	NP_001028190.2	beta-defensin 136 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFB136	NP_001028190.2
	DEFB136	XP_001085891.2
Pan troglodytes (chimpanzee)	DEFB136	NP_001123266.1

Gene Ontology
Bibliography

Related articles in PubMed

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The protein encoded by this gene is thought to display antimicrobial activity.
Title: Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

The following DEFB136 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB136 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30429	NM_001033018.2 Latest version!	Homo sapiens defensin beta 136 (DEFB136), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB136 ( NM_001033018.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001028190.2 Homo sapiens defensin beta 136 (DEFB136), mRNA.

Price & Availability↑

CloneID	OHu30429
Clone ID Related Accession (Same CDS sequence)	NM_001033018.2
Accession Version	NM_001033018.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	beta-defensin 136 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ012026.1. On Oct 21, 2006 this sequence version replaced NM_001033018.1. ##Evidence-Data-START## Transcript exon combination :: DQ012026.1, AY621333.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382209.2/ ENSP00000371644.2 Protein has antimicrobial activity :: PMID: 16033865 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAACCTCT GTCTTTCTGC ATTACTCTTT TTCCTGGTGA TCTTACTGCC TTCAGGAAAA 
GGTATGTTTG GGAATGATGG AGTCAAAGTT CGCACCTGCA CTAGCCAGAA AGCCGTATGT 
TTCTTCGGGT GTCCGCCAGG ATACAGGTGG ATTGCGTTCT GCCACAATAT TCTGTCTTGC 
TGTAAAAATA TGACACGTTT TCAACCCCCG CAAGCCAAAG ATCCATGGGT TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028190.2
CDS	1..237
Translation	MNLCLSALLFFLVILLPSGKGMFGNDGVKVRTCTSQKAVCFFGCPPGYRWIAFCHNILSCCKNMTRFQPPQAKDPWVH

Target ORF information:

RefSeq Version	NM_001033018.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 136 (DEFB136), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033018.2

ORF Insert Sequence:

ATGAACCTCT GTCTTTCTGC ATTACTCTTT TTCCTGGTGA TCTTACTGCC TTCAGGAAAA 
GGTATGTTTG GGAATGATGG AGTCAAAGTT CGCACCTGCA CTAGCCAGAA AGCCGTATGT 
TTCTTCGGGT GTCCGCCAGG ATACAGGTGG ATTGCGTTCT GCCACAATAT TCTGTCTTGC 
TGTAAAAATA TGACACGTTT TCAACCCCCG CAAGCCAAAG ATCCATGGGT TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

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DEFB136 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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