RGS16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS16
Entrez Gene ID	6004
Full Name	regulator of G protein signaling 16
Synonyms	A28-RGS14,A28-RGS14P,RGS-R
General protein information	Preferred Names regulator of G protein signaling 16 Names regulator of G-protein signaling 16 hRGS-r regulator of G-protein signalling 16 retinal-specific RGS retinally abundant regulator of G-protein signaling
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q25.3
Summary	The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008].
Disorder MIM:	602514

mRNA and Protein(s)

mRNA	Protein	Name
XM_024448796.1	XP_024304564.1	regulator of G-protein signaling 16 isoform X1
NM_002928.3	NP_002919.3	regulator of G-protein signaling 16
NM_002928.4	NP_002919.3	regulator of G-protein signaling 16

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rgs16	NP_001071057.1
	RGS16	XP_001114540.1
Danio rerio (zebrafish)	rgs5b	NP_001017821.1
Xenopus tropicalis (tropical clawed frog)	rgs16	NP_001123855.1
Homo sapiens (human)	RGS16	NP_002919.3
Pan troglodytes (chimpanzee)	RGS16	XP_003308675.1
Canis lupus familiaris (dog)	RGS16	XP_003639229.1
Bos taurus (cattle)	RGS16	NP_776875.1
Mus musculus (house mouse)	Rgs16	NP_035397.2
Gallus gallus (chicken)	RGS16	NP_001264473.1

Gene Ontology
Bibliography

Related articles in PubMed

G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
Goto K, Doi M, Wang T, Kunisue S, Murai I, Okamura H
Endocrine journal64(6)571-579(2017 Jun)

The potential role of regulator of G-protein signaling 16 in cell motility mediated by ?EF1 family proteins.
Hoshi Y, Endo K, Shirakihara T, Fukagawa A, Miyazawa K, Saitoh M
FEBS letters590(2)270-8(2016 Jan)

miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis.
Sun X, Charbonneau C, Wei L, Chen Q, Terek RM
Molecular cancer research : MCR13(9)1347-57(2015 Sep)

RGS16 restricts the pro-inflammatory response of monocytes.
Suurv?li J, Pahtma M, Saar R, Paalme V, Nutt A, Tiivel T, Saarem?e M, Fitting C, Cavaillon JM, R??tel Boudinot S
Scandinavian journal of immunology81(1)23-30(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
Title: The potential role of regulator of G-protein signaling 16 in cell motility mediated by ?EF1 family proteins.

The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16.
Title: miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis.

these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells.
Title: RGS16 restricts the pro-inflammatory response of monocytes.

cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy.
Title: Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.

Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.
Title: Chromosome 1q25.3 copy number alterations in primary breast cancers detected by multiplex ligation-dependent probe amplification and allelic imbalance assays and its comparison with fluorescent in situ hybridization assays.

The following RGS16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03171	NM_002928.4 Latest version!	Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu105752	XM_024448796.1 Latest version!	Homo sapiens regulator of G protein signaling 16 (RGS16), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu03171	NM_002928.3	Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS16 ( NM_002928.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002919.3 Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.

Price & Availability↑

CloneID	OHu03171
Clone ID Related Accession (Same CDS sequence)	NM_002928.3 , NM_002928.4
Accession Version	NM_002928.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 16
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC349953.1, BC006243.2, DA060276.1 and AL353778.13. On Aug 24, 2007 this sequence version replaced NM_002928.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U70426.1, SRR1660805.45823.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCCGCA CCCTGGCCGC CTTCCCCACC ACCTGCCTGG AGAGAGCCAA AGAGTTCAAG 
ACACGTCTGG GGATCTTTCT TCACAAATCA GAGCTGGGCT GCGATACTGG GAGTACTGGC 
AAGTTCGAGT GGGGCAGTAA ACACAGCAAA GAGAATAGAA ACTTCTCAGA AGATGTGCTG 
GGGTGGAGAG AGTCGTTCGA CCTGCTGCTG AGCAGTAAAA ATGGAGTGGC TGCCTTCCAC 
GCTTTCCTGA AGACAGAGTT CAGTGAGGAG AACCTGGAGT TCTGGCTGGC CTGTGAGGAG 
TTCAAGAAGA TCCGATCAGC TACCAAGCTG GCCTCCAGGG CACACCAGAT CTTTGAGGAG 
TTCATTTGCA GTGAGGCCCC TAAAGAGGTC AACATTGACC ATGAGACCCA CGAGCTGACG 
AGGATGAACC TGCAGACTGC CACAGCCACA TGCTTTGATG CGGCTCAGGG GAAGACACGT 
ACCCTGATGG AGAAGGACTC CTACCCACGC TTCCTGAAGT CGCCTGCTTA CCGGGACCTG 
GCTGCCCAAG CCTCAGCCGC CTCTGCCACT CTGTCCAGCT GCAGCCTGGA CGAGCCCTCA 
CACACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002919.3
CDS	155..763
Translation	MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT

Target ORF information:

RefSeq Version	NM_002928.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002928.3

ORF Insert Sequence:

ATGTGCCGCA CCCTGGCCGC CTTCCCCACC ACCTGCCTGG AGAGAGCCAA AGAGTTCAAG 
ACACGTCTGG GGATCTTTCT TCACAAATCA GAGCTGGGCT GCGATACTGG GAGTACTGGC 
AAGTTCGAGT GGGGCAGTAA ACACAGCAAA GAGAATAGAA ACTTCTCAGA AGATGTGCTG 
GGGTGGAGAG AGTCGTTCGA CCTGCTGCTG AGCAGTAAAA ATGGAGTGGC TGCCTTCCAC 
GCTTTCCTGA AGACAGAGTT CAGTGAGGAG AACCTGGAGT TCTGGCTGGC CTGTGAGGAG 
TTCAAGAAGA TCCGATCAGC TACCAAGCTG GCCTCCAGGG CACACCAGAT CTTTGAGGAG 
TTCATTTGCA GTGAGGCCCC TAAAGAGGTC AACATTGACC ATGAGACCCA CGAGCTGACG 
AGGATGAACC TGCAGACTGC CACAGCCACA TGCTTTGATG CGGCTCAGGG GAAGACACGT 
ACCCTGATGG AGAAGGACTC CTACCCACGC TTCCTGAAGT CGCCTGCTTA CCGGGACCTG 
GCTGCCCAAG CCTCAGCCGC CTCTGCCACT CTGTCCAGCT GCAGCCTGGA CGAGCCCTCA 
CACACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS16 ( NM_002928.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002919.3 Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.

Price & Availability↑

CloneID	OHu03171
Clone ID Related Accession (Same CDS sequence)	NM_002928.3 , NM_002928.4
Accession Version	NM_002928.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 16
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC349953.1, BC006243.2, DA060276.1 and AL353778.13. On Nov 23, 2018 this sequence version replaced NM_002928.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U70426.1, SRR1660805.45823.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367558.6/ ENSP00000356529.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGCCGCA CCCTGGCCGC CTTCCCCACC ACCTGCCTGG AGAGAGCCAA AGAGTTCAAG 
ACACGTCTGG GGATCTTTCT TCACAAATCA GAGCTGGGCT GCGATACTGG GAGTACTGGC 
AAGTTCGAGT GGGGCAGTAA ACACAGCAAA GAGAATAGAA ACTTCTCAGA AGATGTGCTG 
GGGTGGAGAG AGTCGTTCGA CCTGCTGCTG AGCAGTAAAA ATGGAGTGGC TGCCTTCCAC 
GCTTTCCTGA AGACAGAGTT CAGTGAGGAG AACCTGGAGT TCTGGCTGGC CTGTGAGGAG 
TTCAAGAAGA TCCGATCAGC TACCAAGCTG GCCTCCAGGG CACACCAGAT CTTTGAGGAG 
TTCATTTGCA GTGAGGCCCC TAAAGAGGTC AACATTGACC ATGAGACCCA CGAGCTGACG 
AGGATGAACC TGCAGACTGC CACAGCCACA TGCTTTGATG CGGCTCAGGG GAAGACACGT 
ACCCTGATGG AGAAGGACTC CTACCCACGC TTCCTGAAGT CGCCTGCTTA CCGGGACCTG 
GCTGCCCAAG CCTCAGCCGC CTCTGCCACT CTGTCCAGCT GCAGCCTGGA CGAGCCCTCA 
CACACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002919.3
CDS	131..739
Translation	MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT

Target ORF information:

RefSeq Version	NM_002928.4
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 16 (RGS16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002928.4

ORF Insert Sequence:

ATGTGCCGCA CCCTGGCCGC CTTCCCCACC ACCTGCCTGG AGAGAGCCAA AGAGTTCAAG 
ACACGTCTGG GGATCTTTCT TCACAAATCA GAGCTGGGCT GCGATACTGG GAGTACTGGC 
AAGTTCGAGT GGGGCAGTAA ACACAGCAAA GAGAATAGAA ACTTCTCAGA AGATGTGCTG 
GGGTGGAGAG AGTCGTTCGA CCTGCTGCTG AGCAGTAAAA ATGGAGTGGC TGCCTTCCAC 
GCTTTCCTGA AGACAGAGTT CAGTGAGGAG AACCTGGAGT TCTGGCTGGC CTGTGAGGAG 
TTCAAGAAGA TCCGATCAGC TACCAAGCTG GCCTCCAGGG CACACCAGAT CTTTGAGGAG 
TTCATTTGCA GTGAGGCCCC TAAAGAGGTC AACATTGACC ATGAGACCCA CGAGCTGACG 
AGGATGAACC TGCAGACTGC CACAGCCACA TGCTTTGATG CGGCTCAGGG GAAGACACGT 
ACCCTGATGG AGAAGGACTC CTACCCACGC TTCCTGAAGT CGCCTGCTTA CCGGGACCTG 
GCTGCCCAAG CCTCAGCCGC CTCTGCCACT CTGTCCAGCT GCAGCCTGGA CGAGCCCTCA 
CACACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS16 ( XM_024448796.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304564.1 Homo sapiens regulator of G protein signaling 16 (RGS16), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu105752
Clone ID Related Accession (Same CDS sequence)	XM_024448796.1
Accession Version	XM_024448796.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 16 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCCGCA CCCTGGCCGC CTTCCCCACC ACCTGCCTGG AGAGAGCCAA AGAGTTCAAG 
ACACGTCTGG GGATCTTTCT TCACAAATCA GAGCTGGGCT GCGATACTGG GAGTACTGGC 
AAGTTCGAGT GGGGCAGTAA ACACAGCAAA GAGAAAAACT TCTCAGAAGA TGTGCTGGGG 
TGGAGAGAGT CGTTCGACCT GCTGCTGAGC AGTAAAAATG GAGTGGCTGC CTTCCACGCT 
TTCCTGAAGA CAGAGTTCAG TGAGGAGAAC CTGGAGTTCT GGCTGGCCTG TGAGGAGTTC 
AAGAAGATCC GATCAGCTAC CAAGCTGGCC TCCAGGGCAC ACCAGATCTT TGAGGAGTTC 
ATTTGCAGTG AGGCCCCTAA AGAGGTCAAC ATTGACCATG AGACCCACGA GCTGACGAGG 
ATGAACCTGC AGACTGCCAC AGCCACATGC TTTGATGCGG CTCAGGGGAA GACACGTACC 
CTGATGGAGA AGGACTCCTA CCCACGCTTC CTGAAGTCGC CTGCTTACCG GGACCTGGCT 
GCCCAAGCCT CAGCCGCCTC TGCCACTCTG TCCAGCTGCA GCCTGGACGA GCCCTCACAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304564.1
CDS	131..736
Translation	MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKEKNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT

Target ORF information:

RefSeq Version	XM_024448796.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 16 (RGS16), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448796.1

ORF Insert Sequence:

ATGTGCCGCA CCCTGGCCGC CTTCCCCACC ACCTGCCTGG AGAGAGCCAA AGAGTTCAAG 
ACACGTCTGG GGATCTTTCT TCACAAATCA GAGCTGGGCT GCGATACTGG GAGTACTGGC 
AAGTTCGAGT GGGGCAGTAA ACACAGCAAA GAGAAAAACT TCTCAGAAGA TGTGCTGGGG 
TGGAGAGAGT CGTTCGACCT GCTGCTGAGC AGTAAAAATG GAGTGGCTGC CTTCCACGCT 
TTCCTGAAGA CAGAGTTCAG TGAGGAGAAC CTGGAGTTCT GGCTGGCCTG TGAGGAGTTC 
AAGAAGATCC GATCAGCTAC CAAGCTGGCC TCCAGGGCAC ACCAGATCTT TGAGGAGTTC 
ATTTGCAGTG AGGCCCCTAA AGAGGTCAAC ATTGACCATG AGACCCACGA GCTGACGAGG 
ATGAACCTGC AGACTGCCAC AGCCACATGC TTTGATGCGG CTCAGGGGAA GACACGTACC 
CTGATGGAGA AGGACTCCTA CCCACGCTTC CTGAAGTCGC CTGCTTACCG GGACCTGGCT 
GCCCAAGCCT CAGCCGCCTC TGCCACTCTG TCCAGCTGCA GCCTGGACGA GCCCTCACAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
Endocrine journal64(6)571-579(2017 Jun)
Goto K,Doi M,Wang T,Kunisue S,Murai I,Okamura H

The potential role of regulator of G-protein signaling 16 in cell motility mediated by ?EF1 family proteins.
FEBS letters590(2)270-8(2016 Jan)
Hoshi Y,Endo K,Shirakihara T,Fukagawa A,Miyazawa K,Saitoh M

miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis.
Molecular cancer research : MCR13(9)1347-57(2015 Sep)
Sun X,Charbonneau C,Wei L,Chen Q,Terek RM

RGS16 restricts the pro-inflammatory response of monocytes.
Scandinavian journal of immunology81(1)23-30(2015 Jan)
Suurv?li J,Pahtma M,Saar R,Paalme V,Nutt A,Tiivel T,Saarem?e M,Fitting C,Cavaillon JM,R??tel Boudinot S

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RGS16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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