UBL5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UBL5
Entrez Gene ID	59286
Full Name	ubiquitin like 5
Synonyms	HUB1
General protein information	Preferred Names ubiquitin like 5 Names ubiquitin-like protein 5 beacon testicular tissue protein Li 217
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013].
Disorder MIM:	606849

mRNA and Protein(s)

mRNA	Protein	Name
NM_024292.3	NP_077268.1	ubiquitin-like protein 5
NM_001048241.2	NP_001041706.1	ubiquitin-like protein 5
NM_001048241.3	NP_001041706.1	ubiquitin-like protein 5
NM_024292.4	NP_077268.1	ubiquitin-like protein 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UBL5	NP_001032799.1
Danio rerio (zebrafish)	zgc:66388	NP_957435.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011251	XP_309393.2
Saccharomyces cerevisiae (baker's yeast)	HUB1	NP_014430.1
Xenopus tropicalis (tropical clawed frog)	ubl5	NP_001119591.1
Homo sapiens (human)	UBL5	NP_001041706.1
Canis lupus familiaris (dog)	UBL5	XP_854056.1
Kluyveromyces lactis	KLLA0C08470g	XP_452578.1
Pan troglodytes (chimpanzee)	UBL5	XP_512356.2
Rattus norvegicus (Norway rat)	Ubl5	NP_001041708.2
Schizosaccharomyces pombe (fission yeast)	hub1	NP_595099.1
Oryza sativa (rice)	Os12g0143150	NP_001176788.1
Drosophila melanogaster (fruit fly)	ubl	NP_610239.1
	UBL5	XP_002801110.1
Mus musculus (house mouse)	Ubl5	NP_079677.1
Caenorhabditis elegans (roundworm)	ubl-5	NP_491640.1
Arabidopsis thaliana (thale cress)	AT3G45180	NP_190104.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.
Oka Y, Bekker-Jensen S, Mailand N
The EMBO journal34(10)1385-98(2015 May)

UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells.
Oka Y, Varmark H, Vitting-Seerup K, Beli P, Waage J, Hakobyan A, Mistrik M, Choudhary C, Rohde M, Bekker-Jensen S, Mailand N
EMBO reports15(9)956-64(2014 Sep)

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA, Boerwinkle E
The pharmacogenomics journal14(1)35-40(2014 Feb)

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

Human UBL5 protein interacts with coilin and meets the Cajal bodies.
Sv?da M, Castor?lov? M, Lipov J, Ruml T, Knejzl?k Z
Biochemical and biophysical research communications436(2)240-5(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings establish UBL5 as a factor that promotes the functionality of the FA DNA repair pathway.
Title: Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.

our results show that UBL5 plays an evolutionary conserved role in pre-mRNA splicing, the integrity of which is essential for the fidelity of chromosome segregation.
Title: UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells.

Results suggest that UBL5 could be targeted to Cajal bodies (CBs) via its interaction with coilin.
Title: Human UBL5 protein interacts with coilin and meets the Cajal bodies.

Observational study of gene-disease association. (HuGE Navigator)
Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of sequence variants in the UBL5 (ubiquitin-like 5 or BEACON) gene in obese children by PCR-SSCP: no evidence for association with obesity.

The following UBL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17331	NM_001048241.3 Latest version!	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17331	NM_024292.4 Latest version!	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17331	NM_001048241.2	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17331	NM_024292.3	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UBL5 ( NM_024292.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_077268.1 Homo sapiens ubiquitin like 5 (UBL5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17331
Clone ID Related Accession (Same CDS sequence)	NM_024292.3 , NM_001048241.2 , NM_001048241.3 , NM_024292.4
Accession Version	NM_024292.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	ubiquitin-like protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK128885.1, BC007053.1 and CA418471.1. On Sep 28, 2006 this sequence version replaced NM_024292.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128885.1, SRR1163655.465860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077268.1
CDS	185..406
Translation	MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ

Target ORF information:

RefSeq Version	NM_024292.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024292.3

ORF Insert Sequence:

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBL5 ( NM_001048241.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001041706.1 Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17331
Clone ID Related Accession (Same CDS sequence)	NM_024292.3 , NM_001048241.2 , NM_001048241.3 , NM_024292.4
Accession Version	NM_001048241.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	ubiquitin-like protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AV682189.1, BP213482.1, BC110839.1 and CA418471.1. On Dec 2, 2011 this sequence version replaced NM_001048241.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005530.1, BP263618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041706.1
CDS	117..338
Translation	MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ

Target ORF information:

RefSeq Version	NM_001048241.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048241.2

ORF Insert Sequence:

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBL5 ( NM_001048241.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001041706.1 Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17331
Clone ID Related Accession (Same CDS sequence)	NM_024292.3 , NM_001048241.2 , NM_001048241.3 , NM_024292.4
Accession Version	NM_001048241.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	ubiquitin-like protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP213482.1, BC110839.1 and CA418471.1. On Jun 2, 2019 this sequence version replaced NM_001048241.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB108812.1, CB107673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041706.1
CDS	79..300
Translation	MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ

Target ORF information:

RefSeq Version	NM_001048241.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048241.3

ORF Insert Sequence:

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBL5 ( NM_024292.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_077268.1 Homo sapiens ubiquitin like 5 (UBL5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17331
Clone ID Related Accession (Same CDS sequence)	NM_024292.3 , NM_001048241.2 , NM_001048241.3 , NM_024292.4
Accession Version	NM_024292.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	ubiquitin-like protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK128885.1, BC007053.1 and CA418471.1. On Jun 2, 2019 this sequence version replaced NM_024292.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP208220.1, AK128885.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077268.1
CDS	159..380
Translation	MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ

Target ORF information:

RefSeq Version	NM_024292.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin like 5 (UBL5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024292.4

ORF Insert Sequence:

ATGATCGAGG TTGTTTGCAA CGACCGTCTG GGGAAGAAGG TCCGCGTTAA ATGCAACACG 
GATGATACCA TCGGGGACCT TAAGAAGCTG ATTGCAGCCC AAACTGGTAC CCGTTGGAAC 
AAGATTGTCC TGAAGAAGTG GTACACGATT TTTAAGGACC ACGTGTCTCT GGGGGACTAT 
GAAATCCACG ATGGGATGAA CCTGGAGCTT TATTATCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.
The EMBO journal34(10)1385-98(2015 May)
Oka Y,Bekker-Jensen S,Mailand N

UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells.
EMBO reports15(9)956-64(2014 Sep)
Oka Y,Varmark H,Vitting-Seerup K,Beli P,Waage J,Hakobyan A,Mistrik M,Choudhary C,Rohde M,Bekker-Jensen S,Mailand N

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
The pharmacogenomics journal14(1)35-40(2014 Feb)
Del-Aguila JL,Beitelshees AL,Cooper-Dehoff RM,Chapman AB,Gums JG,Bailey K,Gong Y,Turner ST,Johnson JA,Boerwinkle E

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

Human UBL5 protein interacts with coilin and meets the Cajal bodies.
Biochemical and biophysical research communications436(2)240-5(2013 Jun)
Sv?da M,Castor?lov? M,Lipov J,Ruml T,Knejzl?k Z

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UBL5 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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