RARS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RARS1
Entrez Gene ID	5917
Full Name	arginyl-tRNA synthetase
Synonyms	ArgRS,DALRD1,HLD9
General protein information	Preferred Names arginyl-tRNA synthetase Names arginine--tRNA ligase, cytoplasmic arginine tRNA ligase 1, cytoplasmic arginyl-tRNA synthetase, cytoplasmic
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q34
Summary	Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008].
Disorder MIM:	107820
Disorder Html:	Leukodystrophy, hypomyelinating, 9, 616140 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002887.3	NP_002878.2	arginine--tRNA ligase, cytoplasmic
NM_002887.4	NP_002878.2	arginine--tRNA ligase, cytoplasmic

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rars	NP_080212.2
Rattus norvegicus (Norway rat)	Rars	NP_001099247.2
Gallus gallus (chicken)	RARS	NP_001025778.1
Danio rerio (zebrafish)	rars	NP_956342.1
Drosophila melanogaster (fruit fly)	Aats-arg	NP_573081.1
	RARS	XP_001091294.1
Canis lupus familiaris (dog)	RARS	XP_853102.1
Arabidopsis thaliana (thale cress)	AT1G66530	NP_176826.1
Homo sapiens (human)	RARS	NP_002878.2
Pan troglodytes (chimpanzee)	RARS	NP_001233498.1
Bos taurus (cattle)	RARS	NP_001098808.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004708	XP_318119.3
Caenorhabditis elegans (roundworm)	rars-1	NP_001022551.1
Arabidopsis thaliana (thale cress)	emb1027	NP_194360.1
Oryza sativa (rice)	Os05g0163000	NP_001054732.1
Xenopus tropicalis (tropical clawed frog)	rars	NP_989403.1

Gene Ontology
Bibliography

Related articles in PubMed

The
Zhong Q, Liu ZH, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X, Zeng MS
Clinical cancer research : an official journal of the American Association for Cancer Research(2017 Nov)

Mutations in RARS cause a hypomyelination disorder akin to Pelizaeus-Merzbacher disease.
Nafisinia M, Sobreira N, Riley L, Gold W, Uhlenberg B, Wei? C, Boehm C, Prelog K, Ouvrier R, Christodoulou J
European journal of human genetics : EJHG25(10)1134-1141(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The N terminus of pro-endothelial monocyte-activating polypeptide II (EMAP II) regulates its binding with the C terminus, arginyl-tRNA synthetase, and neurofilament light protein.
Xu H, Malinin NL, Awasthi N, Schwarz RE, Schwarz MA
The Journal of biological chemistry290(15)9753-66(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Missense variant Ser456Leu and a de novo deletion Tyr616Leufs*6 cause disorder akin to Pelizaeus-Merzbacher disease.
Title: Mutations in RARS cause a hypomyelination disorder akin to Pelizaeus-Merzbacher disease.

Data indicate that the N terminus of Pro-EMAP II binds to its C terminus, arginyl-tRNA synthetase, and the neurofilament light subunit.
Title: The N terminus of pro-endothelial monocyte-activating polypeptide II (EMAP II) regulates its binding with the C terminus, arginyl-tRNA synthetase, and neurofilament light protein.

interactions between the N-terminal domains of ArgRS and AIMP1 are important for the catalytic and noncatalytic activities of ArgRS and for the assembly of the higher-order MSC protein complex with ArgRS-GlnRS-AIMP1
Title: Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation.

The mRNA of human cytoplasmic arginyl-tRNA synthetase recruits prokaryotic ribosomes independently.
Title: The mRNA of human cytoplasmic arginyl-tRNA synthetase recruits prokaryotic ribosomes independently.

The crystal structures of the L-arginine-complexed, and L-canavanine-complexed forms of arginyl-tRNA synthetase from Homo sapiens.
Title: The crystal structure of arginyl-tRNA synthetase from Homo sapiens.

The following RARS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RARS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02088	NM_002887.4 Latest version!	Homo sapiens arginyl-tRNA synthetase 1 (RARS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu02088	NM_002887.3	Homo sapiens arginyl-tRNA synthetase (RARS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RARS1 ( NM_002887.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002878.2 Homo sapiens arginyl-tRNA synthetase (RARS), mRNA.

Price & Availability↑

CloneID	OHu02088
Clone ID Related Accession (Same CDS sequence)	NM_002887.3 , NM_002887.4
Accession Version	NM_002887.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1983bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	arginine--tRNA ligase, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU125370.1, BT007394.1, BM984528.1 and CA439316.1. This sequence is a reference standard in the RefSeqGene project. On Dec 18, 2003 this sequence version replaced NM_002887.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222797.1, SRR1803616.190698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGTAC TGGTGTCTGA GTGCTCCGCG CGGCTGCTGC AGCAGGAAGA AGAGATTAAA 
TCTCTGACTG CTGAAATTGA CCGGTTGAAA AACTGTGGCT GTTTAGGAGC TTCTCCAAAT 
TTGGAGCAGT TACAAGAAGA AAATTTAAAA TTAAAGTATC GACTGAATAT TCTTCGAAAG 
AGTCTTCAGG CAGAAAGGAA CAAACCAACT AAAAATATGA TTAACATTAT TAGCCGCCTA 
CAAGAGGTCT TTGGTCATGC AATTAAGGCT GCATATCCAG ATTTGGAAAA TCCTCCTCTG 
CTAGTGACAC CAAGTCAGCA GGCCAAGTTT GGGGACTATC AGTGTAATAG TGCTATGGGT 
ATTTCTCAGA TGCTCAAAAC CAAGGAACAG AAAGTTAATC CAAGAGAAAT TGCTGAAAAC 
ATTACCAAAC ACCTCCCAGA CAATGAATGT ATTGAAAAAG TTGAAATTGC TGGTCCTGGT 
TTTATTAATG TCCACTTAAG AAAGGATTTT GTATCAGAAC AATTGACCAG TCTTCTAGTG 
AATGGAGTTC AACTACCTGC TCTGGGAGAG AATAAAAAGG TTATAGTTGA CTTTTCCTCC 
CCTAATATAG CTAAAGAGAT GCATGTAGGC CACCTGAGGT CAACTATCAT AGGAGAGAGT 
ATAAGCCGCC TCTTTGAATT TGCAGGGTAT GACGTGCTCA GGTTAAATCA TGTAGGAGAC 
TGGGGGACCC AGTTTGGCAT GCTCATCGCT CACCTGCAAG ACAAATTTCC AGATTATCTA 
ACAGTTTCAC CTCCTATTGG GGATCTTCAG GTCTTTTATA AGGAATCTAA GAAGAGGTTT 
GATACTGAGG AGGAATTTAA GAAGCGAGCA TATCAGTGTG TAGTTCTGCT CCAGGGTAAA 
AACCCAGATA TTACAAAAGC TTGGAAGCTT ATCTGTGATG TCTCCCGCCA AGAGTTAAAT 
AAAATCTATG ATGCATTGGA CGTCTCTTTA ATAGAGAGAG GGGAATCCTT CTATCAAGAT 
AGGATGAATG ATATTGTAAA GGAATTTGAA GATAGAGGAT TTGTGCAGGT GGATGATGGC 
AGAAAGATTG TATTTGTCCC AGGGTGTTCC ATACCATTAA CCATAGTAAA ATCAGATGGA 
GGTTATACCT ATGATACATC TGACCTGGCT GCTATTAAAC AAAGACTATT TGAGGAAAAA 
GCAGATATGA TTATCTATGT TGTGGACAAT GGACAATCTG TGCACTTCCA GACAATATTT 
GCTGCTGCTC AAATGATTGG TTGGTATGAC CCTAAAGTAA CTCGAGTCTT CCATGCTGGA 
TTTGGTGTGG TGCTAGGGGA AGACAAGAAA AAGTTTAAAA CACGTTCGGG TGAAACAGTG 
CGCCTCATGG ATCTTCTGGG AGAAGGACTA AAACGATCCA TGGACAAGTT GAAGGAAAAA 
GAAAGAGACA AGGTCTTAAC TGCAGAGGAA TTGAATGCTG CTCAGACATC CGTTGCGTAT 
GGCTGCATCA AATATGCTGA CCTTTCCCAT AACCGGTTGA ATGACTACAT CTTCTCCTTT 
GACAAAATGC TAGATGACAG AGGAAATACA GCTGCTTACT TGTTGTATGC CTTCACTAGA 
ATCAGGTCTA TTGCACGTCT GGCCAATATT GATGAAGAAA TGCTCCAAAA AGCTGCTCGA 
GAAACCAAGA TTCTTTTGGA TCATGAGAAG GAATGGAAAC TAGGCCGGTG CATTTTACGG 
TTCCCTGAGA TTCTGCAAAA GATTTTAGAT GACTTATTTC TCCACACTCT CTGTGATTAT 
ATATATGAGC TGGCAACTGC TTTCACAGAG TTCTATGATA GCTGCTACTG TGTGGAGAAA 
GATAGACAGA CTGGAAAAAT ATTGAAGGTG AACATGTGGC GTATGCTGCT ATGTGAAGCA 
GTAGCTGCTG TCATGGCCAA GGGGTTTGAT ATCCTGGGAA TAAAACCTGT CCAAAGGATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002878.2
CDS	42..2024
Translation	MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM

Target ORF information:

RefSeq Version	NM_002887.3
Organism	Homo sapiens(human)
Definition	Homo sapiens arginyl-tRNA synthetase (RARS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002887.3

ORF Insert Sequence:

ATGGACGTAC TGGTGTCTGA GTGCTCCGCG CGGCTGCTGC AGCAGGAAGA AGAGATTAAA 
TCTCTGACTG CTGAAATTGA CCGGTTGAAA AACTGTGGCT GTTTAGGAGC TTCTCCAAAT 
TTGGAGCAGT TACAAGAAGA AAATTTAAAA TTAAAGTATC GACTGAATAT TCTTCGAAAG 
AGTCTTCAGG CAGAAAGGAA CAAACCAACT AAAAATATGA TTAACATTAT TAGCCGCCTA 
CAAGAGGTCT TTGGTCATGC AATTAAGGCT GCATATCCAG ATTTGGAAAA TCCTCCTCTG 
CTAGTGACAC CAAGTCAGCA GGCCAAGTTT GGGGACTATC AGTGTAATAG TGCTATGGGT 
ATTTCTCAGA TGCTCAAAAC CAAGGAACAG AAAGTTAATC CAAGAGAAAT TGCTGAAAAC 
ATTACCAAAC ACCTCCCAGA CAATGAATGT ATTGAAAAAG TTGAAATTGC TGGTCCTGGT 
TTTATTAATG TCCACTTAAG AAAGGATTTT GTATCAGAAC AATTGACCAG TCTTCTAGTG 
AATGGAGTTC AACTACCTGC TCTGGGAGAG AATAAAAAGG TTATAGTTGA CTTTTCCTCC 
CCTAATATAG CTAAAGAGAT GCATGTAGGC CACCTGAGGT CAACTATCAT AGGAGAGAGT 
ATAAGCCGCC TCTTTGAATT TGCAGGGTAT GACGTGCTCA GGTTAAATCA TGTAGGAGAC 
TGGGGGACCC AGTTTGGCAT GCTCATCGCT CACCTGCAAG ACAAATTTCC AGATTATCTA 
ACAGTTTCAC CTCCTATTGG GGATCTTCAG GTCTTTTATA AGGAATCTAA GAAGAGGTTT 
GATACTGAGG AGGAATTTAA GAAGCGAGCA TATCAGTGTG TAGTTCTGCT CCAGGGTAAA 
AACCCAGATA TTACAAAAGC TTGGAAGCTT ATCTGTGATG TCTCCCGCCA AGAGTTAAAT 
AAAATCTATG ATGCATTGGA CGTCTCTTTA ATAGAGAGAG GGGAATCCTT CTATCAAGAT 
AGGATGAATG ATATTGTAAA GGAATTTGAA GATAGAGGAT TTGTGCAGGT GGATGATGGC 
AGAAAGATTG TATTTGTCCC AGGGTGTTCC ATACCATTAA CCATAGTAAA ATCAGATGGA 
GGTTATACCT ATGATACATC TGACCTGGCT GCTATTAAAC AAAGACTATT TGAGGAAAAA 
GCAGATATGA TTATCTATGT TGTGGACAAT GGACAATCTG TGCACTTCCA GACAATATTT 
GCTGCTGCTC AAATGATTGG TTGGTATGAC CCTAAAGTAA CTCGAGTCTT CCATGCTGGA 
TTTGGTGTGG TGCTAGGGGA AGACAAGAAA AAGTTTAAAA CACGTTCGGG TGAAACAGTG 
CGCCTCATGG ATCTTCTGGG AGAAGGACTA AAACGATCCA TGGACAAGTT GAAGGAAAAA 
GAAAGAGACA AGGTCTTAAC TGCAGAGGAA TTGAATGCTG CTCAGACATC CGTTGCGTAT 
GGCTGCATCA AATATGCTGA CCTTTCCCAT AACCGGTTGA ATGACTACAT CTTCTCCTTT 
GACAAAATGC TAGATGACAG AGGAAATACA GCTGCTTACT TGTTGTATGC CTTCACTAGA 
ATCAGGTCTA TTGCACGTCT GGCCAATATT GATGAAGAAA TGCTCCAAAA AGCTGCTCGA 
GAAACCAAGA TTCTTTTGGA TCATGAGAAG GAATGGAAAC TAGGCCGGTG CATTTTACGG 
TTCCCTGAGA TTCTGCAAAA GATTTTAGAT GACTTATTTC TCCACACTCT CTGTGATTAT 
ATATATGAGC TGGCAACTGC TTTCACAGAG TTCTATGATA GCTGCTACTG TGTGGAGAAA 
GATAGACAGA CTGGAAAAAT ATTGAAGGTG AACATGTGGC GTATGCTGCT ATGTGAAGCA 
GTAGCTGCTG TCATGGCCAA GGGGTTTGAT ATCCTGGGAA TAAAACCTGT CCAAAGGATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RARS1 ( NM_002887.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002878.2 Homo sapiens arginyl-tRNA synthetase 1 (RARS1), mRNA.

Price & Availability↑

CloneID	OHu02088
Clone ID Related Accession (Same CDS sequence)	NM_002887.3 , NM_002887.4
Accession Version	NM_002887.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1983bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	arginine--tRNA ligase, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU125370.1, BT007394.1, BM984528.1 and CA439316.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_002887.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1146952.1, SRR1803616.190698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231572.8/ ENSP00000231572.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGTAC TGGTGTCTGA GTGCTCCGCG CGGCTGCTGC AGCAGGAAGA AGAGATTAAA 
TCTCTGACTG CTGAAATTGA CCGGTTGAAA AACTGTGGCT GTTTAGGAGC TTCTCCAAAT 
TTGGAGCAGT TACAAGAAGA AAATTTAAAA TTAAAGTATC GACTGAATAT TCTTCGAAAG 
AGTCTTCAGG CAGAAAGGAA CAAACCAACT AAAAATATGA TTAACATTAT TAGCCGCCTA 
CAAGAGGTCT TTGGTCATGC AATTAAGGCT GCATATCCAG ATTTGGAAAA TCCTCCTCTG 
CTAGTGACAC CAAGTCAGCA GGCCAAGTTT GGGGACTATC AGTGTAATAG TGCTATGGGT 
ATTTCTCAGA TGCTCAAAAC CAAGGAACAG AAAGTTAATC CAAGAGAAAT TGCTGAAAAC 
ATTACCAAAC ACCTCCCAGA CAATGAATGT ATTGAAAAAG TTGAAATTGC TGGTCCTGGT 
TTTATTAATG TCCACTTAAG AAAGGATTTT GTATCAGAAC AATTGACCAG TCTTCTAGTG 
AATGGAGTTC AACTACCTGC TCTGGGAGAG AATAAAAAGG TTATAGTTGA CTTTTCCTCC 
CCTAATATAG CTAAAGAGAT GCATGTAGGC CACCTGAGGT CAACTATCAT AGGAGAGAGT 
ATAAGCCGCC TCTTTGAATT TGCAGGGTAT GACGTGCTCA GGTTAAATCA TGTAGGAGAC 
TGGGGGACCC AGTTTGGCAT GCTCATCGCT CACCTGCAAG ACAAATTTCC AGATTATCTA 
ACAGTTTCAC CTCCTATTGG GGATCTTCAG GTCTTTTATA AGGAATCTAA GAAGAGGTTT 
GATACTGAGG AGGAATTTAA GAAGCGAGCA TATCAGTGTG TAGTTCTGCT CCAGGGTAAA 
AACCCAGATA TTACAAAAGC TTGGAAGCTT ATCTGTGATG TCTCCCGCCA AGAGTTAAAT 
AAAATCTATG ATGCATTGGA CGTCTCTTTA ATAGAGAGAG GGGAATCCTT CTATCAAGAT 
AGGATGAATG ATATTGTAAA GGAATTTGAA GATAGAGGAT TTGTGCAGGT GGATGATGGC 
AGAAAGATTG TATTTGTCCC AGGGTGTTCC ATACCATTAA CCATAGTAAA ATCAGATGGA 
GGTTATACCT ATGATACATC TGACCTGGCT GCTATTAAAC AAAGACTATT TGAGGAAAAA 
GCAGATATGA TTATCTATGT TGTGGACAAT GGACAATCTG TGCACTTCCA GACAATATTT 
GCTGCTGCTC AAATGATTGG TTGGTATGAC CCTAAAGTAA CTCGAGTCTT CCATGCTGGA 
TTTGGTGTGG TGCTAGGGGA AGACAAGAAA AAGTTTAAAA CACGTTCGGG TGAAACAGTG 
CGCCTCATGG ATCTTCTGGG AGAAGGACTA AAACGATCCA TGGACAAGTT GAAGGAAAAA 
GAAAGAGACA AGGTCTTAAC TGCAGAGGAA TTGAATGCTG CTCAGACATC CGTTGCGTAT 
GGCTGCATCA AATATGCTGA CCTTTCCCAT AACCGGTTGA ATGACTACAT CTTCTCCTTT 
GACAAAATGC TAGATGACAG AGGAAATACA GCTGCTTACT TGTTGTATGC CTTCACTAGA 
ATCAGGTCTA TTGCACGTCT GGCCAATATT GATGAAGAAA TGCTCCAAAA AGCTGCTCGA 
GAAACCAAGA TTCTTTTGGA TCATGAGAAG GAATGGAAAC TAGGCCGGTG CATTTTACGG 
TTCCCTGAGA TTCTGCAAAA GATTTTAGAT GACTTATTTC TCCACACTCT CTGTGATTAT 
ATATATGAGC TGGCAACTGC TTTCACAGAG TTCTATGATA GCTGCTACTG TGTGGAGAAA 
GATAGACAGA CTGGAAAAAT ATTGAAGGTG AACATGTGGC GTATGCTGCT ATGTGAAGCA 
GTAGCTGCTG TCATGGCCAA GGGGTTTGAT ATCCTGGGAA TAAAACCTGT CCAAAGGATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002878.2
CDS	29..2011
Translation	MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM

Target ORF information:

RefSeq Version	NM_002887.4
Organism	Homo sapiens(human)
Definition	Homo sapiens arginyl-tRNA synthetase 1 (RARS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002887.4

ORF Insert Sequence:

ATGGACGTAC TGGTGTCTGA GTGCTCCGCG CGGCTGCTGC AGCAGGAAGA AGAGATTAAA 
TCTCTGACTG CTGAAATTGA CCGGTTGAAA AACTGTGGCT GTTTAGGAGC TTCTCCAAAT 
TTGGAGCAGT TACAAGAAGA AAATTTAAAA TTAAAGTATC GACTGAATAT TCTTCGAAAG 
AGTCTTCAGG CAGAAAGGAA CAAACCAACT AAAAATATGA TTAACATTAT TAGCCGCCTA 
CAAGAGGTCT TTGGTCATGC AATTAAGGCT GCATATCCAG ATTTGGAAAA TCCTCCTCTG 
CTAGTGACAC CAAGTCAGCA GGCCAAGTTT GGGGACTATC AGTGTAATAG TGCTATGGGT 
ATTTCTCAGA TGCTCAAAAC CAAGGAACAG AAAGTTAATC CAAGAGAAAT TGCTGAAAAC 
ATTACCAAAC ACCTCCCAGA CAATGAATGT ATTGAAAAAG TTGAAATTGC TGGTCCTGGT 
TTTATTAATG TCCACTTAAG AAAGGATTTT GTATCAGAAC AATTGACCAG TCTTCTAGTG 
AATGGAGTTC AACTACCTGC TCTGGGAGAG AATAAAAAGG TTATAGTTGA CTTTTCCTCC 
CCTAATATAG CTAAAGAGAT GCATGTAGGC CACCTGAGGT CAACTATCAT AGGAGAGAGT 
ATAAGCCGCC TCTTTGAATT TGCAGGGTAT GACGTGCTCA GGTTAAATCA TGTAGGAGAC 
TGGGGGACCC AGTTTGGCAT GCTCATCGCT CACCTGCAAG ACAAATTTCC AGATTATCTA 
ACAGTTTCAC CTCCTATTGG GGATCTTCAG GTCTTTTATA AGGAATCTAA GAAGAGGTTT 
GATACTGAGG AGGAATTTAA GAAGCGAGCA TATCAGTGTG TAGTTCTGCT CCAGGGTAAA 
AACCCAGATA TTACAAAAGC TTGGAAGCTT ATCTGTGATG TCTCCCGCCA AGAGTTAAAT 
AAAATCTATG ATGCATTGGA CGTCTCTTTA ATAGAGAGAG GGGAATCCTT CTATCAAGAT 
AGGATGAATG ATATTGTAAA GGAATTTGAA GATAGAGGAT TTGTGCAGGT GGATGATGGC 
AGAAAGATTG TATTTGTCCC AGGGTGTTCC ATACCATTAA CCATAGTAAA ATCAGATGGA 
GGTTATACCT ATGATACATC TGACCTGGCT GCTATTAAAC AAAGACTATT TGAGGAAAAA 
GCAGATATGA TTATCTATGT TGTGGACAAT GGACAATCTG TGCACTTCCA GACAATATTT 
GCTGCTGCTC AAATGATTGG TTGGTATGAC CCTAAAGTAA CTCGAGTCTT CCATGCTGGA 
TTTGGTGTGG TGCTAGGGGA AGACAAGAAA AAGTTTAAAA CACGTTCGGG TGAAACAGTG 
CGCCTCATGG ATCTTCTGGG AGAAGGACTA AAACGATCCA TGGACAAGTT GAAGGAAAAA 
GAAAGAGACA AGGTCTTAAC TGCAGAGGAA TTGAATGCTG CTCAGACATC CGTTGCGTAT 
GGCTGCATCA AATATGCTGA CCTTTCCCAT AACCGGTTGA ATGACTACAT CTTCTCCTTT 
GACAAAATGC TAGATGACAG AGGAAATACA GCTGCTTACT TGTTGTATGC CTTCACTAGA 
ATCAGGTCTA TTGCACGTCT GGCCAATATT GATGAAGAAA TGCTCCAAAA AGCTGCTCGA 
GAAACCAAGA TTCTTTTGGA TCATGAGAAG GAATGGAAAC TAGGCCGGTG CATTTTACGG 
TTCCCTGAGA TTCTGCAAAA GATTTTAGAT GACTTATTTC TCCACACTCT CTGTGATTAT 
ATATATGAGC TGGCAACTGC TTTCACAGAG TTCTATGATA GCTGCTACTG TGTGGAGAAA 
GATAGACAGA CTGGAAAAAT ATTGAAGGTG AACATGTGGC GTATGCTGCT ATGTGAAGCA 
GTAGCTGCTG TCATGGCCAA GGGGTTTGAT ATCCTGGGAA TAAAACCTGT CCAAAGGATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The
Clinical cancer research : an official journal of the American Association for Cancer Research(2017 Nov)
Zhong Q,Liu ZH,Lin ZR,Hu ZD,Yuan L,Liu YM,Zhou AJ,Xu LH,Hu LJ,Wang ZF,Guan XY,Hao JJ,Lui VWY,Guo L,Mai HQ,Chen MY,Han F,Xia YF,Grandis JR,Zhang X,Zeng MS

Mutations in RARS cause a hypomyelination disorder akin to Pelizaeus-Merzbacher disease.
European journal of human genetics : EJHG25(10)1134-1141(2017 Oct)
Nafisinia M,Sobreira N,Riley L,Gold W,Uhlenberg B,Wei? C,Boehm C,Prelog K,Ouvrier R,Christodoulou J

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The N terminus of pro-endothelial monocyte-activating polypeptide II (EMAP II) regulates its binding with the C terminus, arginyl-tRNA synthetase, and neurofilament light protein.
The Journal of biological chemistry290(15)9753-66(2015 Apr)
Xu H,Malinin NL,Awasthi N,Schwarz RE,Schwarz MA

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RARS1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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