Gene Symbol | BCL3 |
Entrez Gene ID | 602 |
Full Name | B cell CLL/lymphoma 3 |
Synonyms | BCL4,D19S37 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Leukemia/lymphoma, B-cell, 3 (2) |