SAV1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SAV1
Entrez Gene ID	60485
Full Name	salvador family WW domain containing protein 1
Synonyms	SAV,WW45,WWP4
General protein information	Preferred Names salvador family WW domain containing protein 1 Names protein salvador homolog 1 1700040G09Rik 45 kDa WW domain protein WW domain-containing adaptor 45 hWW45 salvador homolog 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q22.1
Summary	WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012].
Disorder MIM:	607203

mRNA and Protein(s)

mRNA	Protein	Name
XM_011537057.2	XP_011535359.1	protein salvador homolog 1 isoform X1
XM_017021568.1	XP_016877057.1	protein salvador homolog 1 isoform X1
XM_011537057.3	XP_011535359.1	protein salvador homolog 1 isoform X1
XM_017021568.2	XP_016877057.1	protein salvador homolog 1 isoform X1
NM_021818.3	NP_068590.1	protein salvador homolog 1
NM_021818.4	NP_068590.1	protein salvador homolog 1

Pathways from BioSystems

Homologies

	SAV1	XP_001101888.1
Canis lupus familiaris (dog)	SAV1	XP_005623442.1
Gallus gallus (chicken)	SAV1	XP_421467.3
Danio rerio (zebrafish)	sav1	NP_001004560.1
Xenopus tropicalis (tropical clawed frog)	sav1	NP_001004931.1
Rattus norvegicus (Norway rat)	Sav1	NP_001091050.1
Homo sapiens (human)	SAV1	NP_068590.1
Pan troglodytes (chimpanzee)	SAV1	XP_001156407.2
Bos taurus (cattle)	SAV1	NP_001178291.1
Mus musculus (house mouse)	Sav1	NP_071311.1

Gene Ontology
Bibliography

Related articles in PubMed

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Bae SJ, Ni L, Osinski A, Tomchick DR, Brautigam CA, Luo X
eLife6(2017 Oct)

SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.
Jiang J, Chang W, Fu Y, Gao Y, Zhao C, Zhang X, Zhang S
Cell proliferation50(4)(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SAV1 represses the activation of the Akt-mTOR signalling, and rapamycin treatment blunts the effects of SAV1 on in vitro and in vivo growth of colorectal cancer cells.
Title: SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.

using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 refolded under acidic pH.
Title: Low pH-driven folding of WW45-SARAH domain leads to stabilization of the WW45-Mst2 complex.

MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes.
Title: The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.

Mst2 and the Ser-3 residue of human WW45 function independently of each other in the regulation of the stability of human WW45.
Title: A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation.

We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells.
Title: Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system.

The following SAV1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SAV1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16333	NM_021818.4 Latest version!	Homo sapiens salvador family WW domain containing protein 1 (SAV1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu71078	XM_017021568.2 Latest version!	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu71078	XM_011537057.3 Latest version!	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu71078	XM_011537057.2	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu71078	XM_017021568.1	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu16333	NM_021818.3	Homo sapiens salvador family WW domain containing protein 1 (SAV1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SAV1 ( NM_021818.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_068590.1 Homo sapiens salvador family WW domain containing protein 1 (SAV1), mRNA.

Price & Availability↑

CloneID	OHu16333
Clone ID Related Accession (Same CDS sequence)	NM_021818.3 , NM_021818.4
Accession Version	NM_021818.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	protein salvador homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA536352.1, DA479812.1, AK023071.1, BC006385.2 and DB543756.1. On Jul 12, 2012 this sequence version replaced NM_021818.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.200144.1, AK023071.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTCCC GAAAGAAAAC CAAAAACGAA GTGTCCAAGC CGGCCGAGGT GCAGGGGAAG 
TACGTGAAGA AGGAGACGTC GCCTCTGCTT CGGAATCTTA TGCCTTCATT CATCCGGCAT 
GGTCCAACAA TTCCAAGACG AACTGATATC TGTCTTCCAG ATTCAAGCCC TAATGCCTTT 
TCAACTTCTG GAGATGTAGT TTCAAGAAAC CAGAGTTTCC TTAGAACTCC AATTCAAAGA 
ACACCTCATG AAATAATGAG AAGAGAAAGC AACAGATTAT CTGCACCTTC TTATCTTGCC 
AGAAGTCTAG CAGATGTCCC TAGAGAGTAT GGTTCTTCTC AGTCATTTGT AACGGAAGTT 
AGTTTTGCTG TTGAAAATGG AGACTCTGGT TCCCGATATT ATTATTCAGA CAATTTTTTT 
GATGGTCAGA GAAAGCGGCC ACTTGGAGAT CGTGCACATG AAGACTACAG ATATTATGAA 
TACAACCATG ATCTCTTCCA AAGAATGCCA CAGAATCAGG GGAGGCATGC TTCAGGTATT 
GGGAGAGTTG CTGCTACATC TTTAGGAAAT TTGACTAACC ATGGTTCTGA AGATTTACCC 
CTTCCTCCTG GCTGGTCTGT GGACTGGACA ATGAGAGGGA GAAAATATTA TATAGATCAT 
AACACAAATA CAACTCACTG GAGCCATCCT CTTGAGCGAG AAGGACTTCC TCCTGGATGG 
GAACGAGTTG AGTCATCCGA ATTTGGAACC TATTATGTAG ATCACACAAA TAAGAAGGCC 
CAATACAGGC ATCCCTGTGC TCCTAGTGTA CCTCGGTATG ATCAACCACC TCCTGTCACA 
TACCAGCCAC AGCAAACTGA AAGAAATCAG TCCCTTCTGG TACCTGCAAA TCCATATCAT 
ACTGCAGAAA TTCCTGACTG GCTTCAGGTT TACGCACGAG CCCCTGTGAA ATATGACCAC 
ATTCTGAAGT GGGAACTCTT CCAGCTGGCT GACCTGGATA CATACCAGGG AATGCTAAAG 
TTGCTCTTCA TGAAAGAATT GGAGCAGATT GTTAAAATGT ATGAAGCATA CAGACAAGCC 
CTTCTTACAG AGTTGGAAAA CCGAAAGCAG AGACAGCAGT GGTATGCCCA ACAACATGGA 
AAAAATTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068590.1
CDS	387..1538
Translation	MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF

Target ORF information:

RefSeq Version	NM_021818.3
Organism	Homo sapiens(human)
Definition	Homo sapiens salvador family WW domain containing protein 1 (SAV1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021818.3

ORF Insert Sequence:

ATGCTGTCCC GAAAGAAAAC CAAAAACGAA GTGTCCAAGC CGGCCGAGGT GCAGGGGAAG 
TACGTGAAGA AGGAGACGTC GCCTCTGCTT CGGAATCTTA TGCCTTCATT CATCCGGCAT 
GGTCCAACAA TTCCAAGACG AACTGATATC TGTCTTCCAG ATTCAAGCCC TAATGCCTTT 
TCAACTTCTG GAGATGTAGT TTCAAGAAAC CAGAGTTTCC TTAGAACTCC AATTCAAAGA 
ACACCTCATG AAATAATGAG AAGAGAAAGC AACAGATTAT CTGCACCTTC TTATCTTGCC 
AGAAGTCTAG CAGATGTCCC TAGAGAGTAT GGTTCTTCTC AGTCATTTGT AACGGAAGTT 
AGTTTTGCTG TTGAAAATGG AGACTCTGGT TCCCGATATT ATTATTCAGA CAATTTTTTT 
GATGGTCAGA GAAAGCGGCC ACTTGGAGAT CGTGCACATG AAGACTACAG ATATTATGAA 
TACAACCATG ATCTCTTCCA AAGAATGCCA CAGAATCAGG GGAGGCATGC TTCAGGTATT 
GGGAGAGTTG CTGCTACATC TTTAGGAAAT TTGACTAACC ATGGTTCTGA AGATTTACCC 
CTTCCTCCTG GCTGGTCTGT GGACTGGACA ATGAGAGGGA GAAAATATTA TATAGATCAT 
AACACAAATA CAACTCACTG GAGCCATCCT CTTGAGCGAG AAGGACTTCC TCCTGGATGG 
GAACGAGTTG AGTCATCCGA ATTTGGAACC TATTATGTAG ATCACACAAA TAAGAAGGCC 
CAATACAGGC ATCCCTGTGC TCCTAGTGTA CCTCGGTATG ATCAACCACC TCCTGTCACA 
TACCAGCCAC AGCAAACTGA AAGAAATCAG TCCCTTCTGG TACCTGCAAA TCCATATCAT 
ACTGCAGAAA TTCCTGACTG GCTTCAGGTT TACGCACGAG CCCCTGTGAA ATATGACCAC 
ATTCTGAAGT GGGAACTCTT CCAGCTGGCT GACCTGGATA CATACCAGGG AATGCTAAAG 
TTGCTCTTCA TGAAAGAATT GGAGCAGATT GTTAAAATGT ATGAAGCATA CAGACAAGCC 
CTTCTTACAG AGTTGGAAAA CCGAAAGCAG AGACAGCAGT GGTATGCCCA ACAACATGGA 
AAAAATTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SAV1 ( NM_021818.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_068590.1 Homo sapiens salvador family WW domain containing protein 1 (SAV1), mRNA.

Price & Availability↑

CloneID	OHu16333
Clone ID Related Accession (Same CDS sequence)	NM_021818.3 , NM_021818.4
Accession Version	NM_021818.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	protein salvador homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA479812.1, AK023071.1, BC006385.2 and DB543756.1. On May 17, 2019 this sequence version replaced NM_021818.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK021500.1, SRR1660805.200144.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324679.5/ ENSP00000324729.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGTCCC GAAAGAAAAC CAAAAACGAA GTGTCCAAGC CGGCCGAGGT GCAGGGGAAG 
TACGTGAAGA AGGAGACGTC GCCTCTGCTT CGGAATCTTA TGCCTTCATT CATCCGGCAT 
GGTCCAACAA TTCCAAGACG AACTGATATC TGTCTTCCAG ATTCAAGCCC TAATGCCTTT 
TCAACTTCTG GAGATGTAGT TTCAAGAAAC CAGAGTTTCC TTAGAACTCC AATTCAAAGA 
ACACCTCATG AAATAATGAG AAGAGAAAGC AACAGATTAT CTGCACCTTC TTATCTTGCC 
AGAAGTCTAG CAGATGTCCC TAGAGAGTAT GGTTCTTCTC AGTCATTTGT AACGGAAGTT 
AGTTTTGCTG TTGAAAATGG AGACTCTGGT TCCCGATATT ATTATTCAGA CAATTTTTTT 
GATGGTCAGA GAAAGCGGCC ACTTGGAGAT CGTGCACATG AAGACTACAG ATATTATGAA 
TACAACCATG ATCTCTTCCA AAGAATGCCA CAGAATCAGG GGAGGCATGC TTCAGGTATT 
GGGAGAGTTG CTGCTACATC TTTAGGAAAT TTGACTAACC ATGGTTCTGA AGATTTACCC 
CTTCCTCCTG GCTGGTCTGT GGACTGGACA ATGAGAGGGA GAAAATATTA TATAGATCAT 
AACACAAATA CAACTCACTG GAGCCATCCT CTTGAGCGAG AAGGACTTCC TCCTGGATGG 
GAACGAGTTG AGTCATCCGA ATTTGGAACC TATTATGTAG ATCACACAAA TAAGAAGGCC 
CAATACAGGC ATCCCTGTGC TCCTAGTGTA CCTCGGTATG ATCAACCACC TCCTGTCACA 
TACCAGCCAC AGCAAACTGA AAGAAATCAG TCCCTTCTGG TACCTGCAAA TCCATATCAT 
ACTGCAGAAA TTCCTGACTG GCTTCAGGTT TACGCACGAG CCCCTGTGAA ATATGACCAC 
ATTCTGAAGT GGGAACTCTT CCAGCTGGCT GACCTGGATA CATACCAGGG AATGCTAAAG 
TTGCTCTTCA TGAAAGAATT GGAGCAGATT GTTAAAATGT ATGAAGCATA CAGACAAGCC 
CTTCTTACAG AGTTGGAAAA CCGAAAGCAG AGACAGCAGT GGTATGCCCA ACAACATGGA 
AAAAATTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068590.1
CDS	340..1491
Translation	MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF

Target ORF information:

RefSeq Version	NM_021818.4
Organism	Homo sapiens(human)
Definition	Homo sapiens salvador family WW domain containing protein 1 (SAV1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021818.4

ORF Insert Sequence:

ATGCTGTCCC GAAAGAAAAC CAAAAACGAA GTGTCCAAGC CGGCCGAGGT GCAGGGGAAG 
TACGTGAAGA AGGAGACGTC GCCTCTGCTT CGGAATCTTA TGCCTTCATT CATCCGGCAT 
GGTCCAACAA TTCCAAGACG AACTGATATC TGTCTTCCAG ATTCAAGCCC TAATGCCTTT 
TCAACTTCTG GAGATGTAGT TTCAAGAAAC CAGAGTTTCC TTAGAACTCC AATTCAAAGA 
ACACCTCATG AAATAATGAG AAGAGAAAGC AACAGATTAT CTGCACCTTC TTATCTTGCC 
AGAAGTCTAG CAGATGTCCC TAGAGAGTAT GGTTCTTCTC AGTCATTTGT AACGGAAGTT 
AGTTTTGCTG TTGAAAATGG AGACTCTGGT TCCCGATATT ATTATTCAGA CAATTTTTTT 
GATGGTCAGA GAAAGCGGCC ACTTGGAGAT CGTGCACATG AAGACTACAG ATATTATGAA 
TACAACCATG ATCTCTTCCA AAGAATGCCA CAGAATCAGG GGAGGCATGC TTCAGGTATT 
GGGAGAGTTG CTGCTACATC TTTAGGAAAT TTGACTAACC ATGGTTCTGA AGATTTACCC 
CTTCCTCCTG GCTGGTCTGT GGACTGGACA ATGAGAGGGA GAAAATATTA TATAGATCAT 
AACACAAATA CAACTCACTG GAGCCATCCT CTTGAGCGAG AAGGACTTCC TCCTGGATGG 
GAACGAGTTG AGTCATCCGA ATTTGGAACC TATTATGTAG ATCACACAAA TAAGAAGGCC 
CAATACAGGC ATCCCTGTGC TCCTAGTGTA CCTCGGTATG ATCAACCACC TCCTGTCACA 
TACCAGCCAC AGCAAACTGA AAGAAATCAG TCCCTTCTGG TACCTGCAAA TCCATATCAT 
ACTGCAGAAA TTCCTGACTG GCTTCAGGTT TACGCACGAG CCCCTGTGAA ATATGACCAC 
ATTCTGAAGT GGGAACTCTT CCAGCTGGCT GACCTGGATA CATACCAGGG AATGCTAAAG 
TTGCTCTTCA TGAAAGAATT GGAGCAGATT GTTAAAATGT ATGAAGCATA CAGACAAGCC 
CTTCTTACAG AGTTGGAAAA CCGAAAGCAG AGACAGCAGT GGTATGCCCA ACAACATGGA 
AAAAATTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SAV1 ( XM_011537057.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011535359.1 Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu71078
Clone ID Related Accession (Same CDS sequence)	XM_011537057.2 , XM_017021568.1 , XM_011537057.3 , XM_017021568.2
Accession Version	XM_011537057.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein salvador homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537057.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011535359.1
CDS	549..1601
Translation	MPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF

Target ORF information:

RefSeq Version	XM_011537057.2
Organism	Homo sapiens(human)
Definition	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537057.2

ORF Insert Sequence:

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SAV1 ( XM_017021568.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877057.1 Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu71078
Clone ID Related Accession (Same CDS sequence)	XM_011537057.2 , XM_017021568.1 , XM_011537057.3 , XM_017021568.2
Accession Version	XM_017021568.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein salvador homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877057.1
CDS	779..1831
Translation	MPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF

Target ORF information:

RefSeq Version	XM_017021568.1
Organism	Homo sapiens(human)
Definition	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021568.1

ORF Insert Sequence:

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SAV1 ( XM_011537057.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011535359.1 Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu71078
Clone ID Related Accession (Same CDS sequence)	XM_011537057.2 , XM_017021568.1 , XM_011537057.3 , XM_017021568.2
Accession Version	XM_011537057.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein salvador homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011537057.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011535359.1
CDS	549..1601
Translation	MPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF

Target ORF information:

RefSeq Version	XM_011537057.3
Organism	Homo sapiens(human)
Definition	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537057.3

ORF Insert Sequence:

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SAV1 ( XM_017021568.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877057.1 Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu71078
Clone ID Related Accession (Same CDS sequence)	XM_011537057.2 , XM_017021568.1 , XM_011537057.3 , XM_017021568.2
Accession Version	XM_017021568.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein salvador homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017021568.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877057.1
CDS	779..1831
Translation	MPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF

Target ORF information:

RefSeq Version	XM_017021568.2
Organism	Homo sapiens(human)
Definition	Homo sapiens salvador family WW domain containing protein 1 (SAV1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021568.2

ORF Insert Sequence:

ATGCCTTCAT TCATCCGGCA TGGTCCAACA ATTCCAAGAC GAACTGATAT CTGTCTTCCA 
GATTCAAGCC CTAATGCCTT TTCAACTTCT GGAGATGTAG TTTCAAGAAA CCAGAGTTTC 
CTTAGAACTC CAATTCAAAG AACACCTCAT GAAATAATGA GAAGAGAAAG CAACAGATTA 
TCTGCACCTT CTTATCTTGC CAGAAGTCTA GCAGATGTCC CTAGAGAGTA TGGTTCTTCT 
CAGTCATTTG TAACGGAAGT TAGTTTTGCT GTTGAAAATG GAGACTCTGG TTCCCGATAT 
TATTATTCAG ACAATTTTTT TGATGGTCAG AGAAAGCGGC CACTTGGAGA TCGTGCACAT 
GAAGACTACA GATATTATGA ATACAACCAT GATCTCTTCC AAAGAATGCC ACAGAATCAG 
GGGAGGCATG CTTCAGGTAT TGGGAGAGTT GCTGCTACAT CTTTAGGAAA TTTGACTAAC 
CATGGTTCTG AAGATTTACC CCTTCCTCCT GGCTGGTCTG TGGACTGGAC AATGAGAGGG 
AGAAAATATT ATATAGATCA TAACACAAAT ACAACTCACT GGAGCCATCC TCTTGAGCGA 
GAAGGACTTC CTCCTGGATG GGAACGAGTT GAGTCATCCG AATTTGGAAC CTATTATGTA 
GATCACACAA ATAAGAAGGC CCAATACAGG CATCCCTGTG CTCCTAGTGT ACCTCGGTAT 
GATCAACCAC CTCCTGTCAC ATACCAGCCA CAGCAAACTG AAAGAAATCA GTCCCTTCTG 
GTACCTGCAA ATCCATATCA TACTGCAGAA ATTCCTGACT GGCTTCAGGT TTACGCACGA 
GCCCCTGTGA AATATGACCA CATTCTGAAG TGGGAACTCT TCCAGCTGGC TGACCTGGAT 
ACATACCAGG GAATGCTAAA GTTGCTCTTC ATGAAAGAAT TGGAGCAGAT TGTTAAAATG 
TATGAAGCAT ACAGACAAGC CCTTCTTACA GAGTTGGAAA ACCGAAAGCA GAGACAGCAG 
TGGTATGCCC AACAACATGG AAAAAATTTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
eLife6(2017 Oct)
Bae SJ,Ni L,Osinski A,Tomchick DR,Brautigam CA,Luo X

SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.
Cell proliferation50(4)(2017 Aug)
Jiang J,Chang W,Fu Y,Gao Y,Zhao C,Zhang X,Zhang S

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SAV1 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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