RNASE2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNASE2
Entrez Gene ID	6036
Full Name	ribonuclease A family member 2
Synonyms	EDN,RAF3,RNS2
General protein information	Preferred Names ribonuclease A family member 2 Names non-secretory ribonuclease RNase 2 RNase UpI-2 eosinophil-derived neurotoxin ribonuclease 2 ribonuclease A F3 ribonuclease US ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014].
Disorder MIM:	131410

mRNA and Protein(s)

mRNA	Protein	Name
NM_002934.2	NP_002925.1	non-secretory ribonuclease precursor
NM_002934.3	NP_002925.1	non-secretory ribonuclease precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RNASE3	XP_005211584.1
Mus musculus (house mouse)	Ear11	NP_444343.2
Mus musculus (house mouse)	Ear5	NP_062271.2
	RNASE2	XP_001094839.1
Homo sapiens (human)	RNASE2	NP_002925.1
Pan troglodytes (chimpanzee)	RNASE2	NP_001009133.1

Gene Ontology
Bibliography

Related articles in PubMed

Eosinophil-derived neurotoxin as a biomarker for disease severity and relapse in recalcitrant atopic dermatitis.
Kim HS, Kim JH, Seo YM, Chun YH, Yoon JS, Kim HH, Lee JS, Kim JT
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology119(5)441-445(2017 11)

Fecal Calprotectin and Eosinophil-derived Neurotoxin in Healthy Children Between 0 and 12 Years.
Roca M, Rodriguez Varela A, Donat E, Cano F, Hervas D, Armisen A, Vaya MJ, Sj?lander A, Ribes-Koninckx C
Journal of pediatric gastroenterology and nutrition65(4)394-398(2017 Oct)

Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma.
Gon Y, Ito R, Hattori T, Hiranuma H, Kumasawa F, Kozu Y, Endo D, Koyama D, Shintani Y, Eriko T, Soda K, Maruoka S, Hashimoto S
Allergy and asthma proceedings36(6)e113-20(2015 Nov-Dec)

Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis.
Fodil M, Teixeira VH, Chaudru V, Hilliquin P, Bombardieri S, Balsa A, Westhovens R, Barrera P, Alves H, Migliorin P, Bardin T, Cornelis F, Boudjema A, Petit-Teixeira E
Scandinavian journal of rheumatology44(1)2-7(2015)

Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome.
Wada T, Toma T, Muraoka M, Matsuda Y, Yachie A
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology25(6)617-9(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EDN serum level could be considered a candidate molecule as a clinical biomarker for evaluating atopic dermatitis activity and a predictor of relapse
Title: Eosinophil-derived neurotoxin as a biomarker for disease severity and relapse in recalcitrant atopic dermatitis.

Serum EDN level may be a useful marker for monitoring persistent airflow limitation in adult patients with asthma who had positive results for house-dust-specific IgE antibodies.
Title: Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma.

RNASE2 gene expression was differentially expressed in rheumatoid arthritis patients considering a sequence polymorphism.
Title: Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis.

increased in feces after the ingestion of enterocolitis-causative foods
Title: Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome.

mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.
Title: Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation.

The following RNASE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17066	NM_002934.3 Latest version!	Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17066	NM_002934.2	Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNASE2 ( NM_002934.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002925.1 Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.

Price & Availability↑

CloneID	OHu17066
Clone ID Related Accession (Same CDS sequence)	NM_002934.2 , NM_002934.3
Accession Version	NM_002934.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	non-secretory ribonuclease precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X55988.1 and M28129.1. On Mar 8, 2004 this sequence version replaced NM_002934.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X55988.1, M28129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 9826755 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTCCAA AACTGTTCAC TTCCCAAATT TGTCTGCTTC TTCTGTTGGG GCTTCTGGCT 
GTGGAGGGCT CACTCCATGT CAAACCTCCA CAGTTTACCT GGGCTCAATG GTTTGAAACC 
CAGCACATCA ATATGACCTC CCAGCAATGC ACCAATGCAA TGCAGGTCAT TAACAATTAT 
CAACGGCGAT GCAAAAACCA AAATACTTTC CTTCTTACAA CTTTTGCTAA CGTAGTTAAT 
GTTTGTGGTA ACCCAAATAT GACCTGTCCT AGTAACAAAA CTCGCAAAAA TTGTCACCAC 
AGTGGAAGCC AGGTGCCTTT AATCCACTGT AACCTCACAA CTCCAAGTCC ACAGAATATT 
TCAAACTGCA GGTATGCGCA GACACCAGCA AACATGTTCT ATATAGTTGC ATGTGACAAC 
AGAGATCAAC GACGAGACCC TCCACAGTAT CCGGTGGTTC CAGTTCACCT GGATAGAATC 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002925.1
CDS	72..557
Translation	MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII

Target ORF information:

RefSeq Version	NM_002934.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002934.2

ORF Insert Sequence:

ATGGTTCCAA AACTGTTCAC TTCCCAAATT TGTCTGCTTC TTCTGTTGGG GCTTCTGGCT 
GTGGAGGGCT CACTCCATGT CAAACCTCCA CAGTTTACCT GGGCTCAATG GTTTGAAACC 
CAGCACATCA ATATGACCTC CCAGCAATGC ACCAATGCAA TGCAGGTCAT TAACAATTAT 
CAACGGCGAT GCAAAAACCA AAATACTTTC CTTCTTACAA CTTTTGCTAA CGTAGTTAAT 
GTTTGTGGTA ACCCAAATAT GACCTGTCCT AGTAACAAAA CTCGCAAAAA TTGTCACCAC 
AGTGGAAGCC AGGTGCCTTT AATCCACTGT AACCTCACAA CTCCAAGTCC ACAGAATATT 
TCAAACTGCA GGTATGCGCA GACACCAGCA AACATGTTCT ATATAGTTGC ATGTGACAAC 
AGAGATCAAC GACGAGACCC TCCACAGTAT CCGGTGGTTC CAGTTCACCT GGATAGAATC 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNASE2 ( NM_002934.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002925.1 Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.

Price & Availability↑

CloneID	OHu17066
Clone ID Related Accession (Same CDS sequence)	NM_002934.2 , NM_002934.3
Accession Version	NM_002934.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	non-secretory ribonuclease precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X55988.1, M28129.1 and AL355922.4. On Nov 23, 2018 this sequence version replaced NM_002934.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.80020.1, X55988.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304625.3/ ENSP00000303276.2 Protein has antimicrobial activity :: PMID: 9826755 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTTCCAA AACTGTTCAC TTCCCAAATT TGTCTGCTTC TTCTGTTGGG GCTTCTGGCT 
GTGGAGGGCT CACTCCATGT CAAACCTCCA CAGTTTACCT GGGCTCAATG GTTTGAAACC 
CAGCACATCA ATATGACCTC CCAGCAATGC ACCAATGCAA TGCAGGTCAT TAACAATTAT 
CAACGGCGAT GCAAAAACCA AAATACTTTC CTTCTTACAA CTTTTGCTAA CGTAGTTAAT 
GTTTGTGGTA ACCCAAATAT GACCTGTCCT AGTAACAAAA CTCGCAAAAA TTGTCACCAC 
AGTGGAAGCC AGGTGCCTTT AATCCACTGT AACCTCACAA CTCCAAGTCC ACAGAATATT 
TCAAACTGCA GGTATGCGCA GACACCAGCA AACATGTTCT ATATAGTTGC ATGTGACAAC 
AGAGATCAAC GACGAGACCC TCCACAGTAT CCGGTGGTTC CAGTTCACCT GGATAGAATC 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002925.1
CDS	56..541
Translation	MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII

Target ORF information:

RefSeq Version	NM_002934.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002934.3

ORF Insert Sequence:

ATGGTTCCAA AACTGTTCAC TTCCCAAATT TGTCTGCTTC TTCTGTTGGG GCTTCTGGCT 
GTGGAGGGCT CACTCCATGT CAAACCTCCA CAGTTTACCT GGGCTCAATG GTTTGAAACC 
CAGCACATCA ATATGACCTC CCAGCAATGC ACCAATGCAA TGCAGGTCAT TAACAATTAT 
CAACGGCGAT GCAAAAACCA AAATACTTTC CTTCTTACAA CTTTTGCTAA CGTAGTTAAT 
GTTTGTGGTA ACCCAAATAT GACCTGTCCT AGTAACAAAA CTCGCAAAAA TTGTCACCAC 
AGTGGAAGCC AGGTGCCTTT AATCCACTGT AACCTCACAA CTCCAAGTCC ACAGAATATT 
TCAAACTGCA GGTATGCGCA GACACCAGCA AACATGTTCT ATATAGTTGC ATGTGACAAC 
AGAGATCAAC GACGAGACCC TCCACAGTAT CCGGTGGTTC CAGTTCACCT GGATAGAATC 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eosinophil-derived neurotoxin as a biomarker for disease severity and relapse in recalcitrant atopic dermatitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology119(5)441-445(2017 11)
Kim HS,Kim JH,Seo YM,Chun YH,Yoon JS,Kim HH,Lee JS,Kim JT

Fecal Calprotectin and Eosinophil-derived Neurotoxin in Healthy Children Between 0 and 12 Years.
Journal of pediatric gastroenterology and nutrition65(4)394-398(2017 Oct)
Roca M,Rodriguez Varela A,Donat E,Cano F,Hervas D,Armisen A,Vaya MJ,Sj?lander A,Ribes-Koninckx C

Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma.
Allergy and asthma proceedings36(6)e113-20(2015 Nov-Dec)
Gon Y,Ito R,Hattori T,Hiranuma H,Kumasawa F,Kozu Y,Endo D,Koyama D,Shintani Y,Eriko T,Soda K,Maruoka S,Hashimoto S

Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis.
Scandinavian journal of rheumatology44(1)2-7(2015)
Fodil M,Teixeira VH,Chaudru V,Hilliquin P,Bombardieri S,Balsa A,Westhovens R,Barrera P,Alves H,Migliorin P,Bardin T,Cornelis F,Boudjema A,Petit-Teixeira E

Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology25(6)617-9(2014 Oct)
Wada T,Toma T,Muraoka M,Matsuda Y,Yachie A

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RNASE2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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