RGS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS1
Entrez Gene ID	5996
Full Name	regulator of G protein signaling 1
Synonyms	1R20,BL34,HEL-S-87,IER1,IR20
General protein information	Preferred Names regulator of G protein signaling 1 Names regulator of G-protein signaling 1 B-cell activation protein BL34 early response protein 1R20 epididymis secretory protein Li 87 immediate-early response 1, B-cell specific regulator of G-protein signalling 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.2
Summary	This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008].
Disorder MIM:	600323

mRNA and Protein(s)

mRNA	Protein	Name
NM_002922.4	NP_002913.3	regulator of G-protein signaling 1
NM_002922.3	NP_002913.3	regulator of G-protein signaling 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGS1	NP_001185992.1
Rattus norvegicus (Norway rat)	Rgs1	NP_062209.1
Xenopus tropicalis (tropical clawed frog)	rgs1	XP_002939124.2
Danio rerio (zebrafish)	rgs13	NP_001082981.1
Pan troglodytes (chimpanzee)	RGS1	XP_514068.2
Canis lupus familiaris (dog)	RGS1	XP_545702.4
Mus musculus (house mouse)	Rgs1	NP_056626.2
Gallus gallus (chicken)	RGS1	XP_422203.3
Homo sapiens (human)	RGS1	NP_002913.3
	RGS1	XP_001112975.1
Danio rerio (zebrafish)	LOC792554	XP_001332101.5

Gene Ontology
Bibliography

Related articles in PubMed

RGS1 expression is associated with poor prognosis in multiple myeloma.
Roh J, Shin SJ, Lee AN, Yoon DH, Suh C, Park CJ, Huh J, Park CS
Journal of clinical pathology70(3)202-207(2017 Mar)

Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival in DLBCL not otherwise specified (NOS).
Carreras J, Kikuti YY, Be? S, Miyaoka M, Hiraiwa S, Ikoma H, Nagao R, Tomita S, Martin-Garcia D, Salaverria I, Sato A, Ichiki A, Roncador G, Garcia JF, Ando K, Campo E, Nakamura N
Histopathology70(4)595-621(2017 Mar)

Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy.
Zhou XJ, Nath SK, Qi YY, Sun C, Hou P, Zhang YM, Lv JC, Shi SF, Liu LJ, Chen R, Yang W, He KZ, Li Y, Zhang H
Scientific reports635781(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new multiple myeloma therapy.
Title: RGS1 expression is associated with poor prognosis in multiple myeloma.

High RGS1 immunohistochemistry expression associates with poor overall survival in diffuse large B cell lymphoma
Title: Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival in DLBCL not otherwise specified (NOS).

Regulator of G-protein signaling 1 rs2816316 was negatively associated with celiac disease .
Title: Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk.

RGS1 suppresses CXCL12-mediated migration and AKT activation in cultured human plasmacytoma cells and plasmablasts.
Title: Regulator of G protein signaling 1 suppresses CXCL12-mediated migration and AKT activation in RPMI 8226 human plasmacytoma cells and plasmablasts.

RGS1 as a potential marker of CRC tissue quality
Title: Identification and Validation of a Potential Marker of Tissue Quality Using Gene Expression Analysis of Human Colorectal Tissue.

The following RGS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17347	NM_002922.4 Latest version!	Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
View Old Accession Versions >>
OHu17347	NM_002922.3	Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS1 ( NM_002922.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002913.3 Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.

Price & Availability↑

CloneID	OHu17347
Clone ID Related Accession (Same CDS sequence)	NM_002922.4 , NM_002922.3
Accession Version	NM_002922.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG536972.1, BC015510.1 and AL136987.11. On Nov 22, 2018 this sequence version replaced NM_002922.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.75274.1, SRR1163658.201085.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367459.8/ ENSP00000356429.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCGCAG CAGCCATCTC CACTCCAAAG TTAGACAAAA TGCCAGGAAT GTTCTTCTCT 
GCTAACCCAA AGGAATTGAA AGGAACCACT CATTCACTTC TAGACGACAA AATGCAAAAA 
AGGAGGCCAA AGACTTTTGG AATGGATATG AAAGCATACC TGAGATCTAT GATCCCACAT 
CTGGAATCTG GAATGAAATC TTCCAAGTCC AAGGATGTAC TTTCTGCTGC TGAAGTAATG 
CAATGGTCTC AATCTCTGGA AAAACTTCTT GCCAACCAAA CTGGTCAAAA TGTCTTTGGA 
AGTTTCCTAA AGTCTGAATT CAGTGAGGAG AATATTGAGT TCTGGCTGGC TTGTGAAGAC 
TATAAGAAAA CAGAGTCTGA TCTTTTGCCC TGTAAAGCAG AAGAGATATA TAAAGCATTT 
GTGCATTCAG ATGCTGCTAA ACAAATCAAT ATTGACTTCC GCACTCGAGA ATCTACAGCC 
AAGAAGATTA AAGCACCAAC CCCCACGTGT TTTGATGAAG CACAAAAAGT CATATATACT 
CTTATGGAAA AGGACTCTTA TCCCAGGTTC CTCAAATCAG ATATTTACTT AAATCTTCTA 
AATGACCTGC AGGCTAATAG CCTAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002913.3
CDS	21..650
Translation	MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK

Target ORF information:

RefSeq Version	NM_002922.4
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002922.4

ORF Insert Sequence:

ATGCGCGCAG CAGCCATCTC CACTCCAAAG TTAGACAAAA TGCCAGGAAT GTTCTTCTCT 
GCTAACCCAA AGGAATTGAA AGGAACCACT CATTCACTTC TAGACGACAA AATGCAAAAA 
AGGAGGCCAA AGACTTTTGG AATGGATATG AAAGCATACC TGAGATCTAT GATCCCACAT 
CTGGAATCTG GAATGAAATC TTCCAAGTCC AAGGATGTAC TTTCTGCTGC TGAAGTAATG 
CAATGGTCTC AATCTCTGGA AAAACTTCTT GCCAACCAAA CTGGTCAAAA TGTCTTTGGA 
AGTTTCCTAA AGTCTGAATT CAGTGAGGAG AATATTGAGT TCTGGCTGGC TTGTGAAGAC 
TATAAGAAAA CAGAGTCTGA TCTTTTGCCC TGTAAAGCAG AAGAGATATA TAAAGCATTT 
GTGCATTCAG ATGCTGCTAA ACAAATCAAT ATTGACTTCC GCACTCGAGA ATCTACAGCC 
AAGAAGATTA AAGCACCAAC CCCCACGTGT TTTGATGAAG CACAAAAAGT CATATATACT 
CTTATGGAAA AGGACTCTTA TCCCAGGTTC CTCAAATCAG ATATTTACTT AAATCTTCTA 
AATGACCTGC AGGCTAATAG CCTAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS1 ( NM_002922.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002913.3 Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.

Price & Availability↑

CloneID	OHu17347
Clone ID Related Accession (Same CDS sequence)	NM_002922.4 , NM_002922.3
Accession Version	NM_002922.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG536972.1, BC015510.1 and AL136987.11. On Dec 16, 2004 this sequence version replaced NM_002922.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.311249.1, SRR1163658.96503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGCAG CAGCCATCTC CACTCCAAAG TTAGACAAAA TGCCAGGAAT GTTCTTCTCT 
GCTAACCCAA AGGAATTGAA AGGAACCACT CATTCACTTC TAGACGACAA AATGCAAAAA 
AGGAGGCCAA AGACTTTTGG AATGGATATG AAAGCATACC TGAGATCTAT GATCCCACAT 
CTGGAATCTG GAATGAAATC TTCCAAGTCC AAGGATGTAC TTTCTGCTGC TGAAGTAATG 
CAATGGTCTC AATCTCTGGA AAAACTTCTT GCCAACCAAA CTGGTCAAAA TGTCTTTGGA 
AGTTTCCTAA AGTCTGAATT CAGTGAGGAG AATATTGAGT TCTGGCTGGC TTGTGAAGAC 
TATAAGAAAA CAGAGTCTGA TCTTTTGCCC TGTAAAGCAG AAGAGATATA TAAAGCATTT 
GTGCATTCAG ATGCTGCTAA ACAAATCAAT ATTGACTTCC GCACTCGAGA ATCTACAGCC 
AAGAAGATTA AAGCACCAAC CCCCACGTGT TTTGATGAAG CACAAAAAGT CATATATACT 
CTTATGGAAA AGGACTCTTA TCCCAGGTTC CTCAAATCAG ATATTTACTT AAATCTTCTA 
AATGACCTGC AGGCTAATAG CCTAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002913.3
CDS	67..696
Translation	MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK

Target ORF information:

RefSeq Version	NM_002922.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 1 (RGS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002922.3

ORF Insert Sequence:

ATGCGCGCAG CAGCCATCTC CACTCCAAAG TTAGACAAAA TGCCAGGAAT GTTCTTCTCT 
GCTAACCCAA AGGAATTGAA AGGAACCACT CATTCACTTC TAGACGACAA AATGCAAAAA 
AGGAGGCCAA AGACTTTTGG AATGGATATG AAAGCATACC TGAGATCTAT GATCCCACAT 
CTGGAATCTG GAATGAAATC TTCCAAGTCC AAGGATGTAC TTTCTGCTGC TGAAGTAATG 
CAATGGTCTC AATCTCTGGA AAAACTTCTT GCCAACCAAA CTGGTCAAAA TGTCTTTGGA 
AGTTTCCTAA AGTCTGAATT CAGTGAGGAG AATATTGAGT TCTGGCTGGC TTGTGAAGAC 
TATAAGAAAA CAGAGTCTGA TCTTTTGCCC TGTAAAGCAG AAGAGATATA TAAAGCATTT 
GTGCATTCAG ATGCTGCTAA ACAAATCAAT ATTGACTTCC GCACTCGAGA ATCTACAGCC 
AAGAAGATTA AAGCACCAAC CCCCACGTGT TTTGATGAAG CACAAAAAGT CATATATACT 
CTTATGGAAA AGGACTCTTA TCCCAGGTTC CTCAAATCAG ATATTTACTT AAATCTTCTA 
AATGACCTGC AGGCTAATAG CCTAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RGS1 expression is associated with poor prognosis in multiple myeloma.
Journal of clinical pathology70(3)202-207(2017 Mar)
Roh J,Shin SJ,Lee AN,Yoon DH,Suh C,Park CJ,Huh J,Park CS

Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival in DLBCL not otherwise specified (NOS).
Histopathology70(4)595-621(2017 Mar)
Carreras J,Kikuti YY,Be? S,Miyaoka M,Hiraiwa S,Ikoma H,Nagao R,Tomita S,Martin-Garcia D,Salaverria I,Sato A,Ichiki A,Roncador G,Garcia JF,Ando K,Campo E,Nakamura N

Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy.
Scientific reports635781(2016 Nov)
Zhou XJ,Nath SK,Qi YY,Sun C,Hou P,Zhang YM,Lv JC,Shi SF,Liu LJ,Chen R,Yang W,He KZ,Li Y,Zhang H

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RGS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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