RNASEL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNASEL
Entrez Gene ID	6041
Full Name	ribonuclease L
Synonyms	PRCA1,RNS4
General protein information	Preferred Names ribonuclease L Names 2-5A-dependent ribonuclease 2',5'-oligoisoadenylate synthetase-dependent 2-5A-dependent RNase RNase L interferon-induced 2-5A-dependent RNase ribonuclease 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q25.3
Summary	This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008].
Disorder MIM:	180435
Disorder Html:	Prostate cancer 1, 601518 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021133.4	NP_066956.1	2-5A-dependent ribonuclease
NM_021133.3	NP_066956.1	2-5A-dependent ribonuclease

Pathways from BioSystems

Homologies

Homo sapiens (human)	RNASEL	NP_066956.1
Pan troglodytes (chimpanzee)	RNASEL	XP_524990.2
Bos taurus (cattle)	RNASEL	NP_001091634.1
	RNASEL	NP_001035898.1
Mus musculus (house mouse)	Rnasel	NP_036012.1
Canis lupus familiaris (dog)	RNASEL	NP_001091018.1
Rattus norvegicus (Norway rat)	Rnasel	NP_872614.1
Gallus gallus (chicken)	RNASEL	NP_001026438.1

Gene Ontology
Bibliography

Related articles in PubMed

Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery.
Donovan J, Rath S, Kolet-Mandrikov D, Korennykh A
RNA (New York, N.Y.)23(11)1660-1671(2017 11)

Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
Sangalli A, Orlandi E, Poli A, Maurichi A, Santinami M, Nicolis M, Ferronato S, Malerba G, Rodolfo M, Gomez Lira M
Melanoma research27(4)309-314(2017 Aug)

Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.
L?pez-Rodr?guez R, Hern?ndez-Bartolom? ?, Borque MJ, Rodr?guez-Mu?oz Y, Mart?n-V?lchez S, Garc?a-Buey L, Gonz?lez-Moreno L, Real-Mart?nez Y, Mu?oz de Rueda P, Salmer?n J, Vidal-Casti?eira JR, L?pez-Larrea C, Rodrigo L, Moreno-Otero R, Sanz-Cameno P
PloS one12(7)e0180927(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

By sequencing abundant RNA fragments generated by RNase L in cell lines, we identify site-specific cleavage of two groups of noncoding RNAs: Y-RNAs, whose function is poorly understood, and cytosolic tRNAs, which are essential for translation.
Title: Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery.

Serum RNase-L levels were inversely associated with metabolic syndrome and age.
Title: Human serum RNase-L level is inversely associated with metabolic syndrome and age.

These results demonstrate that ablation of RNase L activity promotes survival of ADAR1 deficient cells even in the presence of MDA5 and MAVS, suggesting that the RNase L system is the primary sensor pathway for endogenous dsRNA that leads to cell death.
Title: Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line.

We show that mutations in RNase L found in HPC patients may promote prostate cancer by increasing expression of AR-responsive genes and cell motility and identify novel roles of RNase L as a prostate cancer susceptibility gene.
Title: RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.

RNASEL rs3738579 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Title: Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.

The following RNASEL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASEL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19564	NM_021133.4 Latest version!	Homo sapiens ribonuclease L (RNASEL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19564	NM_021133.3	Homo sapiens ribonuclease L (RNASEL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNASEL ( NM_021133.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066956.1 Homo sapiens ribonuclease L (RNASEL), mRNA.

Price & Availability↑

CloneID	OHu19564
Clone ID Related Accession (Same CDS sequence)	NM_021133.4 , NM_021133.3
Accession Version	NM_021133.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2226bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	2-5A-dependent ribonuclease
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138776.10. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_021133.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.82706.1, SRR1660803.78698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367559.7/ ENSP00000356530.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAGCA GGGATCATAA CAACCCCCAG GAGGGACCCA CGTCCTCCAG CGGTAGAAGG 
GCTGCAGTGG AAGACAATCA CTTGCTGATT AAAGCTGTTC AAAACGAAGA TGTTGACCTG 
GTCCAGCAAT TGCTGGAAGG TGGAGCCAAT GTTAATTTCC AGGAAGAGGA AGGGGGCTGG 
ACACCTCTGC ATAACGCAGT ACAAATGAGC AGGGAGGACA TTGTGGAACT TCTGCTTCGT 
CATGGTGCTG ACCCTGTTCT GAGGAAGAAG AATGGGGCCA CGCCTTTTAT CCTCGCAGCG 
ATTGCGGGGA GCGTGAAGCT GCTGAAACTT TTCCTTTCTA AAGGAGCAGA TGTCAATGAG 
TGTGATTTTT ATGGCTTCAC AGCCTTCATG GAAGCCGCTG TGTATGGTAA GGTCAAAGCC 
CTAAAATTCC TTTATAAGAG AGGAGCAAAT GTGAATTTGA GGCGAAAGAC AAAGGAGGAT 
CAAGAGCGGC TGAGGAAAGG AGGGGCCACA GCTCTCATGG ACGCTGCTGA AAAAGGACAC 
GTAGAGGTCT TGAAGATTCT CCTTGATGAG ATGGGGGCAG ATGTAAACGC CTGTGACAAT 
ATGGGCAGAA ATGCCTTGAT CCATGCTCTC CTGAGCTCTG ACGATAGTGA TGTGGAGGCT 
ATTACGCATC TGCTGCTGGA CCATGGGGCT GATGTCAATG TGAGGGGAGA AAGAGGGAAG 
ACTCCCCTGA TCCTGGCAGT GGAGAAGAAG CACTTGGGTT TGGTGCAGAG GCTTCTGGAG 
CAAGAGCACA TAGAGATTAA TGACACAGAC AGTGATGGCA AAACAGCACT GCTGCTTGCT 
GTTGAACTCA AACTGAAGAA AATCGCCGAG TTGCTGTGCA AACGTGGAGC CAGTACAGAT 
TGTGGGGATC TTGTTATGAC AGCGAGGCGG AATTATGACC ATTCCCTTGT GAAGGTTCTT 
CTCTCTCATG GAGCCAAAGA AGATTTTCAC CCTCCTGCTG AAGACTGGAA GCCTCAGAGC 
TCACACTGGG GGGCAGCCCT GAAGGATCTC CACAGAATAT ACCGCCCTAT GATTGGCAAA 
CTCAAGTTCT TTATTGATGA AAAATACAAA ATTGCTGATA CTTCAGAAGG AGGCATCTAC 
CTGGGGTTCT ATGAGAAGCA AGAAGTAGCT GTGAAGACGT TCTGTGAGGG CAGCCCACGT 
GCACAGCGGG AAGTCTCTTG TCTGCAAAGC AGCCGAGAGA ACAGTCACTT GGTGACATTC 
TATGGGAGTG AGAGCCACAG GGGCCACTTG TTTGTGTGTG TCACCCTCTG TGAGCAGACT 
CTGGAAGCGT GTTTGGATGT GCACAGAGGG GAAGATGTGG AAAATGAGGA AGATGAATTT 
GCCCGAAATG TCCTGTCATC TATATTTAAG GCTGTTCAAG AACTACACTT GTCCTGTGGA 
TACACCCACC AGGATCTGCA ACCACAAAAC ATCTTAATAG ATTCTAAGAA AGCTGCTCAC 
CTGGCAGATT TTGATAAGAG CATCAAGTGG GCTGGAGATC CACAGGAAGT CAAGAGAGAT 
CTAGAGGACC TTGGACGGCT GGTCCTCTAT GTGGTAAAGA AGGGAAGCAT CTCATTTGAG 
GATCTGAAAG CTCAAAGTAA TGAAGAGGTG GTTCAACTTT CTCCAGATGA GGAAACTAAG 
GACCTCATTC ATCGTCTCTT CCATCCTGGG GAACATGTGA GGGACTGTCT GAGTGACCTG 
CTGGGTCATC CCTTCTTTTG GACTTGGGAG AGCCGCTATA GGACGCTTCG GAATGTGGGA 
AATGAATCCG ACATCAAAAC ACGAAAATCT GAAAGTGAGA TCCTCAGACT ACTGCAACCT 
GGGCCTTCTG AACATTCCAA AAGTTTTGAC AAGTGGACGA CTAAGATTAA TGAATGTGTT 
ATGAAAAAAA TGAATAAGTT TTATGAAAAA AGAGGCAATT TCTACCAGAA CACTGTGGGT 
GATCTGCTAA AGTTCATCCG GAATTTGGGA GAACACATTG ATGAAGAAAA GCATAAAAAG 
ATGAAATTAA AAATTGGAGA CCCTTCCCTG TATTTTCAGA AGACATTTCC AGATCTGGTG 
ATCTATGTCT ACACAAAACT ACAGAACACA GAATATAGAA AGCATTTCCC CCAAACCCAC 
AGTCCAAACA AGCCTCAGTG TGATGGAGCT GGTGGGGCCA GTGGGTTGGC CAGCCCTGGG 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066956.1
CDS	255..2480
Translation	MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC

Target ORF information:

RefSeq Version	NM_021133.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease L (RNASEL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021133.4

ORF Insert Sequence:

ATGGAGAGCA GGGATCATAA CAACCCCCAG GAGGGACCCA CGTCCTCCAG CGGTAGAAGG 
GCTGCAGTGG AAGACAATCA CTTGCTGATT AAAGCTGTTC AAAACGAAGA TGTTGACCTG 
GTCCAGCAAT TGCTGGAAGG TGGAGCCAAT GTTAATTTCC AGGAAGAGGA AGGGGGCTGG 
ACACCTCTGC ATAACGCAGT ACAAATGAGC AGGGAGGACA TTGTGGAACT TCTGCTTCGT 
CATGGTGCTG ACCCTGTTCT GAGGAAGAAG AATGGGGCCA CGCCTTTTAT CCTCGCAGCG 
ATTGCGGGGA GCGTGAAGCT GCTGAAACTT TTCCTTTCTA AAGGAGCAGA TGTCAATGAG 
TGTGATTTTT ATGGCTTCAC AGCCTTCATG GAAGCCGCTG TGTATGGTAA GGTCAAAGCC 
CTAAAATTCC TTTATAAGAG AGGAGCAAAT GTGAATTTGA GGCGAAAGAC AAAGGAGGAT 
CAAGAGCGGC TGAGGAAAGG AGGGGCCACA GCTCTCATGG ACGCTGCTGA AAAAGGACAC 
GTAGAGGTCT TGAAGATTCT CCTTGATGAG ATGGGGGCAG ATGTAAACGC CTGTGACAAT 
ATGGGCAGAA ATGCCTTGAT CCATGCTCTC CTGAGCTCTG ACGATAGTGA TGTGGAGGCT 
ATTACGCATC TGCTGCTGGA CCATGGGGCT GATGTCAATG TGAGGGGAGA AAGAGGGAAG 
ACTCCCCTGA TCCTGGCAGT GGAGAAGAAG CACTTGGGTT TGGTGCAGAG GCTTCTGGAG 
CAAGAGCACA TAGAGATTAA TGACACAGAC AGTGATGGCA AAACAGCACT GCTGCTTGCT 
GTTGAACTCA AACTGAAGAA AATCGCCGAG TTGCTGTGCA AACGTGGAGC CAGTACAGAT 
TGTGGGGATC TTGTTATGAC AGCGAGGCGG AATTATGACC ATTCCCTTGT GAAGGTTCTT 
CTCTCTCATG GAGCCAAAGA AGATTTTCAC CCTCCTGCTG AAGACTGGAA GCCTCAGAGC 
TCACACTGGG GGGCAGCCCT GAAGGATCTC CACAGAATAT ACCGCCCTAT GATTGGCAAA 
CTCAAGTTCT TTATTGATGA AAAATACAAA ATTGCTGATA CTTCAGAAGG AGGCATCTAC 
CTGGGGTTCT ATGAGAAGCA AGAAGTAGCT GTGAAGACGT TCTGTGAGGG CAGCCCACGT 
GCACAGCGGG AAGTCTCTTG TCTGCAAAGC AGCCGAGAGA ACAGTCACTT GGTGACATTC 
TATGGGAGTG AGAGCCACAG GGGCCACTTG TTTGTGTGTG TCACCCTCTG TGAGCAGACT 
CTGGAAGCGT GTTTGGATGT GCACAGAGGG GAAGATGTGG AAAATGAGGA AGATGAATTT 
GCCCGAAATG TCCTGTCATC TATATTTAAG GCTGTTCAAG AACTACACTT GTCCTGTGGA 
TACACCCACC AGGATCTGCA ACCACAAAAC ATCTTAATAG ATTCTAAGAA AGCTGCTCAC 
CTGGCAGATT TTGATAAGAG CATCAAGTGG GCTGGAGATC CACAGGAAGT CAAGAGAGAT 
CTAGAGGACC TTGGACGGCT GGTCCTCTAT GTGGTAAAGA AGGGAAGCAT CTCATTTGAG 
GATCTGAAAG CTCAAAGTAA TGAAGAGGTG GTTCAACTTT CTCCAGATGA GGAAACTAAG 
GACCTCATTC ATCGTCTCTT CCATCCTGGG GAACATGTGA GGGACTGTCT GAGTGACCTG 
CTGGGTCATC CCTTCTTTTG GACTTGGGAG AGCCGCTATA GGACGCTTCG GAATGTGGGA 
AATGAATCCG ACATCAAAAC ACGAAAATCT GAAAGTGAGA TCCTCAGACT ACTGCAACCT 
GGGCCTTCTG AACATTCCAA AAGTTTTGAC AAGTGGACGA CTAAGATTAA TGAATGTGTT 
ATGAAAAAAA TGAATAAGTT TTATGAAAAA AGAGGCAATT TCTACCAGAA CACTGTGGGT 
GATCTGCTAA AGTTCATCCG GAATTTGGGA GAACACATTG ATGAAGAAAA GCATAAAAAG 
ATGAAATTAA AAATTGGAGA CCCTTCCCTG TATTTTCAGA AGACATTTCC AGATCTGGTG 
ATCTATGTCT ACACAAAACT ACAGAACACA GAATATAGAA AGCATTTCCC CCAAACCCAC 
AGTCCAAACA AGCCTCAGTG TGATGGAGCT GGTGGGGCCA GTGGGTTGGC CAGCCCTGGG 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNASEL ( NM_021133.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066956.1 Homo sapiens ribonuclease L (RNASEL), mRNA.

Price & Availability↑

CloneID	OHu19564
Clone ID Related Accession (Same CDS sequence)	NM_021133.4 , NM_021133.3
Accession Version	NM_021133.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2226bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Homo sapiens(human)
Product	2-5A-dependent ribonuclease
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA127960.1, BC114433.1, AW968304.1 and BQ006347.1. This sequence is a reference standard in the RefSeqGene project. On Dec 18, 2010 this sequence version replaced NM_021133.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.15139.1, SRR1660803.78698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAGCA GGGATCATAA CAACCCCCAG GAGGGACCCA CGTCCTCCAG CGGTAGAAGG 
GCTGCAGTGG AAGACAATCA CTTGCTGATT AAAGCTGTTC AAAACGAAGA TGTTGACCTG 
GTCCAGCAAT TGCTGGAAGG TGGAGCCAAT GTTAATTTCC AGGAAGAGGA AGGGGGCTGG 
ACACCTCTGC ATAACGCAGT ACAAATGAGC AGGGAGGACA TTGTGGAACT TCTGCTTCGT 
CATGGTGCTG ACCCTGTTCT GAGGAAGAAG AATGGGGCCA CGCCTTTTAT CCTCGCAGCG 
ATTGCGGGGA GCGTGAAGCT GCTGAAACTT TTCCTTTCTA AAGGAGCAGA TGTCAATGAG 
TGTGATTTTT ATGGCTTCAC AGCCTTCATG GAAGCCGCTG TGTATGGTAA GGTCAAAGCC 
CTAAAATTCC TTTATAAGAG AGGAGCAAAT GTGAATTTGA GGCGAAAGAC AAAGGAGGAT 
CAAGAGCGGC TGAGGAAAGG AGGGGCCACA GCTCTCATGG ACGCTGCTGA AAAAGGACAC 
GTAGAGGTCT TGAAGATTCT CCTTGATGAG ATGGGGGCAG ATGTAAACGC CTGTGACAAT 
ATGGGCAGAA ATGCCTTGAT CCATGCTCTC CTGAGCTCTG ACGATAGTGA TGTGGAGGCT 
ATTACGCATC TGCTGCTGGA CCATGGGGCT GATGTCAATG TGAGGGGAGA AAGAGGGAAG 
ACTCCCCTGA TCCTGGCAGT GGAGAAGAAG CACTTGGGTT TGGTGCAGAG GCTTCTGGAG 
CAAGAGCACA TAGAGATTAA TGACACAGAC AGTGATGGCA AAACAGCACT GCTGCTTGCT 
GTTGAACTCA AACTGAAGAA AATCGCCGAG TTGCTGTGCA AACGTGGAGC CAGTACAGAT 
TGTGGGGATC TTGTTATGAC AGCGAGGCGG AATTATGACC ATTCCCTTGT GAAGGTTCTT 
CTCTCTCATG GAGCCAAAGA AGATTTTCAC CCTCCTGCTG AAGACTGGAA GCCTCAGAGC 
TCACACTGGG GGGCAGCCCT GAAGGATCTC CACAGAATAT ACCGCCCTAT GATTGGCAAA 
CTCAAGTTCT TTATTGATGA AAAATACAAA ATTGCTGATA CTTCAGAAGG AGGCATCTAC 
CTGGGGTTCT ATGAGAAGCA AGAAGTAGCT GTGAAGACGT TCTGTGAGGG CAGCCCACGT 
GCACAGCGGG AAGTCTCTTG TCTGCAAAGC AGCCGAGAGA ACAGTCACTT GGTGACATTC 
TATGGGAGTG AGAGCCACAG GGGCCACTTG TTTGTGTGTG TCACCCTCTG TGAGCAGACT 
CTGGAAGCGT GTTTGGATGT GCACAGAGGG GAAGATGTGG AAAATGAGGA AGATGAATTT 
GCCCGAAATG TCCTGTCATC TATATTTAAG GCTGTTCAAG AACTACACTT GTCCTGTGGA 
TACACCCACC AGGATCTGCA ACCACAAAAC ATCTTAATAG ATTCTAAGAA AGCTGCTCAC 
CTGGCAGATT TTGATAAGAG CATCAAGTGG GCTGGAGATC CACAGGAAGT CAAGAGAGAT 
CTAGAGGACC TTGGACGGCT GGTCCTCTAT GTGGTAAAGA AGGGAAGCAT CTCATTTGAG 
GATCTGAAAG CTCAAAGTAA TGAAGAGGTG GTTCAACTTT CTCCAGATGA GGAAACTAAG 
GACCTCATTC ATCGTCTCTT CCATCCTGGG GAACATGTGA GGGACTGTCT GAGTGACCTG 
CTGGGTCATC CCTTCTTTTG GACTTGGGAG AGCCGCTATA GGACGCTTCG GAATGTGGGA 
AATGAATCCG ACATCAAAAC ACGAAAATCT GAAAGTGAGA TCCTCAGACT ACTGCAACCT 
GGGCCTTCTG AACATTCCAA AAGTTTTGAC AAGTGGACGA CTAAGATTAA TGAATGTGTT 
ATGAAAAAAA TGAATAAGTT TTATGAAAAA AGAGGCAATT TCTACCAGAA CACTGTGGGT 
GATCTGCTAA AGTTCATCCG GAATTTGGGA GAACACATTG ATGAAGAAAA GCATAAAAAG 
ATGAAATTAA AAATTGGAGA CCCTTCCCTG TATTTTCAGA AGACATTTCC AGATCTGGTG 
ATCTATGTCT ACACAAAACT ACAGAACACA GAATATAGAA AGCATTTCCC CCAAACCCAC 
AGTCCAAACA AGCCTCAGTG TGATGGAGCT GGTGGGGCCA GTGGGTTGGC CAGCCCTGGG 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066956.1
CDS	258..2483
Translation	MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC

Target ORF information:

RefSeq Version	NM_021133.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease L (RNASEL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021133.3

ORF Insert Sequence:

ATGGAGAGCA GGGATCATAA CAACCCCCAG GAGGGACCCA CGTCCTCCAG CGGTAGAAGG 
GCTGCAGTGG AAGACAATCA CTTGCTGATT AAAGCTGTTC AAAACGAAGA TGTTGACCTG 
GTCCAGCAAT TGCTGGAAGG TGGAGCCAAT GTTAATTTCC AGGAAGAGGA AGGGGGCTGG 
ACACCTCTGC ATAACGCAGT ACAAATGAGC AGGGAGGACA TTGTGGAACT TCTGCTTCGT 
CATGGTGCTG ACCCTGTTCT GAGGAAGAAG AATGGGGCCA CGCCTTTTAT CCTCGCAGCG 
ATTGCGGGGA GCGTGAAGCT GCTGAAACTT TTCCTTTCTA AAGGAGCAGA TGTCAATGAG 
TGTGATTTTT ATGGCTTCAC AGCCTTCATG GAAGCCGCTG TGTATGGTAA GGTCAAAGCC 
CTAAAATTCC TTTATAAGAG AGGAGCAAAT GTGAATTTGA GGCGAAAGAC AAAGGAGGAT 
CAAGAGCGGC TGAGGAAAGG AGGGGCCACA GCTCTCATGG ACGCTGCTGA AAAAGGACAC 
GTAGAGGTCT TGAAGATTCT CCTTGATGAG ATGGGGGCAG ATGTAAACGC CTGTGACAAT 
ATGGGCAGAA ATGCCTTGAT CCATGCTCTC CTGAGCTCTG ACGATAGTGA TGTGGAGGCT 
ATTACGCATC TGCTGCTGGA CCATGGGGCT GATGTCAATG TGAGGGGAGA AAGAGGGAAG 
ACTCCCCTGA TCCTGGCAGT GGAGAAGAAG CACTTGGGTT TGGTGCAGAG GCTTCTGGAG 
CAAGAGCACA TAGAGATTAA TGACACAGAC AGTGATGGCA AAACAGCACT GCTGCTTGCT 
GTTGAACTCA AACTGAAGAA AATCGCCGAG TTGCTGTGCA AACGTGGAGC CAGTACAGAT 
TGTGGGGATC TTGTTATGAC AGCGAGGCGG AATTATGACC ATTCCCTTGT GAAGGTTCTT 
CTCTCTCATG GAGCCAAAGA AGATTTTCAC CCTCCTGCTG AAGACTGGAA GCCTCAGAGC 
TCACACTGGG GGGCAGCCCT GAAGGATCTC CACAGAATAT ACCGCCCTAT GATTGGCAAA 
CTCAAGTTCT TTATTGATGA AAAATACAAA ATTGCTGATA CTTCAGAAGG AGGCATCTAC 
CTGGGGTTCT ATGAGAAGCA AGAAGTAGCT GTGAAGACGT TCTGTGAGGG CAGCCCACGT 
GCACAGCGGG AAGTCTCTTG TCTGCAAAGC AGCCGAGAGA ACAGTCACTT GGTGACATTC 
TATGGGAGTG AGAGCCACAG GGGCCACTTG TTTGTGTGTG TCACCCTCTG TGAGCAGACT 
CTGGAAGCGT GTTTGGATGT GCACAGAGGG GAAGATGTGG AAAATGAGGA AGATGAATTT 
GCCCGAAATG TCCTGTCATC TATATTTAAG GCTGTTCAAG AACTACACTT GTCCTGTGGA 
TACACCCACC AGGATCTGCA ACCACAAAAC ATCTTAATAG ATTCTAAGAA AGCTGCTCAC 
CTGGCAGATT TTGATAAGAG CATCAAGTGG GCTGGAGATC CACAGGAAGT CAAGAGAGAT 
CTAGAGGACC TTGGACGGCT GGTCCTCTAT GTGGTAAAGA AGGGAAGCAT CTCATTTGAG 
GATCTGAAAG CTCAAAGTAA TGAAGAGGTG GTTCAACTTT CTCCAGATGA GGAAACTAAG 
GACCTCATTC ATCGTCTCTT CCATCCTGGG GAACATGTGA GGGACTGTCT GAGTGACCTG 
CTGGGTCATC CCTTCTTTTG GACTTGGGAG AGCCGCTATA GGACGCTTCG GAATGTGGGA 
AATGAATCCG ACATCAAAAC ACGAAAATCT GAAAGTGAGA TCCTCAGACT ACTGCAACCT 
GGGCCTTCTG AACATTCCAA AAGTTTTGAC AAGTGGACGA CTAAGATTAA TGAATGTGTT 
ATGAAAAAAA TGAATAAGTT TTATGAAAAA AGAGGCAATT TCTACCAGAA CACTGTGGGT 
GATCTGCTAA AGTTCATCCG GAATTTGGGA GAACACATTG ATGAAGAAAA GCATAAAAAG 
ATGAAATTAA AAATTGGAGA CCCTTCCCTG TATTTTCAGA AGACATTTCC AGATCTGGTG 
ATCTATGTCT ACACAAAACT ACAGAACACA GAATATAGAA AGCATTTCCC CCAAACCCAC 
AGTCCAAACA AGCCTCAGTG TGATGGAGCT GGTGGGGCCA GTGGGTTGGC CAGCCCTGGG 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery.
RNA (New York, N.Y.)23(11)1660-1671(2017 11)
Donovan J,Rath S,Kolet-Mandrikov D,Korennykh A

Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
Melanoma research27(4)309-314(2017 Aug)
Sangalli A,Orlandi E,Poli A,Maurichi A,Santinami M,Nicolis M,Ferronato S,Malerba G,Rodolfo M,Gomez Lira M

Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.
PloS one12(7)e0180927(2017)
L?pez-Rodr?guez R,Hern?ndez-Bartolom? ?,Borque MJ,Rodr?guez-Mu?oz Y,Mart?n-V?lchez S,Garc?a-Buey L,Gonz?lez-Moreno L,Real-Mart?nez Y,Mu?oz de Rueda P,Salmer?n J,Vidal-Casti?eira JR,L?pez-Larrea C,Rodrigo L,Moreno-Otero R,Sanz-Cameno P

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RNASEL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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