BCL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCL2
Entrez Gene ID	596
Full Name	BCL2, apoptosis regulator
Synonyms	Bcl-2,PPP1R50
General protein information	Preferred Names BCL2, apoptosis regulator Names apoptosis regulator Bcl-2 B-cell CLL/lymphoma 2 protein phosphatase 1, regulatory subunit 50
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.33
Summary	This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	151430
Disorder Html:	Leukemia/lymphoma, B-cell, 2 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017025917.2	XP_016881406.1	apoptosis regulator Bcl-2 isoform X2
XM_011526135.2	XP_011524437.1	apoptosis regulator Bcl-2 isoform X1
XM_017025917.1	XP_016881406.1	apoptosis regulator Bcl-2 isoform X2
XM_011526135.3	XP_011524437.1	apoptosis regulator Bcl-2 isoform X1
NM_000633.2	NP_000624.2	apoptosis regulator Bcl-2 isoform alpha
NM_000657.2	NP_000648.2	apoptosis regulator Bcl-2 isoform beta

Pathways from BioSystems

Homologies

Homo sapiens (human)	BCL2	NP_000624.2
Pan troglodytes (chimpanzee)	BCL2	XP_001145537.1
Canis lupus familiaris (dog)	BCL2	NP_001002949.1
Xenopus tropicalis (tropical clawed frog)	bcl2	XP_002934442.1
Bos taurus (cattle)	BCL2	NP_001159958.1
Rattus norvegicus (Norway rat)	Bcl2	NP_058689.1
Gallus gallus (chicken)	BCL2	NP_990670.1
Mus musculus (house mouse)	Bcl2	NP_033871.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia.
Salomons GS, Buitenhuis CK, Mart?nez Mu?oz C, Verwijs-Jassen M, Behrendt H, Zsiros J, Smets LA
International journal of cancer79(3)273-7(1998 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data strongly suggest that concurrent BCL2 and HDAC inhibition may offer synergy in the treatment of patients with advanced CTCL. By using combination therapies and correlating response to gene expression in this way, we hope to achieve more effective and personalized treatments for CTCL.
Title: Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients.

Our findings suggest that RACK1 promotes proliferation and radioresistance in ESCC cells by activating the AKT pathway, upregulating Bcl-2 expression and downregulating protein levels of Bim. Our study fills in gaps in the field of RACK1 and radiation resistance and may provide new possibilities for improving strategies of radiotherapy in esophageal cancer.
Title: RACK1 promotes radiation resistance in esophageal cancer via regulating AKT pathway and Bcl-2 expression.

miR-143 acts as a suppressor in the growth of HemECs, at least partially, through downregulation of Bcl-2.
Title: microRNA-143 acts as a suppressor of hemangioma growth by targeting Bcl-2.

MYC and BCL2 genetic alterations were profiled using next-generation sequencing and high-resolution single nucleotide polymorphism array in 347 de novo diffuse large B-cell lymphoma cases.
Title: Genetic profiling of

the expression of Bcl2 was significantly increased in the apex, and the left and right ventricle of the heart in patients with dilated cardiomyopathy.
Title: Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy.

The following BCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25321	NM_000657.2 Latest version!	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant beta, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25505	NM_000633.2 Latest version!	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu51275	XM_011526135.3 Latest version!	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu88004	XM_017025917.2 Latest version!	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu88004	XM_017025917.1	Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu51275	XM_011526135.2	Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCL2 ( NM_000657.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000648.2 Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant beta, mRNA.

Price & Availability↑

CloneID	OHu25321
Clone ID Related Accession (Same CDS sequence)	NM_000657.2
Accession Version	NM_000657.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	apoptosis regulator Bcl-2 isoform beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021803.8 and AI401297.1. This sequence is a reference standard in the RefSeqGene project. On Aug 10, 2005 this sequence version replaced NM_000657.1. Transcript Variant: This variant (beta) differs in the 3' UTR and coding region compared to variant alpha. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.381699.1, SRR1163657.449367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta regulatory uORF :: PMID: 9645350 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGTAGG TGCACTTGGT 
GATGTGAGTC TGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000648.2
CDS	494..1111
Translation	MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWVGALGDVSLG

Target ORF information:

RefSeq Version	NM_000657.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant beta, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000657.2

ORF Insert Sequence:

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGTAGG TGCACTTGGT 
GATGTGAGTC TGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( NM_000633.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000624.2 Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA.

Price & Availability↑

CloneID	OHu25505
Clone ID Related Accession (Same CDS sequence)	NM_000633.2
Accession Version	NM_000633.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	apoptosis regulator Bcl-2 isoform alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021803.8, BC027258.1 and AC022726.13. This sequence is a reference standard in the RefSeqGene project. On Aug 10, 2005 this sequence version replaced NM_000633.1. Transcript Variant: This variant (alpha) represents the longer transcript and encodes the longer isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027258.1, SRR1803616.104374.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein regulatory uORF :: PMID: 9645350 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGATGC CTTTGTGGAA 
CTGTACGGCC CCAGCATGCG GCCTCTGTTT GATTTCTCCT GGCTGTCTCT GAAGACTCTG 
CTCAGTTTGG CCCTGGTGGG AGCTTGCATC ACCCTGGGTG CCTATCTGGG CCACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000624.2
CDS	494..1213
Translation	MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

Target ORF information:

RefSeq Version	NM_000633.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000633.2

ORF Insert Sequence:

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGATGC CTTTGTGGAA 
CTGTACGGCC CCAGCATGCG GCCTCTGTTT GATTTCTCCT GGCTGTCTCT GAAGACTCTG 
CTCAGTTTGG CCCTGGTGGG AGCTTGCATC ACCCTGGGTG CCTATCTGGG CCACAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( XM_011526135.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524437.1 Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu51275
Clone ID Related Accession (Same CDS sequence)	XM_011526135.2 , XM_011526135.3
Accession Version	XM_011526135.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	apoptosis regulator Bcl-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526135.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGATGC CCTTGTGTTA 
TTTGCAGGGC TAAGGGAGTT TCAGCATGGG CCAGGAAACT ACTTTCTTAA AAGAAACTTA 
AACGCGAAAT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524437.1
CDS	1113..1787
Translation	MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDALVLFAGLREFQHGPGNYFLKRNLNAKF

Target ORF information:

RefSeq Version	XM_011526135.2
Organism	Homo sapiens(human)
Definition	Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526135.2

ORF Insert Sequence:

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGATGC CCTTGTGTTA 
TTTGCAGGGC TAAGGGAGTT TCAGCATGGG CCAGGAAACT ACTTTCTTAA AAGAAACTTA 
AACGCGAAAT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( XM_011526135.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524437.1 Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu51275
Clone ID Related Accession (Same CDS sequence)	XM_011526135.2 , XM_011526135.3
Accession Version	XM_011526135.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis regulator Bcl-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011526135.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGATGC CCTTGTGTTA 
TTTGCAGGGC TAAGGGAGTT TCAGCATGGG CCAGGAAACT ACTTTCTTAA AAGAAACTTA 
AACGCGAAAT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524437.1
CDS	1397..2071
Translation	MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDALVLFAGLREFQHGPGNYFLKRNLNAKF

Target ORF information:

RefSeq Version	XM_011526135.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526135.3

ORF Insert Sequence:

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGGATGC CCTTGTGTTA 
TTTGCAGGGC TAAGGGAGTT TCAGCATGGG CCAGGAAACT ACTTTCTTAA AAGAAACTTA 
AACGCGAAAT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( XM_017025917.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881406.1 Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu88004
Clone ID Related Accession (Same CDS sequence)	XM_017025917.2 , XM_017025917.1
Accession Version	XM_017025917.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	apoptosis regulator Bcl-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017025917.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGCTTTA CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881406.1
CDS	1392..1988
Translation	MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWLYM

Target ORF information:

RefSeq Version	XM_017025917.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025917.2

ORF Insert Sequence:

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGCTTTA CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( XM_017025917.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881406.1 Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X3, mRNA.

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CloneID	OHu88004
Clone ID Related Accession (Same CDS sequence)	XM_017025917.2 , XM_017025917.1
Accession Version	XM_017025917.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	apoptosis regulator Bcl-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGCTTTA CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881406.1
CDS	892..1488
Translation	MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWLYM

Target ORF information:

RefSeq Version	XM_017025917.1
Organism	Homo sapiens(human)
Definition	Homo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025917.1

ORF Insert Sequence:

ATGGCGCACG CTGGGAGAAC AGGGTACGAT AACCGGGAGA TAGTGATGAA GTACATCCAT 
TATAAGCTGT CGCAGAGGGG CTACGAGTGG GATGCGGGAG ATGTGGGCGC CGCGCCCCCG 
GGGGCCGCCC CCGCACCGGG CATCTTCTCC TCCCAGCCCG GGCACACGCC CCATCCAGCC 
GCATCCCGGG ACCCGGTCGC CAGGACCTCG CCGCTGCAGA CCCCGGCTGC CCCCGGCGCC 
GCCGCGGGGC CTGCGCTCAG CCCGGTGCCA CCTGTGGTCC ACCTGACCCT CCGCCAGGCC 
GGCGACGACT TCTCCCGCCG CTACCGCCGC GACTTCGCCG AGATGTCCAG CCAGCTGCAC 
CTGACGCCCT TCACCGCGCG GGGACGCTTT GCCACGGTGG TGGAGGAGCT CTTCAGGGAC 
GGGGTGAACT GGGGGAGGAT TGTGGCCTTC TTTGAGTTCG GTGGGGTCAT GTGTGTGGAG 
AGCGTCAACC GGGAGATGTC GCCCCTGGTG GACAACATCG CCCTGTGGAT GACTGAGTAC 
CTGAACCGGC ACCTGCACAC CTGGATCCAG GATAACGGAG GCTGGCTTTA CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia.
International journal of cancer79(3)273-7(1998 Jun)
Salomons GS,Buitenhuis CK,Mart?nez Mu?oz C,Verwijs-Jassen M,Behrendt H,Zsiros J,Smets LA

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BCL2 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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