RCVRN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RCVRN
Entrez Gene ID	5957
Full Name	recoverin
Synonyms	RCV1
General protein information	Preferred Names recoverin Names recoverin cancer associated retinopathy antigen cancer-associated retinopathy protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008].
Disorder MIM:	179618

mRNA and Protein(s)

mRNA	Protein	Name
NM_002903.2	NP_002894.1	recoverin
NM_002903.3	NP_002894.1	recoverin

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RCVRN	XP_511841.2
Rattus norvegicus (Norway rat)	Rcvrn	NP_543177.1
Danio rerio (zebrafish)	rcvrna	NP_001025419.1
Homo sapiens (human)	RCVRN	NP_002894.1
	RCVRN	XP_001113548.1
Mus musculus (house mouse)	Rcvrn	NP_033064.1
Danio rerio (zebrafish)	LOC792903	XP_001332545.4
Canis lupus familiaris (dog)	RCVRN	NP_001014303.1
Bos taurus (cattle)	RCVRN	NP_776590.1
Xenopus tropicalis (tropical clawed frog)	rcvrn.1	XP_002937040.1

Gene Ontology
Bibliography

Related articles in PubMed

The cancer-retina antigen recoverin as a potential biomarker for renal tumors.
Golovastova MO, Tsoy LV, Bocharnikova AV, Korolev DO, Gancharova OS, Alekseeva EA, Kuznetsova EB, Savvateeva LV, Skorikova EE, Strelnikov VV, Varshavsky VA, Vinarov AZ, Nikolenko VN, Glybochko PV, Zernii EY, Zamyatnin AA Jr, Bazhin AV, Philippov PP
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(7)9899-907(2016 Jul)

Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.
Kumar RP, Ranaghan MJ, Ganjei AY, Oprian DD
Biochemistry54(49)7222-8(2015 Dec)

Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association.
Permyakov SE, Zernii EY, Knyazeva EL, Denesyuk AI, Nazipova AA, Kolpakova TV, Zinchenko DV, Philippov PP, Permyakov EA, Senin II
Amino acids42(4)1435-42(2012 Apr)

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Oshikawa M, Tsutsui C, Ikegami T, Fuchida Y, Matsubara M, Toyama S, Usami R, Ohtoko K, Kato S
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High RCVRN expression is associated with renal tumors.
Title: The cancer-retina antigen recoverin as a potential biomarker for renal tumors.

Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.
Title: Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.

C39D substitution reduces alpha-helical content, decreases thermal stability and suppresses membrane association.
Title: Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association.

Aberrant hypomethylation of the recoverin gene region, overlapping the promoter up-stream of the first exon and the first exon itself, is involved in the aberrant expression of recoverin in tumor cells.
Title: Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells.

A GRK1 region close to its C-terminus also seemed to be the binding site for S-modulin/recoverin.
Title: Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.

The following RCVRN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RCVRN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03993	NM_002903.3 Latest version!	Homo sapiens recoverin (RCVRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03993	NM_002903.2	Homo sapiens recoverin (RCVRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RCVRN ( NM_002903.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002894.1 Homo sapiens recoverin (RCVRN), mRNA.

Price & Availability↑

CloneID	OHu03993
Clone ID Related Accession (Same CDS sequence)	NM_002903.2 , NM_002903.3
Accession Version	NM_002903.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	recoverin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from S43855.1 and BC001720.1. On Dec 10, 2004 this sequence version replaced NM_002903.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S43855.1, S45545.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAACA GCAAAAGTGG GGCCCTGTCC AAGGAGATCC TGGAGGAGCT GCAGCTGAAC 
ACCAAGTTCT CGGAGGAGGA GCTGTGCTCC TGGTACCAGT CCTTCCTGAA GGACTGTCCC 
ACCGGCCGCA TCACCCAGCA GCAGTTCCAG AGCATCTACG CCAAGTTCTT CCCCGACACC 
GACCCCAAGG CCTACGCCCA GCATGTGTTC CGCAGCTTCG ATTCCAACCT CGACGGCACC 
CTGGACTTCA AGGAGTACGT CATCGCCCTG CACATGACCA CCGCGGGCAA GACCAACCAG 
AAGCTGGAGT GGGCCTTCTC CCTCTACGAC GTGGACGGTA ACGGGACCAT CAGCAAGAAT 
GAAGTGCTGG AGATCGTCAT GGCTATTTTC AAAATGATCA CTCCCGAGGA CGTGAAGCTC 
CTTCCAGACG ATGAAAACAC GCCGGAAAAG CGAGCCGAGA AGATCTGGAA GTACTTTGGA 
AAGAATGATG ATGATAAACT TACAGAGAAA GAATTCATTG AGGGGACACT GGCCAATAAG 
GAAATTCTGC GACTGATCCA GTTTGAGCCT CAAAAAGTGA AGGAAAAGAT GAAGAACGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002894.1
CDS	188..790
Translation	MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKMKNA

Target ORF information:

RefSeq Version	NM_002903.2
Organism	Homo sapiens(human)
Definition	Homo sapiens recoverin (RCVRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002903.2

ORF Insert Sequence:

ATGGGGAACA GCAAAAGTGG GGCCCTGTCC AAGGAGATCC TGGAGGAGCT GCAGCTGAAC 
ACCAAGTTCT CGGAGGAGGA GCTGTGCTCC TGGTACCAGT CCTTCCTGAA GGACTGTCCC 
ACCGGCCGCA TCACCCAGCA GCAGTTCCAG AGCATCTACG CCAAGTTCTT CCCCGACACC 
GACCCCAAGG CCTACGCCCA GCATGTGTTC CGCAGCTTCG ATTCCAACCT CGACGGCACC 
CTGGACTTCA AGGAGTACGT CATCGCCCTG CACATGACCA CCGCGGGCAA GACCAACCAG 
AAGCTGGAGT GGGCCTTCTC CCTCTACGAC GTGGACGGTA ACGGGACCAT CAGCAAGAAT 
GAAGTGCTGG AGATCGTCAT GGCTATTTTC AAAATGATCA CTCCCGAGGA CGTGAAGCTC 
CTTCCAGACG ATGAAAACAC GCCGGAAAAG CGAGCCGAGA AGATCTGGAA GTACTTTGGA 
AAGAATGATG ATGATAAACT TACAGAGAAA GAATTCATTG AGGGGACACT GGCCAATAAG 
GAAATTCTGC GACTGATCCA GTTTGAGCCT CAAAAAGTGA AGGAAAAGAT GAAGAACGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RCVRN ( NM_002903.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002894.1 Homo sapiens recoverin (RCVRN), mRNA.

Price & Availability↑

CloneID	OHu03993
Clone ID Related Accession (Same CDS sequence)	NM_002903.2 , NM_002903.3
Accession Version	NM_002903.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	recoverin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from S43855.1, BC001720.1 and AC026591.15. On May 17, 2019 this sequence version replaced NM_002903.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL712005.1, S43855.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000226193.6/ ENSP00000226193.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGAACA GCAAAAGTGG GGCCCTGTCC AAGGAGATCC TGGAGGAGCT GCAGCTGAAC 
ACCAAGTTCT CGGAGGAGGA GCTGTGCTCC TGGTACCAGT CCTTCCTGAA GGACTGTCCC 
ACCGGCCGCA TCACCCAGCA GCAGTTCCAG AGCATCTACG CCAAGTTCTT CCCCGACACC 
GACCCCAAGG CCTACGCCCA GCATGTGTTC CGCAGCTTCG ATTCCAACCT CGACGGCACC 
CTGGACTTCA AGGAGTACGT CATCGCCCTG CACATGACCA CCGCGGGCAA GACCAACCAG 
AAGCTGGAGT GGGCCTTCTC CCTCTACGAC GTGGACGGTA ACGGGACCAT CAGCAAGAAT 
GAAGTGCTGG AGATCGTCAT GGCTATTTTC AAAATGATCA CTCCCGAGGA CGTGAAGCTC 
CTTCCAGACG ATGAAAACAC GCCGGAAAAG CGAGCCGAGA AGATCTGGAA GTACTTTGGA 
AAGAATGATG ATGATAAACT TACAGAGAAA GAATTCATTG AGGGGACACT GGCCAATAAG 
GAAATTCTGC GACTGATCCA GTTTGAGCCT CAAAAAGTGA AGGAAAAGAT GAAGAACGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002894.1
CDS	92..694
Translation	MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKMKNA

Target ORF information:

RefSeq Version	NM_002903.3
Organism	Homo sapiens(human)
Definition	Homo sapiens recoverin (RCVRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002903.3

ORF Insert Sequence:

ATGGGGAACA GCAAAAGTGG GGCCCTGTCC AAGGAGATCC TGGAGGAGCT GCAGCTGAAC 
ACCAAGTTCT CGGAGGAGGA GCTGTGCTCC TGGTACCAGT CCTTCCTGAA GGACTGTCCC 
ACCGGCCGCA TCACCCAGCA GCAGTTCCAG AGCATCTACG CCAAGTTCTT CCCCGACACC 
GACCCCAAGG CCTACGCCCA GCATGTGTTC CGCAGCTTCG ATTCCAACCT CGACGGCACC 
CTGGACTTCA AGGAGTACGT CATCGCCCTG CACATGACCA CCGCGGGCAA GACCAACCAG 
AAGCTGGAGT GGGCCTTCTC CCTCTACGAC GTGGACGGTA ACGGGACCAT CAGCAAGAAT 
GAAGTGCTGG AGATCGTCAT GGCTATTTTC AAAATGATCA CTCCCGAGGA CGTGAAGCTC 
CTTCCAGACG ATGAAAACAC GCCGGAAAAG CGAGCCGAGA AGATCTGGAA GTACTTTGGA 
AAGAATGATG ATGATAAACT TACAGAGAAA GAATTCATTG AGGGGACACT GGCCAATAAG 
GAAATTCTGC GACTGATCCA GTTTGAGCCT CAAAAAGTGA AGGAAAAGAT GAAGAACGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The cancer-retina antigen recoverin as a potential biomarker for renal tumors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(7)9899-907(2016 Jul)
Golovastova MO,Tsoy LV,Bocharnikova AV,Korolev DO,Gancharova OS,Alekseeva EA,Kuznetsova EB,Savvateeva LV,Skorikova EE,Strelnikov VV,Varshavsky VA,Vinarov AZ,Nikolenko VN,Glybochko PV,Zernii EY,Zamyatnin AA Jr,Bazhin AV,Philippov PP

Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.
Biochemistry54(49)7222-8(2015 Dec)
Kumar RP,Ranaghan MJ,Ganjei AY,Oprian DD

Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association.
Amino acids42(4)1435-42(2012 Apr)
Permyakov SE,Zernii EY,Knyazeva EL,Denesyuk AI,Nazipova AA,Kolpakova TV,Zinchenko DV,Philippov PP,Permyakov EA,Senin II

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Investigative ophthalmology & visual science52(9)6662-70(2011 Aug)
Oshikawa M,Tsutsui C,Ikegami T,Fuchida Y,Matsubara M,Toyama S,Usami R,Ohtoko K,Kato S

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RCVRN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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