OPN1LW cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPN1LW
Entrez Gene ID	5956
Full Name	opsin 1, long wave sensitive
Synonyms	CBBM,CBP,COD5,RCP,ROP
General protein information	Preferred Names opsin 1, long wave sensitive Names long-wave-sensitive opsin 1 cone dystrophy 5 (X-linked) opsin 1 (cone pigments), long-wave-sensitive red cone opsin red cone photoreceptor pigment red-sensitive opsin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008].
Disorder MIM:	300822
Disorder Html:	Colorblindness, protan, 303900 (3); Blue cone monochromacy, 303700 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_020061.6	NP_064445.2	long-wave-sensitive opsin 1
NM_020061.5	NP_064445.2	long-wave-sensitive opsin 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OPN1LW	NP_776991.1
Gallus gallus (chicken)	OPN1LW	NP_990771.1
Danio rerio (zebrafish)	opn1lw1	NP_571250.1
Pan troglodytes (chimpanzee)	OPN1LW	XP_003317827.1
Rattus norvegicus (Norway rat)	Opn1mw	NP_446000.1
Mus musculus (house mouse)	Opn1mw	NP_032132.1
Danio rerio (zebrafish)	opn1lw2	NP_001002443.1
Homo sapiens (human)	OPN1LW	NP_064445.2
Canis lupus familiaris (dog)	OPN1LW	NP_001184001.1
Xenopus tropicalis (tropical clawed frog)	opn1lw	NP_001096331.1

Gene Ontology
Bibliography

Related articles in PubMed

Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X.
Orosz O, Rajta I, Vajas A, Tak?cs L, Csutak A, Fodor M, Kolozsv?ri B, Resch M, S?nyi K, Lesch B, Szab? V, Berta A, Balogh I, Losonczy G
Investigative ophthalmology & visual science58(3)1834-1842(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LVAVA haplotype of the OPN1LW gene and MVAVA haplotype of the OPN1MW gene cause apparently nonsyndromic high myopia in young patients but lead to progressive cone-rod dystrophy with deuteranopia and protanopia in middle-aged patients corresponding to a previously unknown disease course.
Title: Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X.

Data suggest that insights into dimerization interface of red cone opsin should aid investigations of the structure and function of GPCR cell signaling.
Title: A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins.

In conclusion, we showed that normal-order gene array is frequently found in Japanese men with protan color-vision defect and that three novel mutations, Trp177STOP, -99T>G and +3A>C (intron 2) could have caused protanopia in the recently analyzed cases.
Title: Novel mutations in the L visual pigment gene found in Japanese men with protan color-vision defect having a normal order L/M gene array.

Findings show that OPN1LW mutations underlie the cone dysfunction in all of the subjects tested, the color vision defect can be caused either by the same mutation or a gene rearrangement at the same locus
Title: Cone Photoreceptor Structure in Patients With X-Linked Cone Dysfunction and Red-Green Color Vision Deficiency.

The study reports on a different regeneration mechanism among red and green cone opsins with retinal analogs using UV-Vis/fluorescence spectroscopic analyses, molecular modeling and site-directed mutagenesis.
Title: Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration.

The following OPN1LW gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPN1LW cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21082	NM_020061.6 Latest version!	Homo sapiens opsin 1, long wave sensitive (OPN1LW), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu21082	NM_020061.5	Homo sapiens opsin 1, long wave sensitive (OPN1LW), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPN1LW ( NM_020061.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_064445.2 Homo sapiens opsin 1, long wave sensitive (OPN1LW), mRNA.

Price & Availability↑

CloneID	OHu21082
Clone ID Related Accession (Same CDS sequence)	NM_020061.6 , NM_020061.5
Accession Version	NM_020061.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	long-wave-sensitive opsin 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN693335.1, BQ639996.1, EL949562.1, BM688032.1 and BU726889.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_020061.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR749814.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369951.9/ ENSP00000358967.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC 
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG 
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG 
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA 
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG 
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT 
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC 
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG 
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG 
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC 
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC 
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT 
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG 
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG 
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064445.2
CDS	42..1136
Translation	MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA

Target ORF information:

RefSeq Version	NM_020061.6
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 1, long wave sensitive (OPN1LW), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020061.6

ORF Insert Sequence:

ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC 
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG 
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG 
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA 
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG 
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT 
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC 
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG 
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG 
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC 
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC 
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT 
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG 
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG 
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPN1LW ( NM_020061.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_064445.2 Homo sapiens opsin 1, long wave sensitive (OPN1LW), mRNA.

Price & Availability↑

CloneID	OHu21082
Clone ID Related Accession (Same CDS sequence)	NM_020061.6 , NM_020061.5
Accession Version	NM_020061.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	long-wave-sensitive opsin 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN693335.1, BQ639996.1, EL949562.1, BM688032.1 and BU726889.1. This sequence is a reference standard in the RefSeqGene project. On Sep 6, 2013 this sequence version replaced NM_020061.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR749814.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:12051694) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC 
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG 
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG 
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA 
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG 
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT 
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC 
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG 
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG 
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC 
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC 
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT 
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG 
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG 
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064445.2
CDS	61..1155
Translation	MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA

Target ORF information:

RefSeq Version	NM_020061.5
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 1, long wave sensitive (OPN1LW), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020061.5

ORF Insert Sequence:

ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC 
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG 
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG 
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA 
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG 
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT 
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC 
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG 
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG 
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC 
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC 
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT 
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG 
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG 
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X.
Investigative ophthalmology & visual science58(3)1834-1842(2017 03)
Orosz O,Rajta I,Vajas A,Tak?cs L,Csutak A,Fodor M,Kolozsv?ri B,Resch M,S?nyi K,Lesch B,Szab? V,Berta A,Balogh I,Losonczy G

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OPN1LW cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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