RPA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPA3
Entrez Gene ID	6119
Full Name	replication protein A3
Synonyms	REPA3,RP-A p14
General protein information	Preferred Names replication protein A3 Names replication protein A 14 kDa subunit RF-A protein 3 replication factor A protein 3 replication protein A3, 14kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p21.3
Disorder MIM:	179837

mRNA and Protein(s)

mRNA	Protein	Name
NM_002947.4	NP_002938.1	replication protein A 14 kDa subunit
NM_002947.3	NP_002938.1	replication protein A 14 kDa subunit
NM_002947.5	NP_002938.1	replication protein A 14 kDa subunit

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPA3	NP_002938.1
Bos taurus (cattle)	RPA3	NP_001029599.1
Rattus norvegicus (Norway rat)	LOC100362927	XP_002728026.1
Gallus gallus (chicken)	RPA3	XP_418679.1
Pan troglodytes (chimpanzee)	RPA3	XP_527665.2
	RPA3	XP_001086880.1
Canis lupus familiaris (dog)	RPA3	XP_538570.2
Mus musculus (house mouse)	Rpa3	NP_080908.1
Rattus norvegicus (Norway rat)	Rpa3	NP_001100054.1
Danio rerio (zebrafish)	rpa3	NP_956521.1
Xenopus tropicalis (tropical clawed frog)	rpa3	NP_001016626.1

Gene Ontology
Bibliography

Related articles in PubMed

Replication Protein A 3 Is Associated with Hepatocellular Carcinoma Tumorigenesis and Poor Patient Survival.
Xiao W, Zheng J, Zhou B, Pan L
Digestive diseases (Basel, Switzerland)36(1)26-32(2018)

RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma.
Qu C, Zhao Y, Feng G, Chen C, Tao Y, Zhou S, Liu S, Chang H, Zeng M, Xia Y
Journal of cellular and molecular medicine21(11)2872-2883(2017 Nov)

Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival.
Dai Z, Wang S, Zhang W, Yang Y
Digestive diseases and sciences62(9)2369-2375(2017 09)

RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.
Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z
Molecular cell65(2)272-284(2017 Jan)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival.
Title: Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival.

RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation.
Title: RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.

The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma.
Title: TP53 and RPA3 gene variations were associated with risk of glioma in a Chinese Han population.

Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
Title: Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia.

The following RPA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04023	NM_002947.5 Latest version!	Homo sapiens replication protein A3 (RPA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04023	NM_002947.3	Homo sapiens replication protein A3, 14kDa (RPA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04023	NM_002947.4	Homo sapiens replication protein A3 (RPA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPA3 ( NM_002947.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002938.1 Homo sapiens replication protein A3 (RPA3), mRNA.

Price & Availability↑

CloneID	OHu04023
Clone ID Related Accession (Same CDS sequence)	NM_002947.4 , NM_002947.3 , NM_002947.5
Accession Version	NM_002947.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	replication protein A 14 kDa subunit
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC009868.2, AC004948.2 and AI243725.1. On Dec 16, 2015 this sequence version replaced NM_002947.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009868.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END##

ATGGTGGACA TGATGGACTT GCCCAGGTCG CGCATCAACG CCGGCATGCT AGCTCAATTC 
ATCGACAAGC CTGTCTGCTT CGTAGGGAGG CTGGAAAAGA TTCATCCCAC CGGAAAAATG 
TTTATTCTTT CAGATGGAGA AGGAAAAAAT GGAACCATCG AGTTGATGGA ACCCCTTGAT 
GAAGAAATCT CTGGAATTGT GGAAGTGGTT GGAAGAGTAA CCGCCAAGGC CACCATCTTG 
TGTACATCTT ATGTCCAGTT TAAAGAAGAT AGCCATCCTT TTGATCTTGG ACTTTACAAT 
GAAGCTGTGA AAATTATCCA TGACTTCCCT CAGTTTTATC CTTTAGGGAT TGTGCAACAT 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002938.1
CDS	1173..1538
Translation	MVDMMDLPRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSYVQFKEDSHPFDLGLYNEAVKIIHDFPQFYPLGIVQHD

Target ORF information:

RefSeq Version	NM_002947.4
Organism	Homo sapiens(human)
Definition	Homo sapiens replication protein A3 (RPA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002947.4

ORF Insert Sequence:

ATGGTGGACA TGATGGACTT GCCCAGGTCG CGCATCAACG CCGGCATGCT AGCTCAATTC 
ATCGACAAGC CTGTCTGCTT CGTAGGGAGG CTGGAAAAGA TTCATCCCAC CGGAAAAATG 
TTTATTCTTT CAGATGGAGA AGGAAAAAAT GGAACCATCG AGTTGATGGA ACCCCTTGAT 
GAAGAAATCT CTGGAATTGT GGAAGTGGTT GGAAGAGTAA CCGCCAAGGC CACCATCTTG 
TGTACATCTT ATGTCCAGTT TAAAGAAGAT AGCCATCCTT TTGATCTTGG ACTTTACAAT 
GAAGCTGTGA AAATTATCCA TGACTTCCCT CAGTTTTATC CTTTAGGGAT TGTGCAACAT 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPA3 ( NM_002947.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002938.1 Homo sapiens replication protein A3, 14kDa (RPA3), mRNA.

Price & Availability↑

CloneID	OHu04023
Clone ID Related Accession (Same CDS sequence)	NM_002947.4 , NM_002947.3 , NM_002947.5
Accession Version	NM_002947.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	replication protein A 14 kDa subunit
Comment

ATGGTGGACA TGATGGACTT GCCCAGGTCG CGCATCAACG CCGGCATGCT AGCTCAATTC 
ATCGACAAGC CTGTCTGCTT CGTAGGGAGG CTGGAAAAGA TTCATCCCAC CGGAAAAATG 
TTTATTCTTT CAGATGGAGA AGGAAAAAAT GGAACCATCG AGTTGATGGA ACCCCTTGAT 
GAAGAAATCT CTGGAATTGT GGAAGTGGTT GGAAGAGTAA CCGCCAAGGC CACCATCTTG 
TGTACATCTT ATGTCCAGTT TAAAGAAGAT AGCCATCCTT TTGATCTTGG ACTTTACAAT 
GAAGCTGTGA AAATTATCCA TGACTTCCCT CAGTTTTATC CTTTAGGGAT TGTGCAACAT 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002938.1
Translation	MVDMMDLPRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSYVQFKEDSHPFDLGLYNEAVKIIHDFPQFYPLGIVQHD

Target ORF information:

RefSeq Version	NM_002947.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens replication protein A3, 14kDa (RPA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002947.3

ORF Insert Sequence:

ATGGTGGACA TGATGGACTT GCCCAGGTCG CGCATCAACG CCGGCATGCT AGCTCAATTC 
ATCGACAAGC CTGTCTGCTT CGTAGGGAGG CTGGAAAAGA TTCATCCCAC CGGAAAAATG 
TTTATTCTTT CAGATGGAGA AGGAAAAAAT GGAACCATCG AGTTGATGGA ACCCCTTGAT 
GAAGAAATCT CTGGAATTGT GGAAGTGGTT GGAAGAGTAA CCGCCAAGGC CACCATCTTG 
TGTACATCTT ATGTCCAGTT TAAAGAAGAT AGCCATCCTT TTGATCTTGG ACTTTACAAT 
GAAGCTGTGA AAATTATCCA TGACTTCCCT CAGTTTTATC CTTTAGGGAT TGTGCAACAT 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPA3 ( NM_002947.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002938.1 Homo sapiens replication protein A3 (RPA3), mRNA.

Price & Availability↑

CloneID	OHu04023
Clone ID Related Accession (Same CDS sequence)	NM_002947.4 , NM_002947.3 , NM_002947.5
Accession Version	NM_002947.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	replication protein A 14 kDa subunit
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC009868.2, AC004948.2 and AI243725.1. On May 17, 2019 this sequence version replaced NM_002947.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009868.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000223129.8/ ENSP00000223129.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGTGGACA TGATGGACTT GCCCAGGTCG CGCATCAACG CCGGCATGCT AGCTCAATTC 
ATCGACAAGC CTGTCTGCTT CGTAGGGAGG CTGGAAAAGA TTCATCCCAC CGGAAAAATG 
TTTATTCTTT CAGATGGAGA AGGAAAAAAT GGAACCATCG AGTTGATGGA ACCCCTTGAT 
GAAGAAATCT CTGGAATTGT GGAAGTGGTT GGAAGAGTAA CCGCCAAGGC CACCATCTTG 
TGTACATCTT ATGTCCAGTT TAAAGAAGAT AGCCATCCTT TTGATCTTGG ACTTTACAAT 
GAAGCTGTGA AAATTATCCA TGACTTCCCT CAGTTTTATC CTTTAGGGAT TGTGCAACAT 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002938.1
CDS	1173..1538
Translation	MVDMMDLPRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSYVQFKEDSHPFDLGLYNEAVKIIHDFPQFYPLGIVQHD

Target ORF information:

RefSeq Version	NM_002947.5
Organism	Homo sapiens(human)
Definition	Homo sapiens replication protein A3 (RPA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002947.5

ORF Insert Sequence:

ATGGTGGACA TGATGGACTT GCCCAGGTCG CGCATCAACG CCGGCATGCT AGCTCAATTC 
ATCGACAAGC CTGTCTGCTT CGTAGGGAGG CTGGAAAAGA TTCATCCCAC CGGAAAAATG 
TTTATTCTTT CAGATGGAGA AGGAAAAAAT GGAACCATCG AGTTGATGGA ACCCCTTGAT 
GAAGAAATCT CTGGAATTGT GGAAGTGGTT GGAAGAGTAA CCGCCAAGGC CACCATCTTG 
TGTACATCTT ATGTCCAGTT TAAAGAAGAT AGCCATCCTT TTGATCTTGG ACTTTACAAT 
GAAGCTGTGA AAATTATCCA TGACTTCCCT CAGTTTTATC CTTTAGGGAT TGTGCAACAT 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Replication Protein A 3 Is Associated with Hepatocellular Carcinoma Tumorigenesis and Poor Patient Survival.
Digestive diseases (Basel, Switzerland)36(1)26-32(2018)
Xiao W,Zheng J,Zhou B,Pan L

RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma.
Journal of cellular and molecular medicine21(11)2872-2883(2017 Nov)
Qu C,Zhao Y,Feng G,Chen C,Tao Y,Zhou S,Liu S,Chang H,Zeng M,Xia Y

Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival.
Digestive diseases and sciences62(9)2369-2375(2017 09)
Dai Z,Wang S,Zhang W,Yang Y

RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.
Molecular cell65(2)272-284(2017 Jan)
Zhang H,Gan H,Wang Z,Lee JH,Zhou H,Ordog T,Wold MS,Ljungman M,Zhang Z

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

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RPA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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