BCL2A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCL2A1
Entrez Gene ID	597
Full Name	BCL2 related protein A1
Synonyms	ACC-1,ACC-2,ACC1,ACC2,BCL2L5,BFL1,GRS,HBPA1
General protein information	Preferred Names BCL2 related protein A1 Names bcl-2-related protein A1 bcl-2-like protein 5 bcl2-L-5 hematopoietic BCL2-related protein A1 hemopoietic-specific early response protein protein BFL-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.1
Summary	This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	601056

mRNA and Protein(s)

mRNA	Protein	Name
NM_001114735.2	NP_001108207.1	bcl-2-related protein A1 isoform 2
NM_001114735.1	NP_001108207.1	bcl-2-related protein A1 isoform 2
NM_004049.4	NP_004040.1	bcl-2-related protein A1 isoform 1
NM_004049.3	NP_004040.1	bcl-2-related protein A1 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BCL2A1	XP_003314865.1
	BCL2A1	XP_001109281.2
Mus musculus (house mouse)	Bcl2a1b	NP_031560.2
Mus musculus (house mouse)	Bcl2a1d	NP_031562.1
Canis lupus familiaris (dog)	BCL2A1	XP_545888.4
Bos taurus (cattle)	BCL2A1	NP_001032177.1
Rattus norvegicus (Norway rat)	Bcl2a1	NP_596907.1
Homo sapiens (human)	BCL2A1	NP_004040.1
Mus musculus (house mouse)	Bcl2a1a	NP_033872.1
Gallus gallus (chicken)	BCL2A1	NP_990197.1

Gene Ontology
Bibliography

Related articles in PubMed

Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Harvey EP, Seo HS, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD
Structure (London, England : 1993)26(1)153-160.e4(2018 Jan)

Immunohistochemical Expression and Clinical Significance of Wnt11 and BCL2A1 in Complete Moles.
Hao Z, L? W, Cheng X, Zhou C
Analytical and quantitative cytopathology and histopathology38(2)79-86(2016 Apr)

Role of the pro-survival molecule Bfl-1 in melanoma.
Hind CK, Carter MJ, Harris CL, Chan HT, James S, Cragg MS
The international journal of biochemistry & cell biology5994-102(2015 Feb)

IFN-? regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.
Medina-Echeverz J, Haile LA, Zhao F, Gamrekelashvili J, Ma C, M?tais JY, Dunbar CE, Kapoor V, Manns MP, Korangy F, Greten TF
European journal of immunology44(8)2457-67(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Demonstrate immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi.
Title: Immunohistochemical Expression and Clinical Significance of Wnt11 and BCL2A1 in Complete Moles.

Bfl-1 was mitochondrially resident in both resting and apoptotic cells and experienced regulation by the proteasome and NFkappaB pathways.
Title: Role of the pro-survival molecule Bfl-1 in melanoma.

Bcl2a1 overexpressing granulocytic MDSCs demonstrated prolonged survival.
Title: IFN-? regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

Results indicate that mismatches in minor H antigens HA-8 (KIAA0020) and ACC-1 (BCL2A1) predisposed to chronic graft-versus-host disease (GvHD).
Title: Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.

BCL2A1 is a novel marker associated with seizure prognosis following surgery for low-grade brain neoplasms.
Title: BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas.

The following BCL2A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04244	NM_004049.4 Latest version!	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu19217	NM_001114735.2 Latest version!	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19217	NM_001114735.1	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04244	NM_004049.3	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCL2A1 ( NM_004049.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004040.1 Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04244
Clone ID Related Accession (Same CDS sequence)	NM_004049.4 , NM_004049.3
Accession Version	NM_004049.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	bcl-2-related protein A1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG198875.1 and U27467.1. On Nov 22, 2018 this sequence version replaced NM_004049.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y09397.1, SRR1163655.13913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000267953.4/ ENSP00000267953.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GAAAATGGCT TTGTAAAGAA GTTTGAACCT AAATCTGGCT GGATGACTTT TCTAGAAGTT 
ACAGGAAAGA TCTGTGAAAT GCTATCTCTC CTGAAGCAAT ACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004040.1
CDS	78..605
Translation	MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC

Target ORF information:

RefSeq Version	NM_004049.4
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004049.4

ORF Insert Sequence:

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GAAAATGGCT TTGTAAAGAA GTTTGAACCT AAATCTGGCT GGATGACTTT TCTAGAAGTT 
ACAGGAAAGA TCTGTGAAAT GCTATCTCTC CTGAAGCAAT ACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2A1 ( NM_004049.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004040.1 Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04244
Clone ID Related Accession (Same CDS sequence)	NM_004049.4 , NM_004049.3
Accession Version	NM_004049.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	bcl-2-related protein A1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG198875.1, U27467.1 and BG204033.1. On Feb 22, 2008 this sequence version replaced NM_004049.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.156334.1, SRR1163655.504897.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GAAAATGGCT TTGTAAAGAA GTTTGAACCT AAATCTGGCT GGATGACTTT TCTAGAAGTT 
ACAGGAAAGA TCTGTGAAAT GCTATCTCTC CTGAAGCAAT ACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004040.1
CDS	183..710
Translation	MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC

Target ORF information:

RefSeq Version	NM_004049.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004049.3

ORF Insert Sequence:

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GAAAATGGCT TTGTAAAGAA GTTTGAACCT AAATCTGGCT GGATGACTTT TCTAGAAGTT 
ACAGGAAAGA TCTGTGAAAT GCTATCTCTC CTGAAGCAAT ACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2A1 ( NM_001114735.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001108207.1 Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19217
Clone ID Related Accession (Same CDS sequence)	NM_001114735.2 , NM_001114735.1
Accession Version	NM_001114735.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	bcl-2-related protein A1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG198875.1, AY234180.1, CD640106.1 and BG204033.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_001114735.1. Transcript Variant: This variant (2) has an additional exon in the coding region, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.445958.1, SRR1163658.317067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GGGAAATGGC ACAATCACAC ACCTATGCTG GTAGAGTCAG TGGCCCACAA GAAGAGGAAA 
ATGGCTTTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108207.1
CDS	78..569
Translation	MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWGKWHNHTPMLVESVAHKKRKMAL

Target ORF information:

RefSeq Version	NM_001114735.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114735.2

ORF Insert Sequence:

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GGGAAATGGC ACAATCACAC ACCTATGCTG GTAGAGTCAG TGGCCCACAA GAAGAGGAAA 
ATGGCTTTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2A1 ( NM_001114735.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001108207.1 Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19217
Clone ID Related Accession (Same CDS sequence)	NM_001114735.2 , NM_001114735.1
Accession Version	NM_001114735.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	bcl-2-related protein A1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG198875.1, AY234180.1, CD640106.1 and BG204033.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) has an additional exon in the coding region, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.324181.1, SRR1163657.197877.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GGGAAATGGC ACAATCACAC ACCTATGCTG GTAGAGTCAG TGGCCCACAA GAAGAGGAAA 
ATGGCTTTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108207.1
CDS	183..674
Translation	MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWGKWHNHTPMLVESVAHKKRKMAL

Target ORF information:

RefSeq Version	NM_001114735.1
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114735.1

ORF Insert Sequence:

ATGACAGACT GTGAATTTGG ATATATTTAC AGGCTGGCTC AGGACTATCT GCAGTGCGTC 
CTACAGATAC CACAACCTGG ATCAGGTCCA AGCAAAACGT CCAGAGTGCT ACAAAATGTT 
GCGTTCTCAG TCCAAAAAGA AGTGGAAAAG AATCTGAAGT CATGCTTGGA CAATGTTAAT 
GTTGTGTCCG TAGACACTGC CAGAACACTA TTCAACCAAG TGATGGAAAA GGAGTTTGAA 
GACGGCATCA TTAACTGGGG AAGAATTGTA ACCATATTTG CATTTGAAGG TATTCTCATC 
AAGAAACTTC TACGACAGCA AATTGCCCCG GATGTGGATA CCTATAAGGA GATTTCATAT 
TTTGTTGCGG AGTTCATAAT GAATAACACA GGAGAATGGA TAAGGCAAAA CGGAGGCTGG 
GGGAAATGGC ACAATCACAC ACCTATGCTG GTAGAGTCAG TGGCCCACAA GAAGAGGAAA 
ATGGCTTTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Structure (London, England : 1993)26(1)153-160.e4(2018 Jan)
Harvey EP,Seo HS,Guerra RM,Bird GH,Dhe-Paganon S,Walensky LD

Immunohistochemical Expression and Clinical Significance of Wnt11 and BCL2A1 in Complete Moles.
Analytical and quantitative cytopathology and histopathology38(2)79-86(2016 Apr)
Hao Z,L? W,Cheng X,Zhou C

Role of the pro-survival molecule Bfl-1 in melanoma.
The international journal of biochemistry & cell biology5994-102(2015 Feb)
Hind CK,Carter MJ,Harris CL,Chan HT,James S,Cragg MS

IFN-? regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.
European journal of immunology44(8)2457-67(2014 Aug)
Medina-Echeverz J,Haile LA,Zhao F,Gamrekelashvili J,Ma C,M?tais JY,Dunbar CE,Kapoor V,Manns MP,Korangy F,Greten TF

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BCL2A1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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