Gene Symbol | SLC25A19 |
Entrez Gene ID | 60386 |
Full Name | solute carrier family 25 member 19 |
Synonyms | DNC,MCPHA,MUP1,THMD3,THMD4,TPC |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Microcephaly, Amish type, 607196 (3); Thiamine metabolism dysfunction syndrome 4 (progressive polyneuropathy type), 613710 (3) |